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  1. Article ; Online: Prospects for use of bioengineered tissue from stem cells in gynecology.

    Brännström, Mats / Hellström, Mats

    Acta obstetricia et gynecologica Scandinavica

    2023  Volume 102, Issue 7, Page(s) 808–810

    MeSH term(s) Humans ; Gynecology ; Stem Cells
    Language English
    Publishing date 2023-07-05
    Publishing country United States
    Document type Editorial
    ZDB-ID 80019-3
    ISSN 1600-0412 ; 0001-6349
    ISSN (online) 1600-0412
    ISSN 0001-6349
    DOI 10.1111/aogs.14621
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  2. Article ; Online: Transplantation of a bioengineered tissue patch promotes uterine repair in the sheep.

    Sehic, Edina / de Miguel Gómez, Lucía / Rabe, Hardis / Thorén, Emy / Gudmundsdottir, Ingigerdur / Oltean, Mihai / Akouri, Randa / Brännström, Mats / Hellström, Mats

    Biomaterials science

    2024  Volume 12, Issue 8, Page(s) 2136–2148

    Abstract: Innovative bioengineering strategies utilizing extracellular matrix (ECM) based scaffolds derived from decellularized tissue offer new prospects for restoring damaged uterine tissue. Despite successful fertility restoration in small animal models, the ... ...

    Abstract Innovative bioengineering strategies utilizing extracellular matrix (ECM) based scaffolds derived from decellularized tissue offer new prospects for restoring damaged uterine tissue. Despite successful fertility restoration in small animal models, the translation to larger and more clinically relevant models have not yet been assessed. Thus, our study investigated the feasibility to use a 6 cm
    MeSH term(s) Humans ; Female ; Animals ; Sheep ; Tissue Engineering ; Uterus ; Bioengineering ; Mesenchymal Stem Cells/metabolism ; Extracellular Matrix/metabolism ; Tissue Scaffolds
    Language English
    Publishing date 2024-04-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 2693928-9
    ISSN 2047-4849 ; 2047-4830
    ISSN (online) 2047-4849
    ISSN 2047-4830
    DOI 10.1039/d3bm01912h
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  3. Article ; Online: Symptoms and signs did not predict outcome after surgery: a prospective study of 143 patients with idiopathic normal pressure hydrocephalus.

    Andrén, Kerstin / Wikkelsø, Carsten / Laurell, Katarina / Kollén, Lena / Hellström, Per / Tullberg, Mats

    Journal of neurology

    2024  

    Abstract: Objective: To determine the utility of symptoms, signs, comorbidities and background variables for the prediction of outcome of treatment in iNPH.: Methods: A prospective observational study of consecutively included iNPH patients, who underwent ... ...

    Abstract Objective: To determine the utility of symptoms, signs, comorbidities and background variables for the prediction of outcome of treatment in iNPH.
    Methods: A prospective observational study of consecutively included iNPH patients, who underwent neurological, physiotherapeutic and neuropsychological assessments before and after shunt surgery. The primary outcome measure was the total change on the iNPH scale, and patients were defined as improved postoperatively if they had improved by at least five points on that scale.
    Results: 143 iNPH patients were included, and 73% of those were improved after surgery. None of the examined symptoms or signs could predict which patients would improve after shunt surgery. A dominant subjective complaint of memory problems at baseline was predictive of non-improvement. The reported comorbidities, duration of symptoms and BMI were the same in improved and non-improved patients. Each of the symptom domains (gait, neuropsychology, balance, and continence) as well as the total iNPH scale score improved significantly (from median 53 to 69, p < 0.001). The proportions of patients with shuffling gait, broad-based gait, paratonic rigidity and retropulsion all decreased significantly.
    Discussion: This study confirms that the recorded clinical signs, symptoms, and impairments in the adopted clinical tests are characteristic findings in iNPH, based on that most of them improved after shunt surgery. However, our clinical data did not enable predictions of whether patients would respond to shunt surgery, indicating that the phenotype is unrelated to the reversibility of the iNPH state and should mainly support diagnosis. Absence of specific signs should not be used to exclude patients from treatment.
    Language English
    Publishing date 2024-03-05
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 187050-6
    ISSN 1432-1459 ; 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
    ISSN (online) 1432-1459
    ISSN 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
    DOI 10.1007/s00415-024-12248-w
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  4. Article: Mesenchymal stem cells establish a pro-regenerative immune milieu after decellularized rat uterus tissue transplantation.

    Sehic, Edina / Thorén, Emy / Gudmundsdottir, Ingigerdur / Oltean, Mihai / Brännström, Mats / Hellström, Mats

    Journal of tissue engineering

    2022  Volume 13, Page(s) 20417314221118858

    Abstract: Decellularized tissue is generally considered immune privileged after transplantation and is an attractive scaffold type for tissue regeneration, including applications for infertility treatment. However, the immune response following transplantation of ... ...

    Abstract Decellularized tissue is generally considered immune privileged after transplantation and is an attractive scaffold type for tissue regeneration, including applications for infertility treatment. However, the immune response following transplantation of decellularized tissue is insufficiently studied, in particular after they have been recellularized with mesenchymal stem cells (MSCs). Therefore, we replaced a large uterus segment with a bioengineered graft developed from decellularized uterus tissue and analyzed the immune response during the first 4 months in acellular or MSCs-recellularized scaffolds in the rat. Immunohistochemistry-stained infiltrating immune cells and plasma levels for 16 cytokines and chemokines were quantified. Results revealed that MSCs created an advantageous microenvironment by increasing anti-inflammatory interleukin 10 levels, and increasing the population of FOXP3
    Language English
    Publishing date 2022-08-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 2573915-3
    ISSN 2041-7314
    ISSN 2041-7314
    DOI 10.1177/20417314221118858
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  5. Article ; Online: Response to the Letter to the Editor regarding the article entitled 'Early shunt surgery improves survival in idiopathic normal pressure hydrocephalus'.

    Andrén, Kerstin / Wikkelsø, Carsten / Hellström, Per / Tullberg, Mats / Jaraj, Daniel

    European journal of neurology

    2021  Volume 28, Issue 11, Page(s) e90

    MeSH term(s) Cerebrospinal Fluid Shunts ; Humans ; Hydrocephalus, Normal Pressure/surgery
    Language English
    Publishing date 2021-03-22
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 1280785-0
    ISSN 1468-1331 ; 1351-5101 ; 1471-0552
    ISSN (online) 1468-1331
    ISSN 1351-5101 ; 1471-0552
    DOI 10.1111/ene.14804
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  6. Article ; Online: Accuracy of pulse oximetry in preterm and term infants is insufficient to determine arterial oxygen saturation and tension.

    Wackernagel, Dirk / Blennow, Mats / Hellström, Ann

    Acta paediatrica (Oslo, Norway : 1992)

    2020  Volume 109, Issue 11, Page(s) 2251–2257

    Abstract: Aim: Oxygen saturation is frequently monitored with pulse oximetry to assess vital signs in critically ill patients. Optimally, pulse oximetry closely tracks arterial oxygen tension (PaO: Methods: Twenty seven thousand two hundred thirty seven SpO: ...

    Abstract Aim: Oxygen saturation is frequently monitored with pulse oximetry to assess vital signs in critically ill patients. Optimally, pulse oximetry closely tracks arterial oxygen tension (PaO
    Methods: Twenty seven thousand two hundred thirty seven SpO
    Results: SpO
    Conclusions: Based on arterial blood gas analyses as reference, pulse oximetry readings did not fulfil the performance requirements for titrating oxygen in neonatal patients.
    MeSH term(s) Blood Gas Analysis ; Humans ; Hypoxia/diagnosis ; Infant ; Infant, Newborn ; Oximetry ; Oxygen ; Retrospective Studies
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2020-03-06
    Publishing country Norway
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 203487-6
    ISSN 1651-2227 ; 0365-1436 ; 0803-5253
    ISSN (online) 1651-2227
    ISSN 0365-1436 ; 0803-5253
    DOI 10.1111/apa.15225
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  7. Article ; Online: Early shunt surgery improves survival in idiopathic normal pressure hydrocephalus.

    Andrén, Kerstin / Wikkelsø, Carsten / Hellström, Per / Tullberg, Mats / Jaraj, Daniel

    European journal of neurology

    2021  Volume 28, Issue 4, Page(s) 1153–1159

    Abstract: Background and purpose: To examine the effect of delayed compared to early planning of shunt surgery on survival, in patients with idiopathic normal pressure hydrocephalus (iNPH), a long-term follow-up case-control study of patients exposed to a severe ... ...

    Abstract Background and purpose: To examine the effect of delayed compared to early planning of shunt surgery on survival, in patients with idiopathic normal pressure hydrocephalus (iNPH), a long-term follow-up case-control study of patients exposed to a severe delay of treatment was performed.
    Methods: In 2010-2011 our university hospital was affected by an administrative and economic failure that led to postponement of several elective neurosurgical procedures. This resulted in an unintentional delay of planning of treatment for a group of iNPH patients, referred to as iNPH
    Results: Median follow-up time was 6.0 years. Crude 4-year mortality was 39.4% in iNPH
    Conclusions: The present data indicate that shunt surgery is effective in iNPH and that early treatment increases survival.
    MeSH term(s) Case-Control Studies ; Humans ; Hydrocephalus, Normal Pressure/surgery ; Registries ; Treatment Outcome ; Ventriculoperitoneal Shunt
    Language English
    Publishing date 2021-01-25
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1280785-0
    ISSN 1468-1331 ; 1351-5101 ; 1471-0552
    ISSN (online) 1468-1331
    ISSN 1351-5101 ; 1471-0552
    DOI 10.1111/ene.14671
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  8. Article ; Online: Revised Swedish guidelines on intravenous iodine contrast medium-induced acute kidney injury 2022: A summary.

    Nyman, Ulf / Brismar, Torkel / Carlqvist, Jeanette / Hellström, Mikael / Lindblom, Maria / Lidén, Mats / Liss, Per / Sterner, Gunnar / Wikner, Franciska / Leander, Peter

    Acta radiologica (Stockholm, Sweden : 1987)

    2023  Volume 64, Issue 5, Page(s) 1859–1864

    Abstract: The Swedish Society of Uroradiology has revised their computed tomography (CT) guidelines regarding iodine contrast media-induced acute kidney injury (CI-AKI). They are more cautious compared to the European Society of Urogenital Radiology and the ... ...

    Abstract The Swedish Society of Uroradiology has revised their computed tomography (CT) guidelines regarding iodine contrast media-induced acute kidney injury (CI-AKI). They are more cautious compared to the European Society of Urogenital Radiology and the American College of Radiology since the actual risk of CI-AKI remains uncertain in patients with moderate to severe kidney damage due to a lack of prospective controlled studies and mainly based on retrospective propensity score-matched studies with low-grade evidence. Another source of uncertainty is the imprecision of glomerular filtration rate (GFR) estimating equations. However, randomized hydration studies indictae an upper limit risk of CI-AKI of about 5% for outpatients with a GFR in the range of 30-44 or 45-59 mL/min/1.73m
    MeSH term(s) Humans ; Iodine/adverse effects ; Sweden ; Retrospective Studies ; Acute Kidney Injury/chemically induced ; Radiography ; Contrast Media/adverse effects ; Risk Factors ; Glomerular Filtration Rate
    Chemical Substances Iodine (9679TC07X4) ; Contrast Media
    Language English
    Publishing date 2023-02-07
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 105-3
    ISSN 1600-0455 ; 0284-1851 ; 0349-652X
    ISSN (online) 1600-0455
    ISSN 0284-1851 ; 0349-652X
    DOI 10.1177/02841851231151511
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  9. Article ; Online: Donor-derived urologic cancers after renal transplantation: A retrospective non-randomized scientific analysis.

    Hellström, Vivan / Tufveson, Gunnar / Loskog, Angelica / Bengtsson, Mats / Enblad, Gunilla / Lorant, Tomas

    PloS one

    2022  Volume 17, Issue 9, Page(s) e0271293

    Abstract: Background: Malignancies in the urinary tract and the kidney graft are quite common after kidney transplantation. In some selected cases tumours develop from donor-derived tissue.: Objectives: We hypothesised that there is a clinical value to ... ...

    Abstract Background: Malignancies in the urinary tract and the kidney graft are quite common after kidney transplantation. In some selected cases tumours develop from donor-derived tissue.
    Objectives: We hypothesised that there is a clinical value to investigate donor/recipient origin in urologic malignancies in renal transplant recipients.
    Methods: In this retrospective study, including patients transplanted between the years 1969 and 2014 at Uppsala University Hospital, Sweden, 11 patients with malignancies in urinary tract and 4 patients with malignancies in kidney transplants were investigated. Donor/recipient origin of tumour tissue was analysed by polymerase chain reaction (PCR) of human leucocyte antigen (HLA) genotypes or by fluorescence in situ hybridization (FISH analysis) of sex chromosomes. HLA genotype and sex chromosomes of the tumour were compared to the known HLA genotype and sex chromosomes of recipient and donor.
    Results: Three of ten cancers in the urinary tract and three of four cancers in the kidney transplants were donor-derived.
    Conclusions: We suggest that urologic malignancies in renal transplant recipients can be investigated for transplant origin. In addition to conventional therapy the allograft immune response against these tumours can be valuable to treat donor-derived cancers.
    MeSH term(s) Graft Survival ; HLA Antigens ; Humans ; In Situ Hybridization, Fluorescence ; Kidney Transplantation/adverse effects ; Retrospective Studies ; Tissue Donors ; Urologic Neoplasms/genetics
    Chemical Substances HLA Antigens
    Language English
    Publishing date 2022-09-21
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0271293
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  10. Article ; Online: Mucosal Recovery after Intestinal Transplantation in the Rat: A Sequential Histological and Molecular Assessment.

    Bagge, Jasmine / Padma, Arvind Manikantan / Casselbrant, Anna / Hellström, Mats / Oltean, Mihai

    European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes

    2022  Volume 64, Issue 2, Page(s) 201–210

    Abstract: Introduction: Intestinal cold ischemia and subsequent reperfusion during transplantation result in various degrees of mucosal injury ranging from mild edema to extensive mucosal loss. Mucosal barrier impairment favors bacterial translocation and fluid ... ...

    Abstract Introduction: Intestinal cold ischemia and subsequent reperfusion during transplantation result in various degrees of mucosal injury ranging from mild edema to extensive mucosal loss. Mucosal barrier impairment favors bacterial translocation and fluid loss and raises nutritional challenges. The injured intestine also releases proinflammatory mediators and upregulates various epitopes toward an inflammatory phenotype. We studied the process of mucosal injury and repair during the early period after intestinal transplantation from a histological and molecular standpoint.
    Materials and methods: Adult Sprague-Dawley rats were used as donors and recipients. Donor intestines were perfused and stored in saline for 3 h, then transplanted heterotopically using microvascular anastomoses. Intestinal graft segments were obtained after 20 min, 6 h, 12 h, and 24 h after reperfusion. Histology studies (goblet cell count, morphometry), immunofluorescence, and western blot for several tight junction proteins, apoptosis, and inflammation-related proteins were performed.
    Results: Cold storage led to extensive epithelial detachment, whereas reperfusion resulted in extensive villus loss (about 60% of the initial length), and goblet cell numbers were drastically reduced. Over the first 24 h, gradual morphologic and molecular recovery was noted, although several molecular alterations persisted (increased apoptosis and inflammation, altered expression of several tight junctions).
    Conclusions: The current data suggest that a near-complete morphologic recovery from a moderate mucosal injury occurs within the first 24 h after intestinal transplantation. However, several molecular alterations persist and need to be considered when designing intestinal transplant experiments and choosing sampling and endpoints.
    MeSH term(s) Rats ; Animals ; Rats, Sprague-Dawley ; Reperfusion Injury ; Intestines/pathology ; Intestinal Mucosa ; Inflammation/metabolism ; Inflammation/pathology
    Language English
    Publishing date 2022-08-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 205700-1
    ISSN 1421-9921 ; 0014-312X
    ISSN (online) 1421-9921
    ISSN 0014-312X
    DOI 10.1159/000526274
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