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  1. Article ; Online: Piece of Cake: Slicing through the Complex Layers of COPD with Lung Tissue Network Analysis.

    Moll, Matthew / McDonough, John

    American journal of respiratory and critical care medicine

    2024  

    Language English
    Publishing date 2024-04-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202403-0560ED
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  2. Article ; Online: Precision Approaches to Chronic Obstructive Pulmonary Disease Management.

    Moll, Matthew / Silverman, Edwin K

    Annual review of medicine

    2023  Volume 75, Page(s) 247–262

    Abstract: Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide. COPD heterogeneity has hampered progress in developing pharmacotherapies that affect disease progression. This issue can be addressed by precision ... ...

    Abstract Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide. COPD heterogeneity has hampered progress in developing pharmacotherapies that affect disease progression. This issue can be addressed by precision medicine approaches, which focus on understanding an individual's disease risk, and tailoring management based on pathobiology, environmental exposures, and psychosocial issues. There is an urgent need to identify COPD patients at high risk for poor outcomes and to understand at a mechanistic level why certain individuals are at high risk. Genetics, omics, and network analytic techniques have started to dissect COPD heterogeneity and identify patients with specific pathobiology. Drug repurposing approaches based on biomarkers of specific inflammatory processes (i.e., type 2 inflammation) are promising. As larger data sets, additional omics, and new analytical approaches become available, there will be enormous opportunities to identify high-risk individuals and treat COPD patients based on their specific pathophysiological derangements. These approaches show great promise for risk stratification, early intervention, drug repurposing, and developing novel therapeutic approaches for COPD.
    MeSH term(s) Humans ; Disease Progression ; Inflammation ; Precision Medicine ; Pulmonary Disease, Chronic Obstructive/drug therapy ; Pulmonary Disease, Chronic Obstructive/genetics
    Language English
    Publishing date 2023-10-12
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 207930-6
    ISSN 1545-326X ; 0066-4219
    ISSN (online) 1545-326X
    ISSN 0066-4219
    DOI 10.1146/annurev-med-060622-101239
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  3. Article ; Online: When to use anticoagulation in COVID-19.

    Moll, Matthew / Connors, Jean M

    Thrombosis research

    2021  Volume 204, Page(s) 136–137

    MeSH term(s) Anticoagulants/pharmacology ; Anticoagulants/therapeutic use ; Blood Coagulation/drug effects ; COVID-19 ; Humans ; SARS-CoV-2 ; Venous Thromboembolism
    Chemical Substances Anticoagulants
    Language English
    Publishing date 2021-06-16
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 121852-9
    ISSN 1879-2472 ; 0049-3848
    ISSN (online) 1879-2472
    ISSN 0049-3848
    DOI 10.1016/j.thromres.2021.06.005
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  4. Article ; Online: Interpreting recent clinical studies for COVID-19: A continual process with more new data.

    Connors, Jean M / Moll, Matthew / Levy, Jerrold H

    Anaesthesia, critical care & pain medicine

    2021  Volume 41, Issue 1, Page(s) 101016

    MeSH term(s) Anticoagulants ; COVID-19 ; Heparin ; Humans ; SARS-CoV-2
    Chemical Substances Anticoagulants ; Heparin (9005-49-6)
    Language English
    Publishing date 2021-12-24
    Publishing country France
    Document type Editorial
    ISSN 2352-5568
    ISSN (online) 2352-5568
    DOI 10.1016/j.accpm.2021.101016
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  5. Article ; Online: COVID-19 Racial and Ethnic Inequities in Acute Care and Critical Illness Survivorship.

    Tukpah, Ann-Marcia / Moll, Matthew / Gay, Elizabeth

    Annals of the American Thoracic Society

    2021  Volume 18, Issue 1, Page(s) 23–25

    MeSH term(s) COVID-19/ethnology ; Critical Care/methods ; Critical Illness/epidemiology ; Ethnic Groups ; Humans ; Pandemics ; SARS-CoV-2 ; Survivorship
    Keywords covid19
    Language English
    Publishing date 2021-07-15
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2717461-X
    ISSN 2325-6621 ; 1943-5665 ; 2325-6621
    ISSN (online) 2325-6621 ; 1943-5665
    ISSN 2325-6621
    DOI 10.1513/AnnalsATS.202005-549VP
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    Zs.A 5828: Show issues Location:
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  6. Article ; Online: Reply.

    Prisco, Lauren / Moll, Matthew / Doyle, Tracey J / Cho, Michael H / Sparks, Jeffrey A

    Arthritis & rheumatology (Hoboken, N.J.)

    2022  Volume 74, Issue 6, Page(s) 1096–1097

    Language English
    Publishing date 2022-04-28
    Publishing country United States
    Document type Letter ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 2756371-6
    ISSN 2326-5205 ; 2326-5191
    ISSN (online) 2326-5205
    ISSN 2326-5191
    DOI 10.1002/art.42086
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    Zs.A 24: Show issues Location:
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  7. Article ; Online: A longitudinal study combining the Double Diamond framework and Behavior Change Wheel to co-create a sedentary behavior intervention in police control rooms.

    Oliver, Helen / Thomas, Owen / Neil, Rich / Copeland, Robert J / Moll, Tjerk / Chadd, Kathryn / Jukes, Matthew J / Quartermaine, Alisa

    Journal of public health (Oxford, England)

    2024  

    Abstract: Background: Police work can be sedentary and stressful, negatively impacting health and wellbeing. In a novel co-creation approach, we used the Behavior Change Wheel (BCW) and Double Diamond (DD) design framework to guide the collaborative design and ... ...

    Abstract Background: Police work can be sedentary and stressful, negatively impacting health and wellbeing. In a novel co-creation approach, we used the Behavior Change Wheel (BCW) and Double Diamond (DD) design framework to guide the collaborative design and development of a sedentary behavior intervention in the control rooms of two British police forces.
    Methods: Multiple stakeholders participated in four phases of research. In Phase 1, a literature review, focus groups (n = 20) and interviews (n = 10) were conducted to 'discover' the relationship between physical activity and wellbeing in the police. In Phase 2, a steering group consolidated Phase 1 findings to 'define' a specific behavior for intervention. Phases 3 and 4 'developed' the intervention across six workshops with control room workers and six steering group workshops.
    Results: The co-creation process identified contextual sedentary behavior as the target behavior, driven by behavioral regulation, social influence and social norms. The sedentary behavior intervention targeted these drivers and aimed to engage control room workers in short bursts of physical activity throughout their shifts. Key intervention features targeted involvement of staff in decision-making and embedding physical activity into work practices.
    Conclusions: The BCW and DD can be combined to co-create evidence-based and participant-informed interventions and translate science into action.
    Language English
    Publishing date 2024-05-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 2142082-8
    ISSN 1741-3850 ; 1741-3842
    ISSN (online) 1741-3850
    ISSN 1741-3842
    DOI 10.1093/pubmed/fdae061
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  8. Article: Clinical factors associated with racial differences in the prevalence of occult hypoxemia: a retrospective case-control study.

    Mettler, Sofia K / Charoenngam, Nipith / Jaroenlapnopparat, Aunchalee / Tern, Courtney / Xanthavanij, Nutchapon / Economidou, Sofia / Strand, Matthew J / Hobbs, Brian D / Moll, Matthew / Cho, Michael H

    medRxiv : the preprint server for health sciences

    2024  

    Abstract: Background: Recent studies showed that Black patients more often have falsely normal oxygen saturation on pulse oximetry compared to White patients. However, whether the racial differences in occult hypoxemia are mediated by other clinical differences ... ...

    Abstract Background: Recent studies showed that Black patients more often have falsely normal oxygen saturation on pulse oximetry compared to White patients. However, whether the racial differences in occult hypoxemia are mediated by other clinical differences is unknown.
    Methods: We conducted a retrospective case-control study utilizing two large ICU databases (eICU and MIMIC-IV). We defined occult hypoxemia as oxygen saturation on pulse oximetry within 92-98% despite oxygen saturation on arterial blood gas below 90%. We assessed associations of commonly measured clinical factors with occult hypoxemia using multivariable logistic regression and conducted mediation analysis of the racial effect.
    Results: Among 24,641 patients, there were 1,855 occult hypoxemia cases and 23,786 controls. In both datasets, Black patients were more likely to have occult hypoxemia (unadjusted odds ratio 1.66 [95%-CI: 1.41-1.95] in eICU and 2.00 [95%-CI: 1.22-3.14] in MIMIC-IV). In multivariable models, higher respiratory rate, PaCO2 and creatinine as well as lower hemoglobin were associated with increased odds of occult hypoxemia. Differences in the commonly measured clinical markers accounted for 9.2% and 44.4% of the racial effect on occult hypoxemia in eICU and MIMIC-IV, respectively.
    Conclusion: Clinical differences, in addition to skin tone, might mediate some of the racial differences in occult hypoxemia.
    Language English
    Publishing date 2024-03-29
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.03.28.24305036
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  9. Article ; Online: Lower myostatin and higher MUC1 levels are associated with better response to mepolizumab and omalizumab in asthma: a protein-protein interaction analyses.

    Akenroye, Ayobami / Nopsopon, Tanawin / Cho, Laura / Moll, Matthew / Weiss, Scott T

    Respiratory research

    2023  Volume 24, Issue 1, Page(s) 305

    Abstract: Introduction: Biomarkers are needed to inform the choice of biologic therapy in patients with asthma given the increasing number of biologics. We aimed to identify proteins associated with response to omalizumab and mepolizumab.: Methods: Aptamer- ... ...

    Abstract Introduction: Biomarkers are needed to inform the choice of biologic therapy in patients with asthma given the increasing number of biologics. We aimed to identify proteins associated with response to omalizumab and mepolizumab.
    Methods: Aptamer-based proteomic profiling (SomaScan) was used to assess 1437 proteins from 51 patients with moderate to severe asthma who received omalizumab (n = 29) or mepolizumab (n = 22). Response was defined as the change in asthma-related exacerbations in the 12 months following therapy initiation. All models were adjusted for age, sex, and pre-treatment exacerbation rate. Additionally, body mass index was included in the omalizumab model and eosinophil count in the mepolizumab model. We evaluated the association between molecular signatures and response using negative binomial regression correcting for the false discovery rate (FDR) and gene set enrichment analyses (GSEA) to identify associated pathways.
    Results: Over two-thirds of patients were female. The average age for omalizumab patients was 42 years and 57 years for mepolizumab. At baseline, the average exacerbation rate was 1.5/year for omalizumab and 2.4/year for mepolizumab. Lower levels of LOXL2 (unadjusted p: 1.93 × 10E-05, FDR-corrected: 0.028) and myostatin (unadjusted: 3.87 × 10E-05, FDR-corrected: 0.028) were associated with better response to mepolizumab. Higher levels of CD9 antigen (unadjusted: 5.30 × 10E-07, FDR-corrected: 0.0006) and MUC1 (unadjusted: 1.15 × 10E-06, FDR-corrected: 0.0006) were associated with better response to omalizumab, and LTB4R (unadjusted: 1.12 × 10E-06, FDR-corrected: 0.0006) with worse response. Protein-protein interaction network modeling showed an enrichment of the TNF- and NF-kB signaling pathways for patients treated with mepolizumab and multiple pathways involving MAPK, including the FcER1 pathway, for patients treated with omalizumab.
    Conclusions: This study provides novel fundamental data on proteins associated with response to mepolizumab or omalizumab in severe asthma and warrants further validation as potential biomarkers for therapy selection.
    MeSH term(s) Humans ; Female ; Adult ; Male ; Omalizumab/therapeutic use ; Omalizumab/adverse effects ; Anti-Asthmatic Agents ; Myostatin/therapeutic use ; Proteomics ; Asthma/diagnosis ; Asthma/drug therapy ; Asthma/chemically induced ; Biomarkers ; Mucin-1
    Chemical Substances Omalizumab (2P471X1Z11) ; mepolizumab (90Z2UF0E52) ; Anti-Asthmatic Agents ; Myostatin ; Biomarkers ; MUC1 protein, human ; Mucin-1
    Language English
    Publishing date 2023-12-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041675-1
    ISSN 1465-993X ; 1465-993X
    ISSN (online) 1465-993X
    ISSN 1465-993X
    DOI 10.1186/s12931-023-02620-1
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  10. Article ; Online: Lower myostatin and higher MUC1 levels are associated with better response to mepolizumab and omalizumab in asthma

    Ayobami Akenroye / Tanawin Nopsopon / Laura Cho / Matthew Moll / Scott T. Weiss

    Respiratory Research, Vol 24, Iss 1, Pp 1-

    a protein–protein interaction analyses

    2023  Volume 13

    Abstract: Abstract Introduction Biomarkers are needed to inform the choice of biologic therapy in patients with asthma given the increasing number of biologics. We aimed to identify proteins associated with response to omalizumab and mepolizumab. Methods Aptamer- ... ...

    Abstract Abstract Introduction Biomarkers are needed to inform the choice of biologic therapy in patients with asthma given the increasing number of biologics. We aimed to identify proteins associated with response to omalizumab and mepolizumab. Methods Aptamer-based proteomic profiling (SomaScan) was used to assess 1437 proteins from 51 patients with moderate to severe asthma who received omalizumab (n = 29) or mepolizumab (n = 22). Response was defined as the change in asthma-related exacerbations in the 12 months following therapy initiation. All models were adjusted for age, sex, and pre-treatment exacerbation rate. Additionally, body mass index was included in the omalizumab model and eosinophil count in the mepolizumab model. We evaluated the association between molecular signatures and response using negative binomial regression correcting for the false discovery rate (FDR) and gene set enrichment analyses (GSEA) to identify associated pathways. Results Over two-thirds of patients were female. The average age for omalizumab patients was 42 years and 57 years for mepolizumab. At baseline, the average exacerbation rate was 1.5/year for omalizumab and 2.4/year for mepolizumab. Lower levels of LOXL2 (unadjusted p: 1.93 × 10E−05, FDR-corrected: 0.028) and myostatin (unadjusted: 3.87 × 10E−05, FDR-corrected: 0.028) were associated with better response to mepolizumab. Higher levels of CD9 antigen (unadjusted: 5.30 × 10E−07, FDR-corrected: 0.0006) and MUC1 (unadjusted: 1.15 × 10E−06, FDR-corrected: 0.0006) were associated with better response to omalizumab, and LTB4R (unadjusted: 1.12 × 10E−06, FDR-corrected: 0.0006) with worse response. Protein–protein interaction network modeling showed an enrichment of the TNF- and NF-kB signaling pathways for patients treated with mepolizumab and multiple pathways involving MAPK, including the FcER1 pathway, for patients treated with omalizumab. Conclusions This study provides novel fundamental data on proteins associated with response to mepolizumab or omalizumab in severe asthma and ...
    Keywords Asthma ; Mepolizumab ; Omalizumab ; Proteomics ; Network medicine ; Protein–protein interaction ; Diseases of the respiratory system ; RC705-779
    Subject code 610
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
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