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  1. Book: Signal transduction and smooth muscle

    Trebak, Mohamed / Earley, Scott

    (Methods in signal transduction)

    2019  

    Author's details editor(s), Mohamed Trebak and Scott Earley
    Series title Methods in signal transduction
    Keywords Muscle, Smooth / physiology ; Signal Transduction / physiology ; Muscle, Smooth / cytology ; Calcium Channels / physiology
    Language English
    Size xix, 412 Seiten, Illustrationen
    Publisher CRC Press, Taylor & Francis
    Publishing place Boca Raton
    Publishing country United States
    Document type Book
    Note Includes bibliographical references
    HBZ-ID HT019771221
    ISBN 978-1-4987-7422-2 ; 9781315154589 ; 1-4987-7422-9 ; 1315154587
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2018 A 1548 available for loan (reading room) Lesesaal EG

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  2. Book ; Online: Signal Transduction and Smooth Muscle

    Trebak, Mohamed / Earley, Scott

    2019  

    Keywords Medicine ; Smooth muscle cell ; regulation ; organs
    Size 1 electronic resource (412 pages)
    Publisher Taylor and Francis
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021029043
    ISBN 9781315154589 ; 1315154587
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: STIM1 is the key that unlocks airway smooth muscle remodeling and hyperresponsiveness during asthma.

    Thakore, Pratish / Earley, Scott

    Cell calcium

    2022  Volume 104, Page(s) 102589

    Abstract: Airway smooth muscle remodeling and hyperresponsiveness are critical determinants of asthma severity, but the precise mechanisms regulating these disease processes remain elusive. In their latest study published in PNAS, Trebak and colleagues demonstrate ...

    Abstract Airway smooth muscle remodeling and hyperresponsiveness are critical determinants of asthma severity, but the precise mechanisms regulating these disease processes remain elusive. In their latest study published in PNAS, Trebak and colleagues demonstrate that STIM1 (stromal-interacting molecule 1) expression is upregulated in airway smooth muscle cells during asthma and facilitates Ca
    MeSH term(s) Airway Remodeling ; Asthma ; Humans ; Muscle, Smooth ; Myocytes, Smooth Muscle/metabolism ; Neoplasm Proteins/metabolism ; Respiratory System/metabolism ; Stromal Interaction Molecule 1/metabolism
    Chemical Substances Neoplasm Proteins ; STIM1 protein, human ; Stromal Interaction Molecule 1
    Language English
    Publishing date 2022-04-09
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 757687-0
    ISSN 1532-1991 ; 0143-4160
    ISSN (online) 1532-1991
    ISSN 0143-4160
    DOI 10.1016/j.ceca.2022.102589
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1596: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Metabolic Control of Cardiac Pacemaking.

    Earley, Scott / Lederer, W Jonathan

    Function (Oxford, England)

    2021  Volume 2, Issue 5, Page(s) zqab043

    Language English
    Publishing date 2021-08-23
    Publishing country England
    Document type Journal Article ; Comment
    ISSN 2633-8823
    ISSN (online) 2633-8823
    DOI 10.1093/function/zqab043
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  5. Article ; Online: PIP

    Earley, Scott / Kleinfeld, David

    Proceedings of the National Academy of Sciences of the United States of America

    2021  Volume 118, Issue 21

    MeSH term(s) Cerebrovascular Circulation ; Neurovascular Coupling ; Phosphatidylinositol 4,5-Diphosphate
    Chemical Substances Phosphatidylinositol 4,5-Diphosphate
    Language English
    Publishing date 2021-05-05
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2106308118
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1148: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  6. Article ; Online: The physiological sensor channels TRP and piezo: Nobel Prize in Physiology or Medicine 2021.

    Earley, Scott / Santana, L Fernando / Lederer, W Jonathan

    Physiological reviews

    2022  Volume 102, Issue 2, Page(s) 1153–1158

    MeSH term(s) Humans ; Nobel Prize
    Language English
    Publishing date 2022-02-07
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural
    ZDB-ID 209902-0
    ISSN 1522-1210 ; 0031-9333
    ISSN (online) 1522-1210
    ISSN 0031-9333
    DOI 10.1152/physrev.00057.2021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uc I Zs.166: Show issues Location:
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  7. Article ; Online: Vascular mechanotransduction.

    Davis, Michael J / Earley, Scott / Li, Yi-Shuan / Chien, Shu

    Physiological reviews

    2023  Volume 103, Issue 2, Page(s) 1247–1421

    Abstract: This review aims to survey the current state of mechanotransduction in vascular smooth muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical stimuli and transduction of mechanical signals that result in the acute ... ...

    Abstract This review aims to survey the current state of mechanotransduction in vascular smooth muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical stimuli and transduction of mechanical signals that result in the acute functional modulation and longer-term transcriptomic and epigenetic regulation of blood vessels. The mechanosensors discussed include ion channels, plasma membrane-associated structures and receptors, and junction proteins. The mechanosignaling pathways presented include the cytoskeleton, integrins, extracellular matrix, and intracellular signaling molecules. These are followed by discussions on mechanical regulation of transcriptome and epigenetics, relevance of mechanotransduction to health and disease, and interactions between VSMCs and ECs. Throughout this review, we offer suggestions for specific topics that require further understanding. In the closing section on conclusions and perspectives, we summarize what is known and point out the need to treat the vasculature as a system, including not only VSMCs and ECs but also the extracellular matrix and other types of cells such as resident macrophages and pericytes, so that we can fully understand the physiology and pathophysiology of the blood vessel as a whole, thus enhancing the comprehension, diagnosis, treatment, and prevention of vascular diseases.
    MeSH term(s) Humans ; Mechanotransduction, Cellular/physiology ; Endothelial Cells/metabolism ; Epigenesis, Genetic ; Signal Transduction/physiology ; Myocytes, Smooth Muscle ; Stress, Mechanical
    Language English
    Publishing date 2023-01-05
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 209902-0
    ISSN 1522-1210 ; 0031-9333
    ISSN (online) 1522-1210
    ISSN 0031-9333
    DOI 10.1152/physrev.00053.2021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.166: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  8. Article: Endothelial cell TRPA1 activity exacerbates cerebral hemorrhage during severe hypertension.

    Sullivan, Michelle N / Thakore, Pratish / Krishnan, Vivek / Alphonsa, Sushma / Li, Wencheng / Feng Earley, Yumei / Earley, Scott

    Frontiers in molecular biosciences

    2023  Volume 10, Page(s) 1129435

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2023-01-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2814330-9
    ISSN 2296-889X
    ISSN 2296-889X
    DOI 10.3389/fmolb.2023.1129435
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  9. Article ; Online: Transient Receptor Potential Channel Ankyrin 1: A Unique Regulator of Vascular Function.

    Alvarado, Michael G / Thakore, Pratish / Earley, Scott

    Cells

    2021  Volume 10, Issue 5

    Abstract: TRPA1 (transient receptor potential ankyrin 1), the lone member of the mammalian ankyrin TRP subfamily, is a ... ...

    Abstract TRPA1 (transient receptor potential ankyrin 1), the lone member of the mammalian ankyrin TRP subfamily, is a Ca
    MeSH term(s) Aldehydes/pharmacology ; Animals ; Calcitonin/metabolism ; Calcium/metabolism ; Calcium Channels/metabolism ; Cardiovascular System/metabolism ; Crotalus ; Endothelial Cells/metabolism ; Gene Expression Regulation ; Humans ; Hypertension ; Inflammation ; Isothiocyanates/pharmacology ; Molecular Conformation ; Mustard Plant/chemistry ; Nerve Tissue Proteins/metabolism ; Plant Oils/chemistry ; Protein Conformation ; Protein Domains ; Stroke ; TRPA1 Cation Channel/genetics ; TRPA1 Cation Channel/physiology ; Transient Receptor Potential Channels/metabolism ; Vasodilation
    Chemical Substances Aldehydes ; Calcium Channels ; Isothiocyanates ; Nerve Tissue Proteins ; Plant Oils ; TRPA1 Cation Channel ; TRPA1 protein, human ; Transient Receptor Potential Channels ; Calcitonin (9007-12-9) ; allyl isothiocyanate (BN34FX42G3) ; 4-hydroxy-2-nonenal (K1CVM13F96) ; Calcium (SY7Q814VUP) ; mustard oil (TYY1MA9BSY)
    Language English
    Publishing date 2021-05-11
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells10051167
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Transient Receptor Potential Channels and Endothelial Cell Calcium Signaling.

    Thakore, Pratish / Earley, Scott

    Comprehensive Physiology

    2019  Volume 9, Issue 3, Page(s) 1249–1277

    Abstract: The vascular endothelium is a broadly distributed and highly specialized organ. The endothelium has a number of functions including the control of blood vessels diameter through the production and release of potent vasoactive substances or direct ... ...

    Abstract The vascular endothelium is a broadly distributed and highly specialized organ. The endothelium has a number of functions including the control of blood vessels diameter through the production and release of potent vasoactive substances or direct electrical communication with underlying smooth muscle cells, regulates the permeability of the vascular barrier, stimulates the formation of new blood vessels, and influences inflammatory and thrombotic processes. Endothelial cells that make up the endothelium express a variety of cell-surface receptors and ion channels on the plasma membrane that are capable of detecting circulating hormones, neurotransmitters, oxygen tension, and shear stress across the vascular wall. Changes in these stimuli activate signaling cascades that initiate an appropriate physiological response. Increases in the global intracellular Ca
    MeSH term(s) Calcium/metabolism ; Calcium Signaling/physiology ; Capillary Permeability/physiology ; Endothelial Cells/physiology ; Endothelium, Vascular/cytology ; Endothelium, Vascular/metabolism ; Endothelium, Vascular/physiology ; Humans ; Transient Receptor Potential Channels/physiology ; Vasodilation/physiology
    Chemical Substances Transient Receptor Potential Channels ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2019-06-12
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ISSN 2040-4603
    ISSN (online) 2040-4603
    DOI 10.1002/cphy.c180034
    Database MEDical Literature Analysis and Retrieval System OnLINE

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