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Article ; Online: Endoscopic Vacuum-Assisted Wound Closure of a Rectal Perforation in the Setting of Active Ulcerative Colitis.

Slater, Nicholas R / Loomes, Dustin E

The American journal of gastroenterology

2021 Volume 116, Issue 9, Page(s) 1826

MeSH term(s)	Adult ; Colitis, Ulcerative/complications ; Humans ; Male ; Negative-Pressure Wound Therapy ; Rectal Diseases/complications ; Rectal Diseases/therapy ; Treatment Outcome
Language	English
Publishing date	2021-04-10
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	390122-1
ISSN	1572-0241 ; 0002-9270
ISSN (online)	1572-0241
ISSN	0002-9270
DOI	10.14309/ajg.0000000000001208
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Article ; Online: VT storm in long QT resulting from COVID-19 vaccine allergy treated with epinephrine.

Slater, Nicholas R / Murphy, Kyle R / Sikkel, Markus B

European heart journal

2021 Volume 43, Issue 11, Page(s) 1176

MeSH term(s)	COVID-19 ; COVID-19 Vaccines/adverse effects ; Electrocardiography ; Epinephrine ; Humans ; Hypersensitivity ; Long QT Syndrome/chemically induced ; Tachycardia, Ventricular/therapy
Chemical Substances	COVID-19 Vaccines ; Epinephrine (YKH834O4BH)
Language	English
Publishing date	2021-11-17
Publishing country	England
Document type	Journal Article
ZDB-ID	603098-1
ISSN	1522-9645 ; 0195-668X
ISSN (online)	1522-9645
ISSN	0195-668X
DOI	10.1093/eurheartj/ehab748
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Article ; Online: A high-resolution daily global dataset of statistically downscaled CMIP6 models for climate impact analyses.

Gebrechorkos, Solomon / Leyland, Julian / Slater, Louise / Wortmann, Michel / Ashworth, Philip J / Bennett, Georgina L / Boothroyd, Richard / Cloke, Hannah / Delorme, Pauline / Griffith, Helen / Hardy, Richard / Hawker, Laurence / McLelland, Stuart / Neal, Jeffrey / Nicholas, Andrew / Tatem, Andrew J / Vahidi, Ellie / Parsons, Daniel R / Darby, Stephen E

Scientific data

2023 Volume 10, Issue 1, Page(s) 611

Abstract: A large number of historical simulations and future climate projections are available from Global Climate Models, but these are typically of coarse resolution, which limits their effectiveness for assessing local scale changes in climate and attendant ... ...

Abstract	A large number of historical simulations and future climate projections are available from Global Climate Models, but these are typically of coarse resolution, which limits their effectiveness for assessing local scale changes in climate and attendant impacts. Here, we use a novel statistical downscaling model capable of replicating extreme events, the Bias Correction Constructed Analogues with Quantile mapping reordering (BCCAQ), to downscale daily precipitation, air-temperature, maximum and minimum temperature, wind speed, air pressure, and relative humidity from 18 GCMs from the Coupled Model Intercomparison Project Phase 6 (CMIP6). BCCAQ is calibrated using high-resolution reference datasets and showed a good performance in removing bias from GCMs and reproducing extreme events. The globally downscaled data are available at the Centre for Environmental Data Analysis ( https://doi.org/10.5285/c107618f1db34801bb88a1e927b82317 ) for the historical (1981-2014) and future (2015-2100) periods at 0.25° resolution and at daily time step across three Shared Socioeconomic Pathways (SSP2-4.5, SSP5-3.4-OS and SSP5-8.5). This new climate dataset will be useful for assessing future changes and variability in climate and for driving high-resolution impact assessment models.
Language	English
Publishing date	2023-09-11
Publishing country	England
Document type	Dataset ; Journal Article
ZDB-ID	2775191-0
ISSN	2052-4463 ; 2052-4463
ISSN (online)	2052-4463
ISSN	2052-4463
DOI	10.1038/s41597-023-02528-x
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Article ; Online: The Stool Volatile Metabolome of Pre-Term Babies.

Frau, Alessandra / Lett, Lauren / Slater, Rachael / Young, Gregory R / Stewart, Christopher J / Berrington, Janet / Hughes, David M / Embleton, Nicholas / Probert, Chris

Molecules (Basel, Switzerland)

2021 Volume 26, Issue 11

Abstract: The fecal metabolome in early life has seldom been studied. We investigated its evolution in pre-term babies during their first weeks of life. Multiple (n = 152) stool samples were studied from 51 babies, all <32 weeks gestation. Volatile organic ... ...

Abstract	The fecal metabolome in early life has seldom been studied. We investigated its evolution in pre-term babies during their first weeks of life. Multiple (n = 152) stool samples were studied from 51 babies, all <32 weeks gestation. Volatile organic compounds (VOCs) were analyzed by headspace solid phase microextraction gas chromatography mass spectrometry. Data were interpreted using Automated Mass Spectral Deconvolution System (AMDIS) with the National Institute of Standards and Technology (NIST) reference library. Statistical analysis was based on linear mixed modelling, the number of VOCs increased over time; a rise was mainly observed between day 5 and day 10. The shift at day 5 was associated with products of branched-chain fatty acids. Prior to this, the metabolome was dominated by aldehydes and acetic acid. Caesarean delivery showed a modest association with molecules of fungal origin. This study shows how the metabolome changes in early life in pre-term babies. The shift in the metabolome 5 days after delivery coincides with the establishment of enteral feeding and the transition from meconium to feces. Great diversity of metabolites was associated with being fed greater volumes of milk.
MeSH term(s)	Cesarean Section/statistics & numerical data ; Enteral Nutrition ; Feces/chemistry ; Female ; Gas Chromatography-Mass Spectrometry ; Gestational Age ; Humans ; Infant ; Infant, Newborn ; Infant, Premature ; Linear Models ; Metabolomics/methods ; Pregnancy ; Solid Phase Microextraction ; Volatile Organic Compounds/analysis
Chemical Substances	Volatile Organic Compounds
Language	English
Publishing date	2021-06-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules26113341
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Article ; Online: Methanol synthesis from CO

Lawes, Naomi / Gow, Isla E / Smith, Louise R / Aggett, Kieran J / Hayward, James S / Kabalan, Lara / Logsdail, Andrew J / Slater, Thomas J A / Dearg, Malcolm / Morgan, David J / Dummer, Nicholas F / Taylor, Stuart H / Bowker, Michael / Catlow, C Richard A / Hutchings, Graham J

Faraday discussions

2023 Volume 242, Page(s) 193–211

Abstract: A number of Pd based materials have been synthesised and evaluated as catalysts for the conversion of carbon dioxide and hydrogen to methanol, a useful platform chemical and hydrogen storage molecule. Monometallic Pd catalysts show poor methanol ... ...

Abstract	A number of Pd based materials have been synthesised and evaluated as catalysts for the conversion of carbon dioxide and hydrogen to methanol, a useful platform chemical and hydrogen storage molecule. Monometallic Pd catalysts show poor methanol selectivity, but this is improved through the formation of Pd alloys, with both PdZn and PdGa alloys showing greatly enhanced methanol productivity compared with monometallic Pd/Al
Language	English
Publishing date	2023-01-31
Publishing country	England
Document type	Journal Article
ISSN	1364-5498
ISSN (online)	1364-5498
DOI	10.1039/d2fd00119e
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Article ; Online: Probabilistic Graphical Modeling for Estimating Risk of Coronary Artery Disease: Applications of a Flexible Machine-Learning Method.

Gupta, Alind / Slater, Justin J / Boyne, Devon / Mitsakakis, Nicholas / Béliveau, Audrey / Druzdzel, Marek J / Brenner, Darren R / Hussain, Selena / Arora, Paul

Medical decision making : an international journal of the Society for Medical Decision Making

2019 Volume 39, Issue 8, Page(s) 1032–1044

Abstract: Objectives. ...

Abstract	Objectives.
MeSH term(s)	Bayes Theorem ; Computer Graphics ; Coronary Artery Disease/epidemiology ; Humans ; Iran/epidemiology ; Logistic Models ; Machine Learning ; Probability ; ROC Curve ; Risk Assessment/methods
Language	English
Publishing date	2019-10-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	604497-9
ISSN	1552-681X ; 0272-989X
ISSN (online)	1552-681X
ISSN	0272-989X
DOI	10.1177/0272989X19879095
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Article: The Critical Role of βPdZn Alloy in Pd/ZnO Catalysts for the Hydrogenation of Carbon Dioxide to Methanol.

Bowker, Michael / Lawes, Naomi / Gow, Isla / Hayward, James / Esquius, Jonathan Ruiz / Richards, Nia / Smith, Louise R / Slater, Thomas J A / Davies, Thomas E / Dummer, Nicholas F / Kabalan, Lara / Logsdail, Andrew / Catlow, Richard C / Taylor, Stuart / Hutchings, Graham J

ACS catalysis

2022 Volume 12, Issue 9, Page(s) 5371–5379

Abstract: The rise in atmospheric ... ...

Abstract	The rise in atmospheric CO
Language	English
Publishing date	2022-04-20
Publishing country	United States
Document type	Journal Article
ISSN	2155-5435
ISSN	2155-5435
DOI	10.1021/acscatal.2c00552
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Article ; Online: Insecticide resistance management and industry: the origins and evolution of the Insecticide Resistance Action Committee (IRAC) and the mode of action classification scheme.

Sparks, Thomas C / Storer, Nicholas / Porter, Alan / Slater, Russell / Nauen, Ralf

Pest management science

2021 Volume 77, Issue 6, Page(s) 2609–2619

Abstract: Insecticide resistance is a long-standing problem affecting the efficacy and utility of crop protection compounds. Insecticide resistance also impacts the ability and willingness of companies around the world to invest in new crop protection compounds ... ...

Abstract	Insecticide resistance is a long-standing problem affecting the efficacy and utility of crop protection compounds. Insecticide resistance also impacts the ability and willingness of companies around the world to invest in new crop protection compounds and traits. The Insecticide Resistance Action Committee (IRAC) was formed in 1984 to provide a coordinated response by the crop protection industry to the problem of insecticide resistance. Since its inception, participation in IRAC has grown from a few agrochemical companies in Europe and the US to a much larger group of companies with global representation and an active presence (IRAC Country Groups) involving an even wider array of companies in more than 20 countries. The focus of IRAC has also evolved from that of defining and documenting cases of insecticide resistance to a pro-active role in addressing insecticide resistance management (IRM) providing an array of informational and educational tools (videos, posters, pamphlets) on insect pests, bioassay methods, insecticide mode of action and resistance management, all publicly available through its website (https://irac-online.org/). A key tool developed by IRAC is the Insecticide Mode of Action (MoA) Classification Scheme, which has evolved from a relatively simple acaricide classification started in 1998 to the far broader scheme that now includes biologics as well as insecticides and acaricides. A separate MoA Classification Scheme has also been recently developed for nematicides. The IRAC MoA Classification Scheme coupled with expanding use of MoA labeling on insecticide and acaricide product labels provides a straightforward means to implement IRM. An overview of the history of IRAC along with some of its notable accomplishments and future directions are reviewed. © 2021 The Authors. Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
MeSH term(s)	Acaricides/pharmacology ; Animals ; Europe ; Insecta ; Insecticide Resistance ; Insecticides/pharmacology
Chemical Substances	Acaricides ; Insecticides
Language	English
Publishing date	2021-01-28
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2001705-4
ISSN	1526-4998 ; 1526-498X
ISSN (online)	1526-4998
ISSN	1526-498X
DOI	10.1002/ps.6254
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Article ; Online: The Stool Volatile Metabolome of Pre-Term Babies

Alessandra Frau / Lauren Lett / Rachael Slater / Gregory R. Young / Christopher J. Stewart / Janet Berrington / David M. Hughes / Nicholas Embleton / Chris Probert

Molecules, Vol 26, Iss 3341, p

2021 Volume 3341

Abstract	The fecal metabolome in early life has seldom been studied. We investigated its evolution in pre-term babies during their first weeks of life. Multiple (n = 152) stool samples were studied from 51 babies, all <32 weeks gestation. Volatile organic compounds (VOCs) were analyzed by headspace solid phase microextraction gas chromatography mass spectrometry. Data were interpreted using Automated Mass Spectral Deconvolution System (AMDIS) with the National Institute of Standards and Technology (NIST) reference library. Statistical analysis was based on linear mixed modelling, the number of VOCs increased over time; a rise was mainly observed between day 5 and day 10. The shift at day 5 was associated with products of branched-chain fatty acids. Prior to this, the metabolome was dominated by aldehydes and acetic acid. Caesarean delivery showed a modest association with molecules of fungal origin. This study shows how the metabolome changes in early life in pre-term babies. The shift in the metabolome 5 days after delivery coincides with the establishment of enteral feeding and the transition from meconium to feces. Great diversity of metabolites was associated with being fed greater volumes of milk.
Keywords	metabolome ; feces ; neonates ; fermentation ; protein ; carbohydrate ; Organic chemistry ; QD241-441
Subject code	540
Language	English
Publishing date	2021-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Regional quantification of cardiac metabolism with hyperpolarized [1-

Larson, Peder E Z / Tang, Shuyu / Liu, Xiaoxi / Sinha, Avantika / Dwork, Nicholas / Sivalokanathan, Sanjay / Liu, Jing / Bok, Robert / Ordovas, Karen G / Slater, James / Gordon, Jeremy W / Abraham, M Roselle

medRxiv : the preprint server for health sciences

2023

Abstract: Background: The heart has metabolic flexibility, which is influenced by fed/fasting states, and pathologies such as myocardial ischemia and hypertrophic cardiomyopathy (HCM). Hyperpolarized (HP) : Methods: We developed and applied methods for whole- ... ...

Abstract	Background: The heart has metabolic flexibility, which is influenced by fed/fasting states, and pathologies such as myocardial ischemia and hypertrophic cardiomyopathy (HCM). Hyperpolarized (HP) Methods: We developed and applied methods for whole-heart imaging of Results: We demonstrate whole heart coverage for dynamic measurement of pyruvate-to-lactate conversion via LDH and pyruvate-to-bicarbonate conversion via PDH at a resolution of 6×6×21 mm Conclusions: We demonstrate first-in-human regional quantifications of cardiac metabolism by HP
Language	English
Publishing date	2023-10-19
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.10.16.23297052
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