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  1. Article ; Online: Possible Effect of Blonanserin Transdermal Patch on Antiemetic Control in Patients With Terminal Cancer with Refractory Nausea.

    Ando, Katsutoshi / Suzuki, Ayumi / Yoshida, Hiroki

    Journal of palliative medicine

    2023  Volume 26, Issue 9, Page(s) 1247–1251

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Humans ; Antiemetics/therapeutic use ; Transdermal Patch ; Ascites ; Nausea/drug therapy ; Neoplasms ; Antipsychotic Agents/therapeutic use ; Vomiting/drug therapy
    Chemical Substances Antiemetics ; blonanserin (AQ316B4F8C) ; Antipsychotic Agents
    Language English
    Publishing date 2023-04-26
    Publishing country United States
    Document type Observational Study ; Journal Article
    ZDB-ID 1427361-5
    ISSN 1557-7740 ; 1096-6218
    ISSN (online) 1557-7740
    ISSN 1096-6218
    DOI 10.1089/jpm.2023.0076
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    Zs.A 5440: Show issues Location:
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  2. Article ; Online: How to improve planetary health: Devising the 'Planetary Health Approach' from the biogeochemical flow perspectives.

    Aoki, Yoshihiro / Miyagi, Ayumi / Toyokawa, Ayako / Misaka, Shoko / Yoshida, Jin / Makram, Abdelrahman M / Gad, Abdelrahman Gamil / Huy, Nguyen Tien

    Journal of global health

    2024  Volume 14, Page(s) 3014

    MeSH term(s) Humans ; Global Health
    Language English
    Publishing date 2024-02-23
    Publishing country Scotland
    Document type Journal Article
    ZDB-ID 2741629-X
    ISSN 2047-2986 ; 2047-2986
    ISSN (online) 2047-2986
    ISSN 2047-2986
    DOI 10.7189/jogh.14.03014
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  3. Article ; Online: Efficacy of blonanserin transdermal patch on terminal delirium in patients with respiratory diseases.

    Ando, Katsutoshi / Suzuki, Ayumi / Yoshida, Hiroki

    Respiratory investigation

    2023  Volume 61, Issue 2, Page(s) 240–246

    Abstract: Background: Delirium is a common distressing symptom observed in patients with terminal respiratory diseases and is treated with antipsychotic medications such as haloperidol. Its management is difficult, especially in palliative home care, because its ... ...

    Abstract Background: Delirium is a common distressing symptom observed in patients with terminal respiratory diseases and is treated with antipsychotic medications such as haloperidol. Its management is difficult, especially in palliative home care, because its administration is limited to oral or injection methods. Recently, the blonanserin transdermal patch was developed as the first antipsychotic percutaneous agent. After it became available, we recognized its potential for the management of delirium and the alleviation of uncontrolled dyspnea in clinical practice. Thus, this study aimed to assess its efficacy in patients with terminal respiratory diseases.
    Methods: This retrospective study included 113 patients with respiratory diseases who were cared for at home. The efficacy was evaluated through the prevalence of terminal delirium before and after its treatment initiation for uncontrolled dyspnea.
    Results: Blonanserin transdermal patch treatment for uncontrolled dyspnea improved the prevalence and severity of terminal delirium (from 70.4% to 16.3%, p < 0.001) and reduced the number of doctors' visits to patients' homes within a week before their death (from 4.0 to 3.0, p = 0.086). A sub-group analysis of 23 patients with interstitial pneumonia revealed that the treatment prevented dyspnea progression by inhibiting terminal delirium.
    Conclusions: Blonanserin transdermal patch performed similarly to haloperidol, as previously reported, for managing terminal delirium. Our study suggests that a blonanserin transdermal patch potentially prevents terminal delirium and alleviates uncontrolled dyspnea in patients with respiratory diseases. Our findings encourage clinical trials to evaluate the safety and efficacy of blonanserin transdermal patches for patients with terminal illnesses.
    MeSH term(s) Humans ; Haloperidol/therapeutic use ; Antipsychotic Agents/pharmacology ; Antipsychotic Agents/therapeutic use ; Transdermal Patch ; Retrospective Studies ; Dyspnea ; Delirium/drug therapy
    Chemical Substances Haloperidol (J6292F8L3D) ; Antipsychotic Agents ; blonanserin (AQ316B4F8C)
    Language English
    Publishing date 2023-02-13
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2660821-2
    ISSN 2212-5353 ; 2212-5345
    ISSN (online) 2212-5353
    ISSN 2212-5345
    DOI 10.1016/j.resinv.2023.01.006
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  4. Article ; Online: Direct binding of calmodulin to the cytosolic C-terminal regions of sweet/umami taste receptors.

    Yoshida, Atsuki / Ito, Ayumi / Yasui, Norihisa / Yamashita, Atsuko

    Journal of biochemistry

    2023  Volume 174, Issue 5, Page(s) 451–459

    Abstract: Sweet and umami taste receptors recognize chemicals such as sugars and amino acids on their extracellular side and transmit signals into the cytosol of the taste cell. In contrast to ligands that act on the extracellular side of these receptors, little ... ...

    Abstract Sweet and umami taste receptors recognize chemicals such as sugars and amino acids on their extracellular side and transmit signals into the cytosol of the taste cell. In contrast to ligands that act on the extracellular side of these receptors, little is known regarding the molecules that regulate receptor functions within the cytosol. In this study, we analysed the interaction between sweet and umami taste receptors and calmodulin, a representative Ca2+-dependent cytosolic regulatory protein. High prediction scores for calmodulin binding were observed on the C-terminal cytosolic side of mouse taste receptor type 1 subunit 3 (T1r3), a subunit that is common to both sweet and umami taste receptors. Pull-down assay and surface plasmon resonance analyses showed different affinities of calmodulin to the C-terminal tails of distinct T1r subtypes. Furthermore, we found that T1r3 and T1r2 showed the highest and considerable binding to calmodulin, whereas T1r1 showed weaker binding affinity. Finally, the binding of calmodulin to T1rs was consistently higher in the presence of Ca2+ than in its absence. The results suggested a possibility of the Ca2+-dependent feedback regulation process of sweet and umami taste receptor signaling by calmodulin.
    MeSH term(s) Mice ; Animals ; Taste/physiology ; Calmodulin/metabolism ; Receptors, G-Protein-Coupled/metabolism ; Calcium/metabolism ; Cytosol/metabolism
    Chemical Substances Calmodulin ; Receptors, G-Protein-Coupled ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2023-08-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 218073-x
    ISSN 1756-2651 ; 0021-924X
    ISSN (online) 1756-2651
    ISSN 0021-924X
    DOI 10.1093/jb/mvad060
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  5. Article: Diagnosis of a

    Marumo, Yoshiaki / Yoshida, Takashi / Ina, Kenji / Matsunaga, Naohiro / Furukawa, Yuki / Kamiya, Ayumi / Kataoka, Takae / Kayukawa, Satoshi

    Clinical case reports

    2023  Volume 11, Issue 9, Page(s) e7854

    Abstract: Key clinical message: SMARCA4: Abstract: ... ...

    Abstract Key clinical message: SMARCA4
    Abstract: SMARCA4
    Language English
    Publishing date 2023-08-29
    Publishing country England
    Document type Case Reports
    ZDB-ID 2740234-4
    ISSN 2050-0904
    ISSN 2050-0904
    DOI 10.1002/ccr3.7854
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  6. Article: Biochemical Characterizations of the Putative Endolysin Ecd09610 Catalytic Domain from

    Sekiya, Hiroshi / Yamaji, Hina / Yoshida, Ayumi / Matsunami, Risa / Kamitori, Shigehiro / Tamai, Eiji

    Antibiotics (Basel, Switzerland)

    2022  Volume 11, Issue 8

    Abstract: Clostridioides ... ...

    Abstract Clostridioides difficile
    Language English
    Publishing date 2022-08-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics11081131
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  7. Article ; Online: Further analysis of incidence of multiple myeloma among atomic-bomb survivors, 1950 to 1994.

    Yoshida, Noriaki / Fujihara, Megumu / Preston, Dale L / Ozasa, Kotaro / Hida, Ayumi / Ohishi, Waka / Sakata, Ritsu / Mabuchi, Kiyohiko

    Blood advances

    2023  Volume 7, Issue 12, Page(s) 2807–2810

    MeSH term(s) Humans ; Multiple Myeloma/epidemiology ; Multiple Myeloma/etiology ; Incidence ; Survivors
    Language English
    Publishing date 2023-02-11
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2915908-8
    ISSN 2473-9537 ; 2473-9529
    ISSN (online) 2473-9537
    ISSN 2473-9529
    DOI 10.1182/bloodadvances.2022009154
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  8. Article: A Case of Lymphomatoid Granulomatosis Presenting as a Cervical Mass.

    Yoshida, Masafumi / Mori, Ayumi / Kanemoto, Kai / Shoji, Shizuka / Furukawa, Asayo

    Cureus

    2022  Volume 14, Issue 3, Page(s) e23534

    Abstract: An 89-year-old man presented with the chief complaint of a sore throat and a mass in the right side of his neck that tended to increase in size. He displayed the right Horner's sign, and imaging findings showed a 65-mm mass in the right side of the neck, ...

    Abstract An 89-year-old man presented with the chief complaint of a sore throat and a mass in the right side of his neck that tended to increase in size. He displayed the right Horner's sign, and imaging findings showed a 65-mm mass in the right side of the neck, invading the carotid artery. There were no other obvious lesions. The differential diagnosis was carcinoma of an unknown primary or neurogenic tumor. An incisional biopsy was performed, and the pathological diagnosis was lymphomatoid granulomatosis. The patient was started on oral prednisolone, but the disease progressed, and his general condition worsened. Therefore, supportive care was provided. This was a very rare case of a cervical lesion of lymphomatoid granulomatosis.
    Language English
    Publishing date 2022-03-27
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.23534
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  9. Article ; Online: Amino acids to prevent cardiac surgery-associated acute kidney injury: a randomized controlled trial.

    Kazawa, Masahiro / Kabata, Daijiro / Yoshida, Hisako / Minami, Kimito / Maeda, Takuma / Yoshitani, Kenji / Matsuda, Hitoshi / Shintani, Ayumi

    JA clinical reports

    2024  Volume 10, Issue 1, Page(s) 19

    Abstract: Background: This study aimed to examine the preventive effect of amino acids on postoperative acute kidney injury (AKI).: Methods: This was single-center, patient- and assessor-blinded, randomized controlled trial. Patients who underwent aortic ... ...

    Abstract Background: This study aimed to examine the preventive effect of amino acids on postoperative acute kidney injury (AKI).
    Methods: This was single-center, patient- and assessor-blinded, randomized controlled trial. Patients who underwent aortic surgery with cardiopulmonary bypass were included. The intervention group received 60 g/day of amino acids for up to 3 days. The control group received standard care. The primary outcome was the incidence of AKI. We assessed the effect of amino acids on AKI using a Cox proportional hazards regression model.
    Results: Sixty-six patients were randomly assigned to the control or intervention group. One patient in the control group withdrew consent after randomization. The incidence of AKI was 10 patients (30.3%) in the intervention group versus 18 patients (56.2%) in the control group (adjusted hazard ratio, 0.44; 95% confidence interval, 0.20-0.95; P = 0.04).
    Conclusions: This trial demonstrated a significant reduction in AKI incidence with amino acid supplementation.
    Trial registration: jRCT, jRCTs051210154. Registered 31 December 2021, https://jrct.niph.go.jp/re/reports/detail/69916.
    Language English
    Publishing date 2024-03-26
    Publishing country Germany
    Document type Journal Article
    ISSN 2363-9024
    ISSN (online) 2363-9024
    DOI 10.1186/s40981-024-00703-6
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  10. Article ; Online: Lack of GPR180 ameliorates hepatic lipid depot via downregulation of mTORC1 signaling

    Ken Yoshida / Kazuha Yokota / Kazuhisa Watanabe / Hidetoshi Tsuda / Ayumi Matsumoto / Hiroaki Mizukami / Sadahiko Iwamoto

    Scientific Reports, Vol 13, Iss 1, Pp 1-

    2023  Volume 11

    Abstract: Abstract Our previous genome-wide association study to explore genetic loci associated with lean nonalcoholic fatty liver disease (NAFLD) in Japan suggested four candidate loci, which were mapped to chr6, chr7, chr12 and chr13. The present study aimed to ...

    Abstract Abstract Our previous genome-wide association study to explore genetic loci associated with lean nonalcoholic fatty liver disease (NAFLD) in Japan suggested four candidate loci, which were mapped to chr6, chr7, chr12 and chr13. The present study aimed to identify the locus involved functionally in NAFLD around the association signal observed in chr13. Chromosome conformation capture assay and a database survey suggested the intermolecular interaction among DNA fragments in association signals with the adjacent four coding gene promoters. The four genes were further screened by knockdown (KD) in mice using shRNA delivered by an adeno-associated virus vector (AAV8), and KD of G protein-coupled receptor 180 (Gpr180) showed amelioration of hepatic lipid storage. Gpr180 knockout (KO) mice also showed ameliorated hepatic and plasma lipid levels without influencing glucose metabolism after high-fat diet intake. Transcriptome analyses showed downregulation of mTORC1 signaling and cholesterol homeostasis, which was confirmed by weakened phosphorylation of mTOR and decreased activated SREBP1 in Gpr180KO mice and a human hepatoma cell line (Huh7). AAV8-mediated hepatic rescue of GPR180 expression in KO mice showed recovery of plasma and hepatic lipid levels. In conclusion, ablation of GPR180 ameliorated plasma and hepatic lipid levels, which was mediated by downregulation of mTORC1 signaling.
    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2023-02-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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