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Article ; Online: Vaccination for COVID-19: Is it important and what should you know about it?

Wu, Chao-Ping / Adhi, Fatima / Culver, Daniel

2021

Abstract: An effective vaccine is considered the best method to achieve herd immunity. As of February 2021, 12 vaccines were in late-stage clinical trials worldwide, with many more in development. Of those, 8 have received emergency use authorization from at least ...

Abstract	An effective vaccine is considered the best method to achieve herd immunity. As of February 2021, 12 vaccines were in late-stage clinical trials worldwide, with many more in development. Of those, 8 have received emergency use authorization from at least one country's governing body. These vaccines use various platforms to deliver the vaccines, each with pros and cons. Published data show these vaccines are effective in preventing the severe symptoms associated with COVID-19 in adults with few side effects, but challenges remain with storage and delivery and treating virus variants.
Language	English
Publishing date	2021-03-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	639116-3
ISSN	1939-2869 ; 0891-1150
ISSN (online)	1939-2869
ISSN	0891-1150
DOI	10.3949/ccjm.88a.ccc076
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Article ; Online: Transcription factor 21

Yu, Teng-Hung / Lee, Thung-Lip / Tsai, I-Ting / Hsuan, Chin-Feng / Wang, Chao-Ping / Lu, Yung-Chuan / Tang, Wei-Hua / Wei, Ching-Ting / Chung, Fu-Mei / Lee, Yau-Jiunn / Wu, Cheng-Ching

International journal of medical sciences

2024 Volume 21, Issue 3, Page(s) 483–491

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Humans ; Angina, Stable/genetics ; ST Elevation Myocardial Infarction/genetics ; Diabetes Mellitus, Type 2 ; Hypertension ; Hyperlipidemias ; China ; Basic Helix-Loop-Helix Transcription Factors/genetics
Chemical Substances	TCF21 protein, human ; Basic Helix-Loop-Helix Transcription Factors
Language	English
Publishing date	2024-01-01
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2151424-0
ISSN	1449-1907 ; 1449-1907
ISSN (online)	1449-1907
ISSN	1449-1907
DOI	10.7150/ijms.89901
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A Single-Substrate Biosensor with Spin-Coated Liquid Crystal Film for Simple, Sensitive and Label-Free Protein Detection.

Wu, Po-Chang / Pai, Chao-Ping / Lee, Mon-Juan / Lee, Wei

Biosensors

2021 Volume 11, Issue 10

Abstract: A liquid crystal (LC)-based single-substrate biosensor was developed by spin-coating an LC thin film on a dimethyloctadecyl[3-(trimethoxysilyl)propyl]ammonium chloride (DMOAP)-decorated glass slide. Compared with the conventional sandwiched cell ... ...

Abstract	A liquid crystal (LC)-based single-substrate biosensor was developed by spin-coating an LC thin film on a dimethyloctadecyl[3-(trimethoxysilyl)propyl]ammonium chloride (DMOAP)-decorated glass slide. Compared with the conventional sandwiched cell configuration, the simplified procedure for the preparation of an LC film allows the film thickness to be precisely controlled by adjusting the spin rate, thus eliminating personal errors involved in LC cell assembly. The limit of detection (LOD) for bovine serum albumin (BSA) was lowered from 10
MeSH term(s)	Biomarkers, Tumor ; Biosensing Techniques ; Immunoassay ; Liquid Crystals ; Serum Albumin, Bovine
Chemical Substances	Biomarkers, Tumor ; Serum Albumin, Bovine (27432CM55Q)
Language	English
Publishing date	2021-10-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662125-3
ISSN	2079-6374 ; 2079-6374
ISSN (online)	2079-6374
ISSN	2079-6374
DOI	10.3390/bios11100374
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Article ; Online: Recognition and management of respiratory co-infection and secondary bacterial pneumonia in patients with COVID-19.

Wu, Chao-Ping / Adhi, Fatima / Highland, Kristin

Cleveland Clinic journal of medicine

2020 Volume 87, Issue 11, Page(s) 659–663

Abstract: In COVID-19, respiratory infection with SARS-CoV-2 plus another virus (viral co-infection) or with SARS-CoV-2 plus a bacterial pathogen (combined viral and bacterial pneumonia) has been described. Secondary bacterial pneumonia can follow the initial ... ...

Abstract	In COVID-19, respiratory infection with SARS-CoV-2 plus another virus (viral co-infection) or with SARS-CoV-2 plus a bacterial pathogen (combined viral and bacterial pneumonia) has been described. Secondary bacterial pneumonia can follow the initial phase of viral respiratory infection or occur during the recovery phase. No obvious pattern or guidelines exist for viral co-infection, combined viral and bacterial pneumonia, or secondary bacterial pneumonia in COVID-19. Based on existing clinical data and experience with similar viruses such as influenza and SARS-CoV, the management approach in COVID-19 should, ideally, take into consideration the overall presentation and the trajectory of illness.
MeSH term(s)	Anti-Bacterial Agents/administration & dosage ; Bacteria/classification ; Bacteria/isolation & purification ; COVID-19 ; COVID-19 Testing ; Clinical Laboratory Techniques/methods ; Coinfection/diagnosis ; Coinfection/etiology ; Coinfection/therapy ; Community-Acquired Infections/epidemiology ; Community-Acquired Infections/therapy ; Coronavirus Infections/diagnosis ; Coronavirus Infections/epidemiology ; Coronavirus Infections/therapy ; Cross Infection/epidemiology ; Cross Infection/therapy ; Diagnosis, Differential ; Humans ; Pandemics ; Patient Care Management/methods ; Pneumonia, Bacterial/epidemiology ; Pneumonia, Bacterial/etiology ; Pneumonia, Bacterial/therapy ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/therapy ; Virus Diseases/epidemiology ; Virus Diseases/therapy
Chemical Substances	Anti-Bacterial Agents
Keywords	covid19
Language	English
Publishing date	2020-11-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	639116-3
ISSN	1939-2869 ; 0891-1150
ISSN (online)	1939-2869
ISSN	0891-1150
DOI	10.3949/ccjm.87a.ccc015
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Article ; Online: Differential effects of EPA and DHA on PPARγ-mediated sympathetic innervation in infarcted rat hearts by GPR120-dependent and -independent mechanisms.

Wang, Chao-Ping / Lee, Cheng-Che / Wu, De-Yu / Chen, Syue-Yi / Lee, Tsung-Ming

The Journal of nutritional biochemistry

2022 Volume 103, Page(s) 108950

Abstract: The ω-3 fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), have been shown to attenuate inflammation processes, whereas the molecular mechanisms remain unclear. This study was aimed at figuring out the differential effects of EPA ... ...

Abstract	The ω-3 fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), have been shown to attenuate inflammation processes, whereas the molecular mechanisms remain unclear. This study was aimed at figuring out the differential effects of EPA and DHA on fatal arrhythmias and whether the signaling pathway could be a target after myocardial infarction, an inflammatory status. Male Wistar rats after ligating coronary artery were randomized to either vehicle, EPA, or DHA for 4 weeks. Postinfarction was associated with increased myocardial norepinephrine levels and sympathetic innervation. Furthermore, infarction was associated with the activation of NLRP3 inflammasomes and increased the protein and expression of IL-1β and nerve growth factor (NGF). These changes were blunted after adding either EPA or DHA with a greater extent of EPA than DHA. Immunoblotting and immunohistochemical analysis showed that EPA had significantly lower phosphorylation of PPARγ at Ser 112 compared with DHA. Arrhythmic severity during programmed stimulation in the infarcted rats treated with EPA was significantly lower than those treated with DHA. Specific inhibition of GPR120 by AH-7614 and PPARγ by T0070907 reduced the EPA-or DHA-related attenuation of IL-1β and NGF release. Besides, AH-7614 treatment partially reduced the PPARγ levels, whereas T0070907 administration did not affect the GPR120 levels. These results suggest that EPA was more effective than DHA in prevention of fatal arrhythmias by inhibiting NLRP3 inflammasome and sympathetic innervation through activation of PPARγ-mediated GPR120-dependent and -independent signaling pathways in infarcted hearts.
MeSH term(s)	Animals ; Docosahexaenoic Acids/metabolism ; Docosahexaenoic Acids/pharmacology ; Eicosapentaenoic Acid/metabolism ; Eicosapentaenoic Acid/pharmacology ; Inflammasomes/metabolism ; Male ; Myocardial Infarction ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Nerve Growth Factor ; PPAR gamma/metabolism ; Rats ; Rats, Wistar
Chemical Substances	Inflammasomes ; NLR Family, Pyrin Domain-Containing 3 Protein ; PPAR gamma ; Docosahexaenoic Acids (25167-62-8) ; Nerve Growth Factor (9061-61-4) ; Eicosapentaenoic Acid (AAN7QOV9EA)
Language	English
Publishing date	2022-02-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1014929-6
ISSN	1873-4847 ; 0955-2863
ISSN (online)	1873-4847
ISSN	0955-2863
DOI	10.1016/j.jnutbio.2022.108950
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Article: Pretreatment Circulating Albumin, Platelet, and RDW-SD Associated with Worse Disease-Free Survival in Patients with Breast Cancer.

Chen, Chia-Chi / Tang, Wei-Hua / Wu, Cheng-Ching / Lee, Thung-Lip / Tsai, I-Ting / Hsuan, Chin-Feng / Wang, Chao-Ping / Chung, Fu-Mei / Lee, Yau-Jiunn / Yu, Teng-Hung / Wei, Ching-Ting

Breast cancer (Dove Medical Press)

2024 Volume 16, Page(s) 23–39

Abstract: Objective: Breast cancer is the second most common malignancy globally and a leading cause of cancer death in women. Analysis of factors related to disease-free survival (DFS) has improved understanding of the disease and characteristics related to ... ...

Abstract	Objective: Breast cancer is the second most common malignancy globally and a leading cause of cancer death in women. Analysis of factors related to disease-free survival (DFS) has improved understanding of the disease and characteristics related to recurrence. The aim of this study was to investigate the predictors of DFS in patients with breast cancer to enable the identification of patients at high risk who may benefit from prevention interventions. Methods: We retrospectively analyzed 559 women with breast cancer who underwent treatment between 2004 and 2022. The study endpoint was DFS. Recurrence was defined as local recurrence, regional recurrence, distant metastases, contralateral breast cancer, other second primary cancer, and death. Baseline tumor-related characteristics, treatment-related characteristics, sociodemographic and biochemical data were analyzed using Cox proportional hazards analysis. Results: The median DFS was 45 months (range, 2 to 225 months). Breast cancer recurred in 86 patients (15.4%), of whom 10 had local recurrence, 10 had regional recurrence, 17 had contralateral breast cancer, 29 had distant metastases, 10 had second primary cancer, and 10 patients died. Multivariate forward stepwise Cox regression analysis showed that AJCC stage III, Ki67 ≥14%, albumin, platelet, and red cell distribution width-standard deviation (RDW-SD) were predictors of worse DFS. In addition, the effects of albumin, platelet, and RDW-SD on disease recurrence were confirmed by structural equation model (SEM) analysis. Conclusion: In addition to the traditional predictors of worse DFS such as AJCC stage III and Ki67 ≥14%, lower pretreatment circulating albumin, higher pretreatment circulating platelet count and RDW-SD could significantly predict worse DFS in this study, and SEM delineated possible causal pathways and inter-relationships of albumin, platelet, and RDW-SD contributing to the disease recurrence among Chinese women with breast cancer.
Language	English
Publishing date	2024-01-16
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2520722-2
ISSN	1179-1314
ISSN	1179-1314
DOI	10.2147/BCTT.S443292
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Noise reduction by upstream open reading frames.

Wu, Ho-Wei / Fajiculay, Erickson / Wu, Jing-Fen / Yan, Ching-Cher Sanders / Hsu, Chao-Ping / Wu, Shu-Hsing

Nature plants

2022 Volume 8, Issue 5, Page(s) 474–480

Abstract: Gene expression is prone to burst production, making it a highly noisy process that requires additional controls. Upstream open reading frames (uORFs) are widely present in the 5' leader sequences of 30-50% of eukaryotic messenger ... ...

Abstract	Gene expression is prone to burst production, making it a highly noisy process that requires additional controls. Upstream open reading frames (uORFs) are widely present in the 5' leader sequences of 30-50% of eukaryotic messenger RNAs
MeSH term(s)	Open Reading Frames ; Plants/genetics ; Protein Biosynthesis ; RNA, Messenger/genetics
Chemical Substances	RNA, Messenger
Language	English
Publishing date	2022-05-02
Publishing country	England
Document type	Journal Article
ISSN	2055-0278
ISSN (online)	2055-0278
DOI	10.1038/s41477-022-01136-8
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Steroids in COVID-19: An overview.

Chatterjee, Kshitij / Wu, Chao-Ping / Bhardwaj, Abhishek / Siuba, Matthew

Cleveland Clinic journal of medicine

2020

Abstract: Most antiviral or immunomodulatory therapies investigated for use in patients with COVID-19 have failed to show any mortality benefit. Similar to the previous pandemics caused by respiratory viruses, the role and benefit of corticosteroids has been under ...

Abstract	Most antiviral or immunomodulatory therapies investigated for use in patients with COVID-19 have failed to show any mortality benefit. Similar to the previous pandemics caused by respiratory viruses, the role and benefit of corticosteroids has been under debate in COVID-19-related pulmonary disease. In this consult, we discuss the evidence regarding the efficacy of corticosteroid use in hospitalized patients with COVID-19, including data from the first randomized controlled trial on this subject.
Keywords	covid19
Language	English
Publishing date	2020-08-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	639116-3
ISSN	1939-2869 ; 0891-1150
ISSN (online)	1939-2869
ISSN	0891-1150
DOI	10.3949/ccjm.87a.ccc059
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Article ; Online: Thymic Langerhans' cell histiocytosis.

Liu, Hung-Hsien / Wu, Yu-Jie / Yang, Chao-Ping / Wu, Patricia WanPing / Wang, Chao-Jan / Chang, Chih-Chen

Pediatrics and neonatology

2020 Volume 61, Issue 6, Page(s) 661–662

Language	English
Publishing date	2020-08-16
Publishing country	Singapore
Document type	Journal Article
ZDB-ID	2441816-X
ISSN	2212-1692 ; 1875-9572
ISSN (online)	2212-1692
ISSN	1875-9572
DOI	10.1016/j.pedneo.2020.08.011
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Article: Differential effects of EPA and DHA on PPARγ-mediated sympathetic innervation in infarcted rat hearts by GPR120-dependent and -independent mechanisms

Wang, Chao-Ping / Lee, Cheng-Che / Wu, De-Yu / Chen, Syue-yi / Lee, Tsung-Ming

Journal of nutritional biochemistry. 2022 May, v. 103

2022

Abstract	The ω-3 fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), have been shown to attenuate inflammation processes, whereas the molecular mechanisms remain unclear. This study was aimed at figuring out the differential effects of EPA and DHA on fatal arrhythmias and whether the signaling pathway could be a target after myocardial infarction, an inflammatory status. Male Wistar rats after ligating coronary artery were randomized to either vehicle, EPA, or DHA for 4 weeks. Postinfarction was associated with increased myocardial norepinephrine levels and sympathetic innervation. Furthermore, infarction was associated with the activation of NLRP3 inflammasomes and increased the protein and expression of IL-1β and nerve growth factor (NGF). These changes were blunted after adding either EPA or DHA with a greater extent of EPA than DHA. Immunoblotting and immunohistochemical analysis showed that EPA had significantly lower phosphorylation of PPARγ at Ser 112 compared with DHA. Arrhythmic severity during programmed stimulation in the infarcted rats treated with EPA was significantly lower than those treated with DHA. Specific inhibition of GPR120 by AH-7614 and PPARγ by T0070907 reduced the EPA-or DHA-related attenuation of IL-1β and NGF release. Besides, AH-7614 treatment partially reduced the PPARγ levels, whereas T0070907 administration did not affect the GPR120 levels. These results suggest that EPA was more effective than DHA in prevention of fatal arrhythmias by inhibiting NLRP3 inflammasome and sympathetic innervation through activation of PPARγ-mediated GPR120-dependent and -independent signaling pathways in infarcted hearts.
Keywords	coronary vessels ; docosahexaenoic acid ; eicosapentaenoic acid ; immunoblotting ; immunohistochemistry ; infarction ; inflammasomes ; inflammation ; innervation ; males ; myocardial infarction ; nerve growth factor ; norepinephrine ; phosphorylation ; rats
Language	English
Dates of publication	2022-05
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	1014929-6
ISSN	1873-4847 ; 0955-2863
ISSN (online)	1873-4847
ISSN	0955-2863
DOI	10.1016/j.jnutbio.2022.108950
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