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Article: Validation of the Fear of COVID-19 Scale in a US College Sample.

Perz, Catherine A / Lang, Brent A / Harrington, Rick

International journal of mental health and addiction

2020 Volume 20, Issue 1, Page(s) 273–283

Abstract: The COVID-19 pandemic has impacted college students' coursework, stress levels, and perceived health. Various estimates indicate that high proportions of college students have experienced increased amounts of stress (Dziech, ...

Abstract	The COVID-19 pandemic has impacted college students' coursework, stress levels, and perceived health. Various estimates indicate that high proportions of college students have experienced increased amounts of stress (Dziech,
Keywords	covid19
Language	English
Publishing date	2020-06-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	2235886-9
ISSN	1557-1882 ; 1557-1874
ISSN (online)	1557-1882
ISSN	1557-1874
DOI	10.1007/s11469-020-00356-3
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Article ; Online: Validation of the Fear of COVID-19 Scale in a US College Sample

Perz, Catherine A. / Lang, Brent A. / Harrington, Rick

International Journal of Mental Health and Addiction ; ISSN 1557-1874 1557-1882

2020

Keywords	Psychiatry and Mental health ; covid19
Language	English
Publisher	Springer Science and Business Media LLC
Publishing country	us
Document type	Article ; Online
DOI	10.1007/s11469-020-00356-3
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Validation of the Fear of COVID-19 Scale in a US College Sample

Perz, Catherine A / Lang, Brent A / Harrington, Rick

Int J Ment Health Addict

Abstract	The COVID-19 pandemic has impacted college students' coursework, stress levels, and perceived health. Various estimates indicate that high proportions of college students have experienced increased amounts of stress (Dziech, Inside Higher Education, 2020; Hartocollis, New York Times, 2020), yet other sources indicate that many college students respond to these changes with resilience (Kelley, Cornell Chronicle, 2020). A method for assessing student anxiety regarding the pandemic is thus needed. The Fear of COVID-19 Scale (FCV-19S) (Ahorsu et al., International Journal of Mental Health and Addiction, 2020) is a seven-item scale which has been validated and shown to possess good psychometric qualities in studies of participants from multiple countries. The current study used a cross-sectional convenience sample of US college student participants (n = 237) and found that the FCV-19S has high reliability and validity as demonstrated by its internal consistency and strong one-factor solution. Scores on the FCV-19S were positively correlated with anxiety for students who were married or of Asian descent. Additionally, the FCV-19S was only moderately correlated with the Generalized Anxiety Disorder-7 Scale (GAD-7), suggesting that the FCV-19S may bring added utility to research and clinical practice with populations impacted by the COVID-19 pandemic.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #614071
Database	COVID19

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Article: Validation of scales measuring attitudes and norms related to mammography screening in women veterans.

Tiro, Jasmin A / Diamond, Pamela M / Perz, Catherine A / Fernandez, Maria / Rakowski, William / DiClemente, Carlo C / Vernon, Sally W

Health psychology : official journal of the Division of Health Psychology, American Psychological Association

2005 Volume 24, Issue 6, Page(s) 555–566

Abstract: Validation of psychosocial measures for use in mammography screening research has been given inadequate attention in the literature. The authors report on the validation of 5 measures examining 4 attitudinal constructs (i.e., pros, cons, outcome ... ...

Abstract	Validation of psychosocial measures for use in mammography screening research has been given inadequate attention in the literature. The authors report on the validation of 5 measures examining 4 attitudinal constructs (i.e., pros, cons, outcome expectations, and cancer worries) and 1 social influence construct (i.e., subjective norms) in a 22-item inventory. The study participants consisted of a national, randomly sampled population of women veterans (n = 2,910). After minor revision of scales, the authors found independent measures for 4 constructs: pros, cons, cancer worries, and subjective norms. The authors concluded that these scales have acceptable psychometric properties; support construct validity; and provide brief, reliable, and valid measures of attitudes toward and norms regarding mammography screening. These scales may be useful for intervention research.
MeSH term(s)	Attitude to Health ; Breast Neoplasms/epidemiology ; Demography ; Factor Analysis, Statistical ; Female ; Guidelines as Topic ; Humans ; Mammography/methods ; Mass Screening/methods ; Middle Aged ; Registries ; Reproducibility of Results ; Surveys and Questionnaires ; Veterans/psychology
Language	English
Publishing date	2005-11
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Validation Studies
ZDB-ID	226369-5
ISSN	1930-7810 ; 0278-6133
ISSN (online)	1930-7810
ISSN	0278-6133
DOI	10.1037/0278-6133.24.6.555
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Article: Primary care patients' understanding of colorectal cancer screening.

Greisinger, Anthony / Hawley, Sarah T / Bettencourt, Judy L / Perz, Catherine A / Vernon, Sally W

Cancer detection and prevention

2006 Volume 30, Issue 1, Page(s) 67–74

Abstract: Purpose: To determine the current level of awareness and understanding about colorectal cancer (CRC) and colorectal cancer screening (CRCS) among primary care patients in order to develop interventions to educate patients about options for CRCS, help ... ...

Abstract	Purpose: To determine the current level of awareness and understanding about colorectal cancer (CRC) and colorectal cancer screening (CRCS) among primary care patients in order to develop interventions to educate patients about options for CRCS, help them identify CRCS preferences and make informed choices about CRCS options. Methods: During the spring of 2001 and 2003, two sets of focus groups with primary care patients were conducted at a large multi-specialty group practice in Houston, Texas. Results: Participants (n = 42) in both sets of focus groups had low knowledge about CRC and expressed fear and embarrassment about CRC and CRCS. Attitudes towards the fecal occult blood test (FOBT) were mixed, with some participants considering it difficult to finish and others preferring the privacy it afforded. Some participants initially failed to recognize the difference between sigmoidoscopy (SIG) and colonoscopy (COL), and several endoscopy-specific barriers were identified such as fear of pain, embarrassment/humiliation, and dislike or fear of test preparation. Some participants felt that endoscopy was likely to be more effective than FOBT, and others clearly preferred COL to SIG. System-specific barriers to endoscopy (e.g. difficulty scheduling appointments and insurance coverage) were also identified. We found little change in the barriers reported by primary care patients, despite a two-year difference between focus groups. Participants also provided suggestions for improving CRCS including telephone, letters and/or email reminders from the clinic, videotapes and websites. Conclusions: Future interventions focused on improving informed decision-making by educating primary care patients about the risks and benefits of specific test options and about the importance of early detection of CRC could prove to be effective for increasing CRCS.
MeSH term(s)	Aged ; Aged, 80 and over ; Attitude to Health ; Colonoscopy ; Colorectal Neoplasms/diagnosis ; Colorectal Neoplasms/prevention & control ; Decision Making ; Female ; Focus Groups ; Health Knowledge, Attitudes, Practice ; Humans ; Male ; Mass Screening ; Middle Aged ; Occult Blood ; Primary Health Care ; Sigmoidoscopy ; Telephone
Language	English
Publishing date	2006
Publishing country	England
Document type	Journal Article ; Multicenter Study ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	425808-3
ISSN	0361-090X
ISSN	0361-090X
DOI	10.1016/j.cdp.2005.10.001
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Article ; Online: Acute hepatitis B outbreaks related to fingerstick blood glucose monitoring in two assisted living facilities.

Counard, Catherine A / Perz, Joseph F / Linchangco, Purisima C / Christiansen, Demian / Ganova-Raeva, Lilia / Xia, Guoliang / Jones, Steven / Vernon, Michael O

Journal of the American Geriatrics Society

2010 Volume 58, Issue 2, Page(s) 306–311

Abstract: Objectives: To establish the etiology for outbreaks of hepatitis B virus (HBV) infections at two assisted living facilities (ALFs) and devise appropriate control measures.: Design: Multisite outbreak investigations, retrospective cohort.: Setting: ...

Abstract	Objectives: To establish the etiology for outbreaks of hepatitis B virus (HBV) infections at two assisted living facilities (ALFs) and devise appropriate control measures. Design: Multisite outbreak investigations, retrospective cohort. Setting: Two ALFs in Illinois. Participants: Facility A residents (n=120) and Facility B residents (n=105) and nursing staff (n=6). Measurements: For Facility A, a retrospective cohort study to identify risk factors for HBV infection through serological testing of all residents and a medical record extraction. For Facility A and B, investigation of fingerstick blood glucose monitoring techniques. For Facility B, serological HBV testing of nurses and residents receiving fingerstick blood glucose monitoring. Results: At Facility A, five confirmed acute, two probable acute, and one probable chronic HBV infections were identified in the 109 residents tested. All of the eight identified residents with HBV infection had diabetes mellitus. HBV deoxyribonucleic acid (DNA) sequences from the chronic and acute cases were identical. Transmission of HBV was associated with fingerstick blood glucose monitoring (relative risk (RR)=28.5, 95% confidence interval (CI)=1.6-498; P<.001) and insulin injections (RR=7.4, 95% CI=1.3-40.8; P=.03). At Facility B, seven of 21 residents (33.3%) receiving fingerstick blood glucose monitoring had evidence of recent HBV infection. Conclusion: Nurses probably transmitted HBV infection from resident to resident during fingerstick blood glucose monitoring in two separate ALFs, causing outbreaks. Awareness of the high risk for HBV transmission during procedures for the care of diabetes mellitus was limited. Following established infection control measures is critical to prevent spread of this highly contagious virus.
MeSH term(s)	Aged ; Assisted Living Facilities ; Blood Specimen Collection/adverse effects ; Cross Infection/epidemiology ; Cross Infection/etiology ; Cross Infection/prevention & control ; Diabetes Mellitus/blood ; Diabetes Mellitus/nursing ; Disease Outbreaks/prevention & control ; Hepatitis B/epidemiology ; Hepatitis B/etiology ; Hepatitis B/prevention & control ; Humans ; Illinois/epidemiology ; Infection Control/methods ; Long-Term Care ; Retrospective Studies ; Risk Factors
Language	English
Publishing date	2010-02
Publishing country	United States
Document type	Journal Article ; Multicenter Study
ZDB-ID	80363-7
ISSN	1532-5415 ; 0002-8614
ISSN (online)	1532-5415
ISSN	0002-8614
DOI	10.1111/j.1532-5415.2009.02669.x
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Article ; Online: Promoting regular mammography screening I. A systematic assessment of validity in a randomized trial.

del Junco, Deborah J / Vernon, Sally W / Coan, Sharon P / Tiro, Jasmin A / Bastian, Lori A / Savas, Lara S / Perz, Catherine A / Lairson, David R / Chan, Wen / Warrick, Cynthia / McQueen, Amy / Rakowski, William

Journal of the National Cancer Institute

2008 Volume 100, Issue 5, Page(s) 333–346

Abstract: Background: Most health promotion trials in cancer screening offer limited evidence of external validity. We assessed internal and external validity in a nationwide, population-based trial of an intervention to promote regular mammography screening.: ... ...

Abstract	Background: Most health promotion trials in cancer screening offer limited evidence of external validity. We assessed internal and external validity in a nationwide, population-based trial of an intervention to promote regular mammography screening. Methods: Beginning in September 2000, study candidates age 52 years and older (n = 23,000) were randomly selected from the National Registry of Women Veterans and sent an eligibility survey. Consistent with intention-to-treat principles for effectiveness trials, we randomly assigned eligible respondents and nonrespondents to one of five groups. We mailed baseline surveys to groups 1-3 followed by intervention materials of varying personalization to groups 1 and 2. We delayed mailing baseline surveys to two additional control groups to coincide with the mailing of postintervention follow-up surveys to groups 1-3 at year 1 (group 4) and year 2 (group 5). Mammography rates were determined from self-report and Veterans Health Administration records. To assess internal validity, we compared groups on participation and factors associated with mammography screening at each stage. To assess external validity, we compared groups 3, 4, and 5 on mammography rates at the most recent follow-up to detect any cueing effects of prior surveys and at the respective baselines to uncover any secular trends. We also compared nonparticipants with participants on factors associated with mammography screening at the trial's end. Results: We established study eligibility for 21,340 (92.8%) of the study candidates. Groups 1-3 were similar throughout the trial in participation and correlates of mammography screening. No statistically significant survey cueing effects or differences between nonparticipants and participants across groups were observed. Mammography screening rates over the 30 months preceding the respective baselines were lower in group 5 (82.3% by self-report) than in groups 1-4 (85.1%, P = .024, group 5 vs groups 1-4 combined), suggesting a decline over time similar to that reported for US women in general. Conclusion: This systematic assessment provides evidence of the trial's internal and external validity and illustrates an approach to evaluating validity that is readily adaptable to future trials of behavioral interventions.
MeSH term(s)	Aged ; Breast Neoplasms/prevention & control ; Female ; Humans ; Mammography/statistics & numerical data ; Mass Screening/methods ; Mass Screening/statistics & numerical data ; Middle Aged ; Patient Selection ; Registries ; Reproducibility of Results ; Research Design ; United States ; Veterans/statistics & numerical data
Language	English
Publishing date	2008-02-26
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural ; Validation Study
ZDB-ID	2992-0
ISSN	1460-2105 ; 0027-8874 ; 0198-0157
ISSN (online)	1460-2105
ISSN	0027-8874 ; 0198-0157
DOI	10.1093/jnci/djn027
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Article ; Online: Promoting regular mammography screening II. Results from a randomized controlled trial in US women veterans.

Vernon, Sally W / del Junco, Deborah J / Tiro, Jasmin A / Coan, Sharon P / Perz, Catherine A / Bastian, Lori A / Rakowski, William / Chan, Wen / Lairson, David R / McQueen, Amy / Fernandez, Maria E / Warrick, Cynthia / Halder, Arada / DiClemente, Carlo

Journal of the National Cancer Institute

2008 Volume 100, Issue 5, Page(s) 347–358

Abstract: Background: Few health promotion trials have evaluated strategies to increase regular mammography screening. We conducted a randomized controlled trial of two theory-based interventions in a population-based, nationally representative sample of women ... ...

Abstract	Background: Few health promotion trials have evaluated strategies to increase regular mammography screening. We conducted a randomized controlled trial of two theory-based interventions in a population-based, nationally representative sample of women veterans. Methods: Study candidates 52 years and older were randomly sampled from the National Registry of Women Veterans and randomly assigned to three groups. Groups 1 and 2 received interventions that varied in the extent of personalization (tailored and targeted vs targeted-only, respectively); group 3 was a survey-only control group. Postintervention follow-up surveys were mailed to all women after 1 and 2 years. Outcome measures were self-reported mammography coverage (completion of one postintervention mammogram) and compliance (completion of two postintervention mammograms). In decreasingly conservative analyses (intention-to-treat [ITT], modified intention-to-treat [MITT], and per-protocol [PP]), we examined crude coverage and compliance estimates and adjusted for covariates and variable follow-up time across study groups using Cox proportional hazards regression. For the PP analyses, we also used logistic regression. Results: None of the among-group differences in the crude incidence estimates for mammography coverage was statistically significant in ITT, MITT, or PP analyses. Crude estimates of compliance differed at statistically significant levels in the PP analyses and at levels approaching statistical significance in the ITT and MITT analyses. Absolute differences favoring the intervention over the control groups were 1%-3% for ITT analysis, 1%-5% for MITT analysis, and 2%-6% for the PP analysis. Results from Cox modeling showed no statistically significant effect of the interventions on coverage or compliance in the ITT, MITT, or PP analyses, although hazard rate ratios (HRRs) for coverage were consistently slightly higher in the intervention groups than the control group (range for HRRs = 1.05-1.09). A PP analysis using logistic regression produced odds ratios (ORs) that were consistently higher than the corresponding hazard rate ratios for both coverage and compliance (range for ORs = 1.15-1.29). Conclusions: In none of our primary analyses did the tailored and targeted intervention result in higher mammography rates than the targeted-only intervention, and there was limited support for either intervention being more effective than the baseline survey alone. We found that adjustment for variable follow-up time produced more conservative (less favorable) intervention effect estimates.
MeSH term(s)	Adult ; Aged ; Analysis of Variance ; Breast Neoplasms/mortality ; Breast Neoplasms/prevention & control ; Female ; Humans ; Logistic Models ; Mammography/statistics & numerical data ; Mass Screening/methods ; Mass Screening/statistics & numerical data ; Middle Aged ; Patient Compliance ; Patient Selection ; Proportional Hazards Models ; Registries ; Reproducibility of Results ; Research Design ; United States/epidemiology ; Veterans/statistics & numerical data
Language	English
Publishing date	2008-02-26
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural ; Validation Study
ZDB-ID	2992-0
ISSN	1460-2105 ; 0027-8874 ; 0198-0157
ISSN (online)	1460-2105
ISSN	0027-8874 ; 0198-0157
DOI	10.1093/jnci/djn026
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Article ; Online: Hepatitis A among international adoptees and their contacts.

Fischer, Gayle E / Teshale, Eyasu H / Miller, Claudia / Schumann, Casey / Winter, Kathleen / Elson, Franny / Horan, Katherine / Reed, Christie M / Armstrong, Gregory L / Perz, Joseph F

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

2008 Volume 47, Issue 6, Page(s) 812–814

Abstract: We identified 27 cases of hepatitis A among international adoptees (5 persons), their direct or indirect contacts (20 persons), and unvaccinated travelers to the adoptees' countries (2 persons). Most cases occurred among nontraveling contacts of adoptees, ...

Abstract	We identified 27 cases of hepatitis A among international adoptees (5 persons), their direct or indirect contacts (20 persons), and unvaccinated travelers to the adoptees' countries (2 persons). Most cases occurred among nontraveling contacts of adoptees, suggesting the need to extend prevention guidelines to include hepatitis A vaccination for at-risk nontravelers.
MeSH term(s)	Adoption ; Adult ; Child, Preschool ; Contact Tracing ; Ethiopia/ethnology ; Hepatitis A/epidemiology ; Hepatitis A/prevention & control ; Hepatitis A/transmission ; Hepatitis A Vaccines/therapeutic use ; Humans ; Panama/ethnology ; Philippines/ethnology ; Travel ; United States/epidemiology
Chemical Substances	Hepatitis A Vaccines
Language	English
Publishing date	2008-09-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	1099781-7
ISSN	1537-6591 ; 1058-4838
ISSN (online)	1537-6591
ISSN	1058-4838
DOI	10.1086/591199
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Article ; Online: Expanding the diversity of mycobacteriophages: insights into genome architecture and evolution.

Pope, Welkin H / Jacobs-Sera, Deborah / Russell, Daniel A / Peebles, Craig L / Al-Atrache, Zein / Alcoser, Turi A / Alexander, Lisa M / Alfano, Matthew B / Alford, Samantha T / Amy, Nichols E / Anderson, Marie D / Anderson, Alexander G / Ang, Andrew A S / Ares, Manuel / Barber, Amanda J / Barker, Lucia P / Barrett, Jonathan M / Barshop, William D / Bauerle, Cynthia M /

Bayles, Ian M / Belfield, Katherine L / Best, Aaron A / Borjon, Agustin / Bowman, Charles A / Boyer, Christine A / Bradley, Kevin W / Bradley, Victoria A / Broadway, Lauren N / Budwal, Keshav / Busby, Kayla N / Campbell, Ian W / Campbell, Anne M / Carey, Alyssa / Caruso, Steven M / Chew, Rebekah D / Cockburn, Chelsea L / Cohen, Lianne B / Corajod, Jeffrey M / Cresawn, Steven G / Davis, Kimberly R / Deng, Lisa / Denver, Dee R / Dixon, Breyon R / Ekram, Sahrish / Elgin, Sarah C R / Engelsen, Angela E / English, Belle E V / Erb, Marcella L / Estrada, Crystal / Filliger, Laura Z / Findley, Ann M / Forbes, Lauren / Forsyth, Mark H / Fox, Tyler M / Fritz, Melissa J / Garcia, Roberto / George, Zindzi D / Georges, Anne E / Gissendanner, Christopher R / Goff, Shannon / Goldstein, Rebecca / Gordon, Kobie C / Green, Russell D / Guerra, Stephanie L / Guiney-Olsen, Krysta R / Guiza, Bridget G / Haghighat, Leila / Hagopian, Garrett V / Harmon, Catherine J / Harmson, Jeremy S / Hartzog, Grant A / Harvey, Samuel E / He, Siping / He, Kevin J / Healy, Kaitlin E / Higinbotham, Ellen R / Hildebrandt, Erin N / Ho, Jason H / Hogan, Gina M / Hohenstein, Victoria G / Holz, Nathan A / Huang, Vincent J / Hufford, Ericka L / Hynes, Peter M / Jackson, Arrykka S / Jansen, Erica C / Jarvik, Jonathan / Jasinto, Paul G / Jordan, Tuajuanda C / Kasza, Tomas / Katelyn, Murray A / Kelsey, Jessica S / Kerrigan, Larisa A / Khaw, Daryl / Kim, Junghee / Knutter, Justin Z / Ko, Ching-Chung / Larkin, Gail V / Laroche, Jennifer R / Latif, Asma / Leuba, Kohana D / Leuba, Sequoia I / Lewis, Lynn O / Loesser-Casey, Kathryn E / Long, Courtney A / Lopez, A Javier / Lowery, Nicholas / Lu, Tina Q / Mac, Victor / Masters, Isaac R / McCloud, Jazmyn J / McDonough, Molly J / Medenbach, Andrew J / Menon, Anjali / Miller, Rachel / Morgan, Brandon K / Ng, Patrick C / Nguyen, Elvis / Nguyen, Katrina T / Nguyen, Emilie T / Nicholson, Kaylee M / Parnell, Lindsay A / Peirce, Caitlin E / Perz, Allison M / Peterson, Luke J / Pferdehirt, Rachel E / Philip, Seegren V / Pogliano, Kit / Pogliano, Joe / Polley, Tamsen / Puopolo, Erica J / Rabinowitz, Hannah S / Resiss, Michael J / Rhyan, Corwin N / Robinson, Yetta M / Rodriguez, Lauren L / Rose, Andrew C / Rubin, Jeffrey D / Ruby, Jessica A / Saha, Margaret S / Sandoz, James W / Savitskaya, Judith / Schipper, Dale J / Schnitzler, Christine E / Schott, Amanda R / Segal, J Bradley / Shaffer, Christopher D / Sheldon, Kathryn E / Shepard, Erica M / Shepardson, Jonathan W / Shroff, Madav K / Simmons, Jessica M / Simms, Erika F / Simpson, Brandy M / Sinclair, Kathryn M / Sjoholm, Robert L / Slette, Ingrid J / Spaulding, Blaire C / Straub, Clark L / Stukey, Joseph / Sughrue, Trevor / Tang, Tin-Yun / Tatyana, Lyons M / Taylor, Stephen B / Taylor, Barbara J / Temple, Louise M / Thompson, Jasper V / Tokarz, Michael P / Trapani, Stephanie E / Troum, Alexander P / Tsay, Jonathan / Tubbs, Anthony T / Walton, Jillian M / Wang, Danielle H / Wang, Hannah / Warner, John R / Weisser, Emilie G / Wendler, Samantha C / Weston-Hafer, Kathleen A / Whelan, Hilary M / Williamson, Kurt E / Willis, Angelica N / Wirtshafter, Hannah S / Wong, Theresa W / Wu, Phillip / Yang, Yun jeong / Yee, Brandon C / Zaidins, David A / Zhang, Bo / Zúniga, Melina Y / Hendrix, Roger W / Hatfull, Graham F

PloS one

2011 Volume 6, Issue 1, Page(s) e16329

Abstract: Mycobacteriophages are viruses that infect mycobacterial hosts such as Mycobacterium smegmatis and Mycobacterium tuberculosis. All mycobacteriophages characterized to date are dsDNA tailed phages, and have either siphoviral or myoviral morphotypes. ... ...

Abstract	Mycobacteriophages are viruses that infect mycobacterial hosts such as Mycobacterium smegmatis and Mycobacterium tuberculosis. All mycobacteriophages characterized to date are dsDNA tailed phages, and have either siphoviral or myoviral morphotypes. However, their genetic diversity is considerable, and although sixty-two genomes have been sequenced and comparatively analyzed, these likely represent only a small portion of the diversity of the mycobacteriophage population at large. Here we report the isolation, sequencing and comparative genomic analysis of 18 new mycobacteriophages isolated from geographically distinct locations within the United States. Although no clear correlation between location and genome type can be discerned, these genomes expand our knowledge of mycobacteriophage diversity and enhance our understanding of the roles of mobile elements in viral evolution. Expansion of the number of mycobacteriophages grouped within Cluster A provides insights into the basis of immune specificity in these temperate phages, and we also describe a novel example of apparent immunity theft. The isolation and genomic analysis of bacteriophages by freshman college students provides an example of an authentic research experience for novice scientists.
MeSH term(s)	Base Sequence ; Biological Evolution ; DNA, Viral/genetics ; Genetic Variation ; Genome, Viral/genetics ; Geography ; Mycobacteriophages/genetics ; Mycobacteriophages/immunology ; Mycobacteriophages/isolation & purification ; Sequence Analysis, DNA ; United States
Chemical Substances	DNA, Viral
Language	English
Publishing date	2011-01-27
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0016329
Database	MEDical Literature Analysis and Retrieval System OnLINE

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