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  1. Article ; Online: Reducing Grip Uncertainty During Initial Prosthetic Hand Use Improves Eye-Hand Coordination and Lowers Mental Workload.

    Mohamed, M O / Wood, G / Wright, D J / Parr, J V V

    Journal of motor behavior

    2024  , Page(s) 1–11

    Abstract: The reliance on vision to control a myoelectric prosthesis is cognitively burdensome and contributes to device abandonment. The feeling of uncertainty when gripping an object is thought to be the cause of this overreliance on vision in hand-related ... ...

    Abstract The reliance on vision to control a myoelectric prosthesis is cognitively burdensome and contributes to device abandonment. The feeling of uncertainty when gripping an object is thought to be the cause of this overreliance on vision in hand-related actions. We explored if experimentally reducing grip uncertainty alters the visuomotor control and mental workload experienced during initial prosthesis use. In a repeated measures design, twenty-one able-bodied participants took part in a pouring task across three conditions: (a) using their anatomical hand, (b) using a myoelectric prosthetic hand simulator, and (c) using a myoelectric prosthetic hand simulator with Velcro attached to reduce grip uncertainty. Performance, gaze behaviour (using mobile eye-tracking) and self-reported mental workload, was measured. Results showed that using a prosthesis (with or without Velcro) slowed task performance, impaired typical eye-hand coordination and increased mental workload compared to anatomic hand control. However, when using the prosthesis with Velcro, participants displayed better prosthesis control, more effective eye-hand coordination and reduced mental workload compared to when using the prosthesis without Velcro. These positive results indicate that reducing grip uncertainty could be a useful tool for encouraging more effective prosthesis control strategies in the early stages of prosthetic hand learning.
    Language English
    Publishing date 2024-03-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2066611-1
    ISSN 1940-1027 ; 0022-2895
    ISSN (online) 1940-1027
    ISSN 0022-2895
    DOI 10.1080/00222895.2024.2328297
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Peak tibial axial acceleration during walking is related to intact-side lower limb pain in persons with unilateral transtibial amputation.

    Parr, Therese E / Farrokhi, Shawn / Hendershot, Brad D / Butowicz, Courtney M

    Gait & posture

    2024  Volume 109, Page(s) 165–169

    Abstract: ... axial accelerations were smaller on the prosthetic side (0.64 vs. 0.81 g; p = 0.04), similar ... on the intact side (0.82 vs. 0.79 g; p = 0.53), and more asymmetrical between sides (intact > prosthetic) (0.81 ... vs. 1.03 g; p = 0.01).: Significance: Symmetry in peak tibial axial acceleration can assist ...

    Abstract Background: Persons who undergo unilateral transtibial amputation are at an increased risk of secondary musculoskeletal joint pain and degeneration, which has been linked to excessive loading rates of the intact-side limb. Tibial axial acceleration, a feasible measure of loading rates with wearable sensors, would be clinically useful to relate to joint pain in persons with unilateral transtibial amputation.
    Research question: What is the relationship between peak tibial axial accelerations and intact-side joint pain in persons with unilateral transtibial amputation during walking?
    Methods: Persons with unilateral transtibial amputation (n = 51) were separated into two groups based on the presence of intact-side limb pain (with pain: n = 16; without pain: n = 35). Tibial axial accelerations were measured with bilateral shank-mounted IMUs while participants completed three 10-meter walk tests. Peak tibial axial accelerations for each limb and between-limb symmetry were compared between groups using analysis of co-variance; significance was set at 0.05.
    Results: Between persons with vs. without intact-side limb pain, peak tibial axial accelerations were smaller on the prosthetic side (0.64 vs. 0.81 g; p = 0.04), similar on the intact side (0.82 vs. 0.79 g; p = 0.53), and more asymmetrical between sides (intact > prosthetic) (0.81 vs. 1.03 g; p = 0.01).
    Significance: Symmetry in peak tibial axial acceleration can assist with identifying preferential limb loading during walking and, with future research, could serve as a useful clinical target for intact-side limb unloading strategies to help mitigate secondary musculoskeletal pain in persons with unilateral transtibial amputation.
    MeSH term(s) Humans ; Gait ; Walking ; Leg ; Amputation, Surgical ; Pain ; Arthralgia ; Biomechanical Phenomena ; Artificial Limbs ; Amputees
    Language English
    Publishing date 2024-02-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 1162323-8
    ISSN 1879-2219 ; 0966-6362
    ISSN (online) 1879-2219
    ISSN 0966-6362
    DOI 10.1016/j.gaitpost.2024.01.033
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3804: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Evaluation of ATP bioluminescence for rapid determination of cleanliness of livestock trailers after a commercial wash.

    Letsch, Flavia G / Welch, Michael W / Meyer, Matthew / Hedblom, Grant A / Parr, Eric / Classen, Dyneah M / Dillard, Molly / Boler, Dustin D

    Translational animal science

    2024  Volume 8, Page(s) txae052

    Abstract: Pathogens such as porcine epidemic diarrhea virus (PEDV), porcine reproductive and respiratory syndrome (PRRSV), ... ...

    Abstract Pathogens such as porcine epidemic diarrhea virus (PEDV), porcine reproductive and respiratory syndrome (PRRSV), and
    Language English
    Publishing date 2024-04-05
    Publishing country England
    Document type Journal Article
    ISSN 2573-2102
    ISSN (online) 2573-2102
    DOI 10.1093/tas/txae052
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  4. Article ; Online: Resuscitation highlights in 2021.

    Nolan, J P / Ornato, J P / Parr, M J A / Perkins, G D / Soar, J

    Resuscitation

    2022  Volume 172, Page(s) 64–73

    Abstract: Background: This review is the latest in a series of regular annual reviews undertaken by the editors and aims to highlight some of the key papers published in Resuscitation during 2021.: Methods: Hand-searching by the editors of all papers published ...

    Abstract Background: This review is the latest in a series of regular annual reviews undertaken by the editors and aims to highlight some of the key papers published in Resuscitation during 2021.
    Methods: Hand-searching by the editors of all papers published in Resuscitation during 2021. Papers were selected based on then general interest and novelty and were categorised into themes.
    Results: 98 papers were selected for brief mention.
    Conclusions: Resuscitation science continues to evolve and incorporates all links in the chain of survival.
    MeSH term(s) Cardiopulmonary Resuscitation ; Humans
    Language English
    Publishing date 2022-01-22
    Publishing country Ireland
    Document type Journal Article ; Review
    ZDB-ID 189901-6
    ISSN 1873-1570 ; 0300-9572
    ISSN (online) 1873-1570
    ISSN 0300-9572
    DOI 10.1016/j.resuscitation.2022.01.015
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1048: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Detailed pharmacokinetic characterization of advanced topical acyclovir formulations with IVPT and in vivo Open Flow Microperfusion.

    Schwagerle, Gerd / Sharp, Matthew J / Parr, Alan / Schimek, Denise / Mautner, Selma I / Birngruber, Thomas

    International journal of pharmaceutics

    2023  Volume 643, Page(s) 123269

    Abstract: Successful treatment of herpes simplex viruses is currently limited by a lack of effective topical drugs. Commonly used topical acyclovir products only reduce the duration of lesions by a few days. Optimizing topical formulations to achieve an enhanced ... ...

    Abstract Successful treatment of herpes simplex viruses is currently limited by a lack of effective topical drugs. Commonly used topical acyclovir products only reduce the duration of lesions by a few days. Optimizing topical formulations to achieve an enhanced acyclovir solubility and penetration could increase the efficacy of topically applied acyclovir, but new formulations need to show reliable acyclovir delivery into at least the epidermis/dermis and need to provide sustained acyclovir release for extended time periods. The aim of this study was to compare pharmacokinetic data from in vitro permeation testing (IVPT) and preclinical dermal open flow microperfusion (dOFM) experiments regarding the penetration behavior of different acyclovir formulations relative to the reference product Zovirax® 5% cream. Four test formulations that delivered the best penetration data in IVPT were further tested using continuous dOFM in vivo dermal sampling. The use of dOFM identified one of the four tested formulations to perform significantly better than the other three tested formulations and the reference product. In vivo dOFM data showed differences in the dermal acyclovir concentration that had not been detected by using IVPT. Improved acyclovir delivery to the dermis was likely achieved by the new formulation that uses a much lower drug load compared to the reference product. This optimized formulation was able to achieve a dermal concentration similar to oral application and can thus provide the opportunity of more efficacious topical HSV-1 treatment with less side effects than oral systemic treatment.
    MeSH term(s) Acyclovir ; Skin Absorption ; Administration, Cutaneous ; Administration, Topical ; Herpesvirus 1, Human ; Antiviral Agents
    Chemical Substances Acyclovir (X4HES1O11F) ; Antiviral Agents
    Language English
    Publishing date 2023-07-24
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 428962-6
    ISSN 1873-3476 ; 0378-5173
    ISSN (online) 1873-3476
    ISSN 0378-5173
    DOI 10.1016/j.ijpharm.2023.123269
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1409: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Fulminating deep tissue space infection with

    Glover, Joe / Kovacevic, Gorana / Walton, Gary / Parr, David

    BMJ case reports

    2020  Volume 13, Issue 3

    Abstract: Management of sore throat requires robust decision-making to balance successfully the conflicting risks of unnecessary antibiotic use against those of untreated bacterial infection. We present a case of fulminant sepsis caused ... ...

    Abstract Management of sore throat requires robust decision-making to balance successfully the conflicting risks of unnecessary antibiotic use against those of untreated bacterial infection. We present a case of fulminant sepsis caused by
    MeSH term(s) Abscess/diagnostic imaging ; Abscess/microbiology ; Adult ; Humans ; Male ; Neck/diagnostic imaging ; Neck/microbiology ; Pharyngitis/microbiology ; Pharyngitis/therapy ; Sepsis/etiology ; Sepsis/microbiology ; Streptococcal Infections/complications ; Streptococcal Infections/microbiology ; Streptococcal Infections/therapy ; Streptococcus constellatus/isolation & purification
    Language English
    Publishing date 2020-03-31
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2019-233971
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  7. Article ; Online: Resuscitation highlights in 2020.

    Nolan, J P / Ornato, J P / Parr, M J A / Perkins, G D / Soar, J

    Resuscitation

    2021  Volume 162, Page(s) 1–10

    Abstract: Background: This review is the latest in a series of regular annual reviews undertaken by the editors and aims to highlight some of the key papers published in Resuscitation during 2020. The number of papers submitted to the Journal in 2020 increased by ...

    Abstract Background: This review is the latest in a series of regular annual reviews undertaken by the editors and aims to highlight some of the key papers published in Resuscitation during 2020. The number of papers submitted to the Journal in 2020 increased by 25% on the previous year.MethodsHand-searching by the editors of all papers published in Resuscitation during 2020. Papers were selected based on then general interest and novelty and were categorised into general themes.ResultsA total of 103 papers were selected for brief mention in this review.ConclusionsResuscitation science continues to evolve rapidly and incorporate all links in the chain of survival.
    MeSH term(s) Cardiopulmonary Resuscitation ; Humans
    Language English
    Publishing date 2021-02-09
    Publishing country Ireland
    Document type Journal Article ; Review
    ZDB-ID 189901-6
    ISSN 1873-1570 ; 0300-9572
    ISSN (online) 1873-1570
    ISSN 0300-9572
    DOI 10.1016/j.resuscitation.2021.01.037
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1048: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Resuscitation highlights in 2019.

    Nolan, J P / Ornato, J P / Parr, M J A / Perkins, G D / Soar, J

    Resuscitation

    2020  Volume 148, Page(s) 234–241

    MeSH term(s) Heart Arrest/therapy ; Humans ; Resuscitation
    Language English
    Publishing date 2020-02-07
    Publishing country Ireland
    Document type Editorial
    ZDB-ID 189901-6
    ISSN 1873-1570 ; 0300-9572
    ISSN (online) 1873-1570
    ISSN 0300-9572
    DOI 10.1016/j.resuscitation.2020.02.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1048: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Adolescent neurocognitive development and decision-making abilities regarding gender-affirming care.

    Ravindranath, Orma / Perica, Maria I / Parr, Ashley C / Ojha, Amar / McKeon, Shane D / Montano, Gerald / Ullendorff, Naomi / Luna, Beatriz / Edmiston, E Kale

    Developmental cognitive neuroscience

    2024  , Page(s) 101351

    Abstract: Recently, politicians and legislative bodies have cited neurodevelopmental literature to argue that brain immaturity undermines decision-making regarding gender-affirming care (GAC) in youth. Here, we review this literature as it applies to adolescents' ... ...

    Abstract Recently, politicians and legislative bodies have cited neurodevelopmental literature to argue that brain immaturity undermines decision-making regarding gender-affirming care (GAC) in youth. Here, we review this literature as it applies to adolescents' ability to make decisions regarding GAC. The research shows that while adolescence is a time of peak risk-taking behavior that may lead to impulsive decisions, neurocognitive systems supporting adult-level decisions are available given deliberative processes that minimize influence of short-term rewards and peers. Since GAC decisions occur over an extended period and with support from adult caregivers and clinicians, adolescents can engage adult-level decision-making in this context. We also weigh the benefits of providing GAC access during adolescence and consider the significant costs of blocking or delaying GAC. Transgender and non-binary (TNB) adolescents face significant mental health challenges, many of which are mitigated by GAC access. Further, initiating the GAC process during adolescence, which we define as beginning at pubertal onset, leads to better long-term mental health outcomes than waiting until adulthood. Taken together, existing research indicates that many adolescents can make informed decisions regarding gender-affirming care, and that this care is critical for the well-being of TNB youth. We highlight relevant considerations for policy makers, researchers, and clinicians.
    Language English
    Publishing date 2024-02-12
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2572271-2
    ISSN 1878-9307 ; 1878-9307
    ISSN (online) 1878-9307
    ISSN 1878-9307
    DOI 10.1016/j.dcn.2024.101351
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  10. Article: External and Internal Microbiomes of Antarctic Nematodes are Distinct, but More Similar to each other than the Surrounding Environment.

    Parr McQueen, J / Gattoni, K / Gendron, E M S / Schmidt, S K / Sommers, P / Porazinska, D L

    Journal of nematology

    2023  Volume 55, Issue 1, Page(s) 20230004

    Abstract: ... to host physiology. For nematodes, single strains of bacteria are known to adhere to the cuticle (e.g., ...

    Abstract Host-associated microbiomes have primarily been examined in the context of their internal microbial communities, but many animal species also contain microorganisms on external host surfaces that are important to host physiology. For nematodes, single strains of bacteria are known to adhere to the cuticle (e.g.,
    Language English
    Publishing date 2023-03-09
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 410426-2
    ISSN 0022-300X
    ISSN 0022-300X
    DOI 10.2478/jofnem-2023-0004
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    In stock of ZB MED Bonn / Germany

    Z 2645: Show issues

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