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  1. Article ; Online: A Tribute to Michael R. Berman.

    Carter, Emily A / Johnson, Mark A / Leone, Stephen R

    The journal of physical chemistry. A

    2023  Volume 127, Issue 24, Page(s) 5083–5085

    Language English
    Publishing date 2023-06-16
    Publishing country United States
    Document type Journal Article
    ISSN 1520-5215
    ISSN (online) 1520-5215
    DOI 10.1021/acs.jpca.3c03071
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A Tribute to Michael R. Berman.

    Carter, Emily A / Johnson, Mark A / Leone, Stephen R

    The journal of physical chemistry. B

    2023  Volume 127, Issue 24, Page(s) 5371–5373

    Language English
    Publishing date 2023-06-22
    Publishing country United States
    Document type Journal Article
    ISSN 1520-5207
    ISSN (online) 1520-5207
    DOI 10.1021/acs.jpcb.3c03044
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  3. Article ; Online: The R

    Baum, Jake / Pasvol, Geoffrey / Carter, Richard

    Nature

    2020  Volume 582, Issue 7813, Page(s) 488

    MeSH term(s) Animals ; Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Culicidae ; Humans ; Malaria ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-06-23
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/d41586-020-01882-9
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 26: Show issues Location:
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    Zs.MO 244: Show issues

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  4. Article ; Online: Investigating investment in biopharmaceutical R&D.

    Carter, Percy H / Berndt, Ernst R / DiMasi, Joseph A / Trusheim, Mark

    Nature reviews. Drug discovery

    2016  Volume 15, Issue 10, Page(s) 673–674

    MeSH term(s) Animals ; Biopharmaceutics/economics ; Biopharmaceutics/trends ; Drug Industry/economics ; Drug Industry/trends ; Humans ; Investments/economics ; Investments/trends ; Research/economics ; Research/trends
    Language English
    Publishing date 2016-10
    Publishing country England
    Document type News
    ZDB-ID 2062954-0
    ISSN 1474-1784 ; 1474-1776
    ISSN (online) 1474-1784
    ISSN 1474-1776
    DOI 10.1038/nrd.2016.104
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    Zs.A 5564: Show issues Location:
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    Zs.MO 334: Show issues
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  5. Article ; Online: Researcher degrees of freedom in statistical software contribute to unreliable results: A comparison of nonparametric analyses conducted in SPSS, SAS, Stata, and R.

    Hodges, Cooper B / Stone, Bryant M / Johnson, Paula K / Carter, James H / Sawyers, Chelsea K / Roby, Patricia R / Lindsey, Hannah M

    Behavior research methods

    2022  Volume 55, Issue 6, Page(s) 2813–2837

    Abstract: ... and R and compared the results with those obtained through hand calculation using the raw ...

    Abstract Researcher degrees of freedom can affect the results of hypothesis tests and consequently, the conclusions drawn from the data. Previous research has documented variability in accuracy, speed, and documentation of output across various statistical software packages. In the current investigation, we conducted Pearson's chi-square test of independence, Spearman's rank-ordered correlation, Kruskal-Wallis one-way analysis of variance, Wilcoxon Mann-Whitney U rank-sum tests, and Wilcoxon signed-rank tests, along with estimates of skewness and kurtosis, on large, medium, and small samples of real and simulated data in SPSS, SAS, Stata, and R and compared the results with those obtained through hand calculation using the raw computational formulas. Multiple inconsistencies were found in the results produced between statistical packages due to algorithmic variation, computational error, and statistical output. The most notable inconsistencies were due to algorithmic variations in the computation of Pearson's chi-square test conducted on 2 × 2 tables, where differences in p-values reported by different software packages ranged from .005 to .162, largely as a function of sample size. We discuss how such inconsistencies may influence the conclusions drawn from the results of statistical analyses depending on the statistical software used, and we urge researchers to analyze their data across multiple packages to check for inconsistencies and report details regarding the statistical procedure used for data analysis.
    MeSH term(s) Humans ; Software ; Sample Size ; Research Design ; Chi-Square Distribution ; Correlation of Data
    Language English
    Publishing date 2022-08-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 231560-9
    ISSN 1554-3528 ; 0743-3808 ; 1554-351X
    ISSN (online) 1554-3528
    ISSN 0743-3808 ; 1554-351X
    DOI 10.3758/s13428-022-01932-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Kinetics, safety and tolerability of (R)-3-hydroxybutyl (R)-3-hydroxybutyrate in healthy adult subjects.

    Clarke, Kieran / Tchabanenko, Kirill / Pawlosky, Robert / Carter, Emma / Todd King, M / Musa-Veloso, Kathy / Ho, Manki / Roberts, Ashley / Robertson, Jeremy / Vanitallie, Theodore B / Veech, Richard L

    Regulatory toxicology and pharmacology : RTP

    2012  Volume 63, Issue 3, Page(s) 401–408

    Abstract: ... In this study, we determined the kinetic parameters, safety and tolerability of (R)-3-hydroxybutyl (R)-3 ... monoester dose. Together, these results suggest ingestion of (R)-3-hydroxybutyl (R)-3-hydroxybutyrate is ...

    Abstract Induction of mild states of hyperketonemia may improve physical and cognitive performance. In this study, we determined the kinetic parameters, safety and tolerability of (R)-3-hydroxybutyl (R)-3-hydroxybutyrate, a ketone monoester administered in the form of a meal replacement drink to healthy human volunteers. Plasma levels of β-hydroxybutyrate and acetoacetate were elevated following administration of a single dose of the ketone monoester, whether at 140, 357, or 714 mg/kg body weight, while the intact ester was not detected. Maximum plasma levels of ketones were attained within 1-2h, reaching 3.30 mM and 1.19 mM for β-hydroxybutyrate and acetoacetate, respectively, at the highest dose tested. The elimination half-life ranged from 0.8-3.1h for β-hydroxybutyrate and 8-14 h for acetoacetate. The ketone monoester was also administered at 140, 357, and 714 mg/kg body weight, three times daily, over 5 days (equivalent to 0.42, 1.07, and 2.14 g/kg/d). The ketone ester was generally well-tolerated, although some gastrointestinal effects were reported, when large volumes of milk-based drink were consumed, at the highest ketone monoester dose. Together, these results suggest ingestion of (R)-3-hydroxybutyl (R)-3-hydroxybutyrate is a safe and simple method to elevate blood ketone levels, compared with the inconvenience of preparing and consuming a ketogenic diet.
    MeSH term(s) Adolescent ; Adult ; Dietary Supplements ; Female ; Humans ; Hydroxybutyrates/administration & dosage ; Hydroxybutyrates/adverse effects ; Hydroxybutyrates/pharmacokinetics ; Ketones/blood ; Kinetics ; Male ; Middle Aged ; Young Adult
    Chemical Substances Hydroxybutyrates ; Ketones
    Language English
    Publishing date 2012-05-03
    Publishing country Netherlands
    Document type Clinical Trial ; Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 604672-1
    ISSN 1096-0295 ; 0273-2300
    ISSN (online) 1096-0295
    ISSN 0273-2300
    DOI 10.1016/j.yrtph.2012.04.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1711: Show issues Location:
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  7. Article ; Online: Oral 28-day and developmental toxicity studies of (R)-3-hydroxybutyl (R)-3-hydroxybutyrate.

    Clarke, Kieran / Tchabanenko, Kirill / Pawlosky, Robert / Carter, Emma / Knight, Nicholas S / Murray, Andrew J / Cochlin, Lowri E / King, M Todd / Wong, Andrea W / Roberts, Ashley / Robertson, Jeremy / Veech, Richard L

    Regulatory toxicology and pharmacology : RTP

    2012  Volume 63, Issue 2, Page(s) 196–208

    Abstract: R)-3-Hydroxybutyl (R)-3-hydroxybutyrate (ketone monoester) has been developed as an oral source ...

    Abstract (R)-3-Hydroxybutyl (R)-3-hydroxybutyrate (ketone monoester) has been developed as an oral source of ketones, which may be utilized for energy. In a 28-day toxicity study, Crl:WI (Wistar) rats received diets containing, as 30% of the calories, ketone monoester (12 and 15 g/kg body weight/day for male and female rats, respectively). Control groups received either carbohydrate- or fat-based diets. Rats in the test group consumed less feed and gained less weight than control animals; similar findings have been documented in studies of ketogenic diets. Between-group differences were noted in selected hematology, coagulation, and serum chemistry parameters; however, values were within normal physiological ranges and/or were not accompanied by other changes indicative of toxicity. Upon gross and microscopic evaluation, there were no findings associated with the ketone monoester. In a developmental toxicity study, pregnant Crl:WI (Han) rats were administered 2g/kg body weight/day ketone monoester or water (control) via gavage on days 6 through 20 of gestation. No Caesarean-sectioning or litter parameters were affected by the test article. The overall incidence of fetal alterations was higher in the test group; however, there were no specific alterations attributable to the test substance. The results of these studies support the safety of ketone monoester.
    MeSH term(s) Animals ; Diet ; Dietary Carbohydrates/administration & dosage ; Dietary Fats/administration & dosage ; Energy Intake ; Energy Metabolism/drug effects ; Esters ; Female ; Hydroxybutyrates/metabolism ; Hydroxybutyrates/toxicity ; Ketones/metabolism ; Ketones/toxicity ; Male ; Maternal Exposure/adverse effects ; Rats ; Rats, Wistar ; Reproduction/drug effects ; Toxicity Tests, Subacute
    Chemical Substances (R)-3-hydroxybutyl (R)-3-hydroxybutyrate ; Dietary Carbohydrates ; Dietary Fats ; Esters ; Hydroxybutyrates ; Ketones
    Language English
    Publishing date 2012-04-11
    Publishing country Netherlands
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 604672-1
    ISSN 1096-0295 ; 0273-2300
    ISSN (online) 1096-0295
    ISSN 0273-2300
    DOI 10.1016/j.yrtph.2012.04.001
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  8. Article ; Online: Constance E. Lieber, Theodore R. Stanley, and the Enduring Impact of Philanthropy on Psychiatry Research.

    Krystal, John H / Abi-Dargham, Anissa / Akbarian, Schahram / Arnsten, Amy F T / Barch, Deanna M / Bearden, Carrie E / Braff, David L / Brown, E Sherwood / Bullmore, Edward T / Carlezon, William A / Carter, Cameron S / Cook, Edwin H / Daskalakis, Zafiris Jeff / DiLeone, Ralph J / Duman, Ronald S / Grace, Anthony A / Hariri, Ahmad R / Harrison, Paul J / Hiroi, Noboru /
    Kenny, Paul J / Kleinman, Joel E / Krystal, Andrew D / Lewis, David A / Lipska, Barbara K / Marder, Stephen R / Mason, Graeme F / Mathalon, Daniel H / McClung, Colleen A / McDougle, Christopher J / McIntosh, Andrew M / McMahon, Francis J / Mirnics, Károly / Monteggia, Lisa M / Narendran, Rajesh / Nestler, Eric J / Neumeister, Alexander / O'Donovan, Michael C / Öngür, Dost / Pariante, Carmine M / Paulus, Martin P / Pearlson, Godfrey / Phillips, Mary L / Pine, Daniel S / Pizzagalli, Diego A / Pletnikov, Mikhail V / Ragland, J Daniel / Rapoport, Judith L / Ressler, Kerry J / Russo, Scott J / Sanacora, Gerard / Sawa, Akira / Schatzberg, Alan F / Shaham, Yavin / Shamay-Tsoory, Simone G / Sklar, Pamela / State, Matthew W / Stein, Murray B / Strakowski, Stephen M / Taylor, Stephan F / Turecki, Gustavo / Turetsky, Bruce I / Weissman, Myrna M / Zachariou, Venetia / Zarate, Carlos A / Zubieta, Jon-Kar

    Biological psychiatry

    2016  Volume 80, Issue 2, Page(s) 84–86

    Language English
    Publishing date 2016-02-23
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 209434-4
    ISSN 1873-2402 ; 0006-3223
    ISSN (online) 1873-2402
    ISSN 0006-3223
    DOI 10.1016/j.biopsych.2016.05.004
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    Zs.A 720: Show issues Location:
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  9. Article ; Online: Review of "The Relationship Between Surgeon Gender and Stress During the COVID-19 Pandemic" by Mavroudis CL, Landau S, Brooks E, Bergmark R, et al. Annals of Surgery 2021;273:625-629.

    McCarter, Jacob / Hollier, Larry H

    The Journal of craniofacial surgery

    2021  Volume 32, Issue 8, Page(s) e838

    MeSH term(s) COVID-19 ; Humans ; Pandemics ; SARS-CoV-2 ; Surgeons
    Language English
    Publishing date 2021-07-15
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1159501-2
    ISSN 1536-3732 ; 1049-2275
    ISSN (online) 1536-3732
    ISSN 1049-2275
    DOI 10.1097/SCS.0000000000007791
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    Zs.A 3761: Show issues Location:
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    Zs.MO 175: Show issues

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  10. Article ; Online: The GCaMP-R Family of Genetically Encoded Ratiometric Calcium Indicators.

    Cho, Jung-Hwa / Swanson, Carter J / Chen, Jeannie / Li, Ang / Lippert, Lisa G / Boye, Shannon E / Rose, Kasey / Sivaramakrishnan, Sivaraj / Chuong, Cheng-Ming / Chow, Robert H

    ACS chemical biology

    2017  Volume 12, Issue 4, Page(s) 1066–1074

    Abstract: We report on GCaMP-Rs, a new family of genetically encoded ratiometric calcium indicators that extend the virtues of the GCaMP proteins to ratiometric measurements. We have engineered a tandem construct of calcium-dependent GCaMP and calcium-independent ... ...

    Abstract We report on GCaMP-Rs, a new family of genetically encoded ratiometric calcium indicators that extend the virtues of the GCaMP proteins to ratiometric measurements. We have engineered a tandem construct of calcium-dependent GCaMP and calcium-independent mCherry fluorescent proteins. The tandem design assures that the two proteins localize in the same cellular compartment(s) and facilitates pixelwise ratiometric measurements; however, Förster resonance energy transfer (FRET) between the fluorophores reduces brightness of the sensor by up to half (depending on the GCaMP variant). To eliminate FRET, we introduced a rigid α-helix, the ER/K helix, between GCaMP and mCherry. Avoiding FRET significantly increases the brightness (notably, even at low calcium concentrations), the signal-to-noise ratio, and the dynamic range.
    MeSH term(s) Animals ; Calcium/metabolism ; Calibration ; Chickens ; Fluorescence Resonance Energy Transfer ; HEK293 Cells ; Humans ; Kinetics ; Luminescent Proteins/metabolism ; Red Fluorescent Protein
    Chemical Substances Luminescent Proteins ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2017-03-01
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ISSN 1554-8937
    ISSN (online) 1554-8937
    DOI 10.1021/acschembio.6b00883
    Database MEDical Literature Analysis and Retrieval System OnLINE

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