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  1. Article ; Online: EMPROVE 24-Month Follow-Up: Judge Success by Quality of Life, Not Just Spirometry.

    Mahajan, Amit K

    Annals of the American Thoracic Society

    2024  Volume 21, Issue 2, Page(s) 206–207

    MeSH term(s) Humans ; Quality of Life ; Follow-Up Studies ; Pulmonary Emphysema ; Emphysema ; Spirometry
    Language English
    Publishing date 2024-02-01
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2717461-X
    ISSN 2325-6621 ; 1943-5665 ; 2325-6621
    ISSN (online) 2325-6621 ; 1943-5665
    ISSN 2325-6621
    DOI 10.1513/AnnalsATS.202311-1005ED
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    Zs.A 5828: Show issues Location:
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  2. Article ; Online: Comparative analysis of energy expenditure and costs in neuroimaging.

    Signorile, William J / Mahajan, Amit / Fulbright, Robert K / Zubair, Adeel S

    Journal of the neurological sciences

    2024  , Page(s) 123001

    Language English
    Publishing date 2024-04-13
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 80160-4
    ISSN 1878-5883 ; 0022-510X ; 0374-8642
    ISSN (online) 1878-5883
    ISSN 0022-510X ; 0374-8642
    DOI 10.1016/j.jns.2024.123001
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    Zs.A 308: Show issues Location:
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  3. Article ; Online: Cerebral venous thrombosis after COVID-19 vaccination: the role for endovascular treatment.

    Mahajan, Amit / Hirsch, Joshua A

    Journal of neurointerventional surgery

    2022  Volume 14, Issue 9, Page(s) 849–850

    MeSH term(s) COVID-19 ; COVID-19 Vaccines/adverse effects ; Endovascular Procedures/adverse effects ; Humans ; Intracranial Thrombosis/diagnostic imaging ; Intracranial Thrombosis/etiology ; Sinus Thrombosis, Intracranial/therapy ; Thrombectomy ; Thrombolytic Therapy ; Treatment Outcome ; Vaccination ; Venous Thrombosis/etiology ; Venous Thrombosis/therapy
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2022-02-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 2514982-9
    ISSN 1759-8486 ; 1759-8478
    ISSN (online) 1759-8486
    ISSN 1759-8478
    DOI 10.1136/neurintsurg-2021-018516
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    Zs.A 6845: Show issues Location:
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  4. Article ; Online: Comparative transcriptome profiling of contrasting finger millet (Eleusine coracana (L.) Gaertn) genotypes under heat stress.

    Goyal, Etika / Singh, Amit Kumar / Mahajan, Mahesh Mohanrao / Kanika, Kumar

    Molecular biology reports

    2024  Volume 51, Issue 1, Page(s) 283

    Abstract: Background: Eleusine coracana (L.) Gaertn is a crucial C: Methods and results: In the present study, a comparative RNA sequencing analysis was done in the leaf tissue of the finger millet, between the heat-sensitive (KJNS-46) and heat-tolerant (PES- ... ...

    Abstract Background: Eleusine coracana (L.) Gaertn is a crucial C
    Methods and results: In the present study, a comparative RNA sequencing analysis was done in the leaf tissue of the finger millet, between the heat-sensitive (KJNS-46) and heat-tolerant (PES-110) cultivars of Ragi, in response to high temperatures. On average, each sample generated about 24 million reads. Interestingly, a comparison of transcriptomic profiling identified 684 transcripts which were significantly differentially expressed genes (DEGs) examined between the heat-stressed samples of both genotypes. The heat-induced change in the transcriptome was confirmed by qRT-PCR using a set of randomly selected genes. Pathway analysis and functional annotation analysis revealed the activation of various genes involved in response to stress specifically heat, oxidation-reduction process, water deprivation, and changes in heat shock protein (HSP) and transcription factors, calcium signaling, and kinase signaling. The basal regulatory genes, such as bZIP, were involved in response to heat stress, indicating that heat stress activates genes involved in housekeeping or related to basal regulatory processes. A substantial percentage of the DEGs belonged to proteins of unknown functions (PUFs), i.e., not yet characterized.
    Conclusion: These findings highlight the importance of candidate genes, such as HSPs and pathways that can confer tolerance towards heat stress in ragi. These results will provide valuable information to improve the heat tolerance in heat-susceptible agronomically important varieties of ragi and other crops.
    MeSH term(s) Eleusine ; Genotype ; Gene Expression Profiling ; Thermotolerance ; Heat-Shock Proteins
    Chemical Substances Heat-Shock Proteins
    Language English
    Publishing date 2024-02-07
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 186544-4
    ISSN 1573-4978 ; 0301-4851
    ISSN (online) 1573-4978
    ISSN 0301-4851
    DOI 10.1007/s11033-024-09233-x
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    Zs.A 1140: Show issues Location:
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  5. Article ; Online: "Tool-in-lesion" Accuracy of Galaxy System-A Robotic Electromagnetic Navigation BroncHoscopy With Integrated Tool-in-lesion-Tomosynthesis Technology: The MATCH Study.

    Bhadra, Krish / Rickman, Otis B / Mahajan, Amit K / Hogarth, Douglas Kyle

    Journal of bronchology & interventional pulmonology

    2024  Volume 31, Issue 1, Page(s) 23–29

    Abstract: Background: The Galaxy System (Noah Medical) is a novel robotic endoluminal platform using electromagnetic navigation combined with integrated tomosynthesis technology and augmented fluoroscopy. It provides intraprocedural imaging to correct ... ...

    Abstract Background: The Galaxy System (Noah Medical) is a novel robotic endoluminal platform using electromagnetic navigation combined with integrated tomosynthesis technology and augmented fluoroscopy. It provides intraprocedural imaging to correct computerized tomography (CT) to body divergence and novel confirmation of tool-in-lesion (TIL). The primary aim of this study was to assess the TIL accuracy of the robotic bronchoscope with integrated digital tomosynthesis and augmented fluoroscopy.
    Methods: Four operators conducted the experiment using 4 pigs. Each physician performed between 4 and 6 nodule biopsies for 20 simulated lung nodules with purple dye and a radio pacifier. Using Galaxy's "Tool-in-Lesion Tomography (TOMO+)" with augmented fluoroscopy, the physician navigated to the lung nodules, and a tool (needle) was placed into the lesion. TIL was defined by the needle in the lesion determined by cone-beam CT.
    Results: The lung nodule's average size was 16.3 ± 0.97 mm and was predominantly in the lower lobes (65%). All 4 operators successfully navigated to all (100%) of the lesions in an average of 3 minutes and 39 seconds. The median number of tomosynthesis sweeps was 3 and augmented fluoroscopy was utilized in most cases (17/20 or 85%). TIL after the final TOMO sweep was 95% (19/20) and tool-touch-lesion was 5% (1/20). Biopsy yielding purple pigmentation was also 100% (20/20).
    Conclusion: The Galaxy System demonstrated successful digital TOMO confirmed TIL success in 95% (19/20) of lesions and tool-touch-lesion in 5% (1/20) as confirmed by cone-beam CT. Successful diagnostic yield was achieved in 100% (20/20) of lesions as confirmed by intralesional pigment acquisition.
    MeSH term(s) Humans ; Animals ; Swine ; Lung Neoplasms/pathology ; Bronchoscopy/methods ; Robotic Surgical Procedures ; Lung/pathology ; Electromagnetic Phenomena
    Language English
    Publishing date 2024-01-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2478320-1
    ISSN 1948-8270 ; 1944-6586
    ISSN (online) 1948-8270
    ISSN 1944-6586
    DOI 10.1097/LBR.0000000000000923
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    Zs.A 4027: Show issues Location:
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  6. Article: A critical review of Roxadustat formulations, solid state studies, and analytical methodology.

    Mahajan, Rupali / Samanthula, Gananadhamu / Srivastava, Saurabh / Asthana, Amit

    Heliyon

    2023  Volume 9, Issue 6, Page(s) e16595

    Abstract: This review aims to collate information about the analytical methodologies, bioanalytical methodologies, pharmaceutical formulations, solid-state studies, and the current and future market scenario for a relatively new class of drugs, Roxadustat. ... ...

    Abstract This review aims to collate information about the analytical methodologies, bioanalytical methodologies, pharmaceutical formulations, solid-state studies, and the current and future market scenario for a relatively new class of drugs, Roxadustat. Roxadustat is a hypoxia-inducible factor propyl hydroxylase inhibitor that significantly increases blood hemoglobin via the action of transcriptional activator HIF. As the molecule has a promising role in stimulating erythropoiesis, it is considered an ideal therapeutic agent for patients with anemia. In the current review, an attempt has been made to compile the pharmacological, pharmacokinetic, and pharmacodynamic characteristics of Roxadustat and systematically present product development data. This drug has several polymorphs of cocrystal, co-former, and salt, which have been explained in detail in the current work. The comprehensive review summarizes all the chromatographic methods and is presented in table form. This review has extensively covered Liquid chromatography-tandem mass spectrometry methods used to analyze Roxadustat in the biological matrix. The literature needs more data on forced degradation study, impurity profiling, gas chromatography, analytical methods for assay, dissolution, and different formulation aspects of Roxadustat.
    Language English
    Publishing date 2023-06-01
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e16595
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  7. Article ; Online: Reply to "Considering Health Systems Worldwide: Point of View From a Middle-Income Country".

    Tu, Long H / Melnick, Edward / Venkatesh, Arjun K / Sheth, Kevin N / Navaratnam, Dhasakumar / Yaesoubi, Reza / Forman, Howard P / Mahajan, Amit

    AJR. American journal of roentgenology

    2024  Volume 222, Issue 2, Page(s) e2430900

    Language English
    Publishing date 2024-02-28
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 82076-3
    ISSN 1546-3141 ; 0361-803X ; 0092-5381
    ISSN (online) 1546-3141
    ISSN 0361-803X ; 0092-5381
    DOI 10.2214/AJR.24.30900
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    Ue I Zs.57: Show issues Location:
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  8. Article: Role of PET/CT in Oropharyngeal Cancers.

    Avery, Emily W / Joshi, Kavita / Mehra, Saral / Mahajan, Amit

    Cancers

    2023  Volume 15, Issue 9

    Abstract: Oropharyngeal squamous cell carcinoma (OPSCC) comprises cancers of the tonsils, tongue base, soft palate, and uvula. The staging of oropharyngeal cancers varies depending upon the presence or absence of human papillomavirus (HPV)-directed pathogenesis. ... ...

    Abstract Oropharyngeal squamous cell carcinoma (OPSCC) comprises cancers of the tonsils, tongue base, soft palate, and uvula. The staging of oropharyngeal cancers varies depending upon the presence or absence of human papillomavirus (HPV)-directed pathogenesis. The incidence of HPV-associated oropharyngeal cancer (HPV + OPSCC) is expected to continue to rise over the coming decades. PET/CT is a useful modality for the diagnosis, staging, and follow up of patients with oropharyngeal cancers undergoing treatment and surveillance.
    Language English
    Publishing date 2023-05-08
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15092651
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  9. Article ; Online: An inclusive study of recent advancements in Alzheimer's disease: A comprehensive review.

    Singh, Sukanya / Mahajan, Mitali / Kumar, Dhawal / Singh, Kunika / Chowdhary, Mehvish / Amit

    Neuropeptides

    2023  Volume 102, Page(s) 102369

    Abstract: Alzheimer's disease (AD) has remained elusive in revealing its pathophysiology and mechanism of development. In this review paper, we attempt to highlight several theories that abound about the exact pathway of AD development. The number of cases ... ...

    Abstract Alzheimer's disease (AD) has remained elusive in revealing its pathophysiology and mechanism of development. In this review paper, we attempt to highlight several theories that abound about the exact pathway of AD development. The number of cases worldwide has prompted a constant flow of research to detect high-risk patients, slow the progression of the disease and discover improved methods of treatment that may prove effective. We shall focus on the two main classes of drugs that are currently in use; and emerging ones with novel mechanisms that are under development. As of late there has also been increased attention towards factors that were previously thought to be unrelated to AD, such as the gut microbiome, lifestyle habits, and diet. Studies have now shown that all these factors make an impact on AD progression, thus bringing to our attention more areas that could hold the key to combating this disease. This paper covers all the aforementioned factors concisely. We also briefly explore the relationship between mental health and AD, both before and after the diagnosis of the disease.
    MeSH term(s) Humans ; Alzheimer Disease/metabolism ; Life Style
    Language English
    Publishing date 2023-08-12
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 9048-7
    ISSN 1532-2785 ; 0143-4179
    ISSN (online) 1532-2785
    ISSN 0143-4179
    DOI 10.1016/j.npep.2023.102369
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  10. Article ; Online: A sobering addition to the literature on COVID-19 and the brain.

    Mahajan, Amit / Mason, Graeme F

    The Journal of clinical investigation

    2021  Volume 131, Issue 8

    Abstract: Several coronavirus disease 2019 (COVID-19) studies have focused on neuropathology. In this issue of the JCI, Qin, Wu, and Chen et al. focused specifically on people whose acute infection lacked obvious neurological involvement. Severely infected ... ...

    Abstract Several coronavirus disease 2019 (COVID-19) studies have focused on neuropathology. In this issue of the JCI, Qin, Wu, and Chen et al. focused specifically on people whose acute infection lacked obvious neurological involvement. Severely infected patients showed abnormal gray matter volumes, white matter diffusion, and cerebral blood flow compared with healthy controls and those with mild infection. The data remain associative rather than mechanistic, but correlations with systemic immune markers suggest effects of inflammation, hypercoagulation, or other aspects of disease severity. Mechanistic research is warranted. Given the lack of obvious neurological symptoms, neurocognitive assessments were not performed, but the findings suggest that such assessments may be warranted in severely affected patients, even without obvious symptoms. Further, studying CNS involvement of other disorders with overlapping pathophysiologies such as inflammation, coagulation, hypoxia, or direct viral infection may reveal the causes for COVID-19-related neuropathology.
    MeSH term(s) Brain/diagnostic imaging ; COVID-19 ; Cerebrovascular Circulation ; Humans ; Nervous System Diseases ; SARS-CoV-2
    Language English
    Publishing date 2021-04-15
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 3067-3
    ISSN 1558-8238 ; 0021-9738
    ISSN (online) 1558-8238
    ISSN 0021-9738
    DOI 10.1172/JCI148376
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