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Article ; Online: Bengt E. Bjärngard, Ph.D.

Williamson, Jeffrey F / Lutz, Wendell / Zhu, Timothy C

2014 Volume 41, Issue 4, Page(s) 40801

MeSH term(s)	History, 20th Century ; History, 21st Century ; Radiation Oncology/history ; United States
Language	English
Publishing date	2014-04
Publishing country	United States
Document type	Biography ; Historical Article ; Journal Article
ZDB-ID	188780-4
ISSN	2473-4209 ; 0094-2405
ISSN (online)	2473-4209
ISSN	0094-2405
DOI	10.1118/1.4869263
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Article ; Online: Comment to: Retrospective observational study on the incidence of incisional hernias after reversal of a temporary diverting ileostomy following rectal carcinoma resection with follow-up CT scans. De Keersmaecker G, Beckers R, Heindryckx E, Kyle-Leinhase I, Pletinckx P, Claeys D, Vanderstraeten E, Monsaert E, Muysoms F. Hernia 2015 (Epub ahead of print).

Williamson, J S / Williams, G L / Stephenson, B M

Hernia : the journal of hernias and abdominal wall surgery

2015 Volume 20, Issue 2, Page(s) 279–280

MeSH term(s)	Follow-Up Studies ; Humans ; Ileostomy ; Incidence ; Incisional Hernia ; Postoperative Complications/epidemiology ; Rectal Neoplasms/surgery ; Retrospective Studies ; Tomography, X-Ray Computed
Language	English
Publishing date	2015-10-22
Publishing country	France
Document type	Journal Article ; Comment
ZDB-ID	1388125-5
ISSN	1248-9204 ; 1265-4906
ISSN (online)	1248-9204
ISSN	1265-4906
DOI	10.1007/s10029-015-1435-9
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Zs.A 5390: Show issues

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Article: Semi quantitative expression analysis of MDR3, FIC1, BSEP, OATP-A, OATP-C,OATP-D, OATP-E and NTCP gene transcripts in 1st and 3rd trimester human placenta.

Patel, P / Weerasekera, N / Hitchins, M / Boyd, C A R / Johnston, D G / Williamson, C

Placenta

2003 Volume 24, Issue 1, Page(s) 39–44

Abstract: ... transport,MDR3, FIC1, BSEP, OATP-A, OATP-C, OATP-D and OATP-E, in normal human placenta. With the exception ... of OATP-C and OATP-E these genes were found to be differentially expressed in 1st trimester and 3rd ... compared to 1st trimester, OATP-A gene expression was down regulated eight fold, OATP-D was down regulated ...

Abstract	Using real time RT-PCR, we have detected expression of seven genes that influence bile acid transport,MDR3, FIC1, BSEP, OATP-A, OATP-C, OATP-D and OATP-E, in normal human placenta. With the exception of OATP-C and OATP-E these genes were found to be differentially expressed in 1st trimester and 3rd trimester placentae. MDR3 gene expression was found to be up regulated four fold in 3rd trimester placentae compared to 1st trimester, OATP-A gene expression was down regulated eight fold, OATP-D was down regulated 17 fold, while FIC1 expression was reduced by 33 fold in the 3rd trimester. OATP-C and BSEP gene expression was not detected in the 3rd trimester placenta, while low levels of transcripts were detected in the 1st trimester placentae. Transcripts of the hepatic sinusoidal bile acid transporter, NTCP, were not detected in placenta.
MeSH term(s)	ATP Binding Cassette Transporter, Subfamily B/genetics ; ATP Binding Cassette Transporter, Subfamily B/metabolism ; ATP Binding Cassette Transporter, Subfamily B, Member 11 ; ATP-Binding Cassette Transporters/genetics ; ATP-Binding Cassette Transporters/metabolism ; Adenosine Triphosphatases/genetics ; Adenosine Triphosphatases/metabolism ; Adult ; Bile Acids and Salts/metabolism ; Carrier Proteins/genetics ; Carrier Proteins/metabolism ; Down-Regulation ; Female ; Gene Expression Regulation, Developmental ; Humans ; Membrane Transport Proteins ; Organic Anion Transporters/genetics ; Organic Anion Transporters/metabolism ; Organic Anion Transporters, Sodium-Dependent ; Placenta/metabolism ; Pregnancy ; Pregnancy Trimester, First ; Pregnancy Trimester, Third ; RNA, Messenger/metabolism ; Reverse Transcriptase Polymerase Chain Reaction ; Symporters ; Transcription, Genetic ; Up-Regulation
Chemical Substances	ABCB11 protein, human ; ATP Binding Cassette Transporter, Subfamily B ; ATP Binding Cassette Transporter, Subfamily B, Member 11 ; ATP-Binding Cassette Transporters ; Bile Acids and Salts ; Carrier Proteins ; Membrane Transport Proteins ; Organic Anion Transporters ; Organic Anion Transporters, Sodium-Dependent ; RNA, Messenger ; Symporters ; sodium-bile acid cotransporter (145420-23-1) ; multidrug resistance protein 3 (9EI49ZU76O) ; Adenosine Triphosphatases (EC 3.6.1.-) ; ATP8B1 protein, human (EC 3.6.1.3.)
Language	English
Publishing date	2003-01
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	603951-0
ISSN	1532-3102 ; 0143-4004
ISSN (online)	1532-3102
ISSN	0143-4004
DOI	10.1053/plac.2002.0879
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Article ; Online: Flexible variable selection in the presence of missing data.

Williamson, Brian D / Huang, Ying

The international journal of biostatistics

2024

Abstract: ... dimensional statistical model, e.g., a generalized or penalized linear model. In cases where this model is ...

Abstract	In many applications, it is of interest to identify a parsimonious set of features, or panel, from multiple candidates that achieves a desired level of performance in predicting a response. This task is often complicated in practice by missing data arising from the sampling design or other random mechanisms. Most recent work on variable selection in missing data contexts relies in some part on a finite-dimensional statistical model, e.g., a generalized or penalized linear model. In cases where this model is misspecified, the selected variables may not all be truly scientifically relevant and can result in panels with suboptimal classification performance. To address this limitation, we propose a nonparametric variable selection algorithm combined with multiple imputation to develop flexible panels in the presence of missing-at-random data. We outline strategies based on the proposed algorithm that achieve control of commonly used error rates. Through simulations, we show that our proposal has good operating characteristics and results in panels with higher classification and variable selection performance compared to several existing penalized regression approaches in cases where a generalized linear model is misspecified. Finally, we use the proposed method to develop biomarker panels for separating pancreatic cysts with differing malignancy potential in a setting where complicated missingness in the biomarkers arose due to limited specimen volumes.
Language	English
Publishing date	2024-02-13
Publishing country	Germany
Document type	Journal Article
ISSN	1557-4679
ISSN (online)	1557-4679
DOI	10.1515/ijb-2023-0059
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Article ; Online: Vaccines for emerging pathogens: from research to the clinic. Part two.

Williamson, E D

Clinical and experimental immunology

2019 Volume 198, Issue 2, Page(s) 141–142

Abstract: For this two-part Clinical & Experimental Immunology Review Series, Guest Editor E. Diane ... Williamson invited experts in their fields to contribute articles on the status of vaccine ...

Abstract	For this two-part Clinical & Experimental Immunology Review Series, Guest Editor E. Diane Williamson invited experts in their fields to contribute articles on the status of vaccine research and development for emerging pathogens. Part One addressed our progress in developing vaccines for emerging and re-emerging viruses and considered current work on effective vaccines for bacterial pathogens. In this edition of the journal, we are pleased to present Part Two, in which our authors emphasise the importance of vaccine formulation and of the use of effective delivery vehicles, as well as the prospects for licensure for current candidate vaccines.
MeSH term(s)	Communicable Diseases, Emerging/immunology ; Communicable Diseases, Emerging/prevention & control ; Humans ; Vaccination ; Vaccines/immunology ; Vaccines/therapeutic use
Chemical Substances	Vaccines
Language	English
Publishing date	2019-10-17
Publishing country	England
Document type	Editorial
ZDB-ID	218531-3
ISSN	1365-2249 ; 0009-9104 ; 0964-2536
ISSN (online)	1365-2249
ISSN	0009-9104 ; 0964-2536
DOI	10.1111/cei.13378
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Article ; Online: Vaccines for emerging pathogens: from research to the clinic.

Williamson, E D

Clinical and experimental immunology

2019 Volume 196, Issue 2, Page(s) 155–156

Abstract: In this two-part series of reviews, we have invited experts in their fields to contribute articles on the status of vaccine research and development for emerging pathogens. This topic has been brought into sharp focus in recent years following ... ...

Abstract	In this two-part series of reviews, we have invited experts in their fields to contribute articles on the status of vaccine research and development for emerging pathogens. This topic has been brought into sharp focus in recent years following significant outbreaks of viral diseases such as those causing severe acute respiratory syndrome and Middle East respiratory syndrome, as well as devastating outbreaks of diseases caused by the Ebola, Marburg, Zika and Lassa fever viruses, to name only a few examples. Additionally, bacterial infections leading to bubonic and pneumonic plague, most notably in Madagascar in 2018, as well as malaria in many tropical countries, melioidosis in south east Asia and tularaemia in northern Europe and North America, have incurred significant morbidity and mortality. In this review series, the life cycle of these pathogens and the epidemiology of disease have been reviewed in the context of potential points of intervention for the prevention of human infection. Many of the emerging pathogens are zoonoses and, as such, there is scope for intervention at the animal/insect/environmental reservoir. Other pathogens covered in this review series are considered to be re-emerging, such as multi-drug resistant tuberculosis.
MeSH term(s)	Animals ; Bacterial Infections/epidemiology ; Bacterial Infections/prevention & control ; Bacterial Vaccines/therapeutic use ; Communicable Diseases, Emerging/epidemiology ; Communicable Diseases, Emerging/prevention & control ; Disease Outbreaks ; Flaviviridae Infections/epidemiology ; Flaviviridae Infections/prevention & control ; Humans ; Viral Vaccines/therapeutic use
Chemical Substances	Bacterial Vaccines ; Viral Vaccines
Keywords	covid19
Language	English
Publishing date	2019-04-16
Publishing country	England
Document type	Editorial ; Introductory Journal Article
ZDB-ID	218531-3
ISSN	1365-2249 ; 0009-9104 ; 0964-2536
ISSN (online)	1365-2249
ISSN	0009-9104 ; 0964-2536
DOI	10.1111/cei.13303
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Article ; Online: Using evidence-based co-design to develop a hybrid delivered exercise intervention that aims to increase confidence to exercise in people with haemophilia.

Taylor, Stephanie / Barker, Karen / Stephensen, David / Williamson, Esther

Haemophilia : the official journal of the World Federation of Hemophilia

2024

Abstract: Introduction: Due to advances in treatments, people with haemophilia (PWH) are living longer. They are not as active as the general population due to joint damage and lack confidence to be active due to concerns about further bleeds and pain. There is a ...

Abstract	Introduction: Due to advances in treatments, people with haemophilia (PWH) are living longer. They are not as active as the general population due to joint damage and lack confidence to be active due to concerns about further bleeds and pain. There is a need to facilitate healthy aging through promotion of physical activity (PA) and exercise. Changing patient beliefs and increasing physical literacy and confidence to move are thought to be key to helping PWH become more active. Aim: This paper describes the development of an exercise and behaviour change intervention to improve confidence to exercise in PWH. Methods: The 4-stage Medical Research Council framework for complex intervention development was used. Results: Stakeholders included 17 PWH and 7 physiotherapists working in haemophilia. Seven online focus group meetings were held. The final intervention is a hybrid 12-week physiotherapist led progressive exercise programme. Classes are 45 min including Pilates, High intensity interval training and balance elements, together with discussion sessions focusing on PA recommendations, the types and benefits of different exercise styles and the effects of PA, together with the effects of aging for PWH. The COM-B model of behaviour change was used to develop the intervention. Conclusion: Co-design helps to produce an intervention that understands the stakeholders needs. Through this process the intervention developed to incorporate not only increasing PA but also confidence to exercise. The use of behaviour change theory identified the behaviour techniques included in the intervention and aims to increase physical literacy in this population.
Language	English
Publishing date	2024-03-10
Publishing country	England
Document type	Journal Article
ZDB-ID	1229713-6
ISSN	1365-2516 ; 1351-8216 ; 1355-0691
ISSN (online)	1365-2516
ISSN	1351-8216 ; 1355-0691
DOI	10.1111/hae.14972
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Article ; Online: Correction: Considerations for Subgroup Analyses in Cluster-Randomized Trials Based on Aggregated Individual-Level Predictors.

Williamson, Brian D / Coley, R Yates / Hsu, Clarissa / McCracken, Courtney E / Cook, Andrea J

Prevention science : the official journal of the Society for Prevention Research

2024

Language	English
Publishing date	2024-01-15
Publishing country	United States
Document type	Published Erratum
ZDB-ID	2251270-6
ISSN	1573-6695 ; 1389-4986
ISSN (online)	1573-6695
ISSN	1389-4986
DOI	10.1007/s11121-024-01647-0
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Article ; Online: Activity budget and gut microbiota stability and flexibility across reproductive states in wild capuchin monkeys in a seasonal tropical dry forest.

Webb, Shasta E / Orkin, Joseph D / Williamson, Rachel E / Melin, Amanda D

Animal microbiome

2023 Volume 5, Issue 1, Page(s) 63

Abstract: Background: Energy demands associated with pregnancy and lactation are significant forces in mammalian evolution. To mitigate increased energy costs associated with reproduction, female mammals have evolved behavioural and physiological responses. Some ... ...

Abstract	Background: Energy demands associated with pregnancy and lactation are significant forces in mammalian evolution. To mitigate increased energy costs associated with reproduction, female mammals have evolved behavioural and physiological responses. Some species alter activity to conserve energy during pregnancy and lactation, while others experience changes in metabolism and fat deposition. Restructuring of gut microbiota with shifting reproductive states may also help females increase the energy gained from foods, especially during pregnancy. The goal of this study was to examine the relationships among behaviour, gut microbiota composition, and reproductive state in a wild, non-human primate to better understand reproductive ecology. We combined life history data with > 13,000 behavioural scans and 298 fecal samples collected longitudinally across multiple years from 33 white-faced capuchin monkey (Cebus imitator) females. We sequenced the V4 region of the 16S rRNA gene and used the DADA2 pipeline to analyze microbial diversity. We used PICRUSt2 to assess putative functions. Results: Reproductive state explained some variation in activity, but overall resting behaviours were relatively stable across pregnancy and lactation. Foraging was less frequent among females in the early stage of nursing compared to the cycling stage, though otherwise remained at comparable levels. Maximum temperature was a strong, significantly positive predictor of resting, while social dominance had a small but significantly negative effect on resting. Ecological variables such as available fruit biomass and rainfall had a small but significantly positive effects on measures of foraging time. Gut microbial community structure, including richness, alpha diversity, and beta diversity remained stable across the reproductive cycle. In pairwise comparisons, pregnant females exhibited increased relative abundances of multiple microbial ASVs, suggesting small changes in relation to reproductive state. Reproductive state was not linked to differential abundance of putative metabolic pathways. Conclusions: Previous data suggest that activity budget and the gut microbiome shifts considerably during reproduction. The present study finds that both activity and gut microbial communities are less associated with reproduction compared to other predictors, including ecological contexts. This suggests that behavioural flexibility and gut microbial community plasticity is contrained by ecological factors in this population. These data contribute to a broader understanding of plasticity and stability in response to physiological shifts associated with mammalian reproduction.
Language	English
Publishing date	2023-12-15
Publishing country	England
Document type	Journal Article
ISSN	2524-4671
ISSN (online)	2524-4671
DOI	10.1186/s42523-023-00280-6
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Article ; Online: Four decades of regional wet deposition, local bulk deposition, and stream-water chemistry show the influence of nearby land use on forested streams in Central Appalachia.

Williamson, Tanja N / Sena, Kenton L / Shoda, Megan E / Barton, Christopher D

Journal of environmental management

2023 Volume 332, Page(s) 117392

Abstract: Hydrologic monitoring began on two headwater streams (<1 ... ...

Abstract	Hydrologic monitoring began on two headwater streams (<1 km
MeSH term(s)	Rivers ; Water ; Nitrates/analysis ; Forests ; Organic Chemicals ; Appalachian Region ; Sulfates/analysis ; Cations ; Environmental Monitoring
Chemical Substances	Water (059QF0KO0R) ; Nitrates ; Organic Chemicals ; Sulfates ; Cations
Language	English
Publishing date	2023-02-03
Publishing country	England
Document type	Journal Article
ZDB-ID	184882-3
ISSN	1095-8630 ; 0301-4797
ISSN (online)	1095-8630
ISSN	0301-4797
DOI	10.1016/j.jenvman.2023.117392
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