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  1. Article: Google Trends in Breast and Cervical Cancer Searches From 2008 to 2021: An Infodemiology Study.

    Bhagavathula, Akshaya S / Bansil, Surbhi / Nishimura, Yoshito

    Cureus

    2023  Volume 15, Issue 5, Page(s) e39035

    Abstract: Introduction: Breast and cervical cancer are the leading causes of cancer death among women worldwide. Given the growing concern, cervical cancer awareness month (CCAM) in January and Breast cancer awareness month (BCAM) in October occur annually as ... ...

    Abstract Introduction: Breast and cervical cancer are the leading causes of cancer death among women worldwide. Given the growing concern, cervical cancer awareness month (CCAM) in January and Breast cancer awareness month (BCAM) in October occur annually as global health observances to raise public awareness. This infodemiology study aimed to assess trends in public online searches for breast cancer and cervical cancer following the annual BCAM and CCAM from 2008 to 2021.
    Methods: Google Trends (GT) was used to investigate online searches for "breast cancer" and "cervical cancer" from January 1, 2008, to December 31, 2021. (168 months). A joinpoint regression analysis was used to identify statistically significant weekly percentage changes (WPCs) and monthly percentage changes (MPCs) trends over time.
    Results: Breast cancer searches increased in October (BCAM) every year, while cervical cancer searches increased in January (CCAM) in 2013, 2019, and 2020. Joinpoint regression analysis revealed a significant negative trend in "breast cancer" searches from 2008 to 2021 (MPC: -0.2%, 95% CI: -0.3 to -0.1) and an upward trend in "cervical cancer" searches from May 2017 to December 2021 (MPC: 0.5%, 95% CI: 0.2 to 0.7).
    Conclusion: Online searches on "breast cancer" remain consistently high only during BCAM, and "cervical cancer" has increased by 0.5% MPC since May 2017. Our findings can inform online interventions like event-based opportunities (BCAM and CCAM) and Google Ads to raise public awareness of breast and cervical cancer.
    Language English
    Publishing date 2023-05-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.39035
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Monkeypox outbreaks, international health emergency declaration, and Americans' interest in preventing the disease.

    Khubchandani, Jagdish / Aldhaleei, Wafa / Bhagavathula, Akshaya S

    Journal of medical virology

    2022  Volume 95, Issue 1, Page(s) e28291

    MeSH term(s) Humans ; Global Health ; Mpox (monkeypox) ; Disease Outbreaks/prevention & control
    Language English
    Publishing date 2022-11-16
    Publishing country United States
    Document type Letter
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.28291
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1320: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Correction: Modeling the Epidemiological Trend and Behavior of COVID-19 in Italy.

    Rovetta, Alessandro / Bhagavathula, Akshaya S / Castaldo, Lucia

    Cureus

    2020  Volume 12, Issue 9, Page(s) c37

    Abstract: This corrects the article DOI: 10.7759/cureus.9884.]. ...

    Abstract [This corrects the article DOI: 10.7759/cureus.9884.].
    Keywords covid19
    Language English
    Publishing date 2020-09-11
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.c37
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The association between menopausal hormone therapy and gastroesophageal reflux disease: a systematic review and meta-analysis.

    Aldhaleei, Wafa A / Bhagavathula, Akshaya S / Wallace, Michael B / DeVault, Kenneth R / Faubion, Stephanie S

    Menopause (New York, N.Y.)

    2023  Volume 30, Issue 8, Page(s) 867–872

    Abstract: Importance and objective: Gastroesophageal reflux disease (GERD) is a chronic condition associated with several risk factors, but little is known about the association between hormone therapy (HT) and GERD in postmenopausal women.: Evidence review: ... ...

    Abstract Importance and objective: Gastroesophageal reflux disease (GERD) is a chronic condition associated with several risk factors, but little is known about the association between hormone therapy (HT) and GERD in postmenopausal women.
    Evidence review: We investigated the association between ever or current menopausal HT use and GERD using a systematic review and meta-analysis. Studies published between 2008 and August 31, 2022, were pooled using a DerSimonian and Laird random-effects model, and outcomes were reported as adjusted odds ratios (aOR) with a corresponding 95% CI.
    Findings: The pooled analysis of five studies found a significant direct association between estrogen use and GERD (aOR, 1.41; 95% CI, 1.16-1.66; I2 = 97.6%), and progestogen use and GERD (two studies: aOR, 1.39; 95% CI, 1.15-1.64; I2 = 0.0%). The use of combined HT was also associated with GERD (1.16; 95% CI, 1.00-1.33; I2 = 87.9%). Overall, HT use was associated with 29% higher odds for GERD (aOR, 1.29; 95% CI, 1.17-1.42; I2 = 94.8%). The large number of pooled participants, differences in study design, geography, patient characteristics, and outcome assessment resulted in significant high heterogeneity.
    Conclusions and relevance: There is a significant association between ever or current HT use and GERD. However, the results should be interpreted with caution, given the small number of included studies and high heterogeneity. This warrants careful evaluation of GERD risk factors when prescribing HT to reduce the risk of potential GERD complications.
    MeSH term(s) Humans ; Female ; Gastroesophageal Reflux/drug therapy ; Gastroesophageal Reflux/epidemiology ; Gastroesophageal Reflux/complications ; Risk Factors ; Estrogens/adverse effects ; Hormone Replacement Therapy ; Menopause
    Chemical Substances Estrogens
    Language English
    Publishing date 2023-06-27
    Publishing country United States
    Document type Meta-Analysis ; Systematic Review ; Journal Article
    ZDB-ID 1205262-0
    ISSN 1530-0374 ; 1072-3714
    ISSN (online) 1530-0374
    ISSN 1072-3714
    DOI 10.1097/GME.0000000000002214
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4111: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Hypertriglyceridemia-Induced Acute Pancreatitis in a Patient With Type 2 Diabetes Mellitus.

    Aldhaleei, Wafa A / Alnuaimi, Abdulaziz / Bhagavathula, Akshaya S

    Cureus

    2020  Volume 12, Issue 7, Page(s) e9414

    Abstract: Acute pancreatitis (AP) is an uncommon potential complication of severe hypertriglyceridemia (HTG). We reported a case of a 45-year-old man admitted with HTG-induced AP (HTG-AP). The patient was a known diabetic (glycated hemoglobin levels: 9.5%), his ... ...

    Abstract Acute pancreatitis (AP) is an uncommon potential complication of severe hypertriglyceridemia (HTG). We reported a case of a 45-year-old man admitted with HTG-induced AP (HTG-AP). The patient was a known diabetic (glycated hemoglobin levels: 9.5%), his triglycerides level was 3587.2 mg/dl, and the lipase level was 242 IU/L. A CT scan revealed AP. The patient was treated with a low-dose insulin infusion (0.05 unit/kg/hr) with dextrose for six days. His triglycerides came down to 673.1 mg/dl, and he was discharged. Further investigations are needed to understand the efficacy of low-dose insulin in the management of HTG-AP.
    Language English
    Publishing date 2020-07-27
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.9414
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Modeling the Epidemiological Trend and Behavior of COVID-19 in Italy.

    Rovetta, Alessandro / Bhagavathula, Akshaya S / Castaldo, Lucia

    Cureus

    2020  Volume 12, Issue 8, Page(s) e9884

    Abstract: ... by Civil Protection. Through a computational simulation of the Susceptible-Exposed-Infectious-Recovered (S.E.I.R ...

    Abstract As of May 14, 2020, Italy has been one of the red hotspots for the COVID-19 pandemic. In particular, the regions of Emilia Romagna, Piedmont, and especially Lombardy were the most affected and had to face very serious health emergencies, which brought them to the brink of collapse. Since the virus has demonstrated local properties, i.e., greater severity and contagiousness in specific regions, the aim of this study is to model the complex behavior of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Italy. In particular, we further investigated the results of other articles on the correlation with particulate matter pollution 10 (PM 10) and 2.5 (PM 2.5) by extending the research at the intra-regional level, as well as calculated a more plausible number of those infected compared to those officially declared by Civil Protection. Through a computational simulation of the Susceptible-Exposed-Infectious-Recovered (S.E.I.R.) model, we also estimated the most representative basic reproduction number [Formula: see text] for these three regions from February 22 to March 14, 2020. In doing so, we have been able to evaluate the consistency of the first containment measures until the end of April, as well as identify possible SARS-CoV-2 local behavior mutations and specificities.
    Keywords covid19
    Language English
    Publishing date 2020-08-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.9884
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: COVID-19 Induced Hepatitis B Virus Reactivation: A Novel Case From the United Arab Emirates.

    Aldhaleei, Wafa A / Alnuaimi, Abdulaziz / Bhagavathula, Akshaya S

    Cureus

    2020  Volume 12, Issue 6, Page(s) e8645

    Abstract: The novel coronavirus disease 2019 (COVID-19) clinically manifests as respiratory and gastrointestinal presentations, most commonly vomiting, diarrhea, and abdominal pain. Although the impaired liver function is prevalent in COVID-19, it is poorly ... ...

    Abstract The novel coronavirus disease 2019 (COVID-19) clinically manifests as respiratory and gastrointestinal presentations, most commonly vomiting, diarrhea, and abdominal pain. Although the impaired liver function is prevalent in COVID-19, it is poorly understood. We report the first case of hepatitis B virus (HBV) reactivation caused by COVID-19 in a young adult with altered mental status and severe transaminitis. The patient was asymptomatic, hypothermic, his skin was jaundiced with the icteric sclera, with very high levels of aspartate aminotransferase (AST; 4,933 U/L), alanine aminotransferase (ALT; 4,758 U/L), and total bilirubin (183.9 mmol/L) levels. It is warranted that patients with abnormal liver functions tend to have an increased risk of COVID-19. Thus, increased attention should be paid to the care of patients with abnormal liver functions, and testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA is warranted in the COVID era.
    Keywords covid19
    Language English
    Publishing date 2020-06-15
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.8645
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Potentially Inappropriate Medication Use in Older Hospitalized Patients with Type 2 Diabetes: A Cross-Sectional Study.

    Sharma, Rishabh / Chhabra, Manik / Vidyasagar, Kota / Rashid, Muhammed / Fialova, Daniela / Bhagavathula, Akshaya S

    Pharmacy (Basel, Switzerland)

    2020  Volume 8, Issue 4

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2020-11-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2737194-3
    ISSN 2226-4787 ; 2226-4787
    ISSN (online) 2226-4787
    ISSN 2226-4787
    DOI 10.3390/pharmacy8040219
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Prevalence of Polypharmacy, Hyperpolypharmacy and Potentially Inappropriate Medication Use in Older Adults in India: A Systematic Review and Meta-Analysis.

    Bhagavathula, Akshaya S / Vidyasagar, Kota / Chhabra, Manik / Rashid, Muhammed / Sharma, Rishabh / Bandari, Deepak K / Fialova, Daniela

    Frontiers in pharmacology

    2021  Volume 12, Page(s) 685518

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2021-05-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2021.685518
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Vaccines and Drug Therapeutics to Lock Down Novel Coronavirus Disease 2019 (COVID-19): A Systematic Review of Clinical Trials.

    Bhagavathula, Akshaya S / Aldhaleei, Wafa A / Rovetta, Alessandro / Rahmani, Jamal

    Cureus

    2020  Volume 12, Issue 5, Page(s) e8342

    Abstract: The ongoing novel coronavirus disease 2019 (COVID-19) pandemic has been responsible for millions of infections and hundreds of thousands of deaths. To date, there is no approved targeted treatment, and many investigational therapeutic agents and vaccine ... ...

    Abstract The ongoing novel coronavirus disease 2019 (COVID-19) pandemic has been responsible for millions of infections and hundreds of thousands of deaths. To date, there is no approved targeted treatment, and many investigational therapeutic agents and vaccine candidates are being considered for the treatment of COVID-19. To extract and summarize information on potential vaccines and therapeutic agents against COVID-19 at different stages of clinical trials from January to March 2020, we reviewed major clinical trial databases such as ClinicalTrials.gov, WHO International Clinical Trials Registry Platform (ICTRP), and other primary registries between January and March 15, 2020. Interventional studies at different phases under the COVID-19 pipeline were included. A total of 249 clinical trials were identified between January to March 15, 2020. After filtering observational studies (194 studies), a total of 56 interventional trials were considered. The majority of clinical trials have been conducted on chloroquine (n=10) and traditional Chinese medications (TCMs; n=10), followed by antivirals (n=8), anti-inflammatory/immunosuppressants (n=9), cellular therapies (n=4), combinations of different antivirals therapies (n=3), antibacterial (n=1), and other therapies (n=5). Five vaccines are under phase I, and there are a couple of phase III trials on the Bacillus Calmette-Guérin (BCG) vaccine under investigation among healthcare workers. Many novel compounds and vaccines against COVID-19 are currently under investigation. Some candidates have been tested for other viral infections and are listed for clinical trials against the COVID-19 pipeline. Currently, there are no effective specific antivirals or drug combinations available for the treatment of COVID-19.
    Keywords covid19
    Language English
    Publishing date 2020-05-28
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.8342
    Database MEDical Literature Analysis and Retrieval System OnLINE

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