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Article ; Online: Conducting polymer scaffolds: a new frontier in bioelectronics and bioengineering.

Nasser, Rasha A / Arya, Sagar S / Alshehhi, Khulood H / Teo, Jeremy C M / Pitsalidis, Charalampos

2024

Abstract: Conducting polymer (CP) scaffolds have emerged as a transformative tool in bioelectronics and bioengineering, advancing the ability to interface with biological systems. Their unique combination of electrical conductivity, tailorability, and ... ...

Abstract	Conducting polymer (CP) scaffolds have emerged as a transformative tool in bioelectronics and bioengineering, advancing the ability to interface with biological systems. Their unique combination of electrical conductivity, tailorability, and biocompatibility surpasses the capabilities of traditional nonconducting scaffolds while granting them access to the realm of bioelectronics. This review examines recent developments in CP scaffolds, focusing on material and device advancements, as well as their interplay with biological systems. We highlight applications for monitoring, tissue stimulation, and drug delivery and discuss perspectives and challenges currently faced for their ultimate translation and clinical implementation.
Language	English
Publishing date	2024-01-05
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	47474-5
ISSN	1879-3096 ; 0167-7799
ISSN (online)	1879-3096
ISSN	0167-7799
DOI	10.1016/j.tibtech.2023.11.017
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Article: Reduced Genotoxicity of Gold Nanoparticles With Protein Corona in

Arya, Sagar S / Rookes, James E / Cahill, David M / Lenka, Sangram K

Frontiers in bioengineering and biotechnology

2022 Volume 10, Page(s) 849464

Abstract: Increased usage of gold nanoparticles (AuNPs) in biomedicine, biosensing, diagnostics and cosmetics has undoubtedly facilitated accidental and unintentional release of AuNPs into specific microenvironments. This is raising serious questions concerning ... ...

Abstract	Increased usage of gold nanoparticles (AuNPs) in biomedicine, biosensing, diagnostics and cosmetics has undoubtedly facilitated accidental and unintentional release of AuNPs into specific microenvironments. This is raising serious questions concerning adverse effects of AuNPs on off-target cells, tissues and/or organisms. Applications utilizing AuNPs will typically expose the nanoparticles to biological fluids such as cell serum and/or culture media, resulting in the formation of protein corona (PC) on the AuNPs. Evidence for PC altering the toxicological signatures of AuNPs is well studied in animal systems. In this report, we observed significant genotoxicity in
Language	English
Publishing date	2022-04-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2719493-0
ISSN	2296-4185
ISSN	2296-4185
DOI	10.3389/fbioe.2022.849464
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Electronic plants: the future of agriculture and urban ecosystems?

Arya, Sagar / Pappa, Anna-Maria

Trends in biotechnology

2023 Volume 41, Issue 3, Page(s) 289–291

Abstract: Electroactive and functional materials can be integrated with plants to monitor and control their development or to harvest and store energy. Seminal work by Stavrinidou et al. demonstrated electrically conducting polymers that grow inside living plants ... ...

Abstract	Electroactive and functional materials can be integrated with plants to monitor and control their development or to harvest and store energy. Seminal work by Stavrinidou et al. demonstrated electrically conducting polymers that grow inside living plants and form circuitry, unleashing exciting applications in smart agriculture and modern urban ecosystems.
MeSH term(s)	Ecosystem ; Agriculture ; Polymers ; Electricity ; Electronics ; Plants
Chemical Substances	Polymers
Language	English
Publishing date	2023-01-30
Publishing country	England
Document type	Journal Article
ZDB-ID	47474-5
ISSN	1879-3096 ; 0167-7799
ISSN (online)	1879-3096
ISSN	0167-7799
DOI	10.1016/j.tibtech.2023.01.009
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Article ; Online: The convergence of traditional and digital biomarkers through AI-assisted biosensing: A new era in translational diagnostics?

Arya, Sagar S / Dias, Sofia B / Jelinek, Herbert F / Hadjileontiadis, Leontios J / Pappa, Anna-Maria

Biosensors & bioelectronics

2023 Volume 235, Page(s) 115387

Abstract: Advances in consumer electronics, alongside the fields of microfluidics and nanotechnology have brought to the fore low-cost wearable/portable smart devices. Although numerous smart devices that track digital biomarkers have been successfully translated ... ...

Abstract	Advances in consumer electronics, alongside the fields of microfluidics and nanotechnology have brought to the fore low-cost wearable/portable smart devices. Although numerous smart devices that track digital biomarkers have been successfully translated from bench-to-bedside, only a few follow the same fate when it comes to track traditional biomarkers. Current practices still involve laboratory-based tests, followed by blood collection, conducted in a clinical setting as they require trained personnel and specialized equipment. In fact, real-time, passive/active and robust sensing of physiological and behavioural data from patients that can feed artificial intelligence (AI)-based models can significantly improve decision-making, diagnosis and treatment at the point-of-procedure, by circumventing conventional methods of sampling, and in person investigation by expert pathologists, who are scarce in developing countries. This review brings together conventional and digital biomarker sensing through portable and autonomous miniaturized devices. We first summarise the technological advances in each field vs the current clinical practices and we conclude by merging the two worlds of traditional and digital biomarkers through AI/ML technologies to improve patient diagnosis and treatment. The fundamental role, limitations and prospects of AI in realizing this potential and enhancing the existing technologies to facilitate the development and clinical translation of "point-of-care" (POC) diagnostics is finally showcased.
MeSH term(s)	Humans ; Biosensing Techniques/methods ; Artificial Intelligence ; Wearable Electronic Devices ; Point-of-Care Testing ; Biomarkers
Chemical Substances	Biomarkers
Language	English
Publishing date	2023-05-11
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1011023-9
ISSN	1873-4235 ; 0956-5663
ISSN (online)	1873-4235
ISSN	0956-5663
DOI	10.1016/j.bios.2023.115387
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Article: Preclinical models of atherosclerosis: An overview.

Arya, Priyanka / Sharma, Vikram / Thapliyal, Surabhi / Sagar, Rahul / Singh, Priyanka

Iranian journal of basic medical sciences

2024 Volume 27, Issue 5, Page(s) 535–542

Abstract: Atherosclerosis is a primary cause of illness and death globally and its mechanism is still unclear. Different animal models have been created to evaluate the progression of atherosclerosis, allowing researchers to carefully control the circumstances of ... ...

Abstract	Atherosclerosis is a primary cause of illness and death globally and its mechanism is still unclear. Different animal models have been created to evaluate the progression of atherosclerosis, allowing researchers to carefully control the circumstances of the experiment as well as the nutrition and environmental risk factors. To investigate the negative effects of various interventions, pathophysiological alterations might be generated utilizing genetic or pharmacological methods. These models' molecular and pathophysiological mechanisms have been clarified through experiments, and they have served as platforms for the creation of new drugs. Different models can be employed to address various research problems, each with its own benefits and drawbacks. In the current review study, various species of atherosclerosis models are discussed, along with the viability of using them in experiments.
Language	English
Publishing date	2024-03-27
Publishing country	Iran
Document type	Journal Article ; Review
ZDB-ID	2500485-2
ISSN	2008-3874 ; 2008-3866
ISSN (online)	2008-3874
ISSN	2008-3866
DOI	10.22038/IJBMS.2024.74352.16148
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Article ; Online: Chitosan nanoparticles and their combination with methyl jasmonate for the elicitation of phenolics and flavonoids in plant cell suspension cultures.

Arya, Sagar S / Rookes, James E / Cahill, David M / Lenka, Sangram K

International journal of biological macromolecules

2022 Volume 214, Page(s) 632–641

Abstract: ... metabolite(s) yield in in vitro plant cell culture platforms. Application of biotic/abiotic elicitors ...

Abstract	Productivity enhancement approaches, such as elicitation can overcome the limitations of low metabolite(s) yield in in vitro plant cell culture platforms. Application of biotic/abiotic elicitors triggers molecular responses that lead to a concomitant enhancement in the production of metabolites. Nanoparticles have been tested as alternatives to commonly studied biotic/abiotic elicitors. However, most nanoparticles explored are of metallic origin, which raises concerns about their cytotoxicity, disposal post-elicitation, and may limit downstream applications of metabolites. Here, we report the synthesis and application of biopolymeric methyl jasmonate-loaded chitosan nanoparticles (MJ-CNPs) and empty CNPs (size <100 nm) as nano-elicitors, which were simple to synthesize, cost-effective and safe. Enzymatic and metabolic investigations revealed that MJ-CNPs and empty CNPs improve and prolong phenylalanine ammonia-lyase enzyme activity and production of phenolics and flavonoids. The data provides the first evidence of MJ-CNPs and empty CNPs as nano-elicitors that prolong the production of metabolites in plant cell suspension cultures.
MeSH term(s)	Acetates ; Chitosan/metabolism ; Cyclopentanes ; Flavonoids/metabolism ; Nanoparticles ; Oxylipins ; Phenols/metabolism ; Plant Cells
Chemical Substances	Acetates ; Cyclopentanes ; Flavonoids ; Oxylipins ; Phenols ; methyl jasmonate (900N171A0F) ; Chitosan (9012-76-4)
Language	English
Publishing date	2022-06-25
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2022.06.145
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Article ; Online: The convergence of traditional and digital biomarkers through AI-assisted biosensing: A new era in translational diagnostics?

Arya, Sagar S. / Dias, Sofia B. / Jelinek, Herbert F. / Hadjileontiadis, Leontios J. / Pappa, Anna-Maria

Biosensors and Bioelectronics. 2023 Sept., v. 235 p.115387-

2023

Abstract	Advances in consumer electronics, alongside the fields of microfluidics and nanotechnology have brought to the fore low-cost wearable/portable smart devices. Although numerous smart devices that track digital biomarkers have been successfully translated from bench-to-bedside, only a few follow the same fate when it comes to track traditional biomarkers. Current practices still involve laboratory-based tests, followed by blood collection, conducted in a clinical setting as they require trained personnel and specialized equipment. In fact, real-time, passive/active and robust sensing of physiological and behavioural data from patients that can feed artificial intelligence (AI)-based models can significantly improve decision-making, diagnosis and treatment at the point-of-procedure, by circumventing conventional methods of sampling, and in person investigation by expert pathologists, who are scarce in developing countries. This review brings together conventional and digital biomarker sensing through portable and autonomous miniaturized devices. We first summarise the technological advances in each field vs the current clinical practices and we conclude by merging the two worlds of traditional and digital biomarkers through AI/ML technologies to improve patient diagnosis and treatment. The fundamental role, limitations and prospects of AI in realizing this potential and enhancing the existing technologies to facilitate the development and clinical translation of "point-of-care" (POC) diagnostics is finally showcased.
Keywords	artificial intelligence ; biomarkers ; biosensors ; blood sampling ; decision making ; diagnostic techniques ; electronics ; human resources ; microfluidic technology ; nanotechnology ; patients ; Bioelectronics ; Traditional biomarkers ; Digital biomarkers ; Clinical trials
Language	English
Dates of publication	2023-09
Publishing place	Elsevier B.V.
Document type	Article ; Online
Note	Use and reproduction
ZDB-ID	1011023-9
ISSN	1873-4235 ; 0956-5663
ISSN (online)	1873-4235
ISSN	0956-5663
DOI	10.1016/j.bios.2023.115387
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Designer nanoparticles for plant cell culture systems: Mechanisms of elicitation and harnessing of specialized metabolites.

Arya, Sagar S / Lenka, Sangram K / Cahill, David M / Rookes, James E

BioEssays : news and reviews in molecular, cellular and developmental biology

2021 Volume 43, Issue 11, Page(s) e2100081

Abstract: Plant cell culture systems have become an attractive and sustainable approach to produce high-value and commercially significant metabolites under controlled conditions. Strategies involving elicitor supplementation into plant cell culture media are ... ...

Abstract	Plant cell culture systems have become an attractive and sustainable approach to produce high-value and commercially significant metabolites under controlled conditions. Strategies involving elicitor supplementation into plant cell culture media are employed to mimic natural conditions for increasing the metabolite yield. Studies on nanoparticles (NPs) that have investigated elicitation of specialized metabolism have shown the potential of NPs to be a substitute for biotic elicitors such as phytohormones and microbial extracts. Customizable physicochemical characteristics allow the design of monodispersed-, stimulus-responsive-, and hormone-carrying-NPs of precise geometries to enhance their elicitation capabilities based on target metabolite/plant cell culture type. We contextualize advances in NP-mediated elicitation, especially stimulation of specialized metabolic pathways, the underlying mechanisms, impacts on gene regulation, and NP-associated cytotoxicity. The novelty of the concept lies in unleashing the potential of designer NPs to enhance yield, harness metabolites, and transform nanoelicitation from exploratory investigations to a commercially viable strategy.
MeSH term(s)	Cell Culture Techniques ; Nanoparticles ; Plant Cells ; Plant Roots ; Plants
Language	English
Publishing date	2021-10-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	50140-2
ISSN	1521-1878 ; 0265-9247
ISSN (online)	1521-1878
ISSN	0265-9247
DOI	10.1002/bies.202100081
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Article: Chitosan nanoparticles and their combination with methyl jasmonate for the elicitation of phenolics and flavonoids in plant cell suspension cultures

Arya, Sagar S. / Rookes, James E. / Cahill, David M. / Lenka, Sangram K.

International journal of biological macromolecules. 2022 June 21,

2022

Abstract: ... metabolite(s) yield in in vitro plant cell culture platforms. Application of biotic/abiotic elicitors ...

Abstract	Productivity enhancement approaches, such as elicitation can overcome the limitations of low metabolite(s) yield in in vitro plant cell culture platforms. Application of biotic/abiotic elicitors triggers molecular responses that lead to a concomitant enhancement in the production of metabolites. Nanoparticles have been tested as alternatives to commonly studied biotic/abiotic elicitors. However, most nanoparticles explored are of metallic origin, which raises concerns about their cytotoxicity, disposal post-elicitation, and may limit downstream applications of metabolites. Here, we report the synthesis and application of biopolymeric methyl jasmonate-loaded chitosan nanoparticles (MJ-CNPs) and empty CNPs (size <100 nm) as nano-elicitors, which were simple to synthesize, cost-effective and safe. Enzymatic and metabolic investigations revealed that MJ-CNPs and empty CNPs improve and prolong phenylalanine ammonia-lyase enzyme activity and production of phenolics and flavonoids. The data provides the first evidence of MJ-CNPs and empty CNPs as nano-elicitors that prolong the production of metabolites in plant cell suspension cultures.
Keywords	chitosan ; cost effectiveness ; cytotoxicity ; enzyme activity ; flavonoids ; metabolites ; methyl jasmonate ; phenolic compounds ; phenylalanine ammonia-lyase
Language	English
Dates of publication	2022-0621
Publishing place	Elsevier B.V.
Document type	Article
Note	Pre-press version
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2022.06.145
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Bacterial Membrane Mimetics: From Biosensing to Disease Prevention and Treatment.

Arya, Sagar S / Morsy, Nada K / Islayem, Deema K / Alkhatib, Sarah A / Pitsalidis, Charalampos / Pappa, Anna-Maria

Biosensors

2023 Volume 13, Issue 2

Abstract: Plasma membrane mimetics can potentially play a vital role in drug discovery and immunotherapy owing to the versatility to assemble facilely cellular membranes on surfaces and/or nanoparticles, allowing for direct assessment of drug/membrane interactions. ...

Abstract	Plasma membrane mimetics can potentially play a vital role in drug discovery and immunotherapy owing to the versatility to assemble facilely cellular membranes on surfaces and/or nanoparticles, allowing for direct assessment of drug/membrane interactions. Recently, bacterial membranes (BMs) have found widespread applications in biomedical research as antibiotic resistance is on the rise, and bacteria-associated infections have become one of the major causes of death worldwide. Over the last decade, BM research has greatly benefited from parallel advancements in nanotechnology and bioelectronics, resulting in multifaceted systems for a variety of sensing and drug discovery applications. As such, BMs coated on electroactive surfaces are a particularly promising label-free platform to investigate interfacial phenomena, as well as interactions with drugs at the first point of contact: the bacterial membrane. Another common approach suggests the use of lipid-coated nanoparticles as a drug carrier system for therapies for infectious diseases and cancer. Herein, we discuss emerging platforms that make use of BMs for biosensing, bioimaging, drug delivery/discovery, and immunotherapy, focusing on bacterial infections and cancer. Further, we detail the synthesis and characteristics of BMs, followed by various models for utilizing them in biomedical applications. The key research areas required to augment the characteristics of bacterial membranes to facilitate wider applicability are also touched upon. Overall, this review provides an interdisciplinary approach to exploit the potential of BMs and current emerging technologies to generate novel solutions to unmet clinical needs.
MeSH term(s)	Humans ; Cell Membrane ; Bacteria ; Drug Delivery Systems ; Nanotechnology/methods ; Communicable Diseases ; Bacterial Infections ; Biosensing Techniques/methods
Language	English
Publishing date	2023-01-26
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662125-3
ISSN	2079-6374 ; 2079-6374
ISSN (online)	2079-6374
ISSN	2079-6374
DOI	10.3390/bios13020189
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