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  1. Article ; Online: The C-terminus of varicella-zoster virus glycoprotein M contains trafficking motifs that mediate skin virulence in the SCID-human model of VZV pathogenesis.

    Zerboni, Leigh / Sung, Phillip / Sommer, Marvin / Arvin, Ann

    Virology

    2018  Volume 523, Page(s) 110–120

    Abstract: Knowledge about the function of varicella-zoster virus glycoprotein M is limited; the requirement ...

    Abstract Knowledge about the function of varicella-zoster virus glycoprotein M is limited; the requirement of gM for skin and neural tropism are unknown. VZV gM contains two predicted YXXΦ trafficking motifs and a dileucine motif in the carboxyl-terminus. We constructed a recombinant VZV with gM truncated from the first YXXΦ and five additional viruses with YXXΦ tyrosine substitutions, alone and in combination with dileucine substitution. All recombinant viruses grew to high titer but mutation of the membrane-proximal YXXΦ motif reduced plaque size in cultured cells and altered gM localization. C-terminus truncation had a pronounced effect on virion morphogenesis and plaque size, but not on overall replication kinetics in vitro. Mutation of gM trafficking motifs and truncation attenuated replication in human skin xenografts in vivo; gM truncation did not alter neurotropism. Our results demonstrate that the gM C-terminus is dispensable for virus replication in cultured cells but is important for skin pathogenesis.
    MeSH term(s) Amino Acid Motifs ; Amino Acid Substitution ; Animals ; Disease Models, Animal ; Ganglia, Spinal/pathology ; Ganglia, Spinal/virology ; Herpes Zoster/pathology ; Herpes Zoster/virology ; Herpesvirus 3, Human/genetics ; Herpesvirus 3, Human/metabolism ; Herpesvirus 3, Human/pathogenicity ; Heterografts ; Humans ; Male ; Mice ; Protein Domains ; Protein Transport ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Skin/pathology ; Skin/virology ; Viral Load ; Viral Matrix Proteins/chemistry ; Viral Matrix Proteins/genetics ; Viral Matrix Proteins/metabolism ; Viral Plaque Assay ; Viral Tropism ; Virulence ; Virus Replication
    Chemical Substances Recombinant Proteins ; Viral Matrix Proteins
    Language English
    Publishing date 2018-08-14
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 200425-2
    ISSN 1096-0341 ; 0042-6822
    ISSN (online) 1096-0341
    ISSN 0042-6822
    DOI 10.1016/j.virol.2018.08.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  2. Book ; Online ; E-Book: Varicella-zoster virus

    Arvin, Ann M. / Moffat, Jennifer F. / Abendroth, Allison / Oliver, Stefan

    genetics, pathogenesis and immunity

    (Current topics in microbiology and immunology ; 438)

    2023  

    Author's details Ann M. Arvin, Jennifer F. Moffat, Allison Abendroth, Stefan L. Oliver editors
    Series title Current topics in microbiology and immunology ; 438
    Collection
    Keywords Varicella-zoster virus ; Herpesvirus diseases
    Subject code 579.2434
    Language English
    Size 1 Online-Ressource (viii, 272 Seiten), Illustrationen, Diagramme
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT021583221
    ISBN 978-3-031-15305-1 ; 9783031153044 ; 3-031-15305-7 ; 3031153049
    DOI 10.1007/978-3-031-15305-1
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: A Symbolic Deconstructed Colonialism in E. M. Forster’s A Passage to India

    Monireh Arvin

    Environment Conservation Journal, Vol 16, Iss SE (2015)

    2015  

    Abstract: Unlike the title of the novel, A Passage to India, which is an allusion to one of Walt Whitman's poems, here we see the disillusionment of Romanticism. Novel depicts "everything exists, but nothing has values" (Forster, 1985, p.147), the same as the dark ...

    Abstract Unlike the title of the novel, A Passage to India, which is an allusion to one of Walt Whitman's poems, here we see the disillusionment of Romanticism. Novel depicts "everything exists, but nothing has values" (Forster, 1985, p.147), the same as the dark discovery in the Marabar Caves. The novel suggests that we must have a passage through the national barriers, and all human beings should become one nation. However, up to end of the novel, we see each time such possibility of oneness is admitted, but due to the so-called deficiencies or malfunctions of the Indians it is immediately denied; the novel leaves us frustrated that such a unity is never established completely. Despite Walt Whitman's view, this passage through the national barriers is not possible. The present study aims to depict a symbolic deconstructed colonialism on Forster's A Passage to India. As a result, the most important question which was posed at the very beginning of the novel, "Can the English and the Indians become friends or not?" is not answered clearly. Each time we begin to admit an opportunity of integration and unity, this chance is immediately delayed or harshly denied. The novel implicitly depicts the three phases of the Hegelian paradigm: thesis, anti-thesis, and synthesis.
    Keywords Colonialism ; Deconstruction ; E. M. Forster ; Orients ; Symbol ; Environmental sciences ; GE1-350
    Subject code 820
    Language English
    Publishing date 2015-12-01T00:00:00Z
    Publisher Action for Sustainable Efficacious Development and Awareness
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Creating the "Dew Drop on a Rose Petal": the Molecular Pathogenesis of Varicella-Zoster Virus Skin Lesions.

    Arvin, Ann M

    Microbiology and molecular biology reviews : MMBR

    2023  Volume 87, Issue 3, Page(s) e0011622

    Abstract: Varicella-zoster virus (VZV) is a human alphaherpesvirus that causes varicella (chicken pox) as the primary infection in a susceptible host. Varicella is very contagious through its transmission by direct contact with vesicular skin lesions that contain ... ...

    Abstract Varicella-zoster virus (VZV) is a human alphaherpesvirus that causes varicella (chicken pox) as the primary infection in a susceptible host. Varicella is very contagious through its transmission by direct contact with vesicular skin lesions that contain high titers of infectious virus and respiratory droplets. While the clinical manifestations of primary VZV infection are well recognized, defining the molecular mechanisms that drive VZV pathogenesis in the naive host before adaptive antiviral immunity is induced has been a challenge due to species specificity. This review focuses on advances made in identifying the differentiated human host cells targeted by VZV to cause varicella, the processes involved in viral takeover of these heterogenous cell types, and the host cell countermeasures that typically culminate in a benign illness. This work has revealed many unexpected and multifaceted mechanisms used by VZV to achieve its high prevalence and persistence in the human population.
    MeSH term(s) Humans ; Herpesvirus 3, Human ; Chickenpox ; Antiviral Agents
    Chemical Substances Antiviral Agents
    Language English
    Publishing date 2023-06-24
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1376131-6
    ISSN 1098-5557 ; 1070-6275 ; 1092-2172
    ISSN (online) 1098-5557 ; 1070-6275
    ISSN 1092-2172
    DOI 10.1128/mmbr.00116-22
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  5. Book ; Online: Applying Next Generation Sequencing and Transgenic Models to Rare Disease Research

    Gouw, Arvin M. / Jaishankar, Amritha / Brooks, George A. / Brooks, George A.

    2020  

    Keywords Science: general issues ; Medical genetics ; Rare disease ; Genomics ; Next generation sequencing ; transgenic ; genetic analysis
    Size 1 electronic resource (119 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021230257
    ISBN 9782889635245 ; 2889635244
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  6. Article ; Online: Insights From Studies of the Genetics, Pathogenesis, and Immunogenicity of the Varicella Vaccine.

    Arvin, Ann M

    The Journal of infectious diseases

    2022  Volume 226, Issue Suppl 4, Page(s) S385–S391

    Abstract: While the varicella vaccine was created with approaches established for other live attenuated viral vaccines, novel methods to probe virus-host interactions have been used to explore the genetics, pathogenesis, and immunogenicity of the vaccine compared ... ...

    Abstract While the varicella vaccine was created with approaches established for other live attenuated viral vaccines, novel methods to probe virus-host interactions have been used to explore the genetics, pathogenesis, and immunogenicity of the vaccine compared to wild-type varicella-zoster virus (VZV). As summarized here, a mechanism-based understanding of the safety and efficacy of the varicella vaccine has been achieved through these investigations.
    MeSH term(s) Humans ; Chickenpox Vaccine/genetics ; Herpes Zoster/prevention & control ; Herpesvirus 3, Human/genetics ; Vaccines, Attenuated/genetics ; Viral Vaccines ; Antigens, Viral ; Herpes Zoster Vaccine
    Chemical Substances Chickenpox Vaccine ; Vaccines, Attenuated ; Viral Vaccines ; Antigens, Viral ; Herpes Zoster Vaccine
    Language English
    Publishing date 2022-10-20
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 3019-3
    ISSN 1537-6613 ; 0022-1899
    ISSN (online) 1537-6613
    ISSN 0022-1899
    DOI 10.1093/infdis/jiac278
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Brain structural and functional abnormalities in patients with tension-type headache: A systematic review of magnetic resonance imaging studies.

    Parsaei, Mohammadamin / Taebi, Morvarid / Arvin, Alireza / Moghaddam, Hossein Sanjari

    Journal of neuroscience research

    2024  Volume 102, Issue 1, Page(s) e25294

    Abstract: Tension-type headache (TTH) stands as the most prevalent form of headache, yet an adequate understanding of its underlying mechanisms remains elusive. This article endeavors to comprehensively review structural and functional magnetic resonance imaging ( ... ...

    Abstract Tension-type headache (TTH) stands as the most prevalent form of headache, yet an adequate understanding of its underlying mechanisms remains elusive. This article endeavors to comprehensively review structural and functional magnetic resonance imaging (MRI) studies investigating TTH patients, to gain valuable insights into the pathophysiology of TTH, and to explore new avenues for enhanced treatment strategies. We conducted a systematic search to identify relevant articles examining brain MRI disparities between TTH individuals and headache-free controls (HFC). Fourteen studies, encompassing 312 diagnosed TTH patients, were selected for inclusion. Among these, eight studies utilized conventional MRI, one employed diffusion tensor imaging, and five implemented various functional MRI modalities. Consistent findings across these studies revealed a notable increase in white matter hyperintensity (WMH) in TTH patients. Furthermore, the potential involvement of the specific brain areas recognized to be involved in different dimensions of pain perception including cortical regions (anterior and posterior cingulate cortex, prefrontal cortex, anterior and posterior insular cortex), subcortical regions (thalamus, caudate, putamen, and parahippocampus), cerebellum in TTH pathogenesis was identified. However, no significant association was established between TTH and intracranial abnormalities or total intracranial volume. In conclusion, these findings support the hypotheses regarding the role of central mechanisms in TTH pathophysiology and offer probable brain regions implicated in these mechanisms. Due to the scarce data on the precise role of these regions in the TTH, further preclinical and clinical investigations should be done to advance our knowledge and enhance targeted therapeutic options of TTH.
    MeSH term(s) Humans ; Tension-Type Headache/diagnostic imaging ; Diffusion Tensor Imaging ; Brain/diagnostic imaging ; Magnetic Resonance Imaging ; Cerebellum
    Language English
    Publishing date 2024-01-29
    Publishing country United States
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 195324-2
    ISSN 1097-4547 ; 0360-4012
    ISSN (online) 1097-4547
    ISSN 0360-4012
    DOI 10.1002/jnr.25294
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Modulation of Host Cell Signaling Pathways by Varicella-Zoster Virus.

    Sen, Nandini / Arvin, Ann M

    Current topics in microbiology and immunology

    2022  Volume 438, Page(s) 75–84

    Abstract: Host-pathogen interactions involve complex inside-out and outside-in signal transmission through critical cellular networks that dictate disease outcomes. The phosphoinositide 3-kinase (PI3K)/Akt pathway is a pivotal junction that regulates several cell ... ...

    Abstract Host-pathogen interactions involve complex inside-out and outside-in signal transmission through critical cellular networks that dictate disease outcomes. The phosphoinositide 3-kinase (PI3K)/Akt pathway is a pivotal junction that regulates several cell functions, and phospho-Akt (pAkt) is often found to be constitutively active in cancer cells, similar to phospho-STAT3. In this chapter, we discuss the regulation of PI3K/Akt pathway in VZV infected cells and of other pathways including p53 which, unlike pAkt and pSTAT3, directs cells towards apoptosis. The fine spatio-temporal balance of activation of pro- and anti-apoptotic factors during VZV infection likely provides an optimum environment for the virus to replicate and cause disease in the human host.
    MeSH term(s) Humans ; Herpesvirus 3, Human/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Signal Transduction ; Host-Pathogen Interactions
    Chemical Substances Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1)
    Language English
    Publishing date 2022-05-27
    Publishing country Germany
    Document type Journal Article
    ISSN 0070-217X
    ISSN 0070-217X
    DOI 10.1007/82_2021_251
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Einzelsignatur: Show issues

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  9. Article ; Online: Will Measles Virus or Humanity Win the International "Fitness" Challenge?

    Arvin, Ann M

    Annual review of virology

    2019  Volume 6, Issue 1, Page(s) iii–vii

    MeSH term(s) Global Health ; Humanities ; Humans ; Measles/epidemiology ; Measles/mortality ; Measles/prevention & control ; Measles/virology ; Measles Vaccine/administration & dosage ; Measles Vaccine/immunology ; Measles virus/genetics ; Measles virus/immunology ; Measles virus/physiology
    Chemical Substances Measles Vaccine
    Language English
    Publishing date 2019-10-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2764224-0
    ISSN 2327-0578 ; 2327-056X
    ISSN (online) 2327-0578
    ISSN 2327-056X
    DOI 10.1146/annurev-vi-06-072619-100011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Sensitivity of different assay systems for immunoglobulin M responses to varicella-zoster virus in reactivated infections (zoster).

    Schmidt, N J / Arvin, A M

    Journal of clinical microbiology

    1986  Volume 23, Issue 5, Page(s) 978–979

    Abstract: An immunoglobulin M response to varicella-zoster virus was detected in 70% of zoster patients ... variations in their varicella-zoster virus immunoglobulin M responses detectable in the different assays. ...

    Abstract An immunoglobulin M response to varicella-zoster virus was detected in 70% of zoster patients by solid-phase radioimmunoassay, in 52% by indirect immunofluorescence, in 48% by neutralization on sucrose density gradient fractions, and in 27% by an antibody class capture enzyme immunoassay. The patients showed marked variations in their varicella-zoster virus immunoglobulin M responses detectable in the different assays.
    MeSH term(s) Antibodies, Viral/analysis ; Fluorescent Antibody Technique ; Herpes Zoster/immunology ; Herpesvirus 3, Human/immunology ; Humans ; Immunoenzyme Techniques ; Immunoglobulin M/analysis ; Neutralization Tests ; Radioimmunoassay
    Chemical Substances Antibodies, Viral ; Immunoglobulin M
    Language English
    Publishing date 1986-05
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 390499-4
    ISSN 1098-660X ; 0095-1137
    ISSN (online) 1098-660X
    ISSN 0095-1137
    DOI 10.1128/jcm.23.5.978-979.1986
    Database MEDical Literature Analysis and Retrieval System OnLINE

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