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Article: [Prevalence and change of type 2 diabetes mellitus among rural adults in Deqing County, Zhejiang Province in China during 2006-2014].

Chen, Xiaoying / Wu, Zhaofan / Wang, Xuecai / Chen, Yue / Dong, Xiaolian / Zhu, Jianfu / Xiao, Tian / Jiang, Qingwu / Fu, Chaowei

Wei sheng yan jiu = Journal of hygiene research

2018 Volume 46, Issue 6, Page(s) 868–887

Abstract: Objective: To describe the prevalence of type 2 diabetes mellitus( T2 DM) in rural Deqing County ... rural communities in Deqing County, Zhejiang Province, and a cross-sectional survey was conducted in 2006-2008, 2011 ... with T2 DM.: Conclusion: The prevalence of T2 DM increased over time in rural Deqing County, China. Age ...

Abstract	Objective: To describe the prevalence of type 2 diabetes mellitus( T2 DM) in rural Deqing County, Zhejiang Province, and explore its risk factors. Methods: Random cluster sampling was used to select 8 rural communities in Deqing County, Zhejiang Province, and a cross-sectional survey was conducted in 2006-2008, 2011-2012 and 2013-2014, respectively. Totally, 6562 eligible subjects were investigated in 2006-2008, 11 763 eligible subjects in 2011-2012, and 10 904 eligible subjects in 2013-2014. Data on demography, life style and disease history, and physical examination such as height, weight and blood pressure were collected. Also, fasting plasma glucose was tested. T2 DM was defined as who having fasting plasma glucose ≥7. 0 mmol/L or was diagnosed by doctors or receiving diabetic treatment. Results: In 2006-2008, 2011-2012 and 2013-2014, the standardized prevalences of T2 DM were 1. 2%, 1. 6% and 2. 1% and those of impaired fasting glucose( IFG) were 7. 2%, 18. 7% and22. 8%, respectively. There were increasing trends over years for both. After adjustment for other covariates in logistic regression, age( compared with age between 18 to 39. 9 years old: aOR_(40-59. 9)= 5. 20, 95% CI 2. 74-9. 89; aOR_(60-)= 8. 02, 95% CI 4. 19-15. 35), female( aOR = 1. 23, 95% CI 1. 02-1. 49), family history of T2 DM( aOR =4. 86, 95% CI 3. 49-6. 77), overweight/obesity( overweight: aOR = 1. 88, 95% CI1. 61-2. 20; obesity: aOR = 5. 10, 95% CI 4. 06-6. 41), hypertension( aOR = 2. 84, 95% CI 2. 44-3. 31), having meat mainly( aOR = 2. 25, 95% CI 1. 89-2. 69) and tea drinking( aOR = 0. 81, 95% CI 0. 68-0. 95) were significantly correlated with T2 DM. Conclusion: The prevalence of T2 DM increased over time in rural Deqing County, China. Age, gender, family history of T2 DM, overweight or obesity, hypertension, diet and drinking tea were significantly related to T2 DM.
MeSH term(s)	Adolescent ; Adult ; Blood Glucose/analysis ; China/epidemiology ; Cross-Sectional Studies ; Diabetes Mellitus, Type 2/epidemiology ; Female ; Humans ; Prediabetic State ; Prevalence ; Risk Factors ; Rural Population ; Young Adult
Chemical Substances	Blood Glucose
Language	Chinese
Publishing date	2018-06-12
Publishing country	China
Document type	Journal Article
ZDB-ID	1050909-4
ISSN	1000-8020
ISSN	1000-8020
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Evaluation of the Effects of Meal Type and Acid-Reducing Agents on the Pharmacokinetics of Cilofexor, a Selective Nonsteroidal Farnesoid X Receptor Agonist.

Weber, Elijah J / Younis, Islam R / Wang, Lulu / Xiao, Deqing / Barchuk, William T / Othman, Ahmed A

Clinical pharmacology in drug development

2024

Abstract: Cilofexor is a nonsteroidal farnesoid X receptor agonist being developed in combination with firsocostat/semaglutide for the treatment of nonalcoholic steatohepatitis. This phase 1 study evaluated the effects of food and acid-reducing agents (ARAs) on ... ...

Abstract	Cilofexor is a nonsteroidal farnesoid X receptor agonist being developed in combination with firsocostat/semaglutide for the treatment of nonalcoholic steatohepatitis. This phase 1 study evaluated the effects of food and acid-reducing agents (ARAs) on the pharmacokinetics of cilofexor (100- or 30-mg fixed-dose combination with firsocostat) in healthy participants. Cohorts 1 (n = 20, 100 mg) and 2 (n = 30, 30 mg) followed a 3-period, 2-sequence crossover design and evaluated effects of light-fat and high-fat meals. Cohort 3 (n = 30, 100 mg fasting) followed a 2-period, 2-sequence crossover design and evaluated the effects of a 40-mg single dose of famotidine. Cohort 4 (n = 18, 100 mg) followed a 3-period, 2-sequence crossover design and evaluated the effects of a 40-mg once-daily regimen of omeprazole administered under fasting conditions or following a light-fat meal. Administration with light-fat or high-fat meals resulted in no change and an ∼35% reduction in cilofexor AUC, respectively, relative to the fasting conditions. Under fasting conditions, famotidine increased cilofexor AUC by 3.2-fold and C
Language	English
Publishing date	2024-02-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	2649010-9
ISSN	2160-7648 ; 2160-763X
ISSN (online)	2160-7648
ISSN	2160-763X
DOI	10.1002/cpdd.1384
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Article ; Online: UV-stimulated riboflavin exerts immunosuppressive effects in BALB/c mice and human PBMCs.

Chen, Xinghui / Ge, Shuang / Xiao, Pan / Liu, Yulin / Yu, Yang / Liu, Yi / Sun, Liping / Yang, Lu / Wang, Deqing

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2024 Volume 173, Page(s) 116278

Abstract: Riboflavin (RF) as a photosensitizer has been used in corneal surgery and the inactivation of blood products. However, the effect of RF on immune cells after ultraviolet (UV) light stimulation has not been investigated. This study pioneered a novel ... ...

Abstract	Riboflavin (RF) as a photosensitizer has been used in corneal surgery and the inactivation of blood products. However, the effect of RF on immune cells after ultraviolet (UV) light stimulation has not been investigated. This study pioneered a novel application method of RF. Firstly, UV-stimulated RF was co-cultured with human peripheral blood mononuclear cells in vitro, and the apoptosis rate of lymphocyte subsets, cell proliferation inhibition rate and concentrations of IL-1β, IL-6, IL-10, TNF-α were assessed. UV-stimulated RF was then administered intravenously to mice via the tail vein for a consecutive period of 5 days. The levels of immunoglobulin (IgG, IgM, IgA), complement (C3, C4) and cytokines (IFN-γ, IL-4, IL17, TGF-β) were detected by ELISA. Flow cytometry was employed to analyze the populations of CD3+T, CD4+T, CD8+T and CD4+T/CD8+T cells in spleen lymphocytes of mice. The data showed that UV-stimulated RF can effectively induce apoptosis in lymphocytes, and different lymphocyte subtypes exhibited varying degrees of treatment tolerance. Additionally, the proliferative capacity of lymphocytes was suppressed, while their cytokine secretion capability was augmented. The animal experiments demonstrated that UV-stimulated RF led to a significant reduction observed in serum immunoglobulin and complement levels, accompanied by an elevation in IFN-γ, IL-17 and TGF-β levels, as well as a decline in IL-4 level. In summary, the results of both in vitro and in vivo experiments have demonstrated that UV-stimulated RF, exhibits the ability to partially inhibit immune function. This novel approach utilizing RF may offer innovative perspectives for diseases requiring immunosuppressive treatment.
MeSH term(s)	Humans ; Mice ; Animals ; Leukocytes, Mononuclear ; Interleukin-4/pharmacology ; Mice, Inbred BALB C ; Cytokines/pharmacology ; Riboflavin/pharmacology ; Transforming Growth Factor beta/pharmacology ; Immunoglobulins/pharmacology ; CD4-Positive T-Lymphocytes
Chemical Substances	Interleukin-4 (207137-56-2) ; Cytokines ; Riboflavin (TLM2976OFR) ; Transforming Growth Factor beta ; Immunoglobulins
Language	English
Publishing date	2024-02-23
Publishing country	France
Document type	Journal Article
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2024.116278
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Book ; Online: Beneath Surface Similarity

Yuan, Siyu / Chen, Jiangjie / Ge, Xuyang / Xiao, Yanghua / Yang, Deqing

Large Language Models Make Reasonable Scientific Analogies after Structure Abduction

2023

Abstract: The vital role of analogical reasoning in human cognition allows us to grasp novel concepts by linking them with familiar ones through shared relational structures. Despite the attention previous research has given to word analogies, this work suggests ... ...

Abstract	The vital role of analogical reasoning in human cognition allows us to grasp novel concepts by linking them with familiar ones through shared relational structures. Despite the attention previous research has given to word analogies, this work suggests that Large Language Models (LLMs) often overlook the structures that underpin these analogies, raising questions about the efficacy of word analogies as a measure of analogical reasoning skills akin to human cognition. In response to this, our paper introduces a task of analogical structure abduction, grounded in cognitive psychology, designed to abduce structures that form an analogy between two systems. In support of this task, we establish a benchmark called SCAR, containing 400 scientific analogies from 13 distinct fields, tailored for evaluating analogical reasoning with structure abduction. The empirical evidence underlines the continued challenges faced by LLMs, including ChatGPT and GPT-4, in mastering this task, signifying the need for future exploration to enhance their abilities. Comment: Accepted to EMNLP 2023 (Findings)
Keywords	Computer Science - Computation and Language ; Computer Science - Artificial Intelligence
Subject code	401
Publishing date	2023-05-21
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Effects of low-concentration spinetoram wax-based bait stations on Bactrocera dorsalis (Diptera: Tephritidae).

Lin, Jia / Yue, Guoqing / Xiao, Kang / Yang, Deqing / Hao, Xuxing / Zheng, Minlin / Cai, Pumo / Ji, Qing'e

Pesticide biochemistry and physiology

2023 Volume 197, Page(s) 105705

Abstract: Spinetoram wax-based bait station (SWBB) is a maintenance-free, long-lasting, and eco-friendly management measure for Bactrocera dorsalis. However, the impacts of low-concentration spinetoram on B. dorsalis have not yet been determined. Therefore, our ... ...

Abstract	Spinetoram wax-based bait station (SWBB) is a maintenance-free, long-lasting, and eco-friendly management measure for Bactrocera dorsalis. However, the impacts of low-concentration spinetoram on B. dorsalis have not yet been determined. Therefore, our study aimed to determine the impacts of low-concentration SWBBs on the biology, demographics, detoxifying enzymes, and gut microorganisms of B. dorsalis. Our results showed that low-concentration SWBBs posed dose-dependent effects on the lifespan and fecundity of B. dorsalis adults. Both the LC
MeSH term(s)	Animals ; Tephritidae ; Macrolides/pharmacology ; Fertility
Chemical Substances	spinetoram (YGZ1037ELN) ; Macrolides
Language	English
Publishing date	2023-11-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	184819-7
ISSN	1095-9939 ; 0048-3583 ; 0048-3575
ISSN (online)	1095-9939
ISSN	0048-3583 ; 0048-3575
DOI	10.1016/j.pestbp.2023.105705
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Article ; Online: The complete mitochondrial genome of

Yang, Deqing / Hao, Xuxing / Jiang, Lili / Chou, Tsunglin / Lin, Xiang / Yue, Guoqing / Xiao, Kang / Lin, Jia / Ji, Qinge / Cai, Pumo

Mitochondrial DNA. Part B, Resources

2022 Volume 7, Issue 6, Page(s) 1038–1040

Abstract: Psyttalia ... ...

Abstract	Psyttalia incisi
Language	English
Publishing date	2022-06-14
Publishing country	England
Document type	Journal Article
ISSN	2380-2359
ISSN (online)	2380-2359
DOI	10.1080/23802359.2022.2081942
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book ; Online: Factorial User Modeling with Hierarchical Graph Neural Network for Enhanced Sequential Recommendation

Xue, Lyuxin / Yang, Deqing / Xiao, Yanghua

2022

Abstract: Most sequential recommendation (SR) systems employing graph neural networks (GNNs) only model a user's interaction sequence as a flat graph without hierarchy, overlooking diverse factors in the user's preference. Moreover, the timespan between interacted ...

Abstract	Most sequential recommendation (SR) systems employing graph neural networks (GNNs) only model a user's interaction sequence as a flat graph without hierarchy, overlooking diverse factors in the user's preference. Moreover, the timespan between interacted items is not sufficiently utilized by previous models, restricting SR performance gains. To address these problems, we propose a novel SR system employing a hierarchical graph neural network (HGNN) to model factorial user preferences. Specifically, a timespan-aware sequence graph (TSG) for the target user is first constructed with the timespan among interacted items. Next, all original nodes in TSG are softly clustered into factor nodes, each of which represents a certain factor of the user's preference. At last, all factor nodes' representations are used together to predict SR results. Our extensive experiments upon two datasets justify that our HGNN-based factorial user modeling obtains better SR performance than the state-of-the-art SR models. Comment: Accepted by ICME 2022
Keywords	Computer Science - Information Retrieval
Publishing date	2022-07-26
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Effect of Renal Impairment on the Pharmacokinetics of Firsocostat, an Acetyl-Coenzyme A Carboxylase Inhibitor, and Cilofexor, a Selective Nonsteroidal Farnesoid X Receptor Agonist.

Weber, Elijah / Younis, Islam R / Nelson, Cara / Ding, Dora / Qin, Ann / Xiao, Deqing / Watkins, Timothy R / Othman, Ahmed A

Journal of clinical pharmacology

2023 Volume 63, Issue 5, Page(s) 560–568

Abstract: Firsocostat, a liver-targeted acetyl-coenzyme A carboxylase inhibitor, and cilofexor, a nonsteroidal farnesoid X receptor agonist, are being developed in combination for treatment of nonalcoholic steatohepatitis. This phase 1 study evaluated firsocostat ... ...

Abstract	Firsocostat, a liver-targeted acetyl-coenzyme A carboxylase inhibitor, and cilofexor, a nonsteroidal farnesoid X receptor agonist, are being developed in combination for treatment of nonalcoholic steatohepatitis. This phase 1 study evaluated firsocostat and cilofexor pharmacokinetics and tolerability in participants with severe renal impairment (SRI) and healthy matched controls (HMCs). Ten participants with SRI (estimated glomerular filtration rate by Modification of Diet in Renal Disease <30 mL/min/1.73 m
MeSH term(s)	Humans ; Acetyl-CoA Carboxylase/metabolism ; Area Under Curve ; Coenzyme A/metabolism ; Renal Insufficiency/metabolism
Chemical Substances	Acetyl-CoA Carboxylase (EC 6.4.1.2) ; cilofexor (YUN2306954) ; Coenzyme A (SAA04E81UX) ; firsocostat (XE10NJQ95M)
Language	English
Publishing date	2023-02-28
Publishing country	England
Document type	Clinical Trial, Phase I ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	188980-1
ISSN	1552-4604 ; 0091-2700 ; 0021-9754
ISSN (online)	1552-4604
ISSN	0091-2700 ; 0021-9754
DOI	10.1002/jcph.2206
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: NF-κB downstream miR-1262 disturbs colon cancer cell malignant behaviors by targeting FGFR1.

Zhang, Weilin / Huang, Zhongcheng / Xiao, Zhigang / Wang, Hui / Liao, Qianchao / Deng, Zhengru / Wu, Deqing / Wang, Junjiang / Li, Yong

Acta biochimica et biophysica Sinica

2023 Volume 55, Issue 11, Page(s) 1819–1832

Abstract: Despite substantial advancements in screening, surgery, and chemotherapy, colorectal cancer remains the second most lethal form of the disease. Nuclear factor kappa B (NF-κB) signaling is a critical driver facilitating the malignant transformation of ... ...

Abstract	Despite substantial advancements in screening, surgery, and chemotherapy, colorectal cancer remains the second most lethal form of the disease. Nuclear factor kappa B (NF-κB) signaling is a critical driver facilitating the malignant transformation of chronic inflammatory bowel diseases. In this study, deregulated miRNAs that could play a role in colon cancer are analyzed and investigated for specific functions
MeSH term(s)	Animals ; Humans ; Mice ; Cell Line, Tumor ; Cell Movement/genetics ; Cell Proliferation/genetics ; Colonic Neoplasms/genetics ; Disease Models, Animal ; Gene Expression Regulation, Neoplastic ; MicroRNAs/genetics ; MicroRNAs/metabolism ; NF-kappa B/genetics ; NF-kappa B/metabolism ; Receptor, Fibroblast Growth Factor, Type 1/genetics ; Receptor, Fibroblast Growth Factor, Type 1/metabolism
Chemical Substances	FGFR1 protein, human (EC 2.7.10.1) ; MicroRNAs ; NF-kappa B ; Receptor, Fibroblast Growth Factor, Type 1 (EC 2.7.10.1) ; MIRN1262 microRNA, human
Language	English
Publishing date	2023-10-20
Publishing country	China
Document type	Journal Article
ZDB-ID	2175256-4
ISSN	1745-7270 ; 0582-9879 ; 1672-9145
ISSN (online)	1745-7270
ISSN	0582-9879 ; 1672-9145
DOI	10.3724/abbs.2023235
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Association between acute kidney injury and prognoses of cardiac surgery patients: Analysis of the MIMIC-III database.

Sun, Chun / Chen, Deqing / Jin, Xin / Xu, Guangtao / Tang, Chenye / Guo, Xiao / Tang, Zhiling / Bao, Yixin / Wang, Fei / Shen, Ruilin

Frontiers in surgery

2023 Volume 9, Page(s) 1044937

Abstract: Background: Acute kidney injury (AKI) is the most common major complication of cardiac surgery field. The purpose of this study is to investigate the association between acute kidney injury and the prognoses of cardiac surgery patients in the Medical ... ...

Abstract	Background: Acute kidney injury (AKI) is the most common major complication of cardiac surgery field. The purpose of this study is to investigate the association between acute kidney injury and the prognoses of cardiac surgery patients in the Medical Information Mart for Intensive Care III (MIMIC-III) database. Methods: Clinical data were extracted from the MIMIC-III database. Adult (≥18 years) cardiac surgery patients in the database were enrolled. Multivariable logistic regression analyses were employed to assess the associations between acute kidney injury (AKI) comorbidity and 30-day mortality, 90-day mortality and hospital mortality. Different adjusting models were used to adjust for potential confounders. Results: A total of 6,002 patients were involved, among which 485 patients (8.08%) had comorbid AKI. Patients with AKI were at higher risks of prolonged ICU stay, hospital mortality, 90-day mortality (all Conclusion: Comorbid AKI increased the risk of hospital mortality, 30-day mortality, and 90-day mortality of cardiac surgery patients in the MIMIC-III database.
Language	English
Publishing date	2023-01-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2773823-1
ISSN	2296-875X
ISSN	2296-875X
DOI	10.3389/fsurg.2022.1044937
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