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  1. Article ; Online: Diagnostic Performance of a Comprehensive Risk Model for Posthepatectomy Liver Failure.

    Chung, Yong Eun

    Gut and liver

    2022  Volume 16, Issue 2, Page(s) 143–144

    MeSH term(s) Hepatectomy/adverse effects ; Humans ; Liver Failure/diagnosis ; Liver Failure/etiology ; Liver Failure/surgery ; Liver Neoplasms/surgery ; Postoperative Complications/etiology ; Postoperative Complications/surgery
    Language English
    Publishing date 2022-03-15
    Publishing country Korea (South)
    Document type Editorial
    ZDB-ID 2399010-7
    ISSN 2005-1212 ; 1976-2283
    ISSN (online) 2005-1212
    ISSN 1976-2283
    DOI 10.5009/gnl220066
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Erdheim-Chester Disease Involving the Biliary System and Mimicking Immunoglobulin G4-Related Disease: A Case Report.

    Hong, Hyuk Gi / Chung, Yong Eun / Park, June / Kim, Yeo Eun

    Journal of the Korean Society of Radiology

    2023  Volume 84, Issue 3, Page(s) 757–762

    Abstract: First described in 1930 as a lipoid granulomatosis, Erdheim-Chester disease (ECD) is a rare histiocytosis encompassing a group of disorders caused by overproduction of histiocytes, a subtype of white blood cells. This disease most commonly involves the ... ...

    Abstract First described in 1930 as a lipoid granulomatosis, Erdheim-Chester disease (ECD) is a rare histiocytosis encompassing a group of disorders caused by overproduction of histiocytes, a subtype of white blood cells. This disease most commonly involves the bones and can affect organs in the abdomen; however, biliary involvement is rarely reported. We report a case of ECD with biliary involvement, which rendered it difficult to radiologically distinguish ECD from immunoglobulin G4-related disease.
    Language English
    Publishing date 2023-05-28
    Publishing country Korea (South)
    Document type Case Reports
    ISSN 2951-0805
    ISSN (online) 2951-0805
    DOI 10.3348/jksr.2022.0114
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Prophylactic effect of pilocarpine on acute sialadenitis following radioactive iodine therapy in thyroid cancer patients.

    Choi, Eun Kyoung / Oh, Jin Kyoung / Chung, Yong-An / Jeong, Hyeonseok / Choi, Hoon / Jo, Kwanhoon

    International journal of medical sciences

    2024  Volume 21, Issue 3, Page(s) 492–495

    Abstract: Purpose: ...

    Abstract Purpose:
    MeSH term(s) Male ; Humans ; Female ; Middle Aged ; Thyroid Neoplasms/drug therapy ; Thyroid Neoplasms/radiotherapy ; Iodine Radioisotopes/adverse effects ; Pilocarpine/adverse effects ; Sialadenitis/etiology ; Sialadenitis/prevention & control ; Acute Disease ; Adenocarcinoma
    Chemical Substances Iodine Radioisotopes ; Pilocarpine (01MI4Q9DI3)
    Language English
    Publishing date 2024-01-01
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2151424-0
    ISSN 1449-1907 ; 1449-1907
    ISSN (online) 1449-1907
    ISSN 1449-1907
    DOI 10.7150/ijms.84590
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Safety of Administering Intravenous CT Contrast Agents Repeatedly or Using Both CT and MRI Contrast Agents on the Same Day: An Animal Study.

    Bae, Heejin / Oh, Hyewon / Park, Ga Bin / Chung, Yong Eun

    Korean journal of radiology

    2024  Volume 25, Issue 3, Page(s) 257–266

    Abstract: Objective: To investigate molecular and functional consequences of additional exposures to iodine- or gadolinium-based contrast agents within 24 hours from the initial intravenous administration of iodine-based contrast agents through an animal study.!## ...

    Abstract Objective: To investigate molecular and functional consequences of additional exposures to iodine- or gadolinium-based contrast agents within 24 hours from the initial intravenous administration of iodine-based contrast agents through an animal study.
    Materials and methods: Fifty-six Sprague-Dawley male rats were equally divided into eight groups: negative control, positive control (PC) with single-dose administration of CT contrast agent, and additional administration of either CT or MR contrast agents 2, 4, or 24 hours from initial CT contrast agent injection. A 12 µL/g of iodinated contrast agent or a 0.47 µL/g of gadolinium-based contrast agent were injected into the tail vein. Serum levels of blood urea nitrogen, creatinine, cystatin C (Cys C), and malondialdehyde (MDA) were measured. mRNA and protein levels of kidney injury molecule-1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) were evaluated.
    Results: Levels of serum creatinine (SCr) were significantly higher in repeated CT contrast agent injection groups than in PC (0.21 ± 0.02 mg/dL for PC; 0.40 ± 0.02, 0.34 ± 0.03, and 0.41 ± 0.10 mg/dL for 2-, 4-, and 24-hour interval groups, respectively;
    Conclusion: A sufficient time interval, probably more than 24 hours, between repeated contrast-enhanced CT examinations may be necessary to avoid deterioration in renal function. However, conducting contrast-enhanced MRI on the same day as contrast-enhanced CT may not induce clinically significant kidney injury.
    MeSH term(s) Rats ; Animals ; Male ; Contrast Media/adverse effects ; Lipocalin-2 ; Rats, Sprague-Dawley ; Gadolinium ; Kidney ; Acute Kidney Injury ; Magnetic Resonance Imaging ; Tomography, X-Ray Computed ; Administration, Intravenous ; RNA, Messenger ; Iodine ; Creatinine ; Biomarkers
    Chemical Substances Contrast Media ; Lipocalin-2 ; Gadolinium (AU0V1LM3JT) ; RNA, Messenger ; Iodine (9679TC07X4) ; Creatinine (AYI8EX34EU) ; Biomarkers
    Language English
    Publishing date 2024-02-25
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2046981-0
    ISSN 2005-8330 ; 1229-6929
    ISSN (online) 2005-8330
    ISSN 1229-6929
    DOI 10.3348/kjr.2023.0712
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Erdheim–Chester Disease Involving the Biliary System and Mimicking Immunoglobulin G4-Related Disease

    Hyuk Gi Hong / Yong Eun Chung / June Park / Yeo Eun Kim

    Journal of the Korean Society of Radiology, Vol 84, Iss 3, Pp 757-

    A Case Report

    2023  Volume 762

    Abstract: First described in 1930 as a lipoid granulomatosis, Erdheim-Chester disease (ECD) is a rare histiocytosis encompassing a group of disorders caused by overproduction of histiocytes, a subtype of white blood cells. This disease most commonly involves the ... ...

    Abstract First described in 1930 as a lipoid granulomatosis, Erdheim-Chester disease (ECD) is a rare histiocytosis encompassing a group of disorders caused by overproduction of histiocytes, a subtype of white blood cells. This disease most commonly involves the bones and can affect organs in the abdomen; however, biliary involvement is rarely reported. We report a case of ECD with biliary involvement, which rendered it difficult to radiologically distinguish ECD from immunoglobulin G4-related disease.
    Keywords erdheim-chester disease ; histiocytes ; immunoglobulin g4-related disease ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
    Language English
    Publishing date 2023-05-01T00:00:00Z
    Publisher The Korean Society of Radiology
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Lowering of Blood Glucose Levels with the Peptide Mixture Deglusterol in

    Kim, Eun Mi / Kim, Seon Soo / Chung, Yong Ji

    Journal of medicinal food

    2022  Volume 25, Issue 2, Page(s) 166–176

    Abstract: This study aimed to investigate the blood glucose-lowering effect of the peptide complex Deglusterol, which was isolated from corn extract, in insulin-resistance models. It was found to inhibit insulin receptor substrate (IRS) Ser302 phosphorylation, ... ...

    Abstract This study aimed to investigate the blood glucose-lowering effect of the peptide complex Deglusterol, which was isolated from corn extract, in insulin-resistance models. It was found to inhibit insulin receptor substrate (IRS) Ser302 phosphorylation, known as the insulin resistance mechanism, through the inhibition of tumor necrosis factor-
    Language English
    Publishing date 2022-02-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1427365-2
    ISSN 1557-7600 ; 1096-620X
    ISSN (online) 1557-7600
    ISSN 1096-620X
    DOI 10.1089/jmf.2021.K.0159
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Dual-Mode Graphene Field-Effect Transistor Biosensor with Isothermal Nucleic Acid Amplification.

    Kim, Hyo Eun / Schuck, Ariadna / Park, Hyeonseek / Chung, Doo Ryeon / Kang, Minhee / Kim, Yong-Sang

    Biosensors

    2024  Volume 14, Issue 2

    Abstract: Despite a substantial increase in testing facilities during the pandemic, access remains a major obstacle, particularly in low-resource and remote areas. This constraint emphasizes the need for high-throughput potential point-of-care diagnostic tools in ... ...

    Abstract Despite a substantial increase in testing facilities during the pandemic, access remains a major obstacle, particularly in low-resource and remote areas. This constraint emphasizes the need for high-throughput potential point-of-care diagnostic tools in environments with limited resources. Loop-mediated isothermal amplification (LAMP) is a promising technique, but improvements in sensitivity are needed for accurate detection, especially in scenarios where the virus is present in low quantities. To achieve this objective, we present a highly sensitive detection approach of a dual-mode graphene-based field-effect transistor (G-FET) biosensor with LAMP. The G-FET biosensor, which has a transparent graphene microelectrode array on a glass substrate, detects LAMP products in less than 30 min using both observable color changes and Dirac point voltage measurements, even in samples with low viral concentrations. This dual-mode G-FET biosensor emerges as a potential alternative to conventional RT-PCR for severe acute respiratory syndrome-associated coronavirus (SARS-CoV)-2 detection or point-of-care testing, particularly in resource-constrained scenarios such as developing countries. Moreover, its capacity for colorimetric detection with the naked eye enhances its applicability in diverse settings.
    MeSH term(s) Humans ; COVID-19 ; Graphite ; SARS-CoV-2/genetics ; Molecular Diagnostic Techniques/methods ; Nucleic Acid Amplification Techniques/methods ; Biosensing Techniques/methods ; Nucleic Acids ; Sensitivity and Specificity
    Chemical Substances Graphite (7782-42-5) ; Nucleic Acids
    Language English
    Publishing date 2024-02-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662125-3
    ISSN 2079-6374 ; 2079-6374
    ISSN (online) 2079-6374
    ISSN 2079-6374
    DOI 10.3390/bios14020091
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Impact of Cardiac Rehabilitation Health Insurance Coverage on Cardiac Rehabilitation Use in Korea Using an Interrupted Time Series.

    Park, Yu Shin / Song, In Sun / Jang, Suk-Yong / Nam, Chung Mo / Park, Eun-Cheol

    Journal of the American Heart Association

    2024  Volume 13, Issue 3, Page(s) e031395

    Abstract: Background: Since 2017, the cardiac rehabilitation (CR) program in Korea has been included in the coverage provided by the National Health Insurance to alleviate financial burden. Our study aimed to identify changes in the CR program use according to ... ...

    Abstract Background: Since 2017, the cardiac rehabilitation (CR) program in Korea has been included in the coverage provided by the National Health Insurance to alleviate financial burden. Our study aimed to identify changes in the CR program use according to the implementation of CR coverage.
    Methods and results: We obtained data from the electronic medical records of a tertiary hospital in Seoul, Korea from January 2014 to February 2020. Data from 2988 patients with acute coronary syndrome who underwent percutaneous coronary intervention were included. To examine the CR use trend among patients undergoing percutaneous coronary intervention, the electronic medical records data of the patients were aggregated quarterly, resulting in a maximum of 24 repeated measures for each patient. Segmented regression is often used to estimate the effects of interventions in an interrupted time series. Policy implementation led to a prompt increase in the probability of CR use (odds ratio [OR], 3.99 [95% CI, 2.89-5.51]). After the implementation of CR coverage, no significant change in CR use (OR, 0.97 [95% CI, 0.92-1.01]) was observed. After percutaneous coronary intervention, more patients opted for CR, especially those receiving education compared with exercise (education: OR, 87.44 [95% CI, 36.79-207.83] versus exercise: OR, 1.99 [95% CI, 1.43-2.76]).
    Conclusions: The implementation of CR coverage resulted in a rapid increase in the probability of CR use. Use of the educational program was higher than that of the exercise program. Given the persistently low use of CR, it is imperative to stimulate its adoption by increasing its availability.
    MeSH term(s) Humans ; Cardiac Rehabilitation/methods ; Interrupted Time Series Analysis ; Exercise ; Insurance Coverage ; Republic of Korea/epidemiology
    Language English
    Publishing date 2024-01-31
    Publishing country England
    Document type Journal Article
    ZDB-ID 2653953-6
    ISSN 2047-9980 ; 2047-9980
    ISSN (online) 2047-9980
    ISSN 2047-9980
    DOI 10.1161/JAHA.123.031395
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: New targeted therapy for Non-small cell lung cancer.

    Chung, Eun Ki / Yong, Seung Hyun / Lee, Eun Hye / Kim, Eun Young / Chang, Yoon Soo / Lee, Sang Hoon

    Tuberculosis and respiratory diseases

    2022  

    Abstract: Lung cancer ranks first in cancer mortality in Korea and in cancer incidence in Korean men. More than half of the Korean lung cancer patients are subjected to chemotherapy including adjuvant therapy. Cytotoxic agents, targeted therapy, and immune ... ...

    Abstract Lung cancer ranks first in cancer mortality in Korea and in cancer incidence in Korean men. More than half of the Korean lung cancer patients are subjected to chemotherapy including adjuvant therapy. Cytotoxic agents, targeted therapy, and immune checkpoint inhibitors are used in chemotherapy according to the biopsy and genetic test results. Among chemotherapy, the one that has developed rapidly is targeted therapy. The National Comprehensive Cancer Network (NCCN) guidelines have been updated recently for targeted therapy of multiple gene mutations, and targeted therapy is used not only for chemotherapy but also for adjuvant therapy. While previous targeted therapies have been developed for common genetic mutations, recent targeted therapies have been developed to overcome uncommon mutations or drug resistance that have occurred since the use of previous targeted treatments and have also been developed for gene mutations such as KRAS, which are common but have not been developed due to development difficulties. Therefore, in this study, we describe the recent, rapidly developing target agents.
    Language English
    Publishing date 2022-10-05
    Publishing country Korea (South)
    Document type Journal Article ; Review
    ZDB-ID 2161256-0
    ISSN 1738-3536 ; 0378-0066
    ISSN 1738-3536 ; 0378-0066
    DOI 10.4046/trd.2022.0066
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Dysfunction in parkin aggravates inflammatory bone erosion by reinforcing osteoclast activity.

    Kim, Eun-Young / Kim, Ji-Eun / Kim, Young-Eun / Choi, Bongkun / Sohn, Dong Hyun / Park, Si-On / Chung, Yeon-Ho / Kim, Yongsub / Robinson, William H / Kim, Yong-Gil / Chang, Eun-Ju

    Cell & bioscience

    2023  Volume 13, Issue 1, Page(s) 48

    Abstract: Background: Parkin dysfunction associated with the progression of parkinsonism contributes to a progressive systemic skeletal disease characterized by low bone mineral density. However, the role of parkin in bone remodeling has not yet been elucidated ... ...

    Abstract Background: Parkin dysfunction associated with the progression of parkinsonism contributes to a progressive systemic skeletal disease characterized by low bone mineral density. However, the role of parkin in bone remodeling has not yet been elucidated in detail.
    Result: We observed that decreased parkin in monocytes is linked to osteoclastic bone-resorbing activity. siRNA-mediated knockdown of parkin significantly enhanced the bone-resorbing activity of osteoclasts (OCs) on dentin without any changes in osteoblast differentiation. Moreover, Parkin-deficient mice exhibited an osteoporotic phenotype with a lower bone volume accompanied by increased OC-mediated bone-resorbing capacity displaying increased acetylation of α-tubulin compared to wild-type (WT) mice. Notably, compared to WT mice, the Parkin-deficient mice displayed increased susceptibility to inflammatory arthritis, reflected by a higher arthritis score and a marked bone loss after arthritis induction using K/BxN serum transfer, but not ovariectomy-induced bone loss. Intriguingly, parkin colocalized with microtubules and parkin-depleted-osteoclast precursor cells (Parkin
    Conclusion: These results indicate that a deficiency in the function of parkin caused by a decrease in parkin expression in OCPs under the inflammatory condition may enhance inflammatory bone erosion by altering microtubule dynamics to maintain OC activity.
    Language English
    Publishing date 2023-03-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2593367-X
    ISSN 2045-3701
    ISSN 2045-3701
    DOI 10.1186/s13578-023-00973-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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