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  1. Article: Effects of Food and Temperature on

    Hara, Yusuke / Yamamoto, Daisuke

    Frontiers in physiology

    2022  Volume 12, Page(s) 803144

    Abstract: When exposed to harsh environmental conditions, such as food scarcity and/or low temperature, ...

    Abstract When exposed to harsh environmental conditions, such as food scarcity and/or low temperature,
    Language English
    Publishing date 2022-01-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2021.803144
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  2. Article ; Online: Interspecific tandem flights in nocturnally migrating terrestrial birds.

    Senzaki, Masayuki / Aoki, Daisuke / Kitazawa, Munehiro / Hara, Seiichi

    Ecology

    2023  Volume 104, Issue 3, Page(s) e3937

    MeSH term(s) Animals ; Birds ; Animal Migration
    Language English
    Publishing date 2023-01-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2010140-5
    ISSN 1939-9170 ; 0012-9658
    ISSN (online) 1939-9170
    ISSN 0012-9658
    DOI 10.1002/ecy.3937
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  3. Article: Nonepisodic angioedema with eosinophilia with remarkably high blood eosinophil counts.

    Hara, Kenji / Akasaka, Eijiro / Nakano, Hajime / Sawamura, Daisuke

    JAAD case reports

    2022  Volume 29, Page(s) 177–180

    Language English
    Publishing date 2022-09-23
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2834220-3
    ISSN 2352-5126
    ISSN 2352-5126
    DOI 10.1016/j.jdcr.2022.09.018
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  4. Article: Reconceptualization of Proximal Nail Fold Reconstruction: Skin Grafting over the Nail Plate.

    Hara, Runa / Matsumoto, Daisuke / Funabashi, Hitomi

    Plastic and reconstructive surgery. Global open

    2023  Volume 11, Issue 6, Page(s) e5047

    Abstract: The structure of the periungual area is complicated, resulting in historically difficult morphological reconstruction after trauma or cancer resection. There is also no established standard for its reconstruction; thus, we aimed to use a full-thickness ... ...

    Abstract The structure of the periungual area is complicated, resulting in historically difficult morphological reconstruction after trauma or cancer resection. There is also no established standard for its reconstruction; thus, we aimed to use a full-thickness skin graft (FTSG) over the nail plate. Three patients with Bowen disease on their proximal nail fold (PNF) underwent excision with a 2-mm margin preserving the nail matrix, and a temporary wound dressing was applied. The FTSG was harvested from the ipsilateral ulnar wrist joint and placed over the skin defect, including the nail plate. Initially, the FTSG seemed to have shrunken; however, after 3 months, it extended and the PNF had a good color and texture match. Remarkably, the FTSG adhered to the nail plate, and the complex PNF structure appeared well reconstructed. Occasionally, a local flap is used; however, it is limited to small defects and causes a deformity of the periungual structure. In this study, the reconstructed PNF showed good results. We presumed that the bridging phenomenon caused graft survival on the nail plate, and that the presence of stem cells near the nail matrix caused graft extension and eponychium and cuticle regeneration. Specifically, the acquisition of sufficient raw surface around the nail plate and wound preparation after excision resulted in the former, and the nail matrix preservation after excision contributed to the latter. This surgical technique is simple and can therefore be considered a remarkably effective method for periungual area reconstruction to date.
    Language English
    Publishing date 2023-06-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2851682-5
    ISSN 2169-7574 ; 2169-7574
    ISSN (online) 2169-7574
    ISSN 2169-7574
    DOI 10.1097/GOX.0000000000005047
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 7091: Show issues Location:
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  5. Article: Improvement of vertigo symptoms and acoustic power absorbance in cases with endolymphatic hydrops.

    Kobayashi, Masumi / Yoshida, Tadao / Fukunaga, Yukari / Hara, Daisuke / Sugimoto, Satofumi / Naganawa, Shinji / Sone, Michihiko

    Laryngoscope investigative otolaryngology

    2024  Volume 9, Issue 1, Page(s) e1210

    Abstract: Objective: The pathophysiology and symptoms underlying Meniere's disease (MD) manifest as endolymphatic hydrops (EH), potentially impacting acoustic power absorbance in vestibular EH. The longitudinal effects of middle ear pressure therapy (MEPT) and ... ...

    Abstract Objective: The pathophysiology and symptoms underlying Meniere's disease (MD) manifest as endolymphatic hydrops (EH), potentially impacting acoustic power absorbance in vestibular EH. The longitudinal effects of middle ear pressure therapy (MEPT) and conservative therapies for EH by magnetic resonance imaging (MRI) and on acoustic power absorbance on wideband acoustic immittance (WAI) were evaluated, and their changes were compared with clinical symptoms.
    Methods: Eleven patients with definite MD or delayed endolymphatic hydrops (DEH), resistant to conservative therapies and who continued MEPT for 1 year, were included. Vertigo scores, hearing levels, acoustic power absorbance on WAI, and degrees of EH on 3-T MRI were evaluated and compared before and after the treatments.
    Results: One year after the start of MEPT, all cases showed symptomatic improvement in vertigo score; however, the degrees of EH showed no improvements except in one case. In the affected ears with EH, their absorbances on WAI improved, particularly at 1580-1905 or 2400-2953 Hz (
    Conclusion: Alleviation of vestibular symptoms with the therapy of MD was not necessarily associated with improved EH. Vestibular symptoms could be related to the change in the impedance of inner ear pressure, which was proven by the normalization of acoustic power absorbance. Assessments of acoustic power absorbance may provide useful information for physiological conditions and causative factors of vertigo in ears with EH.
    Level of evidence: 4.
    Language English
    Publishing date 2024-01-08
    Publishing country United States
    Document type Journal Article
    ISSN 2378-8038
    ISSN 2378-8038
    DOI 10.1002/lio2.1210
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  6. Article ; Online: Sarcopenia is associated with lower step count in patients with peripheral artery disease following endovascular treatment.

    Takino, Koya / Hara, Yasutaka / Sakui, Daisuke / Kawamura, Itta / Kikuchi, Jun / Komoda, Takuyuki / Koeda, Tomoko

    Physiotherapy theory and practice

    2024  , Page(s) 1–8

    Abstract: Introduction: Patients with peripheral artery disease (PAD) often complain of reduced physical activity (PA) despite improvements in intermittent claudication after successful endovascular treatment (EVT). Sarcopenia resulting from chronic ischemia can ... ...

    Abstract Introduction: Patients with peripheral artery disease (PAD) often complain of reduced physical activity (PA) despite improvements in intermittent claudication after successful endovascular treatment (EVT). Sarcopenia resulting from chronic ischemia can affect post-EVT PA levels.
    Objective: This study aims to assess the association between sarcopenia and post-EVT PA levels.
    Methods: One hundred five patients with PAD were consecutively enrolled in this study. PA was assessed using the post-EVT step count and the pre-EVT International Physical Activity Questionnaire. Sarcopenia was diagnosed based on the Asia Working Group for Sarcopenia and defined as low muscle mass and strength, and/or slow walking speed. The patients were categorized into three groups: 1) patients with sarcopenia (Sarcopenia Group); 2) patients with only low muscle mass or strength, and/or slow walking speed (Suspected-Sarcopenia Group); and 3) patients who did not fulfill all the sarcopenia criteria (No-Sarcopenia Group).
    Results: Proportions of patients in the Sarcopenia, Suspected-Sarcopenia, and No-Sarcopenia Groups were 31.4, 38.1, and 30.5%, respectively. After controlling for potential confounders, the Sarcopenia Group demonstrated significantly lower step counts than the Suspected-Sarcopenia Group (
    Conclusions: Our findings indicate that patients with PAD and sarcopenia require rehabilitation strategies to enhance physical performance.
    Language English
    Publishing date 2024-02-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 1045333-7
    ISSN 1532-5040 ; 0959-3985
    ISSN (online) 1532-5040
    ISSN 0959-3985
    DOI 10.1080/09593985.2024.2319780
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    Zs.A 2190: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  7. Article ; Online: Endoscopic submucosal dissection for complete removal of a residual colorectal tumor involving a diverticulum.

    Hosotani, Kazuya / Yabuuchi, Yohei / Yamashita, Daisuke / Hara, Shigeo / Inokuma, Tetsuro

    Endoscopy

    2022  Volume 54, Issue S 02, Page(s) E908–E909

    Language English
    Publishing date 2022-07-01
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 80120-3
    ISSN 1438-8812 ; 0013-726X
    ISSN (online) 1438-8812
    ISSN 0013-726X
    DOI 10.1055/a-1864-9146
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    Zs.A 669: Show issues Location:
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    Zs.MO 162: Show issues

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  8. Article ; Online: Comparative Efficacy and Safety of Standard and Biweekly Trifluridine/Tipiracil Regimen in Patients With Colorectal Cancer.

    Hara, Shinsuke / Sakai, Daisuke / Ikemura, Kenji / Shintani, Takuya / Yamamoto, Tomoya / Satoh, Taroh / Okuda, Masahiro

    Anticancer research

    2024  Volume 44, Issue 3, Page(s) 1219–1226

    Abstract: Background/aim: Trifluridine/tipiracil (FTD/TPI) is used to treat metastatic colorectal cancer (mCRC). Since the standard regimen of FTD/TPI features a complex dosing schedule and frequently results in severe hematological toxicities, a simplified ... ...

    Abstract Background/aim: Trifluridine/tipiracil (FTD/TPI) is used to treat metastatic colorectal cancer (mCRC). Since the standard regimen of FTD/TPI features a complex dosing schedule and frequently results in severe hematological toxicities, a simplified regimen has emerged, in which FTD/TPI is orally administered biweekly. However, the survival benefits and potential adverse events associated with the biweekly FTD/TPI regimen have not been fully evaluated in previous reports. Therefore, in this study, the differences in efficacy and safety between the standard and biweekly FTD/TPI regimens were retrospectively investigated in patients with mCRC.
    Patients and methods: Data from 90 patients who received FTD/TPI for mCRC were extracted from the electronic medical records at the Osaka University Hospital. According to the inclusion and exclusion criteria, 85 of the 90 patients were enrolled in the study. We compared patient characteristics, overall survival (OS), progression-free survival (PFS), and adverse events between the standard (n=56) and biweekly groups (n=29).
    Results: The biweekly group exhibited prolonged OS and PFS compared to patients in the standard group. Multivariate analysis for OS and PFS demonstrated that the biweekly regimen was the only significant factor that affected OS, and not PFS (HR=0.561, p=0.049). Kaplan-Meier analysis indicated that neutropenia (grade ≥3) in the biweekly group was significantly prolonged compared to the standard group (p=0.012). However, there were no significant differences in adverse events between the two groups (p>0.999).
    Conclusion: The biweekly FTD/TPI regimen, compared to the standard regimen, should enhance both OS and PFS in patients with mCRC without escalating any adverse event.
    MeSH term(s) Humans ; Uracil/adverse effects ; Retrospective Studies ; Trifluridine/adverse effects ; Frontotemporal Dementia/chemically induced ; Colorectal Neoplasms/pathology ; Colonic Neoplasms/chemically induced ; Rectal Neoplasms ; Drug Combinations ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Pyrrolidines ; Thymine
    Chemical Substances tipiracil (NGO10K751P) ; Uracil (56HH86ZVCT) ; Trifluridine (RMW9V5RW38) ; Drug Combinations ; Pyrrolidines ; Thymine (QR26YLT7LT)
    Language English
    Publishing date 2024-02-29
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 604549-2
    ISSN 1791-7530 ; 0250-7005
    ISSN (online) 1791-7530
    ISSN 0250-7005
    DOI 10.21873/anticanres.16917
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    Zs.A 1642: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  9. Article ; Online: Gut microbiota of one-and-a-half-year-old food-allergic and healthy children.

    Hara, Monami / Suzuki, Hisato / Hayashi, Daisuke / Morii, Wataru / Nakamura, Takako / Kiyoki, Kaori / Hara, Hideki / Ishii, Ryota / Noguchi, Emiko / Takada, Hidetoshi

    Allergology international : official journal of the Japanese Society of Allergology

    2024  

    Abstract: Background: Intestinal bacteria may play a role in the development of food allergies. This study aimed to analyze and compare the gut microbiota of food-allergic children with that of healthy children of the same age.: Methods: Stool samples were ... ...

    Abstract Background: Intestinal bacteria may play a role in the development of food allergies. This study aimed to analyze and compare the gut microbiota of food-allergic children with that of healthy children of the same age.
    Methods: Stool samples were collected from one-and-a-half-year-old food-allergic (FA group, n = 29) and healthy controls (HC group, n = 19). A questionnaire was provided to examine the children's birth, dietary, medical, and social histories. The gut microbiota was profiled by 16S rRNA sequencing. Differences in taxonomic composition were assessed using linear discriminant analysis effect size (LEfSe), and microbial functional profiles were predicted with Tax4Fun2.
    Results: No significant difference in the alpha diversity index between the two groups; however, a negative correlation was observed between the Shannon diversity index and the relative abundance of Bacteroides. A significant difference was observed in beta diversity (permutational multivariate analysis of variance) in the bacterial composition between the FA and HC groups (P < 0.05). The FA group had a higher abundance of Escherichia and Anaeromassilibacillus and a lower abundance of Bacteroides, Oscillibacter, Ruminococcus, Hungateiclostridium and Anaerotaenia than the HC group (LEfSe: linear discriminant analysis score >2). The FA group showed a predicted increase in the expression levels of genes associated with intestinal pathogenicity compared with that in the HC group.
    Conclusions: The gut microbiota of food-allergic children has a higher abundance of bacteria involved in intestinal inflammation and a lower abundance of bacteria involved in immune tolerance than that of healthy children. This dysbiosis may also be associated with food allergies.
    Language English
    Publishing date 2024-04-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 1336498-4
    ISSN 1440-1592 ; 1323-8930
    ISSN (online) 1440-1592
    ISSN 1323-8930
    DOI 10.1016/j.alit.2024.03.004
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    Zs.A 5248: Show issues Location:
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  10. Article: Two Cases of Atypical Teratoid/Rhabdoid Tumor in the Spinal Cord: Loss of SMARCB1 in a Child and Loss of SMARCA4 in an Adult.

    Morisako, Tamaki / Umebayashi, Daisuke / Nagai, Toshiki / Yamanaka, Takumi / Hirose, Takanori / Shishido-Hara, Yukiko / Konishi, Eiich / Hashimoto, Naoya

    NMC case report journal

    2024  Volume 11, Page(s) 27–32

    Abstract: We compare two cases of primary spinal atypical teratoid/rhabdoid tumor (AT/RT), which rarely occurs in adults marked ... ...

    Abstract We compare two cases of primary spinal atypical teratoid/rhabdoid tumor (AT/RT), which rarely occurs in adults marked by
    Language English
    Publishing date 2024-01-31
    Publishing country Japan
    Document type Case Reports
    ISSN 2188-4226
    ISSN 2188-4226
    DOI 10.2176/jns-nmc.2022-0096
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