LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 76

Search options

  1. Book ; Online ; Thesis: Das Recht des Arbeitnehmers auf tatsächliche Beschäftigung

    Eckel, Florian [Verfasser]

    Begründung und Grenzen des allgemeinen Beschäftigungsanspruchs

    2021  

    Author's details Florian Eckel
    Keywords Recht ; Law
    Subject code sg340
    Language German
    Publisher Peter Lang GmbH, Internationaler Verlag der Wissenschaften
    Publishing place Frankfurt a.M.
    Document type Book ; Online ; Thesis
    ISBN 978-3-631-85295-8 ; 3-631-85295-9
    Database Digital theses on the web

    Full text online

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  2. Book ; Thesis: Lebensqualität nach Gastrektomie wegen Magencarcinoms

    Eckel, Florian

    subtotale versus totale Gastrektomie

    1997  

    Author's details Florian Eckel
    Language German
    Size 65, 2, 4 S. : graph. Darst.
    Edition [Mikrofiche-Ausg.]
    Document type Book ; Thesis
    Thesis / German Habilitation thesis München, Techn. Univ., Diss., 1997
    Note Mikrofiche-Ausg.: 1 Mikrofiche : 24x
    HBZ-ID HT008592703
    Database Catalogue ZB MED Medicine, Health

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1998 MB 1033 order for loan Magazin

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Book: Credit constraints, endogenous innovation, and price setting in international trade

    Eckel, Carsten / Unger, Florian

    (Discussion paper series / Centre for Economic Policy Research : International trade and regional economics ; DP 11727)

    2016  

    Author's details Carsten Eckel and Florian Unger
    Series title Discussion paper series / Centre for Economic Policy Research : International trade and regional economics ; DP 11727
    Language English
    Size Illustrationen
    Publishing place 38 Seiten
    Document type Book
    Note Erscheint auch als Online-Ausgabe
    Database ECONomics Information System

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Article ; Online: Variplex™ test system fails to reliably detect SARS-CoV-2 directly from respiratory samples without RNA extraction.

    Eckel, Florian / Küsters, Franziska / Drossel, Bernhard / Konert, Markus / Mattes, Hans / Schopf, Stefan

    European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology

    2020  Volume 39, Issue 12, Page(s) 2373–2377

    Abstract: Diagnosis of COVID is performed by PCR methods, but their capacity is limited by the requirement of high-level facilities and instruments. The loop-mediated isothermal amplification (LAMP) method has been utilized for the detection of isolated virus- ... ...

    Abstract Diagnosis of COVID is performed by PCR methods, but their capacity is limited by the requirement of high-level facilities and instruments. The loop-mediated isothermal amplification (LAMP) method has been utilized for the detection of isolated virus-specific RNA. Preliminary data suggest the possibility of isothermal amplification directly from respiratory samples without RNA extraction. All patients admitted to our hospital were screened for SARS-CoV-2 by routine. Respiratory samples were tested by variplex system based on LAMP method directly without RNA extraction and by PCR. Primary endpoint was the false-negative rate of variplex test compared with PCR as gold standard. In 109 patients variplex test and PCR assay were performed simultaneously. Median age was 80 years and male/female ratio was 40/60%. The prevalence of PCR-confirmed COVID diagnosis was 43.1%. Variplex test was positive in 13.8%. False-negative rate of variplex test compared with PCR was 83.0%. The potential of LAMP technology using isolated RNA has been demonstrated impressively by others, and excellent sensitivity and specificity of detecting SARS-CoV-2 has been reported. However, without RNA extraction, the variplex test system failed to reliably detect SARS-CoV-2 directly in respiratory samples.
    MeSH term(s) Aged ; Aged, 80 and over ; Betacoronavirus/genetics ; Betacoronavirus/pathogenicity ; COVID-19 ; COVID-19 Testing ; Clinical Laboratory Techniques/methods ; Coronavirus Infections/blood ; Coronavirus Infections/diagnosis ; Coronavirus Infections/epidemiology ; Coronavirus Infections/mortality ; False Negative Reactions ; Female ; Germany/epidemiology ; Humans ; Male ; Molecular Diagnostic Techniques/methods ; Nasopharynx/virology ; Nucleic Acid Amplification Techniques/methods ; Oropharynx/virology ; Pandemics ; Pneumonia, Viral/blood ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/mortality ; RNA, Viral/blood ; RNA, Viral/genetics ; Reagent Kits, Diagnostic/standards ; Retrospective Studies ; Reverse Transcriptase Polymerase Chain Reaction/standards ; SARS-CoV-2 ; Sensitivity and Specificity ; Severity of Illness Index ; Survival Analysis
    Chemical Substances RNA, Viral ; Reagent Kits, Diagnostic
    Keywords covid19
    Language English
    Publishing date 2020-07-17
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 603155-9
    ISSN 1435-4373 ; 0934-9723 ; 0722-2211
    ISSN (online) 1435-4373
    ISSN 0934-9723 ; 0722-2211
    DOI 10.1007/s10096-020-03983-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1732: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Book ; Online: Credit constraints, endogenous innovations, and price setting in international trade

    Eckel, Carsten / Unger, Florian

    (Munich discussion paper ; 2015-8)

    2015  

    Abstract: We introduce credit frictions motivated by moral hazard in a general equilibrium model of international trade with two dimensions of heterogeneity and endogenous investments. Firms' competitiveness consists of capabilities to conduct process and quality ... ...

    Author's details Carsten Eckel und Florian Unger
    Series title Munich discussion paper ; 2015-8
    Abstract We introduce credit frictions motivated by moral hazard in a general equilibrium model of international trade with two dimensions of heterogeneity and endogenous investments. Firms' competitiveness consists of capabilities to conduct process and quality innovations at low costs, whereas investment outlays have to be financed by external capital. We show that the scope for vertical product differentiation in a sector determines how credit tightening affects investment and price setting. Consistent with recent empirical evidence, our model rationalizes positive as well as negative correlations of firm-level FOB prices with financial frictions and variable trade costs. Faced with an increase in the borrowing rate, producers reduce both types of innovation resulting in opposing effects on marginal production costs and prices. In general equilibrium, financial frictions intensify quality-based (cost-based) sorting of firms if the scope for vertical product differentiation is high (low). Consequently, credit tightening leads to firm exit, increased innovation activity among existing suppliers, and welfare losses that are larger in sectors with low investment intensity.
    Keywords international trade ; external finance ; credit constraints ; moral hazard ; quality ; innovation ; product prices
    Language English
    Size Online-Ressource (39 S.), graph. Darst.
    Publisher Univ., Volkswirtschaftl. Fak
    Publishing place München
    Document type Book ; Online
    Database ECONomics Information System

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  6. Article ; Online: Chemotherapy and targeted therapy in advanced biliary tract carcinoma: a pooled analysis of clinical trials.

    Eckel, Florian / Schmid, Roland M

    Chemotherapy

    2014  Volume 60, Issue 1, Page(s) 13–23

    Abstract: Background: In biliary tract cancer, gemcitabine platinum (GP) doublet palliative chemotherapy is the current standard treatment. The aim of this study was to analyze recent trials, even those small and nonrandomized, and identify superior new regimens.! ...

    Abstract Background: In biliary tract cancer, gemcitabine platinum (GP) doublet palliative chemotherapy is the current standard treatment. The aim of this study was to analyze recent trials, even those small and nonrandomized, and identify superior new regimens.
    Methods: Trials published in English between January 2000 and January 2014 were analyzed, as well as ASCO abstracts from 2010 to 2013.
    Results: In total, 161 trials comprising 6,337 patients were analyzed. The pooled results of standard therapy GP (no fluoropyrimidine, F, or other drug) were as follows: the median response rate (RR), tumor control rate (TCR), time to tumor progression (TTP) and overall survival (OS) were 25.9 and 63.5%, and 5.3 and 9.5 months, respectively. GFP triplets as well as G-based chemotherapy plus targeted therapy were significantly superior to GP concerning tumor control (TCR, TTP) and OS, with no difference in RR.
    Conclusion: Triplet combinations of GFP as well as G-based chemotherapy with (predominantly EGFR) targeted therapy are most effective concerning tumor control and survival.
    MeSH term(s) Antimetabolites, Antineoplastic/therapeutic use ; Biliary Tract Neoplasms/drug therapy ; Biliary Tract Neoplasms/mortality ; Biliary Tract Neoplasms/pathology ; Carcinoma/drug therapy ; Carcinoma/mortality ; Carcinoma/pathology ; Databases, Factual ; Deoxycytidine/analogs & derivatives ; Deoxycytidine/therapeutic use ; Disease Progression ; Humans ; Neoplasm Staging ; Survival Rate ; Treatment Outcome
    Chemical Substances Antimetabolites, Antineoplastic ; Deoxycytidine (0W860991D6) ; gemcitabine (B76N6SBZ8R)
    Language English
    Publishing date 2014
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 6708-8
    ISSN 1421-9794 ; 0009-3157
    ISSN (online) 1421-9794
    ISSN 0009-3157
    DOI 10.1159/000365781
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uf I Zs.174: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: Selective ablation of P53 in pancreatic beta cells fails to ameliorate glucose metabolism in genetic, dietary and pharmacological models of diabetes mellitus

    Celina Uhlemeyer / Nadine Müller / Michael Rieck / Jennifer Kuboth / Caroline Schlegel / Kerstin Grieß / Tim Florian Dorweiler / Sonja Heiduschka / Jürgen Eckel / Michael Roden / Eckhard Lammert / Markus Stoffel / Bengt-Frederik Belgardt

    Molecular Metabolism, Vol 67, Iss , Pp 101650- (2023)

    1480  

    Abstract: Objective: Beta cell dysfunction and death are critical steps in the development of both type 1 and type 2 diabetes (T1D and T2D), but the underlying mechanisms are incompletely understood. Activation of the essential tumor suppressor and transcription ... ...

    Abstract Objective: Beta cell dysfunction and death are critical steps in the development of both type 1 and type 2 diabetes (T1D and T2D), but the underlying mechanisms are incompletely understood. Activation of the essential tumor suppressor and transcription factor P53 (also known as TP53 and Trp53 in mice) was linked to beta cell death in vitro and has been reported in several diabetes mouse models and beta cells of humans with T2D. In this article, we set out to determine the beta cell specific role of P53 in beta cell dysfunction, cell death and development of diabetes in vivo. Methods: We generated beta cell specific P53 knockout (P53BKO) mice and used complementary genetic, dietary and pharmacological models of glucose intolerance, beta cell dysfunction and diabetes development to evaluate the functional role of P53 selectively in beta cells. We further analyzed the effect of P53 ablation on beta cell survival in isolated pancreatic islets exposed to diabetogenic stress inducers ex vivo by flow cytometry. Results: Beta cell specific ablation of P53/Trp53 failed to ameliorate glucose tolerance, insulin secretion or to increase beta cell numbers in genetic, dietary and pharmacological models of diabetes. Additionally, loss of P53 in beta cells did not protect against streptozotocin (STZ) induced hyperglycemia and beta cell death, although STZ-induced activation of classical pro-apoptotic P53 target genes was significantly reduced in P53BKO mice. In contrast, Olaparib mediated PARP1 inhibition protected against acute ex vivo STZ-induced beta cell death and islet destruction. Conclusions: Our study reveals that ablation of P53 specifically in beta cells is unexpectedly unable to attenuate beta cell failure and death in vivo and ex vivo. While during development and progression of diabetes, P53 and P53-regulated pathways are activated, our study suggests that P53 signaling is not essential for loss of beta cells or beta cell dysfunction. P53 in other cell types and organs may predominantly regulate systemic glucose ...
    Keywords Pancreatic beta cell ; Apoptosis ; Type 1 diabetes ; Type 2 diabetes ; Internal medicine ; RC31-1245
    Subject code 571
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  8. Article ; Conference proceedings: Selective ablation of P53 in pancreatic beta cells fails to ameliorate glucose metabolism in genetic, dietary and pharmacological models of diabetes mellitus

    Uhlemeyer, Celina / Müller, Nadine / Rieck, Michael / Kuboth, Jennifer / Schlegel, Caroline / Griess, Kerstin / Dorweiler, Tim Florian / Heiduschka, Sonja / Eckel, Jürgen / Roden, Michael / Lammert, Eckhard / Stoffel, Markus / Belgardt, Bengt-Frederik

    Diabetologie und Stoffwechsel

    2023  Volume 18, Issue S 01

    Event/congress Diabetes Kongress 2023 - 57. Jahrestagung der DDG, CityCube Berlin, 2023-05-17
    Language German
    Publishing date 2023-04-01
    Publisher Georg Thieme Verlag
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 2222993-0
    ISSN 1861-9010 ; 1861-9002
    ISSN (online) 1861-9010
    ISSN 1861-9002
    DOI 10.1055/s-0043-1767849
    Database Thieme publisher's database

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 6479: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.A 6479/X: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: Comparison of the First and Second Waves of Hospitalized Patients With SARS-CoV-2.

    Budweiser, Stephan / Baş, Şevki / Jörres, Rudolf A / Engelhardt, Sebastian / Thilo, Christian / Delius, Stefan von / Eckel, Florian / Biller, Uwe / Lenherr, Katharina / Deerberg-Wittram, Jens / Bauer, Andreas

    Deutsches Arzteblatt international

    2021  Volume 118, Issue 18, Page(s) 326–327

    MeSH term(s) COVID-19 ; Humans ; SARS-CoV-2
    Language English
    Publishing date 2021-07-23
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2406159-1
    ISSN 1866-0452 ; 1866-0452
    ISSN (online) 1866-0452
    ISSN 1866-0452
    DOI 10.3238/arztebl.m2021.0215
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: Selective ablation of P53 in pancreatic beta cells fails to ameliorate glucose metabolism in genetic, dietary and pharmacological models of diabetes mellitus.

    Uhlemeyer, Celina / Müller, Nadine / Rieck, Michael / Kuboth, Jennifer / Schlegel, Caroline / Grieß, Kerstin / Dorweiler, Tim Florian / Heiduschka, Sonja / Eckel, Jürgen / Roden, Michael / Lammert, Eckhard / Stoffel, Markus / Belgardt, Bengt-Frederik

    Molecular metabolism

    2022  Volume 67, Page(s) 101650

    Abstract: Objective: Beta cell dysfunction and death are critical steps in the development of both type 1 and type 2 diabetes (T1D and T2D), but the underlying mechanisms are incompletely understood. Activation of the essential tumor suppressor and transcription ... ...

    Abstract Objective: Beta cell dysfunction and death are critical steps in the development of both type 1 and type 2 diabetes (T1D and T2D), but the underlying mechanisms are incompletely understood. Activation of the essential tumor suppressor and transcription factor P53 (also known as TP53 and Trp53 in mice) was linked to beta cell death in vitro and has been reported in several diabetes mouse models and beta cells of humans with T2D. In this article, we set out to determine the beta cell specific role of P53 in beta cell dysfunction, cell death and development of diabetes in vivo.
    Methods: We generated beta cell specific P53 knockout (P53
    Results: Beta cell specific ablation of P53/Trp53 failed to ameliorate glucose tolerance, insulin secretion or to increase beta cell numbers in genetic, dietary and pharmacological models of diabetes. Additionally, loss of P53 in beta cells did not protect against streptozotocin (STZ) induced hyperglycemia and beta cell death, although STZ-induced activation of classical pro-apoptotic P53 target genes was significantly reduced in P53
    Conclusions: Our study reveals that ablation of P53 specifically in beta cells is unexpectedly unable to attenuate beta cell failure and death in vivo and ex vivo. While during development and progression of diabetes, P53 and P53-regulated pathways are activated, our study suggests that P53 signaling is not essential for loss of beta cells or beta cell dysfunction. P53 in other cell types and organs may predominantly regulate systemic glucose homeostasis.
    MeSH term(s) Humans ; Mice ; Animals ; Insulin-Secreting Cells/metabolism ; Tumor Suppressor Protein p53/genetics ; Tumor Suppressor Protein p53/metabolism ; Diabetes Mellitus, Type 2/metabolism ; Insulin/metabolism ; Glucose/metabolism
    Chemical Substances Tumor Suppressor Protein p53 ; Insulin ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2022-12-05
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2708735-9
    ISSN 2212-8778 ; 2212-8778
    ISSN (online) 2212-8778
    ISSN 2212-8778
    DOI 10.1016/j.molmet.2022.101650
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top