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  1. Book ; Online: Fast Facts: Ottimizzazione del trattamento delle fluttuazioni motorie nella malattia di Parkinson

    Stocchi, Fabrizio

    2020  

    Abstract: Sebbene la terapia dopaminergica rappresenti la forma di trattamento più efficace per i pazienti con malattia di Parkinson (MP), l’uso a lungo termine di questi farmaci è associato a fluttuazioni motorie invalidanti. Poiché i pazienti potrebbero non ... ...

    Title variant Fast Facts
    Author's details Fabrizio Stocchi, Thomas Foltynie
    Abstract Sebbene la terapia dopaminergica rappresenti la forma di trattamento più efficace per i pazienti con malattia di Parkinson (MP), l’uso a lungo termine di questi farmaci è associato a fluttuazioni motorie invalidanti. Poiché i pazienti potrebbero non richiedere spontaneamente assistenza quando si manifestano fluttuazioni, occorre adottare opportune strategie per identificare e alleviare la disfunzione motoria. Questo breve opuscolo intende sensibilizzare il lettore su quanto segue: • le diverse tipologie di fluttuazione motoria, il motivo per cui si manifestano e come riconoscerle • i farmaci eventualmente associabili alla levodopa per ridurre le fluttuazioni • terapie avanzate ed emergenti che consentiranno di migliorare i risultati Nessun paziente è uguale all’altro in termini di progressione della MP o risposta alla terapia. Questa pubblicazione di Fast Facts fornisce ai medici le informazioni necessarie per offrire un’assistenza personalizzata efficace, che migliorerà la qualità di vita dei pazienti. Indice: • Definizioni e fisiopatologia delle fluttuazioni motorie • Agenti che potenziano l’azione della levodopa • Terapie avanzate • Principi di gestione • Direzioni future
    Keywords Neurology
    Language Italian
    Size 1 online resource (48 pages) : , 12 figures, 11 in color, 4 tables
    Publisher S. Karger
    Publishing place Basel
    Document type Book ; Online
    ISBN 3-318-06630-3 ; 978-3-318-06630-2
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online: Fast Facts: Optimización del tratamiento de las fluctuaciones motoras en la enfermedad de Parkinson

    Stocchi, Fabrizio

    Adaptando el tratamiento al paciente

    2019  

    Abstract: Aunque la medicación dopaminérgica es el tratamiento más eficaz para los pacientes que padecen la enfermedad de Parkinson (EP), su uso prolongado está asociado con fluctuaciones motoras debilitantes. Es posible que los pacientes no busquen inmediatamente ...

    Title variant Fast Facts
    Author's details Fabrizio Stocchi, Thomas Foltynie
    Abstract Aunque la medicación dopaminérgica es el tratamiento más eficaz para los pacientes que padecen la enfermedad de Parkinson (EP), su uso prolongado está asociado con fluctuaciones motoras debilitantes. Es posible que los pacientes no busquen inmediatamente asistencia médica cuando aparecen las fluctuaciones, por eso es necesario implementar estrategias que permitan identificar y aliviar la disfunción motora. Este conciso recurso permitirá a los lectores conocer mejor: • los diferentes tipos de fluctuaciones motoras, por qué se producen y cómo reconocerlas • los fármacos que se pueden añadir a la levodopa para reducir las fluctuaciones • las terapias avanzadas y emergentes que ayudan a mejorar los resultados. No hay dos pacientes parkinsonianos con el mismo progreso de la enfermedad ni la misma respuesta al tratamiento. Esta obra Fast Facts proporciona a los profesionales de la salud la información que necesitan para ofrecer a sus pacientes una atención personalizada que mejore su calidad de vida.
    Keywords Neurology
    Language Spanish
    Size 1 online resource (48 pages) : , 12 figures, 11 in color, 4 tables
    Publisher S. Karger
    Publishing place Basel
    Document type Book ; Online
    ISBN 3-318-06614-1 ; 978-3-318-06614-2
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Book ; Online: Fast Facts : Treatment Optimization of Motor Fluctuations in Parkinson's Disease

    Stocchi, Fabrizio

    2019  

    Abstract: Although dopaminergic medication is the most effective treatment for patients with Parkinson’s disease (PD), its long-term use is associated with debilitating motor fluctuations. Patients may not spontaneously seek assistance when fluctuations develop, ... ...

    Title variant Fast Facts
    Author's details Fabrizio Stocchi, Thomas Foltynie
    Abstract Although dopaminergic medication is the most effective treatment for patients with Parkinson’s disease (PD), its long-term use is associated with debilitating motor fluctuations. Patients may not spontaneously seek assistance when fluctuations develop, so strategies need to be put in place to identify and alleviate motor dysfunction. This concise resource will increase readers’ awareness of: • the different types of motor fluctuation, why they occur and how to recognize them • the drugs that can be added to levodopa to reduce fluctuations • advanced and emerging therapies that will help to improve outcomes. No two patients with PD are alike in their disease progression or response to treatment. This 'Fast Facts' title provides the information healthcare professionals need to provide effective individualized care that will improve their patients’ quality of life.
    Keywords Neurology ; Gerontology / Geriatrics
    Language English
    Size 1 online resource (48 pages) :, 12 figures, 11 in color, 4 tables
    Publisher S. Karger
    Publishing place Basel
    Document type Book ; Online
    ISBN 1-912776-25-1 ; 1-912776-24-3 ; 978-1-912776-25-2 ; 978-1-912776-24-5
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Book: Parkinson's disease

    Olanow, Charles W. / Stocchi, Fabrizio / Lang, Anthony E.

    non-motor and non-dopaminergic features

    2011  

    Author's details ed. by C. Warren Olanow ; Fabrizio Stocchi ; Anthony E. Lang
    Keywords Parkinson Disease / complications ; Parkinson Disease / physiopathology ; Dopamine / physiology
    Language English
    Size X, 474 S. : Ill., graph. Darst., 29 cm
    Publisher Wiley-Blackwell
    Publishing place Chichester u.a.
    Publishing country Great Britain
    Document type Book
    Note Formerly CIP Uk. - Includes bibliographical references and index
    HBZ-ID HT016950527
    ISBN 978-1-4051-9185-2 ; 1-4051-9185-6
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2011 A 3417 order for loan Magazin

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  5. Article ; Online: Neuroprotection in Parkinson's disease: a difficult challenge.

    Stocchi, Fabrizio

    The Lancet. Neurology

    2015  Volume 14, Issue 8, Page(s) 780–781

    MeSH term(s) Female ; Humans ; Male ; Neuroprotective Agents/pharmacology ; Parkinson Disease/drug therapy ; Thiazolidinediones/pharmacology
    Chemical Substances Neuroprotective Agents ; Thiazolidinediones
    Language English
    Publishing date 2015-08
    Publishing country England
    Document type Comment ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2079704-7
    ISSN 1474-4465 ; 1474-4422
    ISSN (online) 1474-4465
    ISSN 1474-4422
    DOI 10.1016/S1474-4422(15)00143-X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book: Levodopa, benserazide in formulazione dispersibile

    Stocchi, Fabrizio

    (Nuova rivista di neurologia ; 5,6, Suppl.)

    1995  

    Author's details Fabrizio Stocchi
    Series title Nuova rivista di neurologia ; 5,6, Suppl.
    Collection
    Keywords Levodopa / therapeutic use ; Levodopa / pharmacokinetics ; Benserazide / pharmacokinetics ; Benserazide / therapeutic use ; Antiparkinson Agents / therapeutic use ; Drug Combinations ; Parkinson Disease / drug therapy ; Dosage Forms
    Language Italian
    Size 18 S. : Ill., graph. Darst.
    Publisher Pensiero Scientifico Ed
    Publishing place Roma
    Publishing country Italy
    Document type Book
    HBZ-ID HT007157295
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Ui II Zs 183 -5,6,Suppl.[6]- verfügbar in Königswinter Königswinter

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  7. Article ; Online: A systematic review on the clinical experience with melevodopa/carbidopa fixed combination in patients with Parkinson disease.

    Stocchi, Fabrizio / Vacca, Laura

    Minerva medica

    2020  Volume 110, Issue 6, Page(s) 575–585

    Abstract: Introduction: We have performed a systematic literature review to evaluate the current evidence of the pharmacokinetic (PK), efficacy and safety profile of oral melevodopa/carbidopa fixed combination in the management of motor fluctuations in patients ... ...

    Abstract Introduction: We have performed a systematic literature review to evaluate the current evidence of the pharmacokinetic (PK), efficacy and safety profile of oral melevodopa/carbidopa fixed combination in the management of motor fluctuations in patients with Parkinson disease (PD).
    Evidence acquisition: Search has been started from common libraries and was then restricted to articles of studies in humans with melevodopa/carbidopa as fixed combination. Abstracts of international congresses have been also explored. The search has led to the identification of one PK study and five efficacy/safety studies that included more 743 PD patients overall, 488 of which treated with melevodopa/carbidopa effervescent tablets (Sirio®, Chiesi Farmaceutici S.p.A., Parma, Italy).
    Evidence synthesis: Melevodopa/carbidopa has a more rapid absorption, less apparent drug accumulation, less inter-patient variability and more effective LD delivery after the early morning and early afternoon dose compared to standard LD. Although they differed in used dose regimens, duration of treatment and endpoints, the results of the efficacy/safety studies suggest that treatment with melevodopa/carbidopa may determine improvements in motor fluctuations compared to treatment with standard LD/CD formulations, with no increased risk of adverse effects or LD-induced dyskinesias.
    Conclusions: Data from literature have shown that melevodopa/carbidopa in a highly soluble formulation as effervescent oral tablets is effective in improving control of motor complications in PD patients compared to conventional levodopa. Further research is needed to confirm this evidence in large controlled trials and to explore if melevodopa/carbidopa may have a potential role in the earlier phases of the disease or in special PD populations.
    MeSH term(s) Antiparkinson Agents/administration & dosage ; Carbidopa/therapeutic use ; Drug Combinations ; Humans ; Levodopa/therapeutic use ; Parkinson Disease/drug therapy
    Chemical Substances Antiparkinson Agents ; Drug Combinations ; carbidopa, levodopa drug combination ; Levodopa (46627O600J) ; Carbidopa (MNX7R8C5VO)
    Language English
    Publishing date 2020-01-22
    Publishing country Italy
    Document type Journal Article ; Systematic Review
    ZDB-ID 123586-2
    ISSN 1827-1669 ; 0026-4806
    ISSN (online) 1827-1669
    ISSN 0026-4806
    DOI 10.23736/S0026-4806.19.06330-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.132: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: An evaluation of the efficacy and value of CVT-301 for the treatment of Parkinson's disease.

    Stocchi, Fabrizio / Vacca, Laura / Grassi, Andrea / Torti, Margherita

    Expert opinion on pharmacotherapy

    2021  Volume 22, Issue 8, Page(s) 965–972

    Abstract: ... ...

    Abstract Introduction
    MeSH term(s) Administration, Inhalation ; Antiparkinson Agents/therapeutic use ; Biological Availability ; Humans ; Levodopa/therapeutic use ; Parkinson Disease/drug therapy
    Chemical Substances Antiparkinson Agents ; Levodopa (46627O600J)
    Language English
    Publishing date 2021-04-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2001535-5
    ISSN 1744-7666 ; 1465-6566
    ISSN (online) 1744-7666
    ISSN 1465-6566
    DOI 10.1080/14656566.2021.1895748
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5130: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Physical activity and neurotrophic factors as potential drivers of neuroplasticity in Parkinson's Disease: A systematic review and meta-analysis.

    Rotondo, Rossella / Proietti, Stefania / Perluigi, Marzia / Padua, Elvira / Stocchi, Fabrizio / Fini, Massimo / Stocchi, Vilberto / Volpe, Daniele / De Pandis, Maria Francesca

    Ageing research reviews

    2023  Volume 92, Page(s) 102089

    Abstract: Parkinson's disease (PD) is a neurodegenerative disorder, characterized by motor and non-motor symptoms, that still lacks of a disease-modifying treatment. Consistent evidence proved the benefits of physical therapy on motor and non-motor symptoms in PD ... ...

    Abstract Parkinson's disease (PD) is a neurodegenerative disorder, characterized by motor and non-motor symptoms, that still lacks of a disease-modifying treatment. Consistent evidence proved the benefits of physical therapy on motor and non-motor symptoms in PD patients, leading the scientific community to propose physical activity as disease-modifying therapy for PD and suggesting the involvement of neurotrophic factors (NFs) as key mediators of neuroplasticity. However, the lack of standardized exercise training and methodological flaws of clinical trials have limited the evidence demonstrating the exercise-induced changes in serum and plasma neurotrophic factors concentration. A systematic search, covering 20 years of research in this field and including randomized and non-randomized controlled trials (RCTs and non-RCTs), which reported changes in serum and plasma NFs after a specific intervention, were reviewed. Pooled effect sizes (p-ESs) and 95% confidence intervals (95%CIs) were calculated using a random effects model with R software. A total of 18 articles, of which exercise programs of interventions were codified in terms of type, intensity and duration adopting a standardisation methodology, were included in the systematic review. Six papers, describing the effect of different training programs on BDNF and IGF-1 levels, were included and independently analysed in two meta-analyses. Quantitative analysis for BDNF indicated a statistically significant improvement in serum concentration of PD patients (MD: 5.99 ng/mL; 95%IC: 0.15 -11.83; I
    MeSH term(s) Humans ; Parkinson Disease/drug therapy ; Insulin-Like Growth Factor I ; Brain-Derived Neurotrophic Factor ; Exercise ; Neuronal Plasticity ; Quality of Life
    Chemical Substances Insulin-Like Growth Factor I (67763-96-6) ; Brain-Derived Neurotrophic Factor
    Language English
    Publishing date 2023-10-14
    Publishing country England
    Document type Meta-Analysis ; Systematic Review ; Journal Article ; Review
    ZDB-ID 2075672-0
    ISSN 1872-9649 ; 1568-1637
    ISSN (online) 1872-9649
    ISSN 1568-1637
    DOI 10.1016/j.arr.2023.102089
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5579: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Importance of time to ON versus wearing OFF in total daily OFF time experienced by patients with Parkinson's disease.

    Isaacson, Stuart H / Kremens, Daniel / Torres-Yaghi, Yasar / Stocchi, Fabrizio / Antonini, Angelo

    Parkinsonism & related disorders

    2023  Volume 114, Page(s) 105495

    Abstract: Most patients with Parkinson's disease (PD) receiving levodopa (LD)/DOPA decarboxylase inhibitors develop motor fluctuations with an increasing amount of OFF time, negatively impacting patient quality of life. Herein, we review the evidence supporting ... ...

    Abstract Most patients with Parkinson's disease (PD) receiving levodopa (LD)/DOPA decarboxylase inhibitors develop motor fluctuations with an increasing amount of OFF time, negatively impacting patient quality of life. Herein, we review the evidence supporting the substantial, yet underappreciated contribution of delays in time to ON (including delayed ON and no ON) to total daily OFF time. Most clinical studies use patient diaries that do not capture time to ON and wearing OFF separately as related to LD dosing, and consequently, most OFF time has generally been attributed to wearing OFF. Hence, most treatment regimens focus on reducing wearing OFF by changing LD dosing/formulations and/or using "ON-extenders" (eg, catechol-o-methyltransferase inhibitors, monoamine oxidase-B inhibitors, extended-release amantadine, and adenosine A
    MeSH term(s) Humans ; Parkinson Disease/drug therapy ; Antiparkinson Agents/therapeutic use ; Quality of Life ; Catechol O-Methyltransferase ; Levodopa/therapeutic use
    Chemical Substances Antiparkinson Agents ; Catechol O-Methyltransferase (EC 2.1.1.6) ; Levodopa (46627O600J)
    Language English
    Publishing date 2023-07-22
    Publishing country England
    Document type Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1311489-x
    ISSN 1873-5126 ; 1353-8020
    ISSN (online) 1873-5126
    ISSN 1353-8020
    DOI 10.1016/j.parkreldis.2023.105495
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4553: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 420: Show issues

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