LIVIVO - Search results -

Search results

Result 1 - 10 of total 64

Search options

Article ; Online: Fabrication and characterization of gold nanoparticles using alginate:

Hashemzadeh, Vahideh / Hashemzadeh, Alireza / Mohebbati, Reza / Arefi, Reza Gharari / Yazdi, Mohammad Ehsan Taghavizadeh

Open life sciences

2024 Volume 19, Issue 1, Page(s) 20220869

Abstract: Gold nanoparticles (AuNPs) have unique features that might lead to the development of a new class of diabetic medicines. AuNPs were biosynthesized utilizing sodium-alginate. UV-Vis-spectroscopy, Fourier transforms infrared, field emission scanning ... ...

Abstract	Gold nanoparticles (AuNPs) have unique features that might lead to the development of a new class of diabetic medicines. AuNPs were biosynthesized utilizing sodium-alginate. UV-Vis-spectroscopy, Fourier transforms infrared, field emission scanning electron microscopy (FESEM), and energy dispersive X-ray were used to examine the particles. The potential of AuNPs for improving the diabetes condition was examined along with swimming in rats. FESEM image revealed the spherical morphology with an average particle size of 106.6 ± 20.8 nm. In the diabetic group, serum glucose, blood urea nitrogen (BUN), creatinine, cholesterol, and triglyceride (TG) levels were significantly higher than the control group. Low-density lipoprotein (LDL) was significantly higher and high-density lipoprotein (HDL) was significantly lower in the diabetic group compared to the control group. Malondialdehyde (MDA) levels were also significantly higher in the D group. However, in the groups treated with swimming and gold, these parameters were significantly improved. Specifically, serum-glucose, BUN, creatinine, cholesterol, and TG levels were significantly reduced, while LDL was significantly decreased in the diabetic + swimming + AuNPs group and HDL was significantly increased in the diabetic + AuNPs group. MDA levels were significantly decreased in the treated groups, and other antioxidants were significantly improved in the diabetic + swimming + AuNPs group. Catalase levels were also significantly improved in the D + gold group. It can be concluded that both AuNPs and swimming can decrease diabetic complications.
Language	English
Publishing date	2024-04-17
Publishing country	Poland
Document type	Journal Article
ZDB-ID	2817958-4
ISSN	2391-5412 ; 2391-5412
ISSN (online)	2391-5412
ISSN	2391-5412
DOI	10.1515/biol-2022-0869
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article ; Online: A new era in cancer treatment: harnessing ZIF-8 nanoparticles for PD-1 inhibitor delivery.

Rastin, Farangis / Oryani, Mahsa Akbari / Iranpour, Sonia / Javid, Hossein / Hashemzadeh, Alireza / Karimi-Shahri, Mehdi

Journal of materials chemistry. B

2024 Volume 12, Issue 4, Page(s) 872–894

Abstract: This review delves into the potential of zeolitic imidazolate framework-8 (ZIF-8) nanoparticles in augmenting the efficacy of cancer immunotherapy, with a special focus on the delivery of programmed cell death receptor 1 (PD-1) inhibitors. The ... ...

Abstract	This review delves into the potential of zeolitic imidazolate framework-8 (ZIF-8) nanoparticles in augmenting the efficacy of cancer immunotherapy, with a special focus on the delivery of programmed cell death receptor 1 (PD-1) inhibitors. The multifunctional nature of ZIF-8 nanoparticles as drug carriers is emphasized, with their ability to encapsulate a range of therapeutic agents, including PD-1 inhibitors, and facilitate their targeted delivery to tumor locations. By manipulating the pore size and surface characteristics of ZIF-8 nanoparticles, controlled drug release can be realized. The strategic use of ZIF-8 nanoparticles to deliver PD-1 inhibitors presents a precise and targeted modality for cancer treatment, reducing off-target impacts and enhancing therapeutic effectiveness. This combined strategy addresses the existing challenges and constraints of current immunotherapy techniques, with the ultimate goal of enhancing patient outcomes in cancer therapy.
MeSH term(s)	Humans ; Immune Checkpoint Inhibitors ; Zeolites ; Drug Carriers/therapeutic use ; Nanoparticles/therapeutic use ; Neoplasms/drug therapy
Chemical Substances	Immune Checkpoint Inhibitors ; Zeolites (1318-02-1) ; Drug Carriers
Language	English
Publishing date	2024-01-24
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2702241-9
ISSN	2050-7518 ; 2050-750X
ISSN (online)	2050-7518
ISSN	2050-750X
DOI	10.1039/d3tb02471g
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: The applications of epigallocatechin gallate (EGCG)-nanogold conjugate in cancer therapy.

Karimi-Shahri, Mehdi / Alalikhan, Abbas / Hashemian, Pedram / Hashemzadeh, Alireza / Javid, Hossein

Nanotechnology

2023 Volume 34, Issue 21

Abstract: Cancer has recently increased the death toll worldwide owing to inadequate therapy and decreased drug bioavailability. Long-term and untargeted chemotherapeutic exposure causes toxicity to healthy cells and drug resistance. These challenges necessitate ... ...

Abstract	Cancer has recently increased the death toll worldwide owing to inadequate therapy and decreased drug bioavailability. Long-term and untargeted chemotherapeutic exposure causes toxicity to healthy cells and drug resistance. These challenges necessitate the development of new methods to increase drug efficacy. Nanotechnology is an emerging field in the engineering of new drug delivery platforms. The phytochemical epigallocatechin gallate (EGCG), the main component of green tea extract and its most bioactive component, offers novel approaches to cancer cell eradication. The current review focuses on the nanogold-based carriers containing EGCG, with an emphasis on the chemotherapeutic effects of EGCG in cancer treatment. The nanoscale vehicle may improve the EGCG solubility and bioavailability while overcoming constraints and cellular barriers. This article reviewed the phytochemical EGCG-based gold nanoplatforms and their major anticancer applications, both individually, and in combination therapy in a few cases.
MeSH term(s)	Humans ; Neoplasms/drug therapy ; Drug Delivery Systems ; Catechin/pharmacology ; Catechin/therapeutic use ; Biological Availability ; Tea
Chemical Substances	epigallocatechin gallate (BQM438CTEL) ; Catechin (8R1V1STN48) ; Tea
Language	English
Publishing date	2023-03-13
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1362365-5
ISSN	1361-6528 ; 0957-4484
ISSN (online)	1361-6528
ISSN	0957-4484
DOI	10.1088/1361-6528/acaca3
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Targeted cancer treatment using folate-conjugated sponge-like ZIF-8 nanoparticles: a review.

Oryani, Mahsa Akbari / Nosrati, Shamim / Javid, Hossein / Mehri, Ali / Hashemzadeh, Alireza / Karimi-Shahri, Mehdi

Naunyn-Schmiedeberg's archives of pharmacology

2023 Volume 397, Issue 3, Page(s) 1377–1404

Abstract: ZIF-8 (zeolitic imidazolate framework-8) is a potential drug delivery system because of its unique properties, which include a large surface area, a large pore capacity, a large loading capacity, and outstanding stability under physiological conditions. ... ...

Abstract	ZIF-8 (zeolitic imidazolate framework-8) is a potential drug delivery system because of its unique properties, which include a large surface area, a large pore capacity, a large loading capacity, and outstanding stability under physiological conditions. ZIF-8 nanoparticles may be readily functionalized with targeting ligands for the identification and absorption of particular cancer cells, enhancing the efficacy of chemotherapeutic medicines and reducing adverse effects. ZIF-8 is also pH-responsive, allowing medication release in the acidic milieu of cancer cells. Because of its tunable structure, it can be easily functionalized to design cancer-specific targeted medicines. The delivery of ZIF-8 to cancer cells can be facilitated by folic acid-conjugation. Hence, it can bind to overexpressed folate receptors on the surface of cancer cells, which holds the promise of reducing unwanted deliveries. As a result of its importance in cancer treatment, the folate-conjugated ZIF-8 was the major focus of this review.
MeSH term(s)	Humans ; Folic Acid ; Metal-Organic Frameworks/chemistry ; Drug Delivery Systems ; Nanoparticles ; Neoplasms/drug therapy
Chemical Substances	Folic Acid (935E97BOY8) ; Metal-Organic Frameworks
Language	English
Publishing date	2023-09-16
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	121471-8
ISSN	1432-1912 ; 0028-1298
ISSN (online)	1432-1912
ISSN	0028-1298
DOI	10.1007/s00210-023-02707-y
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Ud II Zs.5: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article: Synthesis and evaluation of gene delivery vectors based on PEI-modified metal-organic framework (MOF) nanoparticles.

Khosrojerdi, Somayeh / Gholami, Leila / Khazaei, Majid / Hashemzadeh, Alireza / Darroudi, Majid / Kazemi Oskuee, Reza

Iranian journal of basic medical sciences

2023 Volume 27, Issue 2, Page(s) 203–213

Abstract: Objectives: Zirconium-based metal-organic frameworks (MOFs) nanostructures, due to their capability of easy surface modification, are considered interesting structures for delivery. In the present study, the surfaces of UIO-66 and NH2-UIO-66 MOFs were ... ...

Abstract	Objectives: Zirconium-based metal-organic frameworks (MOFs) nanostructures, due to their capability of easy surface modification, are considered interesting structures for delivery. In the present study, the surfaces of UIO-66 and NH2-UIO-66 MOFs were modified by polyethyleneimine (PEI) 10000 Da, and their efficiency for plasmid delivery was evaluated. Materials and methods: Two different approaches, were employed to prepare surface-modified nanoparticles. The physicochemical characteristics of the resulting nanoparticles, as well as their transfection efficiency and cytotoxicity, were investigated on the A549 cell line. Results: The sizes of DNA/nanocarriers for PEI-modified UIO-66 (PEI-UIO-66) were between 212-291 nm and 267-321 nm for PEI 6-bromohexanoic acid linked UIO-66 (PEI-HEX-UIO-66). The zeta potential of all was positive with the ranges of +16 to +20 mV and +23 to +26 mV for PEI-UIO-66 and PEI-HEX-UIO-66, respectively. Cellular assay results showed that the PEI linking method had a higher rate of gene transfection efficiency with minimal cytotoxicity than the wet impregnation method. The difference between transfection of modified nanoparticles compared to the PEI 10 kDa was not significant but the PEI-HEX-UIO-66 showed less cytotoxicity. Conclusion: The present study suggested that the post-synthetic modification of MOFs with PEI 10000 Da through EDC/NHS+6-bromohexanoic acid reaction can be considered as an effective approach for modifying MOFs' structure in order to obtain nanoparticles with better biological function in the gene delivery process.
Language	English
Publishing date	2023-11-02
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2500485-2
ISSN	2008-3874 ; 2008-3866
ISSN (online)	2008-3874
ISSN	2008-3866
DOI	10.22038/IJBMS.2023.71892.15644
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Icariin: A Promising Natural Product in Biomedicine and Tissue Engineering.

Seyedi, Zahra / Amiri, Mohammad Sadegh / Mohammadzadeh, Vahideh / Hashemzadeh, Alireza / Haddad-Mashadrizeh, Aliakbar / Mashreghi, Mohammad / Qayoomian, Mohsen / Hashemzadeh, Mohammad Reza / Simal-Gandara, Jesus / Taghavizadeh Yazdi, Mohammad Ehsan

Journal of functional biomaterials

2023 Volume 14, Issue 1

Abstract: Among scaffolds used in tissue engineering, natural biomaterials such as plant-based materials show a crucial role in cellular function due to their biocompatibility and chemical indicators. Because of environmentally friendly behavior and safety, green ... ...

Abstract	Among scaffolds used in tissue engineering, natural biomaterials such as plant-based materials show a crucial role in cellular function due to their biocompatibility and chemical indicators. Because of environmentally friendly behavior and safety, green methods are so important in designing scaffolds. A key bioactive flavonoid of the
Language	English
Publishing date	2023-01-12
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2648525-4
ISSN	2079-4983
ISSN	2079-4983
DOI	10.3390/jfb14010044
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Zn(II) porphyrin-encapsulated MIL-101 for photodynamic therapy of breast cancer cells.

Ghoochani, Samaneh Hashemi / Hosseini, Hasan Ali / Sabouri, Zahra / Soheilifar, Mohammad Hasan / Neghab, Hoda Keshmiri / Hashemzadeh, Alireza / Velayati, Mahin / Darroudi, Majid

Lasers in medical science

2023 Volume 38, Issue 1, Page(s) 151

Abstract: The photodynamic treatment is a non-aggressive and clinically accepted procedure for removing selected cancer cells with the activation of a photosensitizer agent at a specific light. In this study, the zinc porphyrin (Zn[TPP]) was prepared and ... ...

Abstract	The photodynamic treatment is a non-aggressive and clinically accepted procedure for removing selected cancer cells with the activation of a photosensitizer agent at a specific light. In this study, the zinc porphyrin (Zn[TPP]) was prepared and encapsulated into the MIL-101 (Zn[TPP]@MIL-101). It was used in photodynamic therapy (PDT) against MCF-7 breast cancer cells under a red light-emitting diode. The structure, morphology, surface area, and compositional changes were investigated using conventional characterization methods including FTIR, FESEM, EDX, and BET analyses. The MTT assay was performed under light and dark conditions to explore the ability of Zn[TPP]@MIL-101 in PDT. The results have demonstrated the IC
MeSH term(s)	Humans ; Female ; Porphyrins/therapeutic use ; Photochemotherapy/methods ; Breast Neoplasms/drug therapy ; Photosensitizing Agents/therapeutic use ; Zinc/pharmacology ; Zinc/therapeutic use ; Cell Line, Tumor
Chemical Substances	Porphyrins ; MIL-101 ; Photosensitizing Agents ; Zinc (J41CSQ7QDS)
Language	English
Publishing date	2023-06-28
Publishing country	England
Document type	Journal Article
ZDB-ID	632808-8
ISSN	1435-604X ; 0268-8921
ISSN (online)	1435-604X
ISSN	0268-8921
DOI	10.1007/s10103-023-03813-2
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 2148: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: History of the development of antifungal azoles: A review on structures, SAR, and mechanism of action.

Shafiei, Mohammad / Peyton, Lee / Hashemzadeh, Mehrnoosh / Foroumadi, Alireza

Bioorganic chemistry

2020 Volume 104, Page(s) 104240

Abstract: With the increasing risk of invasive and life threating fungal infections, there is now a great concern regarding the lower discovery rate of antifungal drugs in comparison to antimicrobial agents. Drugs conventionally used in clinics are not adequate ... ...

Abstract	With the increasing risk of invasive and life threating fungal infections, there is now a great concern regarding the lower discovery rate of antifungal drugs in comparison to antimicrobial agents. Drugs conventionally used in clinics are not adequate enough to combat the increasing fungal infections, especially fungal forms resistant to fluconazole. Among the limited antifungal agents in clinics, azoles have the largest number of drug candidates in clinical trials and are partly marketed due to the particular focus of pharmaceutical companies and medicinal scientific centers. With the rise in the number of papers on azole antifungal design and discovery, a more in-depth understanding the most recent and authentic information about this class of drugs might be beneficial. To this end, we for the first time summarized the state-of-the-art information about azole drugs, with a specific focus on those in the pipelines of pharmaceutical companies, into four generations with regard to their structural similarity. More importantly, this review highlights information on the structure activity relationship (SAR), target description, hybrid antifungal agents as possible future generation, and other useful issues to streamline research towards designing new efficient azole antifungal structures in future.
MeSH term(s)	Antifungal Agents/chemistry ; Antifungal Agents/pharmacology ; Azoles/chemistry ; Azoles/pharmacology ; Dose-Response Relationship, Drug ; Fungi/drug effects ; Humans ; Microbial Sensitivity Tests ; Molecular Structure ; Structure-Activity Relationship
Chemical Substances	Antifungal Agents ; Azoles
Language	English
Publishing date	2020-08-28
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	120080-x
ISSN	1090-2120 ; 0045-2068
ISSN (online)	1090-2120
ISSN	0045-2068
DOI	10.1016/j.bioorg.2020.104240
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 4207: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Biosynthesis of Gold Nanoparticles Using Quince Seed Water Extract and Investigation of Their Anticancer Effect Against Cancer Cell Lines.

Ahmadpour, Mohammad Reza / Yousefi, Mahdi / Rakhshandeh, Hassan / Darroudi, Majid / Mousavi, Seyed Hadi / Soukhtanloo, Mohammad / Sabouri, Zahra / Askari, Vahid Reza / Hashemzadeh, Alireza / Manjiri, Mohammad Azad / Motavasselian, Malihe

IEEE transactions on nanobioscience

2024 Volume 23, Issue 1, Page(s) 118–126

Abstract: In this study, gold nanoparticles (Au-NPs) were synthesized using HAuCl4 and quince seed mucilage (QSM) extract, which was characterized by conventional methods including Fourier transforms electron microscopy (FTIR), UV-Visible spectroscopy (UV-Vis), ... ...

Abstract	In this study, gold nanoparticles (Au-NPs) were synthesized using HAuCl4 and quince seed mucilage (QSM) extract, which was characterized by conventional methods including Fourier transforms electron microscopy (FTIR), UV-Visible spectroscopy (UV-Vis), Field emission electron microscopy (FESEM), Transmission electron microscopy (TEM), Dynamic light spectroscopy (DLS), and Zeta-potential. The QSM acted as reductant and stabilizing agents simultaneously. The NP's anticancer activity was also investigated against osteosarcoma cell lines (MG-63), which showed an IC50 of [Formula: see text]/mL.
MeSH term(s)	Humans ; Gold/pharmacology ; Gold/chemistry ; Metal Nanoparticles/chemistry ; MCF-7 Cells ; Rosaceae ; Spectroscopy, Fourier Transform Infrared ; Neoplasms
Chemical Substances	Gold (7440-57-5)
Language	English
Publishing date	2024-01-03
Publishing country	United States
Document type	Journal Article
ISSN	1558-2639
ISSN (online)	1558-2639
DOI	10.1109/TNB.2023.3287805
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Down-regulation and Clinic-pathological Correlation of SIK-1 and SIK-1-LNC in Non-small Cell Lung Cancer Patients

Anvarnia, Alireza / Panahizadeh, Reza / Zarredar, Habib / Asadi, Milad / Hashemzadeh, Shahriyar / Vatankhah, Mohammad Amin / Valizadeh, Hamed / Raeisi, Mortaza

Asian Pacific journal of cancer prevention : APJCP

2023 Volume 24, Issue 4, Page(s) 1407–1411

Abstract: Background: Non-small-cell lung cancer (NSCLC) is currently the leading cause of mortality cancer. Introducing noninvasive approaches to diagnose NSCLC, especially at an early phase, might improve the disease's prognosis. Long noncoding RNAs (lncRNAs), ... ...

Abstract	Background: Non-small-cell lung cancer (NSCLC) is currently the leading cause of mortality cancer. Introducing noninvasive approaches to diagnose NSCLC, especially at an early phase, might improve the disease's prognosis. Long noncoding RNAs (lncRNAs), which are important regulators of the expression genes inside the cells, have been linked to a range of biological processes, such as cancer progression and metastasis, including NSCLC. The present work aims to determine the potential involvement of SIK-1-LNC and SIK-1 in NSCLC pathogenesis and the possible use of these molecules as novel biomarkers or therapeutic targets. Methods: In this work, the expression levels of SIK-1-LNC and SIK-1 in 50 pairs of NSCLC tumor and tumor marginal tissues were evaluated. So, after total RNA extraction and complementary DNA synthesis, the SIK-1-LNC and SIK-1 expression levels were evaluated by real-time PCR. In the study groups, clinical and pathological characteristics of the NSCLC patients were also examined. Results: Our findings showed that tumor samples had much lower levels of SIK-1 and SIK-1-LNC expression than tumor margin samples. SIK-1-LNC expression was correlated with SIK-1 levels in NSCLC samples. Interestingly, both stage and lymph node metastasis features of the tumor were associated significantly with SIK-1 and SIK-1-LNC expression levels. A ROC curve analysis indicated a biomarker index of 0.69 and 0.74 for SIK-1 and SIK-1-LNC, respectively. Conclusion: Collectively, our study emphasized the role of SIK-1-LNC and SIK-1 downregulation in NSCLC oncogenesis. Additionally, SIK-1 and SIK-1-LNC, particularly the latter, have shown remarkable potential to be utilized as new NSCLC biomarkers and therapeutic targets.
MeSH term(s)	Humans ; Carcinoma, Non-Small-Cell Lung/pathology ; Lung Neoplasms/pathology ; Down-Regulation ; Prognosis ; Gene Expression ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism ; Gene Expression Regulation, Neoplastic ; Cell Line, Tumor
Chemical Substances	RNA, Long Noncoding
Language	English
Publishing date	2023-04-01
Publishing country	Thailand
Document type	Journal Article
ZDB-ID	2218955-5
ISSN	2476-762X ; 1513-7368
ISSN (online)	2476-762X
ISSN	1513-7368
DOI	10.31557/APJCP.2023.24.4.1407
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

To top

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito