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Article ; Online: Assessment of genotoxic instability markers in peripheral blood lymphocytes of breast cancer patients: a case control study.

Raj, Smitha G / Rajitha, V

Journal of biomolecular structure & dynamics

2023 Volume 42, Issue 3, Page(s) 1559–1563

Abstract: Changes in genetic constitution of an individual leads to uncontrollable cell growth and tumour formation. The acquisition of genomic instability predisposes cells to accumulate stable genome mutations causing carcinogenesis. The cytokinesis-block ... ...

Abstract	Changes in genetic constitution of an individual leads to uncontrollable cell growth and tumour formation. The acquisition of genomic instability predisposes cells to accumulate stable genome mutations causing carcinogenesis. The cytokinesis-block micronucleus cytome assay (CBMN), a well-established marker assay for chromosomal mutagen sensitivity, was applied in this study enrolling breast cancer patients and age and sex-matched controls. This work aimed to assess the predictive value of the frequency of genotoxic markers in peripheral blood lymphocytes for the risk/susceptibility of breast cancer. Samples from a hundred untreated breast cancer patients and age and sex matched controls were enrolled in the study from Government Medical College, Alappuzha. The genomic instability was assessed using cytokinesis block micronucleus assay where cytome events were marked. The results showed a significant increase in the frequency of micronucleus, nucleoplasmic bridge, and buds in the binucleated cells of breast cancer patients compared to the control samples. The variability was assessed by CBMN Cyt assay. The frequency of Micronuclei and Nucleoplasmic buds was significantly higher in the patient groups than in the controls (
MeSH term(s)	Humans ; Female ; Case-Control Studies ; Breast Neoplasms/genetics ; Breast Neoplasms/pathology ; DNA Damage/genetics ; Genomic Instability ; Lymphocytes
Language	English
Publishing date	2023-05-24
Publishing country	England
Document type	Journal Article
ZDB-ID	49157-3
ISSN	1538-0254 ; 0739-1102
ISSN (online)	1538-0254
ISSN	0739-1102
DOI	10.1080/07391102.2023.2214226
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Article: Bubble Continuous Positive Airway Pressure Oxygen Therapy in Children Under Five Years of Age with Respiratory Distress in Pediatric Intensive Care Unit.

Lalitha, A V / Pujari, Chandrakant G / Raj, John Michael

Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine

2023 Volume 27, Issue 11, Page(s) 847–854

Abstract: ... safe and effective.: How to cite this article: Lalitha AV, Pujari CG, Raj JM. Bubble ...

Abstract	Background: Continuous positive airway pressure (CPAP) has been used in children with bronchiolitis for a long time. Currently in the low-resource settings, the method of providing oxygen therapy via bubble CPAP (bCPAP) to children with respiratory distress is not standardized and the existing low-flow oxygen therapy has a high mortality rate. Objectives: To study the effectiveness and safety of bCPAP as a respiratory support in children with respiratory distress. Materials and methods: This prospective observational study was conducted in a tertiary care pediatric intensive care unit (PICU) over a period of 3 months. Children with respiratory distress were administered with bCPAP oxygen therapy. Baseline demographic data, such as age, sex, weight, severity of illness was collected. Changes in heart rate, respiratory rate, saturation, respiratory distress score and failure rate after bCPAP therapy were studied. Results: During the study period, 30 children were recruited. Most common cause of respiratory distress requiring bCPAP was pneumonia (66.7%) followed by pleural effusion (20%) and bronchiolitis (13.3%). The median (IQR) CPAP duration and PICU stay in the study was 48 hours (27-48) and 4 days (4-8), respectively. Heart rate and respiratory rate, respiratory distress score improved significantly after CPAP therapy ( Conclusion: The use of bCPAP in the treatment of respiratory distress is safe and effective. How to cite this article: Lalitha AV, Pujari CG, Raj JM. Bubble Continuous Positive Airway Pressure Oxygen Therapy in Children Under Five Years of Age with Respiratory Distress in Pediatric Intensive Care Unit. Indian J Crit Care Med 2023;27(11):847-854.
Language	English
Publishing date	2023-03-23
Publishing country	India
Document type	Case Reports
ZDB-ID	2121263-6
ISSN	1998-359X ; 0972-5229
ISSN (online)	1998-359X
ISSN	0972-5229
DOI	10.5005/jp-journals-10071-24563
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Article ; Online: Effect of intermittent microwave convective drying on physicochemical properties of dragon fruit.

Raj, G V S Bhagya / Dash, Kshirod K

Food science and biotechnology

2022 Volume 31, Issue 5, Page(s) 549–560

Abstract: ... ranged between 5.750 and 6.575 mg GAE/g dry weight. Within the experimental range of process variables ...

Abstract	The study was carried out to investigate the effect of Intermittent microwave convective drying (IMCD) on the overall quality of dried dragon fruit in terms of total phenolic content, color change, and rehydration ratio. Three levels of microwave power (200-600 W) and a temperature of 60 °C for hot air were applied alternately throughout the process with three levels of pulse ratio such as 1:10, 1:20, and 1:40, respectively. The total phenolic content of the dragon fruit slice obtained by IMCD was ranged between 5.750 and 6.575 mg GAE/g dry weight. Within the experimental range of process variables under IMCD conditions, the drying efficiency, color change, and rehydration ratio of the dried dragon fruit slices were 15.287-51.930%, 18.643-24.847, and 1.908-3.239, respectively. The Weibull model scale (
Language	English
Publishing date	2022-03-24
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2000008-X
ISSN	2092-6456 ; 1226-7708
ISSN (online)	2092-6456
ISSN	1226-7708
DOI	10.1007/s10068-022-01057-4
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Article ; Online: Dragon fruit peel extract microcapsule incorporated pearl millet and dragon fruit pulp powder based functional pasta: formulation, characterization, and release kinetics study.

Raj, G V S Bhagya / Dash, Kshirod K

Food science and biotechnology

2022 Volume 32, Issue 6, Page(s) 779–792

Abstract: ... properties of the pasta. The total phenolic content (0.24-0.43 mg GAE/100 g d.w.), antioxidant activity (17 ... 76-30.67%), and betacyanin content (0.149-0.152 mg/g d.w.) of the pasta was increased ...

Abstract	The pearl millet based functional pasta was formulated by incorporating freeze dried dragon fruit pulp powder and 2% (w/w) microcapsule containing dragon fruit peel extract. The control pasta consisted of 100% pearl millet flour. The other four functional pasta samples consisted of pearl millet and freeze-dried dragon fruit pulp powder (DFP) in the ratio of 95:5, 90:10, 85:15, and 80:20 (w/w), respectively. The inclusion of dragon fruit powder enhanced the swelling index, water absorption index, color, and functional properties of the pasta. The total phenolic content (0.24-0.43 mg GAE/100 g d.w.), antioxidant activity (17.76-30.67%), and betacyanin content (0.149-0.152 mg/g d.w.) of the pasta was increased with the increase of dragon fruit pulp level in the formulation. The release kinetics of phenolic compounds into the simulated gastric juice was modeled using Higuchi and Peppas- Sahlin models. Out of these two models Peppas- Sahlin model (
Language	English
Publishing date	2022-12-21
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2000008-X
ISSN	2092-6456 ; 1226-7708
ISSN (online)	2092-6456
ISSN	1226-7708
DOI	10.1007/s10068-022-01220-x
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Article: Microencapsulation of Dragon Fruit Peel Extract by Freeze-Drying Using Hydrocolloids: Optimization by Hybrid Artificial Neural Network and Genetic Algorithm

Raj, G. V. S. Bhagya / Dash, Kshirod K.

Food and bioprocess technology. 2022 Sept., v. 15, no. 9

2022

Abstract: ... g), while the fourth was ultrasonication power. The four output neurons were encapsulation ... The optimal wall material composition for encapsulation obtained by the integrated ANN and GA was 4.461 g ... maltodextrin, 3.863 g gum arabic, and 3.198 g gelatin. The optimal ultrasonication power for achieving ...

Abstract	The freeze-drying encapsulation process was used to encapsulate dragon fruit peel extract with three distinct wall materials: maltodextrin, gum arabica, and gelatin. The process was modeled using a feed forward back propagation artificial neural network with four, eleven, and four neurons in the input, hidden, and output layers. Three of the four input neurons were concentrations of wall material (g), while the fourth was ultrasonication power. The four output neurons were encapsulation efficiency, antioxidant activity, hygroscopicity, and solubility of freeze-dried encapsulation powder. The procedure was optimized using hybrid artificial neural network (ANN) and genetic algorithm (GA) approach. The optimal wall material composition for encapsulation obtained by the integrated ANN and GA was 4.461 g maltodextrin, 3.863 g gum arabic, and 3.198 g gelatin. The optimal ultrasonication power for achieving a homogenous mixture was determined to be 123 W. At the optimal condition, the predicted values for the responses encapsulation efficiency, antioxidant activity, hygroscopicity, and solubility were found to be 88.143%, 81.702%, 6.924 g/100 g, and 32.841%, respectively. Under optimal conditions, the relative deviation between the predicted model and experimental outcomes was less than 2.077%. The thermal stability of the encapsulated powder followed the first order kinetic modeling. The results showed that the sample treated at pH of 7 was more thermally stable at 80 °C than the sample treated at pH of 3.6. The half-life time was found to be 140 min and 103 min for the sample treated at pH of 7 and 3.6, respectively.
Keywords	Hylocereus ; algorithms ; antioxidant activity ; bioprocessing ; freeze drying ; fruit peels ; gelatin ; gum arabic ; half life ; hydrocolloids ; hygroscopicity ; maltodextrins ; microencapsulation ; neural networks ; pH ; solubility ; thermal stability ; ultrasonic treatment
Language	English
Dates of publication	2022-09
Size	p. 2035-2049.
Publishing place	Springer US
Document type	Article
ZDB-ID	2425455-1
ISSN	1935-5149 ; 1935-5130
ISSN (online)	1935-5149
ISSN	1935-5130
DOI	10.1007/s11947-022-02867-4
Database	NAL-Catalogue (AGRICOLA)

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Article: Effect of intermittent microwave convective drying on physicochemical properties of dragon fruit

Raj, G. V. S. Bhagya / Dash, Kshirod K.

Food science and biotechnology. 2022 May, v. 31, no. 5

2022

Abstract: ... ranged between 5.750 and 6.575 mg GAE/g dry weight. Within the experimental range of process variables ...

Abstract	The study was carried out to investigate the effect of Intermittent microwave convective drying (IMCD) on the overall quality of dried dragon fruit in terms of total phenolic content, color change, and rehydration ratio. Three levels of microwave power (200–600 W) and a temperature of 60 °C for hot air were applied alternately throughout the process with three levels of pulse ratio such as 1:10, 1:20, and 1:40, respectively. The total phenolic content of the dragon fruit slice obtained by IMCD was ranged between 5.750 and 6.575 mg GAE/g dry weight. Within the experimental range of process variables under IMCD conditions, the drying efficiency, color change, and rehydration ratio of the dried dragon fruit slices were 15.287–51.930%, 18.643–24.847, and 1.908–3.239, respectively. The Weibull model scale (α) parameter was found to vary between [Formula: see text]-[Formula: see text], while the shape (β) parameter was found to vary between [Formula: see text]. The Weibull model parameters were shown to decrease with increasing microwave power at constant pulse ratio. The IMCD method produced a dried dragon fruit slices with reduced color changes and higher total phenolic content and rehydration ratio values. This investigation would contribute to the development of effective drying techniques for increased food quality and product consistency in the drying of diverse fruits and vegetables.
Keywords	Hylocereus ; Weibull statistics ; air ; biotechnology ; color ; food quality ; rehydration ; temperature
Language	English
Dates of publication	2022-05
Size	p. 549-560.
Publishing place	Springer Nature Singapore
Document type	Article
ZDB-ID	2000008-X
ISSN	1226-7708
ISSN	1226-7708
DOI	10.1007/s10068-022-01057-4
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Ultrasound assisted microwave vacuum drying of persimmon fruit: Modeling by artificial neural network and optimization by genetic algorithm

Dash, Kshirod Kumar / Bhagya Raj, G. V. S.

Journal of Food Process Engineering. 2023 June, v. 46, no. 6 p.e14315-

2023

Abstract: The present investigation studied the influence of ultrasonication power (XUp), microwave power (XMp), and vacuum level (XVl) on the quality attributes of dried persimmon fruit. The range of independent variables selected for the study was 100–200 W for ... ...

Abstract	The present investigation studied the influence of ultrasonication power (XUp), microwave power (XMp), and vacuum level (XVl) on the quality attributes of dried persimmon fruit. The range of independent variables selected for the study was 100–200 W for XUp, 400–800 W for microwave power and 380–680 mmHg of vacuum level. The best artificial neural network with the lowest relative deviation comprised three input neurons, nine hidden neurons, and four output neurons. According to the experimental design, the range of response rehydration ratio YRR, total change in color YΔE, drying efficiency (YDE), and antioxidant activity YAA was found to be 1.524%–2.148, 8.933%–28.854, 33.603%–42.155% and 68.640%–87.809% respectively. The optimized condition according to the integrated ANN‐GA model for the process parameters XUp, XMp, and XVl was found to be 106.227 W, 421.189 W, and 668.051 mmHg, respectively. PRACTICAL APPLICATIONS: Persimmon is a perishable fruit with a short shelf life. Fruits necessitate preservation strategies to extend their shelf life by reducing moisture content and water activity. Microwave vacuum drying with ultrasound treatment preserves quality characteristics like color, texture, chemical components, and shrinkage while reducing moisture content. Ultrasound pretreated microwave vacuum drying process lowered drying time while improving the quality and efficiency of dried persimmon fruit. Moisture can rapidly diffuse into the surrounding vacuum and prevent structure collapse due to the high vapor pressure caused by microwave vacuum drying. Prior to drying, sonication alters the structure of the fruit tissue, significantly accelerates the drying process and reduces overall processing time.
Keywords	algorithms ; antioxidant activity ; color ; experimental design ; fruits ; neural networks ; persimmons ; rehydration ; shelf life ; shrinkage ; sonication ; texture ; ultrasonic treatment ; ultrasonics ; vapor pressure ; water activity ; water content
Language	English
Dates of publication	2023-06
Publishing place	John Wiley & Sons, Inc.
Document type	Article ; Online
Note	JOURNAL ARTICLE
ZDB-ID	752358-0
ISSN	0145-8876
ISSN	0145-8876
DOI	10.1111/jfpe.14315
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Ultrasound assisted phytochemical extraction of red cabbage by using deep eutectic solvent: Modelling using ANFIS and optimization by genetic algorithms.

Pusty, Kasturi / Kumar Dash, Kshirod / Giri, Souvik / Raj, G V S Bhagya / Tiwari, Ajita / Shaikh, Ayaz Mukarram / Béla, Kovács

Ultrasonics sonochemistry

2024 Volume 102, Page(s) 106762

Abstract: The present investigation studied the effect of process parameters on the extraction of phytochemicals from red cabbage by the application of ultrasonication and temperature. The solvent selected for the study was deep eutectic solvent (DES) prepared by ... ...

Abstract	The present investigation studied the effect of process parameters on the extraction of phytochemicals from red cabbage by the application of ultrasonication and temperature. The solvent selected for the study was deep eutectic solvent (DES) prepared by choline chloride and citric acid. The ultrasound assisted extraction process was modeled using adaptive neuro-fuzzy inference system (ANFIS) algorithm and integrated with the genetic algorithm for optimization purposes. The independent variables that influenced the responses (total phenolic content, antioxidant activity, total anthocyanin activity, and total flavonoid content) were ultrasonication power, temperature, molar ratio of DES, and water content of DES. Each ANFIS model was formed by the training of three Gaussian-type membership functions (MF) for each input, trained by a hybrid algorithm with 500 epochs and linear type MF for output MF. The ANFIS model predicted each response close to the experimental data which is evident by the statistical parameters (R
MeSH term(s)	Deep Eutectic Solvents ; Fuzzy Logic ; Antioxidants ; Anthocyanins ; Algorithms ; Phytochemicals ; Water ; Brassica
Chemical Substances	Deep Eutectic Solvents ; Antioxidants ; Anthocyanins ; Phytochemicals ; Water (059QF0KO0R)
Language	English
Publishing date	2024-01-09
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1208333-1
ISSN	1873-2828 ; 1350-4177
ISSN (online)	1873-2828
ISSN	1350-4177
DOI	10.1016/j.ultsonch.2024.106762
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Article ; Online: Single crystal XRD and DFT investigation of 1,5-dimethyl-4-[(2-oxo-1,2-diphenylethylidene) amino]-2-phenyl-1,2-dihydro-3H-pyrazol-3-one

S. Anila Raj / V.G. Vidya / V. Preethi / V.G. Viju Kumar

Results in Chemistry, Vol 4, Iss , Pp 100665- (2022)

2022

Abstract: The single crystal 1,5-dimethyl-4-[(2-oxo-1,2-diphenylethylidene) amine]-2-phenyl-1,2-dihydro-3H-pyrazol-3-one [DDAPDP] was designed to enhance luminescence property using benzil and 4-aminoantipyrine. DFT calculations of DDAPDP were done with Gaussian ... ...

Abstract	The single crystal 1,5-dimethyl-4-[(2-oxo-1,2-diphenylethylidene) amine]-2-phenyl-1,2-dihydro-3H-pyrazol-3-one [DDAPDP] was designed to enhance luminescence property using benzil and 4-aminoantipyrine. DFT calculations of DDAPDP were done with Gaussian 16 W program employing hybrid functional B3LYP with 6–311++G (d,p) basis set for geometry optimization without symmetry constraints. The single crystal was studied based on theoretical aspects such as Frontier Molecular Orbital (FMO), Natural Bond Orbital (NBO), Mullikan atomic charge and Molecular Electrostatic Potential (MEP) using density functional method. The experimental and theoretical spectral analysis of the single crystal system was investigated using FTIR, Raman, UV –visible, 1H NMR and 13C NMR techniques. Positive electrostatic potential regions dispersed throughout the rings and represent possible nucleophilic attack sites, whereas negative electrostatic potential regions are typically grouped around the CO group. Energy gap −3.776391 eV, confirmed by the estimated HOMO and LUMO energies. Natural bond orbital analysis (NBO) was used to assess the molecule's stability as a result of charge delocalization and hyper conjugation. Electron population of each atom was calculated by Mulliken atomic charge distribution analysis. The bacterium E. coli (Gram negative) and the organism S. aureus, together with a standard medication, were used to study and assess the compounds' antimicrobial activity in vitro, which reveals the antibacterial and antifungal activities of DDAPDP.
Keywords	Aminoantipyrine ; Benzil ; Density Functional Theory ; Schiff base ; Single Crystal XRD ; Antimicrobial activity ; Chemistry ; QD1-999
Subject code	541 ; 540
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Feasibility and Acceptability of Teleconsultation During COVID-19: A Cross-Sectional Study.

Raj, Manish / Rai, Priyanka / G V L, Narasimha / Onkar, Abhishek / Angral, Sumeet / Varshney, Saurabh

Cureus

2022 Volume 14, Issue 10, Page(s) e30937

Abstract: Background The coronavirus disease 2019 (COVID-19) pandemic created an aberrant challenge for healthcare delivery systems, forcing public health policies across the globe to be shifted from traditional medical care in hospitals to virtual care in the ... ...

Abstract	Background The coronavirus disease 2019 (COVID-19) pandemic created an aberrant challenge for healthcare delivery systems, forcing public health policies across the globe to be shifted from traditional medical care in hospitals to virtual care in the homes of patients. To tackle this pandemic, telemedicine had taken center stage. This study aims to learn about patient satisfaction, feasibility, and acceptability of the use of telemedicine for clinical encounters during the COVID-19 pandemic. Methodology This single-center, cross-sectional, observational study was done on a total of 758 patients who were provided with teleconsultations during the COVID-19 pandemic. We developed a 49-item questionnaire consisting of patients' quality of consultation and patients' expectations to evaluate the feasibility, acceptability, and patient satisfaction with their telemedicine consultations. Results The majority of survey participants (97.1%) expressed satisfaction with the quality of the consultations provided through telemedicine. A large percentage of participants (96.8%) reported the benefits of teleconsultation in treating their problems. Overall, 93.3% of participants responded positively to the continuation of teleconsultation services after the pandemic. Conclusions The study revealed a wide extent of satisfaction among patients. The feasibility and acceptability of telemedicine services have transformed the mode of healthcare delivery systems.
Language	English
Publishing date	2022-10-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.30937
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