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  1. Article ; Online: Why Haven't We Found an Effective Treatment for COVID-19?

    Spicer, Alexander James / Jalkanen, Sirpa

    Frontiers in immunology

    2021  Volume 12, Page(s) 644850

    MeSH term(s) COVID-19/epidemiology ; COVID-19/immunology ; COVID-19/therapy ; Humans ; Pandemics ; SARS-CoV-2/growth & development
    Language English
    Publishing date 2021-03-31
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2021.644850
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Letter to the Editor:

    Spicer, Alexander J / Jalkanen, Juho / Louramo, Elina / Hakovirta, Harri / Venermo, Maarit / Jalkanen, Sirpa

    Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research

    2022  Volume 42, Issue 11, Page(s) 590–591

    MeSH term(s) Interferon Type I ; Autoantibodies
    Chemical Substances Interferon Type I ; Autoantibodies
    Language English
    Publishing date 2022-09-30
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1226675-9
    ISSN 1557-7465 ; 1079-9907
    ISSN (online) 1557-7465
    ISSN 1079-9907
    DOI 10.1089/jir.2022.0156
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    Zs.A 1748: Show issues Location:
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  3. Article ; Online: Lymph node lymphatic endothelial cells as multifaceted gatekeepers in the immune system.

    Takeda, Akira / Salmi, Marko / Jalkanen, Sirpa

    Trends in immunology

    2022  Volume 44, Issue 1, Page(s) 72–86

    Abstract: Single-cell technologies have recently allowed the identification of multiple lymphatic endothelial cell (LEC) subsets in subcapsular, paracortical, medullary, and other lymph node (LN) sinus systems in mice and humans. New analyses show that LECs serve ... ...

    Abstract Single-cell technologies have recently allowed the identification of multiple lymphatic endothelial cell (LEC) subsets in subcapsular, paracortical, medullary, and other lymph node (LN) sinus systems in mice and humans. New analyses show that LECs serve key immunological functions in the LN stroma during immune responses. We discuss the roles of different LEC types in guiding leukocyte and cancer cell trafficking to and from the LN parenchyma, in capturing microbes, and in transporting, presenting, and storing lymph-borne antigens in distinct types of lymphatic sinuses. We underscore specific adaptations of human LECs and raise unanswered questions concerning LEC functions in human disease. Despite our limited understanding of human lymphatics - hampering clinical translation in inflammation and metastasis - we support the potential of LN LECs as putative targets for boosting/inhibiting immunoreactivity.
    MeSH term(s) Mice ; Humans ; Animals ; Endothelial Cells ; Lymphatic Vessels/pathology ; Inflammation ; Lymph Nodes ; Lymphatic System
    Language English
    Publishing date 2022-11-30
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2036831-8
    ISSN 1471-4981 ; 1471-4906
    ISSN (online) 1471-4981
    ISSN 1471-4906
    DOI 10.1016/j.it.2022.10.010
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    Zs.A 1601: Show issues Location:
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  4. Article ; Online: Single-Cell Transcriptomics of Human Lymph Node Stroma.

    Takeda, Akira / Jalkanen, Sirpa

    STAR protocols

    2020  Volume 1, Issue 1, Page(s) 100021

    Abstract: Accumulating evidence indicates that the immune system is regulated not only by immune cells but also by stromal cells in the tissue microenvironment. Characterization of non-hematopoietic cells has not been performed in depth, since markers of the ... ...

    Abstract Accumulating evidence indicates that the immune system is regulated not only by immune cells but also by stromal cells in the tissue microenvironment. Characterization of non-hematopoietic cells has not been performed in depth, since markers of the subsets are limited. Recent advances of single-cell technology allow researchers to characterize comprehensively the heterogeneity of stromal cells in an unbiased manner. In this article, we provide step-by-step protocols for cell preparation for single-cell RNA sequencing to characterize the heterogeneity of stroma in human lymph nodes. For complete details on the use and execution of this protocol, please refer to Takeda et al. (2019).
    MeSH term(s) Cells, Cultured ; Gene Expression Profiling/methods ; Humans ; Lymph Nodes/pathology ; Single-Cell Analysis/methods ; Stromal Cells/cytology
    Language English
    Publishing date 2020-06-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2666-1667
    ISSN (online) 2666-1667
    DOI 10.1016/j.xpro.2020.100021
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  5. Article ; Online: Interferon beta-1a for COVID-19: critical importance of the administration route.

    Jalkanen, Juho / Hollmén, Maija / Jalkanen, Sirpa

    Critical care (London, England)

    2020  Volume 24, Issue 1, Page(s) 335

    MeSH term(s) Antiviral Agents/administration & dosage ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/drug therapy ; Dose-Response Relationship, Drug ; Humans ; Injections, Intramuscular ; Injections, Intravenous ; Interferon beta-1a/administration & dosage ; Pandemics ; Pneumonia, Viral/drug therapy ; SARS-CoV-2
    Chemical Substances Antiviral Agents ; Interferon beta-1a (XRO4566Q4R)
    Keywords covid19
    Language English
    Publishing date 2020-06-12
    Publishing country England
    Document type Letter
    ZDB-ID 2041406-7
    ISSN 1466-609X ; 1364-8535
    ISSN (online) 1466-609X
    ISSN 1364-8535
    DOI 10.1186/s13054-020-03048-5
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    Zs.A 5517: Show issues Location:
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  6. Article ; Online: Lymphatic endothelial cells of the lymph node.

    Jalkanen, Sirpa / Salmi, Marko

    Nature reviews. Immunology

    2020  Volume 20, Issue 9, Page(s) 566–578

    Abstract: The influx and efflux of cells and antigens to and from the draining lymph nodes largely take place through the subcapsular, cortical and medullary sinus systems. Recent analyses in mice and humans have revealed unexpected diversity in the lymphatic ... ...

    Abstract The influx and efflux of cells and antigens to and from the draining lymph nodes largely take place through the subcapsular, cortical and medullary sinus systems. Recent analyses in mice and humans have revealed unexpected diversity in the lymphatic endothelial cells, which form the distinct regions of the sinuses. As a semipermeable barrier, the lymphatic endothelial cells regulate the sorting of lymph-borne antigens to the lymph node parenchyma and can themselves serve as antigen-presenting cells. The leukocytes entering the lymph node via the sinus system and the lymphocytes egressing from the parenchyma migrate through the lymphatic endothelial cell layer. The sinus lymphatic endothelial cells also orchestrate the organogenesis of lymph nodes, and they undergo bidirectional signalling with other sinus-resident cells, such as subcapsular sinus macrophages, to generate a unique lymphatic niche. In this Review, we consider the structural and functional basis of how the lymph node sinus system coordinates immune responses under physiological conditions, and in inflammation and cancer.
    MeSH term(s) Animals ; Endothelial Cells/immunology ; Endothelium, Lymphatic/cytology ; Endothelium, Lymphatic/immunology ; Humans ; Immunity, Cellular ; Inflammation/immunology ; Lymph Nodes/cytology ; Lymph Nodes/immunology ; Neoplasms/immunology
    Language English
    Publishing date 2020-02-24
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2062776-2
    ISSN 1474-1741 ; 1474-1733
    ISSN (online) 1474-1741
    ISSN 1474-1733
    DOI 10.1038/s41577-020-0281-x
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    Zs.A 5565: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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    Zs.MG 34: Show issues

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  7. Article ; Online: Single-Cell Transcriptomics of Human Lymph Node Stroma

    Akira Takeda / Sirpa Jalkanen

    STAR Protocols, Vol 1, Iss 1, Pp 100021- (2020)

    2020  

    Abstract: Summary: Accumulating evidence indicates that the immune system is regulated not only by immune cells but also by stromal cells in the tissue microenvironment. Characterization of non-hematopoietic cells has not been performed in depth, since markers of ... ...

    Abstract Summary: Accumulating evidence indicates that the immune system is regulated not only by immune cells but also by stromal cells in the tissue microenvironment. Characterization of non-hematopoietic cells has not been performed in depth, since markers of the subsets are limited. Recent advances of single-cell technology allow researchers to characterize comprehensively the heterogeneity of stromal cells in an unbiased manner. In this article, we provide step-by-step protocols for cell preparation for single-cell RNA sequencing to characterize the heterogeneity of stroma in human lymph nodes. For complete details on the use and execution of this protocol, please refer to Takeda et al. (2019).
    Keywords Science (General) ; Q1-390
    Language English
    Publishing date 2020-06-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Interferon beta-1a for COVID-19

    Juho Jalkanen / Maija Hollmén / Sirpa Jalkanen

    Critical Care, Vol 24, Iss 1, Pp 1-

    critical importance of the administration route

    2020  Volume 3

    Keywords Medical emergencies. Critical care. Intensive care. First aid ; RC86-88.9 ; covid19
    Language English
    Publishing date 2020-06-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Glucocorticoids inhibit type I IFN beta signaling and the upregulation of CD73 in human lung.

    Jalkanen, Juho / Pettilä, Ville / Huttunen, Teppo / Hollmén, Maija / Jalkanen, Sirpa

    Intensive care medicine

    2020  Volume 46, Issue 10, Page(s) 1937–1940

    MeSH term(s) Glucocorticoids ; Humans ; Lung ; Signal Transduction ; Up-Regulation
    Chemical Substances Glucocorticoids
    Keywords covid19
    Language English
    Publishing date 2020-05-19
    Publishing country United States
    Document type Letter
    ZDB-ID 80387-x
    ISSN 1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
    ISSN (online) 1432-1238
    ISSN 0340-0964 ; 0342-4642 ; 0935-1701
    DOI 10.1007/s00134-020-06086-3
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    Zs.A 1089: Show issues Location:
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  10. Article ; Online: Aerobic exercise training and gut microbiome-associated metabolic shifts in women with overweight: a multi-omic study.

    Hintikka, Jukka E / Ahtiainen, Juha P / Permi, Perttu / Jalkanen, Sirpa / Lehtonen, Marko / Pekkala, Satu

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 11228

    Abstract: Physical activity is essential in weight management, improves overall health, and mitigates obesity-related risk markers. Besides inducing changes in systemic metabolism, habitual exercise may improve gut's microbial diversity and increase the abundance ... ...

    Abstract Physical activity is essential in weight management, improves overall health, and mitigates obesity-related risk markers. Besides inducing changes in systemic metabolism, habitual exercise may improve gut's microbial diversity and increase the abundance of beneficial taxa in a correlated fashion. Since there is a lack of integrative omics studies on exercise and overweight populations, we studied the metabolomes and gut microbiota associated with programmed exercise in obese individuals. We measured the serum and fecal metabolites of 17 adult women with overweight during a 6-week endurance exercise program. Further, we integrated the exercise-responsive metabolites with variations in the gut microbiome and cardiorespiratory parameters. We found clear correlation with several serum and fecal metabolites, and metabolic pathways, during the exercise period in comparison to the control period, indicating increased lipid oxidation and oxidative stress. Especially, exercise caused co-occurring increase in levels of serum lyso-phosphatidylcholine moieties and fecal glycerophosphocholine. This signature was associated with several microbial metagenome pathways and the abundance of Akkermansia. The study demonstrates that, in the absence of body composition changes, aerobic exercise can induce metabolic shifts that provide substrates for beneficial gut microbiota in overweight individuals.
    MeSH term(s) Adult ; Humans ; Female ; Overweight/therapy ; Gastrointestinal Microbiome ; Multiomics ; Exercise ; Obesity/therapy ; Lecithins
    Chemical Substances Lecithins
    Language English
    Publishing date 2023-07-11
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-38357-6
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