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Article: Wenxin Keli for the Treatment of Arrhythmia-Systems Pharmacology and

Li, Xiaofeng / Tian, Gang / Xu, Liang / Sun, Lili / Tao, Rui / Zhang, Shaoqiang / Cong, Zidong / Deng, Fangjun / Chen, Jinhong / Yu, Yang / Du, Wuxun / Zhao, Hucheng

Frontiers in pharmacology

2021 Volume 12, Page(s) 704622

Abstract: ... mechanisms of Wenxin Keli for arrhythmia treatment. Sixty-eight components identified ...

Abstract	This study employed a systems pharmacology approach to identify the active compounds and action mechanisms of Wenxin Keli for arrhythmia treatment. Sixty-eight components identified
Language	English
Publishing date	2021-08-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2021.704622
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Efficacy and safety of Wenxin Keli combined with metoprolol tartrate in the treatment of premature ventricular contractions: A systematic review and meta-analysis.

Huang, Ping / Luo, Yining / Chen, Jiaxue / Xu, Jingke / Shi, Yuanshu / Chen, Guoren / Ma, Ping

Frontiers in cardiovascular medicine

2022 Volume 9, Page(s) 952657

Abstract: Background: Wenxin Keli (WXKL) has good clinical value in the treatment ... premature ventricular contractions (RR = 1.32, 95% CI: [1.24, 1.40], : Conclusion: This study found that Wenxin Keli combined ...

Abstract	Background: Wenxin Keli (WXKL) has good clinical value in the treatment of premature ventricular contractions, but there is insufficient evidence to support it. This study evaluates the efficacy and safety of WXKL combined with metoprolol tartrate in the treatment of ventricular premature beats (VPCs). Methods: We searched seven databases to identify randomized controlled trials (RCTs) for this study. Two reviewers independently screened and extracted the data. The Cochrane Manual criteria were used for methodological quality assessment. Meta-analyses were performed using Review Manager 5.4.1 software. Risk ratios (RR) were used for effect sizes for dichotomous data, demonstrated in effect sizes and 95% confidence intervals (CIs). Results: A total of 11 RCTs of WXKL combined with metoprolol tartrate in the treatment of premature ventricular contractions were included in this study. Meta-analysis showed that WXKL combined with metoprolol tartrate (treatment group) was more effective than metoprolol tartrate (control group) in improving premature ventricular contractions (RR = 1.32, 95% CI: [1.24, 1.40], Conclusion: This study found that Wenxin Keli combined with metoprolol tartrate in the treatment of premature ventricular contractions increased the efficacy of the drug, reduced the occurrence of adverse reactions, and reduced the severity of adverse reactions. Due to the quality limitations of the included studies, more high-quality RCTs are needed in the future to provide more evidence for longer-term analyses.
Language	English
Publishing date	2022-07-29
Publishing country	Switzerland
Document type	Systematic Review
ZDB-ID	2781496-8
ISSN	2297-055X
ISSN	2297-055X
DOI	10.3389/fcvm.2022.952657
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Article: Efficacy of Wenxin Keli Plus Amiodarone versus Amiodarone Monotherapy in Treating Recent-Onset Atrial Fibrillation.

Zhang, Nixiao / Tse, Gary / Dahal, Shristi / Yang, Yajuan / Gong, Mengqi / Chan, Calista Zhuo Yi / Liu, Enzhao / Xu, Gang / Letsas, Konstantinos P / Korantzopoulos, Panagiotis / Li, Guangping / Liu, Tong

Cardiology research and practice

2018 Volume 2018, Page(s) 6047271

Abstract: ... prolonged periods. Wenxin Keli (WXKL), a Chinese herb extract, has been shown to be effective in atrial ...

Abstract	Background: Use of amiodarone (AMIO) in atrial fibrillation (AF) has significant side effects over prolonged periods. Wenxin Keli (WXKL), a Chinese herb extract, has been shown to be effective in atrial-selective inhibiting peak Methods: A total of 41 patients (71 ± 12 years, 44% male) with recent-onset (<48 h) AF eligible for conversion were randomized to receive either intravenous amiodarone (loading dose 5 mg/kg in 1 hour followed by 50 mg/h; Results: Conversion rate at 24 hours was of no difference between the two groups (75.0% vs. 81.0%, Conclusion: Administration of amiodarone plus WXKL for recent-onset AF conversion was safe and effective, with faster sinus rhythm restoration compared with amiodarone alone.
Language	English
Publishing date	2018-12-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	2506187-2
ISSN	2090-0597 ; 2090-8016
ISSN (online)	2090-0597
ISSN	2090-8016
DOI	10.1155/2018/6047271
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Article ; Online: Systematic Qualitative and Quantitative Analyses of Wenxin Granule via Ultra-High Performance Liquid Chromatography Coupled with Ion Mobility Quadrupole Time-of-Flight Mass Spectrometry and Triple Quadrupole-Linear Ion Trap Mass Spectrometry.

Mi, Yueguang / Hu, Wandi / Li, Weiwei / Wan, Shiyu / Xu, Xiaoyan / Liu, Meiyu / Wang, Hongda / Mei, Quanxi / Chen, Qinhua / Yang, Yang / Chen, Boxue / Jiang, Meiting / Li, Xue / Yang, Wenzhi / Guo, Dean

Molecules (Basel, Switzerland)

2022 Volume 27, Issue 11

Abstract: Wenxin granule (WXG) is a popular traditional Chinese medicine (TCM) preparation for the treatment ...

Abstract	Wenxin granule (WXG) is a popular traditional Chinese medicine (TCM) preparation for the treatment of arrhythmia disease. Potent analytical technologies are needed to elucidate its chemical composition and assess the quality differences among multibatch samples. In this work, both a multicomponent characterization and quantitative assay of WXG were conducted using two liquid chromatography-mass spectrometry (LC-MS) approaches. An ultra-high performance liquid chromatography-ion mobility quadrupole time-of-flight mass spectrometry (UHPLC/IM-QTOF-MS) approach combined with intelligent peak annotation workflows was developed to characterize the multicomponents of WXG. A hybrid scan approach enabling alternative data-independent and data-dependent acquisitions was established. We characterized 205 components, including 92 ginsenosides, 53 steroidal saponins, 14 alkaloids, and 46 others. Moreover, an optimized scheduled multiple reaction monitoring (sMRM) method was elaborated, targeting 24 compounds of WXG via ultra-high performance liquid chromatography-triple quadrupole linear ion trap mass spectrometry (UHPLC/QTrap-MS), which was validated based on its selectivity, precision, stability, repeatability, linearity, sensitivity, recovery, and matrix effect. By applying this method to 27 batches of WXG samples, the content variations of multiple markers from Notoginseng Radix et Rhizoma (21) and Codonopsis Radix (3) were depicted. Conclusively, we achieved the comprehensive multicomponent characterization and holistic quality assessment of WXG by targeting the non-volatile components.
MeSH term(s)	Chromatography, High Pressure Liquid/methods ; Chromatography, Liquid ; Drugs, Chinese Herbal ; Ginsenosides/analysis ; Mass Spectrometry/methods
Chemical Substances	Drugs, Chinese Herbal ; Ginsenosides ; wenxin keli
Language	English
Publishing date	2022-06-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules27113647
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Article ; Online: Systematic Qualitative and Quantitative Analyses of Wenxin Granule via Ultra-High Performance Liquid Chromatography Coupled with Ion Mobility Quadrupole Time-of-Flight Mass Spectrometry and Triple Quadrupole–Linear Ion Trap Mass Spectrometry

Yueguang Mi / Wandi Hu / Weiwei Li / Shiyu Wan / Xiaoyan Xu / Meiyu Liu / Hongda Wang / Quanxi Mei / Qinhua Chen / Yang Yang / Boxue Chen / Meiting Jiang / Xue Li / Wenzhi Yang / Dean Guo

Molecules, Vol 27, Iss 3647, p

2022 Volume 3647

Abstract: Wenxin granule (WXG) is a popular traditional Chinese medicine (TCM) preparation for the treatment ...

Abstract	Wenxin granule (WXG) is a popular traditional Chinese medicine (TCM) preparation for the treatment of arrhythmia disease. Potent analytical technologies are needed to elucidate its chemical composition and assess the quality differences among multibatch samples. In this work, both a multicomponent characterization and quantitative assay of WXG were conducted using two liquid chromatography–mass spectrometry (LC-MS) approaches. An ultra-high performance liquid chromatography–ion mobility quadrupole time-of-flight mass spectrometry (UHPLC/IM-QTOF-MS) approach combined with intelligent peak annotation workflows was developed to characterize the multicomponents of WXG. A hybrid scan approach enabling alternative data-independent and data-dependent acquisitions was established. We characterized 205 components, including 92 ginsenosides, 53 steroidal saponins, 14 alkaloids, and 46 others. Moreover, an optimized scheduled multiple reaction monitoring (sMRM) method was elaborated, targeting 24 compounds of WXG via ultra-high performance liquid chromatography–triple quadrupole linear ion trap mass spectrometry (UHPLC/QTrap-MS), which was validated based on its selectivity, precision, stability, repeatability, linearity, sensitivity, recovery, and matrix effect. By applying this method to 27 batches of WXG samples, the content variations of multiple markers from Notoginseng Radix et Rhizoma (21) and Codonopsis Radix (3) were depicted. Conclusively, we achieved the comprehensive multicomponent characterization and holistic quality assessment of WXG by targeting the non-volatile components.
Keywords	Wenxin granule ; multicomponent characterization ; HDMS E -HDDDA ; UHPLC-sMRM ; quality evaluation ; Organic chemistry ; QD241-441
Subject code	540 ; 621
Language	English
Publishing date	2022-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The Efficacy and Safety of Wenxin Keli in Patients with Frequent Premature Ventricular Contractions

Wei Hua / Run-Lin Gao / Bu-Chang Zhao / Jing Wang / Xu-Hua Chen / Chi Cai / Shu Zhang

Chinese Medical Journal, Vol 128, Iss 19, Pp 2557-

A Randomized, Double-blind, Placebo-controlled, Parallel-group, Multicenter Trial

2015 Volume 2564

Abstract: ... the efficacy and safety of a traditional Chinese medicine Wenxin Keli for the treatment of frequent PVCs ... of 1:1 to receive Wenxin Keli or the placebo for 4 weeks. The primary and secondary endpoint was ... were observed between the Wenxin Keli group and the placebo group. A smaller number of PVCs was ...

Abstract	Background: Premature ventricular contractions (PVCs) are common in the general population, and frequent PVCs may result in the poor quality of life or even the damage of cardiac function. We examined the efficacy and safety of a traditional Chinese medicine Wenxin Keli for the treatment of frequent PVCs among a relatively large Chinese cohort. Methods: We performed a randomized, double-blind, placebo-controlled, parallel-group, multicenter trial. A total of 1200 eligible participants were randomly assigned in a ratio of 1:1 to receive Wenxin Keli or the placebo for 4 weeks. The primary and secondary endpoint was the change of PVC numbers and PVC-related symptoms after a 4-week treatment compared with baseline, respectively. In addition, vital signs, laboratory values, and electrocardiographic parameters were assessed in a safety analysis. Results: At the initial evaluation, no significant differences in the baseline characteristics were observed between the Wenxin Keli group and the placebo group. A smaller number of PVCs was observed after the 4-week treatment than at baseline, in both the Wenxin Keli group (5686 ± 5940 vs. 15,138 ± 7597 beats/d, P < 0.001) and the placebo group (10,592 ± 8009 vs. 14,529 ± 5929 beats/d, P < 0.001); moreover, the Wenxin Keli group demonstrated a significantli greater reduction in the frequency of PVCs than the placebo group (P < 0.001). In a full analysis set, patients in the Wenxin Keli group exhibited significantly higher total effective responses in the reduction of PVCs compared to those in the placebo group (83.8% vs. 43.5%,P < 0.001). The per-protocol analysis yielded similar results (83.0% vs. 39.3%,P < 0.001). Treatment with Wenxin Keli also demonstrated superior performance compared to the placebo with respect to PVC-related symptoms. No severe adverse effects attributable to Wenxin Keli were reported. Conclusions: Wenxin Keli treatment effectively reduced the overall number of PVCs and alleviated PVC-related symptoms in patients without structural heart ...
Keywords	Wenxin Keli ; Premature Ventricular Contractions ; Efficacy ; Safety ; Clinical Trial ; Medicine ; R
Subject code	610
Language	English
Publishing date	2015-01-01T00:00:00Z
Publisher	Wolters Kluwer
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: The Efficacy and Safety of Wenxin Keli in Patients with Frequent Premature Ventricular Contractions: A Randomized, Double-blind, Placebo-controlled, Parallel-group, Multicenter Trial.

Hua, Wei / Gao, Run-Lin / Zhao, Bu-Chang / Wang, Jing / Chen, Xu-Hua / Cai, Chi / Zhang, Shu

Chinese medical journal

2015 Volume 128, Issue 19, Page(s) 2557–2564

Abstract: ... the efficacy and safety of a traditional Chinese medicine Wenxin Keli for the treatment of frequent PVCs ... of 1:1 to receive Wenxin Keli or the placebo for 4 weeks. The primary and secondary endpoint was ... characteristics were observed between the Wenxin Keli group and the placebo group. A smaller number of PVCs was ...

Abstract	Background: Premature ventricular contractions (PVCs) are common in the general population, and frequent PVCs may result in the poor quality of life or even the damage of cardiac function. We examined the efficacy and safety of a traditional Chinese medicine Wenxin Keli for the treatment of frequent PVCs among a relatively large Chinese cohort. Methods: We performed a randomized, double-blind, placebo-controlled, parallel-group, multicenter trial. A total of 1200 eligible participants were randomly assigned in a ratio of 1:1 to receive Wenxin Keli or the placebo for 4 weeks. The primary and secondary endpoint was the change of PVC numbers and PVC-related symptoms after a 4-week treatment compared with baseline, respectively. In addition, vital signs, laboratory values, and electrocardiographic parameters were assessed in a safety analysis. Results: At the initial evaluation, no significant differences in the baseline characteristics were observed between the Wenxin Keli group and the placebo group. A smaller number of PVCs was observed after the 4-week treatment than at baseline, in both the Wenxin Keli group (5686 ± 5940 vs. 15,138 ± 7597 beats/d, P < 0.001) and the placebo group (10,592 ± 8009 vs. 14,529 ± 5929 beats/d, P < 0.001); moreover, the Wenxin Keli group demonstrated a significantli greater reduction in the frequency of PVCs than the placebo group (P < 0.001). In a full analysis set, patients in the Wenxin Keli group exhibited significantly higher total effective responses in the reduction of PVCs compared to those in the placebo group (83.8% vs. 43.5%,P < 0.001). The per-protocol analysis yielded similar results (83.0% vs. 39.3%,P < 0.001). Treatment with Wenxin Keli also demonstrated superior performance compared to the placebo with respect to PVC-related symptoms. No severe adverse effects attributable to Wenxin Keli were reported. Conclusions: Wenxin Keli treatment effectively reduced the overall number of PVCs and alleviated PVC-related symptoms in patients without structural heart diseases and had no severe side effects.
MeSH term(s)	Adult ; Aged ; Double-Blind Method ; Drugs, Chinese Herbal/adverse effects ; Drugs, Chinese Herbal/therapeutic use ; Female ; Humans ; Male ; Middle Aged ; Quality of Life ; Treatment Outcome ; Ventricular Premature Complexes/drug therapy
Chemical Substances	Drugs, Chinese Herbal ; wenxin keli
Language	English
Publishing date	2015-10-05
Publishing country	China
Document type	Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	127089-8
ISSN	0366-6999 ; 1002-0187
ISSN	0366-6999 ; 1002-0187
DOI	10.4103/0366-6999.166026
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Article ; Online: Mechanistic insights into manganese oxide impacting the oxidation and transport of Cr(III) immobilized by nano-zero valent charged ion particles in water-saturated porous media.

Sun, Wu / Xu, Nan / Jiang, Wenxin / Cheng, Gongbi

Journal of hazardous materials

2024 Volume 469, Page(s) 134050

Abstract: The presence of manganese oxide ( ... ...

Abstract	The presence of manganese oxide (MnO
Language	English
Publishing date	2024-03-16
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1491302-1
ISSN	1873-3336 ; 0304-3894
ISSN (online)	1873-3336
ISSN	0304-3894
DOI	10.1016/j.jhazmat.2024.134050
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Article ; Online: Morphological characteristics and phylogenetic evidence reveal two new species and the first report of

Xu, Rong / Su, Wenxin / Wang, Yang / Tian, Shangqing / Li, Yu / Phukhamsakda, Chayanard

MycoKeys

2024 Volume 101, Page(s) 95–112

Abstract: ... Two ... ...

Abstract	Two novel
Language	English
Publishing date	2024-01-12
Publishing country	Bulgaria
Document type	Journal Article
ZDB-ID	2630648-7
ISSN	1314-4049 ; 1314-4049
ISSN (online)	1314-4049
ISSN	1314-4049
DOI	10.3897/mycokeys.101.113040
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Article: Anti-

Yan, Weifeng / Cui, Zhe / Li, Wenxin / An, Xin / Cheng, Xu / Wang, Sihong / Jin, Chunmei

Die Pharmazie

2024 Volume 78, Issue 11, Page(s) 225–230

Abstract: New anti- ...

Abstract	New anti-
MeSH term(s)	Animals ; Mice ; Saponins/pharmacology ; Toxoplasma ; Panax ; Polysaccharides/pharmacology
Chemical Substances	Saponins ; Polysaccharides
Language	English
Publishing date	2024-01-05
Publishing country	Germany
Document type	Journal Article
ZDB-ID	208793-5
ISSN	0031-7144
ISSN	0031-7144
DOI	10.1691/ph.2023.3622
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