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Article: Genomic Insights Into Last-Line Antimicrobial Resistance in Multidrug-Resistant

Turner, Adrianna M / Lee, Jean Y H / Gorrie, Claire L / Howden, Benjamin P / Carter, Glen P

2021 Volume 12, Page(s) 637656

Abstract: Multidrug- ... ...

Abstract	Multidrug-resistant
Language	English
Publishing date	2021-03-16
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2021.637656
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Article ; Online: Prevalence of negative emotional eating and its associated psychosocial factors among urban Chinese undergraduates in Hong Kong: a cross-sectional study.

Sze, Katherine Y P / Lee, Eric K P / Chan, Rufina H W / Kim, Jean H

BMC public health

2021 Volume 21, Issue 1, Page(s) 583

Abstract: Background: Emotional eating (EE), defined as eating in response to a range of emotions, has been previously associated with poor diet and obesity. Since there are limited data from non-Western populations, this study aims to examine the prevalence and ... ...

Abstract	Background: Emotional eating (EE), defined as eating in response to a range of emotions, has been previously associated with poor diet and obesity. Since there are limited data from non-Western populations, this study aims to examine the prevalence and factors associated with EE among urban Chinese university students. Methods: A cross-sectional study was conducted on 424 university students (aged 18-24 years) from two large universities in Hong Kong in 2019. Respondents completed an anonymous online questionnaire that contained background questions, an emotional eating subscale of the Dutch Eating Behaviour Questionnaire (DEBQ), and Depression Anxiety and Stress Scales (DASS-21). Two-sample independent t-test and multiple regression analyses were conducted to test the association of study variables with negative emotional eating. Results: There was over a three-fold higher likelihood of negative EE among females (14.8%) when compared with their male counterparts (4.5%) (OR = 3.7, p < 0.05). Having at least mild depressive symptoms was the only independent factor associated with negative EE among males (OR = 10.1) while for females, negative EE was independently associated with not having a romantic partner (OR = 3.45), having depressive symptoms (OR = 44.5), and having at least mild stress (OR = 5.65). Anxiety levels were not independently associated with negative EE for either gender. Both male and female students with negative EE had significantly lower self-perceived health scores, higher body mass index, and lower life satisfaction scores. Conclusions: This study revealed that negative EE is prevalent among female Chinese university students and not uncommon among male students. Management of negative EE should be included as a component of university mental health promotion programmes in the region.
MeSH term(s)	Adolescent ; Adult ; China/epidemiology ; Cross-Sectional Studies ; Eating ; Emotions ; Feeding Behavior ; Female ; Hong Kong/epidemiology ; Humans ; Male ; Prevalence ; Students ; Surveys and Questionnaires ; Universities ; Young Adult
Language	English
Publishing date	2021-03-24
Publishing country	England
Document type	Journal Article
ISSN	1471-2458
ISSN (online)	1471-2458
DOI	10.1186/s12889-021-10531-3
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Article ; Online: Efficacy and feasibility of 3D printed redesigned Venezia™ applicator for treating advanced cervix and recurrent endometrial cancer.

Lee, Venus W Y / Yip, Winnie W L / Tang, Steven Y K / Leung, Mike P H / Kwan, Keith K K / Liu, Alex C H / Chan, Vincent Ngai Yui / Wu, Jenna W S / Cheng, Jean N S / Chiang, Chi-Leung / Ho-Fun Lee, Victor

Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)

2023 Volume 114, Page(s) 103150

Abstract: Purpose: Venezia™ is an interstitial brachytherapy applicator for treating advanced cervical and vaginal vault recurrent cancer. However, there are limitations that lead to suboptimal target coverage. 3D printing introduction allows the redesign of ... ...

Abstract	Purpose: Venezia™ is an interstitial brachytherapy applicator for treating advanced cervical and vaginal vault recurrent cancer. However, there are limitations that lead to suboptimal target coverage. 3D printing introduction allows the redesign of Venezia™ for bulky and irregular-shaped tumors. Methods: This study first describes three new designs included: 1) add-on needles template allowed for an extra layer of straight and oblique needles, 2) redesigned vaginal cap so straight and oblique needles can be used together and 3) redesigned central tube allowed vaginal vault interstitial needle insertion. Drawbacks to original Venezia™ and rationale for using these new designs were discussed. Dosimetric analysis by comparing the original Venezia™ with new design for 10 cases in Oncentra treatment planning system v4.5 (Elekta, Stockholm, Sweden) to observe the dose differences in gross tumor volume (GTV), high risk clinical target volume (HRCTV), intermediate clinical target volume (IRCTV) and organs at risk. Results: For the dosimetric comparison, there were statistically significantly increased median minimal dose to 98% (D Conclusions: Dosimetric comparison revealed the new designs increased the dose to GTV, HRCTV and IRCTV and fulfilled the dose constraints of bladder, rectum and sigmoid. The 3D printed new design is biocompatible, inexpensive and can be patient specific.
MeSH term(s)	Female ; Humans ; Uterine Cervical Neoplasms/diagnostic imaging ; Uterine Cervical Neoplasms/radiotherapy ; Uterine Cervical Neoplasms/pathology ; Cervix Uteri ; Radiotherapy Dosage ; Feasibility Studies ; Radiotherapy Planning, Computer-Assisted ; Endometrial Neoplasms ; Brachytherapy
Language	English
Publishing date	2023-09-25
Publishing country	Italy
Document type	Journal Article
ZDB-ID	1122650-x
ISSN	1724-191X ; 1120-1797
ISSN (online)	1724-191X
ISSN	1120-1797
DOI	10.1016/j.ejmp.2023.103150
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Zs.B 2941: Show issues

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Article ; Online: Augmentation of natriuretic peptide (NP) receptor A and B (NPR-A and NPR-B) and cyclic guanosine monophosphate (cGMP) signalling as a therapeutic strategy in heart failure.

Ajay, Ashwin / Rasoul, Debar / Abdullah, Alend / Lee Wei En, Benjamin / Mashida, Knievel / Al-Munaer, Marwan / Ajay, Hanan / Duvva, Dileep / Mathew, Jean / Adenaya, Adeoye / Lip, Gregory Y H / Sankaranarayanan, Rajiv

Expert opinion on investigational drugs

2023 Volume 32, Issue 12, Page(s) 1157–1170

Abstract: Introduction: Heart failure is a complex, debilitating condition and despite advances in treatment, it remains a significant cause of morbidity and mortality worldwide. Therefore, the need for alternative treatment strategies is essential. In this ... ...

Abstract	Introduction: Heart failure is a complex, debilitating condition and despite advances in treatment, it remains a significant cause of morbidity and mortality worldwide. Therefore, the need for alternative treatment strategies is essential. In this review, we explore the therapeutic strategies of augmenting natriuretic peptide receptors (NPR-A and NPR-B) and cyclic guanosine monophosphate (cGMP) in heart failure. Areas covered: We aim to provide an overview of the evidence of preclinical and clinical studies on novel heart failure treatment strategies. Papers collected in this review have been filtered and screened following PubMed searches. This includes epigenetics, modulating enzyme activity in natriuretic peptide (NP) synthesis, gene therapy, modulation of downstream signaling by augmenting soluble guanylate cyclase (sGC) and phosphodiesterase (PDE) inhibition, nitrates, c-GMP-dependent protein kinase, synthetic and designer NP and RNA therapy. Expert opinion: The novel treatment strategies mentioned above have shown great potential, however, large randomized controlled trials are still lacking. The biggest challenge is translating the results seen in preclinical trials into clinical trials. We recommend a multi-disciplinary team approach with cardiologists, geneticist, pharmacologists, bioengineers, researchers, regulators, and patients to improve heart failure outcomes. Future management can involve telemedicine, remote monitoring, and artificial intelligence to optimize patient care.
MeSH term(s)	Humans ; Guanosine Monophosphate/therapeutic use ; Artificial Intelligence ; Heart Failure/drug therapy ; Signal Transduction ; Natriuretic Peptides/metabolism ; Natriuretic Peptides/therapeutic use ; Cyclic GMP/metabolism
Chemical Substances	Guanosine Monophosphate (85-32-5) ; Natriuretic Peptides ; Cyclic GMP (H2D2X058MU)
Language	English
Publishing date	2023-12-28
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1182884-5
ISSN	1744-7658 ; 0967-8298 ; 1354-3784
ISSN (online)	1744-7658
ISSN	0967-8298 ; 1354-3784
DOI	10.1080/13543784.2023.2290064
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Zs.A 3739: Show issues

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Jg. 1995 - 2021: Lesesall (2.OG)
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Article: Emergence of the zoonotic tick Dermacentor (Indocentor) auratus Supino, 1897 (Acari: Ixodidae) in Singapore

Kwak, Mackenzie L / Chavatte, Jean-Marc / Chew, Ka Lip / Lee, Benjamin P.Y.-H

Ticks and tick-borne diseases. 2021 Jan., v. 12, no. 1

2021

Abstract: Though ticks pose a significant public health risk, until recently, little research had focused on the diversity of ticks and tick-borne diseases in Singapore. To date, only fourteen tick species in five genera have been recorded there. For the first ... ...

Abstract	Though ticks pose a significant public health risk, until recently, little research had focused on the diversity of ticks and tick-borne diseases in Singapore. To date, only fourteen tick species in five genera have been recorded there. For the first time, Dermacentor auratus is recorded from Singapore from a range of hosts, including humans. DNA sequences are provided at 2 loci, for D. auratus, the cytochrome c oxidase I (COI) for DNA barcoding and the 16S large subunit ribosomal RNA (16S lsu rRNA). The health risk posed by D. auratus in Singapore is discussed.
Keywords	DNA ; DNA barcoding ; Dermacentor ; cytochrome-c oxidase ; hosts ; humans ; loci ; nucleotide sequences ; public health ; ribosomal RNA ; risk ; tick-borne diseases ; ticks ; Singapore
Language	English
Dates of publication	2021-01
Publishing place	Elsevier GmbH
Document type	Article
ZDB-ID	2541872-5
ISSN	1877-9603 ; 1877-959X
ISSN (online)	1877-9603
ISSN	1877-959X
DOI	10.1016/j.ttbdis.2020.101574
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Article ; Online: Staphylococcus aureus host interactions and adaptation.

Howden, Benjamin P / Giulieri, Stefano G / Wong Fok Lung, Tania / Baines, Sarah L / Sharkey, Liam K / Lee, Jean Y H / Hachani, Abderrahman / Monk, Ian R / Stinear, Timothy P

Nature reviews. Microbiology

2023 Volume 21, Issue 6, Page(s) 380–395

Abstract: Invasive Staphylococcus aureus infections are common, causing high mortality, compounded by the propensity of the bacterium to develop drug resistance. S. aureus is an excellent case study of the potential for a bacterium to be commensal, colonizing, ... ...

Abstract	Invasive Staphylococcus aureus infections are common, causing high mortality, compounded by the propensity of the bacterium to develop drug resistance. S. aureus is an excellent case study of the potential for a bacterium to be commensal, colonizing, latent or disease-causing; these states defined by the interplay between S. aureus and host. This interplay is multidimensional and evolving, exemplified by the spread of S. aureus between humans and other animal reservoirs and the lack of success in vaccine development. In this Review, we examine recent advances in understanding the S. aureus-host interactions that lead to infections. We revisit the primary role of neutrophils in controlling infection, summarizing the discovery of new immune evasion molecules and the discovery of new functions ascribed to well-known virulence factors. We explore the intriguing intersection of bacterial and host metabolism, where crosstalk in both directions can influence immune responses and infection outcomes. This Review also assesses the surprising genomic plasticity of S. aureus, its dualism as a multi-mammalian species commensal and opportunistic pathogen and our developing understanding of the roles of other bacteria in shaping S. aureus colonization.
MeSH term(s)	Animals ; Humans ; Staphylococcus aureus/genetics ; Staphylococcal Infections ; Immune Evasion ; Virulence Factors/genetics ; Adaptation, Physiological ; Host-Pathogen Interactions ; Mammals
Chemical Substances	Virulence Factors
Language	English
Publishing date	2023-01-27
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2139054-X
ISSN	1740-1534 ; 1740-1526
ISSN (online)	1740-1534
ISSN	1740-1526
DOI	10.1038/s41579-023-00852-y
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Zs.A 5865: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Cryptic susceptibility to penicillin/β-lactamase inhibitor combinations in emerging multidrug-resistant, hospital-adapted Staphylococcus epidermidis lineages.

Ba, Xiaoliang / Raisen, Claire L / Restif, Olivier / Cavaco, Lina Maria / Vingsbo Lundberg, Carina / Lee, Jean Y H / Howden, Benjamin P / Bartels, Mette D / Strommenger, Birgit / Harrison, Ewan M / Larsen, Anders Rhod / Holmes, Mark A / Larsen, Jesper

Nature communications

2023 Volume 14, Issue 1, Page(s) 6479

Abstract: Global spread of multidrug-resistant, hospital-adapted Staphylococcus epidermidis lineages underscores the need for new therapeutic strategies. Here we show that many S. epidermidis isolates belonging to these lineages display cryptic susceptibility to ... ...

Abstract	Global spread of multidrug-resistant, hospital-adapted Staphylococcus epidermidis lineages underscores the need for new therapeutic strategies. Here we show that many S. epidermidis isolates belonging to these lineages display cryptic susceptibility to penicillin/β-lactamase inhibitor combinations under in vitro conditions, despite carrying the methicillin resistance gene mecA. Using a mouse thigh model of S. epidermidis infection, we demonstrate that single-dose treatment with amoxicillin/clavulanic acid significantly reduces methicillin-resistant S. epidermidis loads without leading to detectable resistance development. On the other hand, we also show that methicillin-resistant S. epidermidis is capable of developing increased resistance to amoxicillin/clavulanic acid during long-term in vitro exposure to these drugs. These findings suggest that penicillin/β-lactamase inhibitor combinations could be a promising therapeutic candidate for treatment of a high proportion of methicillin-resistant S. epidermidis infections, although the in vivo risk of resistance development needs to be further addressed before they can be incorporated into clinical trials.
MeSH term(s)	Humans ; Penicillins/pharmacology ; Penicillins/therapeutic use ; beta-Lactamase Inhibitors/pharmacology ; Staphylococcus epidermidis ; Staphylococcal Infections/drug therapy ; Clavulanic Acid/pharmacology ; Clavulanic Acid/therapeutic use ; Amoxicillin/pharmacology ; Amoxicillin/therapeutic use ; Microbial Sensitivity Tests ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use
Chemical Substances	Penicillins ; beta-Lactamase Inhibitors ; Clavulanic Acid (23521W1S24) ; Amoxicillin (804826J2HU) ; Anti-Bacterial Agents
Language	English
Publishing date	2023-10-14
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-023-42245-y
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Article ; Online: Low-Cost, Open-Source Device for High-Performance Fluorescence Detection of Isothermal Nucleic Acid Amplification Reactions.

Buultjens, Andrew H / Vandelannoote, Koen / Sharkey, Liam K / Howden, Benjamin P / Monk, Ian R / Lee, Jean Y H / Stinear, Timothy P

ACS biomaterials science & engineering

2021 Volume 7, Issue 10, Page(s) 4982–4990

Abstract: The ability to detect SARS-CoV-2 is critical to implementing evidence-based strategies to address the COVID-19 global pandemic. Expanding SARS-CoV-2 diagnostic ability beyond well-equipped laboratories widens the opportunity for surveillance and control ... ...

Abstract	The ability to detect SARS-CoV-2 is critical to implementing evidence-based strategies to address the COVID-19 global pandemic. Expanding SARS-CoV-2 diagnostic ability beyond well-equipped laboratories widens the opportunity for surveillance and control efforts. However, such advances are predicated on the availability of rapid, scalable, accessible, yet high-performance diagnostic platforms. Methods to detect viral RNA using reverse transcription loop-mediated isothermal amplification (RT-LAMP) show promise as rapid and field-deployable tests; however, the per-unit costs of the required diagnostic hardware can be a barrier for scaled deployment. Here, we describe a diagnostic hardware configuration for LAMP technology, named the
MeSH term(s)	COVID-19/diagnosis ; Humans ; Molecular Diagnostic Techniques ; Nucleic Acid Amplification Techniques ; RNA, Viral/genetics ; RNA, Viral/isolation & purification ; SARS-CoV-2
Chemical Substances	RNA, Viral
Language	English
Publishing date	2021-09-14
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2373-9878
ISSN (online)	2373-9878
DOI	10.1021/acsbiomaterials.1c01105
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Article ; Online: The two-component system WalKR provides an essential link between cell wall homeostasis and DNA replication in

Sharkey, Liam K R / Guerillot, Romain / Walsh, Calum J / Turner, Adrianna M / Lee, Jean Y H / Neville, Stephanie L / Klatt, Stephan / Baines, Sarah L / Pidot, Sacha J / Rossello, Fernando J / Seemann, Torsten / McWilliam, Hamish E G / Cho, Ellie / Carter, Glen P / Howden, Benjamin P / McDevitt, Christopher A / Hachani, Abderrahman / Stinear, Timothy P / Monk, Ian R

mBio

2023 , Page(s) e0226223

Abstract: Among the 16 two-component systems in the opportunistic human ... ...

Abstract	Among the 16 two-component systems in the opportunistic human pathogen
Language	English
Publishing date	2023-10-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	2557172-2
ISSN	2150-7511 ; 2161-2129
ISSN (online)	2150-7511
ISSN	2161-2129
DOI	10.1128/mbio.02262-23
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Article ; Online: Emergence of the zoonotic tick Dermacentor (Indocentor) auratus Supino, 1897 (Acari: Ixodidae) in Singapore.

Kwak, Mackenzie L / Chavatte, Jean-Marc / Chew, Ka Lip / Lee, Benjamin P Y-H

Ticks and tick-borne diseases

2020 Volume 12, Issue 1, Page(s) 101574

Abstract	Though ticks pose a significant public health risk, until recently, little research had focused on the diversity of ticks and tick-borne diseases in Singapore. To date, only fourteen tick species in five genera have been recorded there. For the first time, Dermacentor auratus is recorded from Singapore from a range of hosts, including humans. DNA sequences are provided at 2 loci, for D. auratus, the cytochrome c oxidase I (COI) for DNA barcoding and the 16S large subunit ribosomal RNA (16S lsu rRNA). The health risk posed by D. auratus in Singapore is discussed.
MeSH term(s)	Animal Distribution ; Animals ; Child ; DNA Barcoding, Taxonomic ; DNA, Mitochondrial/analysis ; Dermacentor/enzymology ; Dermacentor/genetics ; Dermacentor/physiology ; Electron Transport Complex IV/analysis ; Female ; Humans ; Male ; Middle Aged ; RNA, Ribosomal, 16S/analysis ; Sequence Analysis, DNA ; Singapore ; Tick Infestations/parasitology
Chemical Substances	DNA, Mitochondrial ; RNA, Ribosomal, 16S ; Electron Transport Complex IV (EC 1.9.3.1)
Language	English
Publishing date	2020-09-24
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2541872-5
ISSN	1877-9603 ; 1877-959X
ISSN (online)	1877-9603
ISSN	1877-959X
DOI	10.1016/j.ttbdis.2020.101574
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