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Article: A Recombinant Raccoon Poxvirus Vaccine Expressing both Yersinia pestis F1 and Truncated V Antigens Protects Animals against Lethal Plague.

Rocke, Tonie E / Kingstad-Bakke, Brock / Berlier, Willy / Osorio, Jorge E

2014 Volume 2, Issue 4, Page(s) 772–784

Abstract: ... version of the V protein) provided superior protection against plague challenge compared to individual ...

Abstract	In previous studies, we demonstrated in mice and prairie dogs that simultaneous administration of two recombinant raccoon poxviruses (rRCN) expressing Yersinia pestis antigens (F1 and V307-a truncated version of the V protein) provided superior protection against plague challenge compared to individual single antigen constructs. To reduce costs of vaccine production and facilitate implementation of a sylvatic plague vaccine (SPV) control program for prairie dogs, a dual antigen construct is more desirable. Here we report the construction and characterization of a novel RCN-vectored vaccine that simultaneously expresses both F1 and V307 antigens. This dual antigen vaccine provided similar levels of protection against plague in both mice and prairie dogs as compared to simultaneous administration of the two single antigen constructs and was also shown to protect mice against an F1 negative strain of Y. pestis. The equivalent safety, immunogenicity and efficacy profile of the dual RCN-F1/V307 construct warrants further evaluation in field efficacy studies in sylvatic plague endemic areas.
Language	English
Publishing date	2014-10-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2703319-3
ISSN	2076-393X
ISSN	2076-393X
DOI	10.3390/vaccines2040772
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Article ; Online: A Recombinant Raccoon Poxvirus Vaccine Expressing both Yersinia pestis F1 and Truncated V Antigens Protects Animals against Lethal Plague

Tonie E. Rocke / Brock Kingstad-Bakke / Willy Berlier / Jorge E. Osorio

Vaccines, Vol 2, Iss 4, Pp 772-

2014 Volume 784

Abstract: ... version of the V protein) provided superior protection against plague challenge compared to individual ...

Abstract	In previous studies, we demonstrated in mice and prairie dogs that simultaneous administration of two recombinant raccoon poxviruses (rRCN) expressing Yersinia pestis antigens (F1 and V307—a truncated version of the V protein) provided superior protection against plague challenge compared to individual single antigen constructs. To reduce costs of vaccine production and facilitate implementation of a sylvatic plague vaccine (SPV) control program for prairie dogs, a dual antigen construct is more desirable. Here we report the construction and characterization of a novel RCN-vectored vaccine that simultaneously expresses both F1 and V307 antigens. This dual antigen vaccine provided similar levels of protection against plague in both mice and prairie dogs as compared to simultaneous administration of the two single antigen constructs and was also shown to protect mice against an F1 negative strain of Y. pestis. The equivalent safety, immunogenicity and efficacy profile of the dual RCN-F1/V307 construct warrants further evaluation in field efficacy studies in sylvatic plague endemic areas.
Keywords	raccoon poxvirus ; Yersinia pestis ; plague ; vaccine ; prairie dogs ; Medicine ; R
Subject code	630
Language	English
Publishing date	2014-10-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Saddlepoint approximations to score test statistics in logistic regression for analyzing genome-wide association studies.

Johnsen, Pål V / Bakke, Øyvind / Bjørnland, Thea / DeWan, Andrew Thomas / Langaas, Mette

Statistics in medicine

2023 Volume 42, Issue 16, Page(s) 2746–2759

Abstract: We investigate saddlepoint approximations of tail probabilities of the score test statistic in logistic regression for genome-wide association studies. The inaccuracy in the normal approximation of the score test statistic increases with increasing ... ...

Abstract	We investigate saddlepoint approximations of tail probabilities of the score test statistic in logistic regression for genome-wide association studies. The inaccuracy in the normal approximation of the score test statistic increases with increasing imbalance in the response and with decreasing minor allele counts. Applying saddlepoint approximation methods greatly improve the accuracy, even far out in the tails of the distribution. By using exact results for a simple logistic regression model, as well as simulations for models with nuisance parameters, we compare double saddlepoint methods for computing two-sided
MeSH term(s)	Logistic Models ; Genome-Wide Association Study/methods ; Phenotype ; Probability ; Polymorphism, Single Nucleotide
Language	English
Publishing date	2023-04-24
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	843037-8
ISSN	1097-0258 ; 0277-6715
ISSN (online)	1097-0258
ISSN	0277-6715
DOI	10.1002/sim.9746
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Article: Correlation of Chronotype (Lark versus Night Owl Status) with Mind-Set and Effect of Chronotype on Examination Performance in Veterinary School.

Root Kustritz, Margaret V / Bakke, Hannah J / Rendahl, Aaron

Journal of veterinary medical education

2021 Volume 49, Issue 4, Page(s) 500–502

Abstract: Chronotype describes what time of day people are most productive, with the specific terminology ... ...

Abstract	Chronotype describes what time of day people are most productive, with the specific terminology of
MeSH term(s)	Animals ; Circadian Rhythm ; Education, Veterinary ; Humans ; Passeriformes ; Schools, Veterinary ; Surveys and Questionnaires
Language	English
Publishing date	2021-06-11
Publishing country	Canada
Document type	Journal Article
ISSN	0748-321X
ISSN	0748-321X
DOI	10.3138/jvme-2021-0033
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Article ; Online: Clinical and digital assessment of tooth wear.

Al-Seelawi, Zahra / Hermann, Nuno V / Peutzfeldt, Anne / Baram, Sara / Bakke, Merete / Sonnesen, Liselotte / Tsakanikou, Angeliki / Rahiotis, Christos / Benetti, Ana R

Scientific reports

2024 Volume 14, Issue 1, Page(s) 592

Abstract: The aim of this study was to compare the assessment of tooth wear performed on digital models with the one conducted at the clinical examination. Seventy-eight volunteers (29 males and 49 females, age range 20-30 years) with at least 24 teeth, normal ... ...

Abstract	The aim of this study was to compare the assessment of tooth wear performed on digital models with the one conducted at the clinical examination. Seventy-eight volunteers (29 males and 49 females, age range 20-30 years) with at least 24 teeth, normal oral function, and a neutral transverse relationship were examined. During the clinical examination, dental wear was registered according to the Basic Erosive Wear Examination (BEWE) index. Subsequently, the BEWE index was blindly applied by two examiners on digital models obtained from the volunteers. Data were analyzed using weighted Cohen's kappa coefficient and correlation tests with a confidence interval of 95%. All volunteers showed signs of tooth wear. Anterior teeth showed increased severity of tooth wear than first molars. Early loss of tooth substance could be identified on the digital models, including in areas with challenging direct intraoral visual access. Approximately 50% of the scores based on clinical examination agreed with those based on examination of digital models (k = 0.543, p < 0.01). A moderate, positive correlation was observed between scores registered clinically and on digital models (Spearman's rho = 0.560, p < 0.001). Considering the rather low agreement between the clinical and digital scores, alternatives to using BEWE on digital models are needed.
MeSH term(s)	Female ; Male ; Humans ; Young Adult ; Adult ; Molar ; Physical Examination ; Volunteers ; Tooth Wear/diagnosis
Language	English
Publishing date	2024-01-05
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-50107-2
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Article: T cell receptor V beta gene expression in monozygotic twins. Discordance in CD8 subset and in disease states.

Davey, M P / Meyer, M M / Bakke, A C

Journal of immunology (Baltimore, Md. : 1950)

1994 Volume 152, Issue 1, Page(s) 315–321

Abstract: ... in monozygotic twins. To investigate this question the percentage of CD4 and CD8 T cells expressing TCR V beta gene ... products was determined for seven sets of healthy monozygotic twins ages 2 through 44. V beta expression ... was determined by three-color flow cytometric analysis using antibodies to V beta-5.1, -5.2, -5.3, -6 ...

Abstract	The peripheral T cell repertoire is shaped by positive and negative selection. These intrathymic events are dependent on the direct interaction of MHC and TCR molecules. Inasmuch as one possible mechanism for HLA-linked disease involves the role that these molecules play in shaping the peripheral T cell repertoire, an understanding of how stable the repertoire remains is an important question that will influence future studies. The purpose of this study was to analyze the stability of the T cell repertoire in monozygotic twins. To investigate this question the percentage of CD4 and CD8 T cells expressing TCR V beta gene products was determined for seven sets of healthy monozygotic twins ages 2 through 44. V beta expression was determined by three-color flow cytometric analysis using antibodies to V beta-5.1, -5.2, -5.3, -6.7, -8, and -12. The percentage of CD4 cells expressing each V beta gene was highly concordant between twins. In contrast, differences were noted for V beta expression within the CD8 subset. This was especially marked when sets of twins were studied (n = 3) where one individual had an underlying disease. Although expression in the CD4 subset was again concordant, significant differences were noted within the CD8 subset compared to the healthy twin. These data indicate that in both health and disease, the CD4 T cell repertoire is tightly regulated although often sizable differences have developed in the CD8 compartment.
MeSH term(s)	Adolescent ; Adult ; CD4-Positive T-Lymphocytes/immunology ; CD8 Antigens/blood ; Child ; Child, Preschool ; Diseases in Twins/genetics ; Gene Expression ; Humans ; Receptors, Antigen, T-Cell, alpha-beta/biosynthesis ; Receptors, Antigen, T-Cell, alpha-beta/genetics ; T-Lymphocyte Subsets/immunology ; Twins, Monozygotic/genetics
Chemical Substances	CD8 Antigens ; Receptors, Antigen, T-Cell, alpha-beta
Language	English
Publishing date	1994-01-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	3056-9
ISSN	1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
ISSN (online)	1550-6606
ISSN	0022-1767 ; 1048-3233 ; 1047-7381
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Article: The metabolism of biphenyl. V. Phenolic metabolites in some marine organisms.

Meyer, T / Bakke, T

Acta pharmacologica et toxicologica

1977 Volume 40, Issue 2, Page(s) 201–208

Abstract: The phenolic metabolites of biphenyl in the crustacean Cirolana borealis LILJEBORG (ISOPODA), the gastropod Buccinum undatum L and the ophiuroid Ophiocomina nigra ABILDGAARD have been analysed qualitatively and semi-quantitatively as trimethylsilyl (TMS) ...

Abstract	The phenolic metabolites of biphenyl in the crustacean Cirolana borealis LILJEBORG (ISOPODA), the gastropod Buccinum undatum L and the ophiuroid Ophiocomina nigra ABILDGAARD have been analysed qualitatively and semi-quantitatively as trimethylsilyl (TMS) ethers by combined gas chromatography/mass spectrometry and gas chromatography, respectively. The findings demonstrate the in vivo metabolic capacity of these organisms to convert biphenyl into its hydroxylated derivatives. Thus, 2-hydroxybiphenyl is the most prominent metabolite detected in all these experiments, which also showed that minor amounts of the 4-hydroxy and 4,4'-dihydroxy metabolites are formed. Metabolites of biphenyl origin are found both in the sea water from the aquaria and in the tissue of the respective marine organisms. The experiments, moreover, indicate a slow metabolism of biphenyl in C. borealis, B. undatum and O. nigra, between which no qualitative metabolic differences are found.
MeSH term(s)	Animals ; Biphenyl Compounds/metabolism ; Crustacea/metabolism ; Echinodermata/metabolism ; Mollusca/metabolism ; Phenols/metabolism ; Trimethylsilyl Compounds/metabolism
Chemical Substances	Biphenyl Compounds ; Phenols ; Trimethylsilyl Compounds
Language	English
Publishing date	1977-02
Publishing country	Denmark
Document type	Journal Article
ZDB-ID	80047-8
ISSN	0001-6683 ; 0065-1508
ISSN	0001-6683 ; 0065-1508
DOI	10.1111/j.1600-0773.1977.tb02069.x
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Article: A TCR V alpha CDR3-specific motif associated with Lewis rat autoimmune encephalomyelitis and basic protein-specific T cell clones.

Buenafe, A C / Tsu, R C / Bebo, B / Bakke, A C / Vandenbark, A A / Offner, H

Journal of immunology (Baltimore, Md. : 1950)

1997 Volume 158, Issue 11, Page(s) 5472–5483

Abstract: To investigate TCR V alpha gene expression in the Lewis rat model of experimental autoimmune ... encephalomyelitis, we obtained V alpha chain sequences from two V beta8.2+-encephalitogenic, BP72-89-specific T ... cell clones. Two different V alpha genes, a V alpha2 gene and a V alpha23 gene, are utilized, but both were ...

Abstract	To investigate TCR V alpha gene expression in the Lewis rat model of experimental autoimmune encephalomyelitis, we obtained V alpha chain sequences from two V beta8.2+-encephalitogenic, BP72-89-specific T cell clones. Two different V alpha genes, a V alpha2 gene and a V alpha23 gene, are utilized, but both were found to contain an asparagine repeat (Asn3+) sequence present in the V alpha CDR3 region. This Asn3+ motif is also present in the previously reported sequence of a BP68-88-specific hybridoma, 510, which utilizes a different V alpha2 gene family member. In further experiments, spinal cord T cells were isolated at the onset of basic protein (BP)-induced disease and sorted for the OX-40 activation marker, which we have previously used to enrich for specifically activated T cells. Analysis of V alpha expression in the OX-40+ population revealed the biased use of three V alpha genes, V alpha1, V alpha2, and V alpha23. The Asn3+ motif was present in the V alpha CDR3 region of V alpha1, V alpha2, and V alpha23 cDNA derived from OX-40+ spinal cord T cells but found to be generally absent in the OX-40- spinal cord population. Since these Asn3+ motif-bearing V alpha chain sequences are nearly identical to those utilized by the BP-specific encephalitogenic clones described, it is likely that these V alpha sequences are derived from disease-associated T cells in the spinal cord. Thus, we demonstrate that the Asn3+ V alpha CDR3 motif is strongly associated with experimental autoimmune encephalomyelitis in the Lewis rat and propose that it plays a role in TCR recognition of a specific BP peptide/MHC complex.
MeSH term(s)	Amino Acid Sequence ; Animals ; Autoantigens ; Base Sequence ; CD4 Antigens/genetics ; CD4 Antigens/immunology ; Clone Cells ; Encephalomyelitis, Autoimmune, Experimental/immunology ; Female ; Immunoglobulin Variable Region/genetics ; Immunoglobulin Variable Region/immunology ; Molecular Sequence Data ; Myelin Basic Protein/immunology ; Rats ; Rats, Inbred Lew ; Receptors, Antigen, T-Cell, alpha-beta/genetics ; Receptors, Antigen, T-Cell, alpha-beta/immunology ; Sequence Analysis ; T-Lymphocytes/immunology
Chemical Substances	Autoantigens ; CD4 Antigens ; Immunoglobulin Variable Region ; Myelin Basic Protein ; Receptors, Antigen, T-Cell, alpha-beta
Language	English
Publishing date	1997-06-01
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	3056-9
ISSN	1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
ISSN (online)	1550-6606
ISSN	0022-1767 ; 1048-3233 ; 1047-7381
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Article ; Online: Intramuscular uptake of tranexamic acid during haemorrhagic shock in a swine model.

Bakke, Håkon Kvåle / Fuskevåg, Ole Martin / Nielsen, Erik Waage / Dietrichs, Erik Sveberg

Scandinavian journal of trauma, resuscitation and emergency medicine

2021 Volume 29, Issue 1, Page(s) 171

Abstract: ... fibrinolysis. Normally administered intravenously (i.v.), TXA can also be administered intramuscularly (i.m ... the impact of shock on the pharmacokinetics of i.m. TXA, and (2) Compare the pharmacokinetics of i.v. versus ... either i.v. or i.m. A control group without injury, or surgery, received intramuscular TXA. Blood samples ...

Abstract	Background: Tranexamic acid (TXA) reduce mortality in bleeding trauma patients, with greater effect if administered early. Serum concentrations above 10 µg/mL are considered sufficient to inhibit fibrinolysis. Normally administered intravenously (i.v.), TXA can also be administered intramuscularly (i.m.). This could be advantageous in low resource and military settings, if sufficient serum concentrations can be reached in shocked patients with reduced muscular blood perfusion. Accordingly, we aimed to: (1) Determine the impact of shock on the pharmacokinetics of i.m. TXA, and (2) Compare the pharmacokinetics of i.v. versus i.m. TXA in ongoing shock. Materials and methods: In a prospective experimental study, N = 18 Norwegian landrace pigs (40-50 kg), utilised in a surgical course in haemostatic emergency surgery, were subjected to various abdominal and thoracic trauma. After 1 h of surgery the animals were given 15 mg/kg TXA either i.v. or i.m. A control group without injury, or surgery, received intramuscular TXA. Blood samples were drawn at 0, 5, 15, 25, 35, 45, 60 and 85 min. The samples were centrifuged and analysed with liquid chromatography-tandem mass spectrometry (LC-MS/MS) for TXA serum-concentrations. Results: In shocked pigs, i.m. administration resulted in a mean maximum serum concentration (C Conclusions: I.m. administration of TXA in shocked pigs provides serum concentrations associated with inhibition of fibrinolysis. It may be an alternative to i.v. and intraosseous administration during stabilisation and transport of trauma patients to advanced medical care.
MeSH term(s)	Animals ; Chromatography, Liquid ; Humans ; Prospective Studies ; Shock, Hemorrhagic/drug therapy ; Swine ; Tandem Mass Spectrometry ; Tranexamic Acid
Chemical Substances	Tranexamic Acid (6T84R30KC1)
Language	English
Publishing date	2021-12-18
Publishing country	England
Document type	Journal Article
ZDB-ID	2455990-8
ISSN	1757-7241 ; 1757-7241
ISSN (online)	1757-7241
ISSN	1757-7241
DOI	10.1186/s13049-021-00983-2
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Article: Development of a Novel Hygiene Monitoring System Based on the Detection of Total Adenylate (ATP+ADP+AMP)

Bakke, Mikio / Shigeya Suzuki

Journal of food protection. 2018 May, v. 81, no. 5

2018

Abstract: ATP is the universal energy molecule found in animals, plants, and microorganisms. ATP rapid hygiene monitoring tests have been employed in the food industry to ensure that adequate cleanliness is being maintained. However, because ATP is hydrolyzed to ... ...

Abstract	ATP is the universal energy molecule found in animals, plants, and microorganisms. ATP rapid hygiene monitoring tests have been employed in the food industry to ensure that adequate cleanliness is being maintained. However, because ATP is hydrolyzed to ADP and AMP by metabolic processes, by heat treatment, or under acidic or alkaline conditions, total adenylate (ATP+ADP+AMP [A3]) could be a more reliable sanitation indicator of food residues that may cause biofilm formation and allergen contamination. Therefore, a novel hygiene monitoring system to measure A3 was developed based on the luciferin-luciferase assay with the combination of two enzymes, pyruvate kinase and pyruvate phosphate dikinase, that can convert ADP into ATP and recycle AMP into ATP, respectively. The newly developed A3 assay system afforded stable bioluminescence signals and equivalent linear calibration curves between relative light units (RLU) and the amounts of ATP, ADP, and AMP, respectively. To verify the significance of the A3 method, the ratios of ATP, ADP, and AMP in various food samples were determined; large amounts of ADP and AMP were found in a variety of foods, such as meat, seafood, dairy, nuts, fruits, vegetables, and fermented foods. Sanitation monitoring of stainless steel exposed to raw meat was also examined, and the A3 method achieved a 200-RLU level, the typical benchmark value, after complete washing with detergent and rinsing. In contrast, a conventional ATP method showed less than 200 RLU after only a light cold and hot water rinse. In conclusion, the A3 assay appeared to be suitable for detection of adenylates from food residues that are not detected by the conventional ATP assay.
Keywords	adenosine diphosphate ; adenosine monophosphate ; adenosine triphosphate ; allergens ; animals ; biofilm ; bioluminescence ; detergents ; energy ; fermented foods ; food industry ; fruits ; heat treatment ; hygiene ; meat ; microorganisms ; monitoring ; nuts ; plants (botany) ; pyruvate kinase ; pyruvate phosphate dikinase ; raw meat ; sanitation ; seafoods ; stainless steel ; vegetables ; washing
Language	English
Dates of publication	2018-05
Size	p. 729-737.
Publishing place	International Association of Milk, Food, and Environmental Sanitarians.
Document type	Article
ZDB-ID	243284-5
ISSN	1944-9097 ; 0362-028X
ISSN (online)	1944-9097
ISSN	0362-028X
DOI	10.4315/0362-028X.JFP-17-432
Database	NAL-Catalogue (AGRICOLA)

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