LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 81

Search options

  1. Book ; Online: First dialogue about opportunities and challenges for the Argentinian agriculture sector ; Diálogo de Innovación y Transformación sobre la Nueva Regulación Libre de Deforestación de la Unión Europea

    Doorn, Marnix / Fischer, Richard / Strub, Lea / Malessa, Ulrich

    2023  

    Keywords Text ; ddc:630
    Language English
    Publishing country de
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  2. Article ; Online: Nix interacts with WIPI2 to induce mitophagy.

    Bunker, Eric N / Le Guerroué, François / Wang, Chunxin / Strub, Marie-Paule / Werner, Achim / Tjandra, Nico / Youle, Richard J

    The EMBO journal

    2023  Volume 42, Issue 22, Page(s) e113491

    Abstract: Nix is a membrane-anchored outer mitochondrial protein that induces mitophagy. While Nix has an LC3-interacting (LIR) motif that binds to ATG8 proteins, it also contains a minimal essential region (MER) that induces mitophagy through an unknown mechanism. ...

    Abstract Nix is a membrane-anchored outer mitochondrial protein that induces mitophagy. While Nix has an LC3-interacting (LIR) motif that binds to ATG8 proteins, it also contains a minimal essential region (MER) that induces mitophagy through an unknown mechanism. We used chemically induced dimerization (CID) to probe the mechanism of Nix-mediated mitophagy and found that both the LIR and MER are required for robust mitophagy. We find that the Nix MER interacts with the autophagy effector WIPI2 and recruits WIPI2 to mitochondria. The Nix LIR motif is also required for robust mitophagy and converts a homogeneous WIPI2 distribution on the surface of the mitochondria into puncta, even in the absence of ATG8s. Together, this work reveals unanticipated mechanisms in Nix-induced mitophagy and the elusive role of the MER, while also describing an interesting example of autophagy induction that acts downstream of the canonical initiation complexes.
    MeSH term(s) Mitophagy ; Autophagy ; Mitochondria/metabolism ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Autophagy-Related Protein 8 Family/metabolism ; Mitochondrial Proteins/genetics ; Mitochondrial Proteins/metabolism
    Chemical Substances Membrane Proteins ; Autophagy-Related Protein 8 Family ; Mitochondrial Proteins
    Language English
    Publishing date 2023-08-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 586044-1
    ISSN 1460-2075 ; 0261-4189
    ISSN (online) 1460-2075
    ISSN 0261-4189
    DOI 10.15252/embj.2023113491
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1808: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 100: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article: Vascular dementia.

    Strub, Richard L

    The Ochsner journal

    2011  Volume 5, Issue 1, Page(s) 40–43

    Abstract: Many cases of age-related cognitive dementia are caused by cerebrovascular lesions, and various vascular syndromes can lead to cognitive impairment and dementia. Repeated cortical infarcts due to embolic disease of the heart or major cerebral vessels can ...

    Abstract Many cases of age-related cognitive dementia are caused by cerebrovascular lesions, and various vascular syndromes can lead to cognitive impairment and dementia. Repeated cortical infarcts due to embolic disease of the heart or major cerebral vessels can cause progressive deterioration towards dementia and incapacitation. In classic multi-infarct dementia, cognitive deterioration is stepwise rather than smoothly progressive. While diagnostic technologies have vastly improved and added to general knowledge of the pathology of cerebrovascular disease, MRI, PET, and transcranial Doppler scans have demonstrated that significant white matter change is possible without clinically recognized TIA or completed stroke. In addition, patients may have initial complaints that are not serious enough to produce changes on mental status examination. Many patients have mixed dementia, exhibiting aspects of both degenerative brain disease and clinical evidence of strokes or significant changes on MRI scan. The overlap between vascular and degenerative disease is significant, yet the exact interaction of the pathophysiology of the vascular lesions and the degenerative changes is not known. The treatment of vascular or mixed dementia involves control of the risk factors for continued vascular events and treatment with the cholinesterase inhibitors.
    Language English
    Publishing date 2011-10-12
    Publishing country United States
    Document type Journal Article
    ISSN 1524-5012
    ISSN 1524-5012
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Article ; Online: QuikSCAT Climatological Data Record

    Alexander G. Fore / Bryan W. Stiles / Paul Ted Strub / Richard D. West

    Remote Sensing, Vol 14, Iss 2487, p

    Land Contamination Flagging and Correction

    2022  Volume 2487

    Abstract: We develop, utilize, and validate techniques to produce a global data set of accurate coastal ocean surface vector winds. The dataset extends as near to the coast as 5 km and includes 10 years of SeaWinds on QuikSCAT ocean scatterometer data obtained ... ...

    Abstract We develop, utilize, and validate techniques to produce a global data set of accurate coastal ocean surface vector winds. The dataset extends as near to the coast as 5 km and includes 10 years of SeaWinds on QuikSCAT ocean scatterometer data obtained from 1999 to 2009. We demonstrate improved retrievals over other large land-locked bodies of water as well, such as the Caspian Sea and the Great lakes. To determine the coastal winds we quantify the extent of land contamination in each scatterometer backscatter measurement and to the extent possible remove that contamination. After the measurements are thus corrected we retrieve winds with the corrected measurements using a previously published algorithm which has been extensively used for JPL scatterometer wind products. The coastal processing vastly increases the number of wind vector cells near coasts. We have ten times the number of wind vectors within 10 km of coast as without coastal processing, and over twice as many at 20 km from coast. These new wind vectors are high-quality, and have zero effect on non-coastal wind vectors. The effect of residual land contamination is quantified by comparing to buoys at varying distance from the coast and comparing coastal wind vector cells to oceanward neighbors. We show that the non-coastal QuikSCAT processing has very few good wind vectors nearer to the coast than about 22.5 km. In comparison to buoys, and oceanward neighbors, we find a small increase in speed errors of these new coastal wind vectors versus the performance of non-coastal QuikSCAT at 22.5 km, indicating the high-quality of these new coastal wind vectors. A quality control scheme is employed that flags regions where the coastal wind retrieval is poor due to the assumptions inherent in the technique being locally invalid. The coastal winds retrieved in this manner have been publicly distributed to the oceanography community and utilized in other published works.
    Keywords scatterometery ; radar ; coastal winds ; ocean vector winds ; Science ; Q
    Subject code 551
    Language English
    Publishing date 2022-05-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  5. Book: Neurobehavioral disorders

    Strub, Richard L. / Black, F. William

    a clinical approach

    1988  

    Author's details Richard L. Strub ; F. William Black
    Keywords Delirium, Dementia, Amnestic, Cognitive Disorders ; Neuropsychiatrie
    Size XIV, 507 S. : Ill., graph. Darst.
    Edition 2. print.
    Publisher Davis
    Publishing place Philadelphia
    Publishing country United States
    Document type Book
    Old title 1. Aufl. u.d.T. Organic brain syndromes / Richard L. Strub
    F. W. Black
    HBZ-ID HT003535626
    ISBN 0-8036-8213-1 ; 978-0-8036-8213-9
    Database Catalogue ZB MED Medicine, Health

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1990 A 3809 order for loan Magazin

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: Upconversion in a d-f [RuYb

    Knighton, Richard C / Soro, Lohona K / Thor, Waygen / Strub, Jean-Marc / Cianférani, Sarah / Mély, Yves / Lenertz, Marc / Wong, Ka-Leung / Platas-Iglesias, Carlos / Przybilla, Frédéric / Charbonnière, Loïc J

    Journal of the American Chemical Society

    2022  Volume 144, Issue 29, Page(s) 13356–13365

    Abstract: We have prepared a hetero-tetrametallic assembly consisting of three ytterbium ions coordinated to a central [Ru(bpm) ...

    Abstract We have prepared a hetero-tetrametallic assembly consisting of three ytterbium ions coordinated to a central [Ru(bpm)
    MeSH term(s) Energy Transfer ; Ions ; Ytterbium
    Chemical Substances Ions ; Ytterbium (MNQ4O4WSI1)
    Language English
    Publishing date 2022-06-30
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.2c05037
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Bonn / Germany

    Z 4' 55/32: Show issues
    Z 7.3: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  7. Article: Vascular dementia.

    Strub, Richard

    Southern medical journal

    2003  Volume 96, Issue 4, Page(s) 363–366

    MeSH term(s) Cognition Disorders/etiology ; Dementia, Vascular/classification ; Dementia, Vascular/etiology ; Dementia, Vascular/physiopathology ; Humans ; Hypertension/complications ; Risk Factors ; Tomography, X-Ray Computed
    Language English
    Publishing date 2003-04
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 185329-6
    ISSN 1541-8243 ; 0038-4348
    ISSN (online) 1541-8243
    ISSN 0038-4348
    DOI 10.1097/01.SMJ.0000063470.95541.6B
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.117: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 336: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Book: The mental status examination in neurology

    Strub, Richard L. / Black, F. William

    1987  

    Author's details Richard L. Strub, F. William Black
    Keywords Nervous System Diseases / diagnosis ; Neurologic Examination ; Kopfschmerz ; Neuropsychologie
    Subject Cephalaea ; Cephalgia ; Kopfschmerzen
    Size XI, 232 S. : Ill., graph. Darst.
    Edition 2. ed., 3. print.
    Publisher Davis
    Publishing place Philadelphia
    Publishing country United States
    Document type Book
    HBZ-ID HT003369651
    ISBN 0-8036-8211-5 ; 978-0-8036-8211-5
    Database Catalogue ZB MED Medicine, Health

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1989 A 4173 order for loan Magazin

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Book: Neurologische Entscheidungen

    Weisberg, Leon A. / Strub, Richard L. / Garcia, Carlos A. / Petrovici, Jon N.

    (Die original Decision-making-Reihe)

    1995  

    Author's details Weisberg ; Strub ; Garcia
    Series title Die original Decision-making-Reihe
    Keywords Nervous System Diseases / diagnosis ; Decision Making ; Nervensystem ; Krankheit ; Diagnose ; Entscheidungsfindung ; Flussdiagramm
    Subject Ablaufdiagramm ; Ablaufplan ; Flow-chart ; Flussplan ; Programmablaufplan ; Programmstruktur ; Programmstrukturplan ; Ärztliche Diagnose ; Erkrankung ; Krankheitszustand ; Krankheiten ; Morbus ; Nosos ; Pathos ; Systema nervosum ; NS
    Language German
    Size VII, 318 S. : Ill.
    Edition Dt. Ausg.
    Publisher Ullstein Mosby
    Publishing place Berlin u.a.
    Document type Book
    Note Aus dem Engl. übers.
    HBZ-ID HT006703976
    ISBN 3-86126-076-X ; 978-3-86126-076-9
    Database Catalogue ZB MED Medicine, Health

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1996 A 3025 order for loan Magazin

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Book ; Online: The Edge of Orthogonality

    Richemond, Pierre H. / Tam, Allison / Tang, Yunhao / Strub, Florian / Piot, Bilal / Hill, Felix

    A Simple View of What Makes BYOL Tick

    2023  

    Abstract: Self-predictive unsupervised learning methods such as BYOL or SimSiam have shown impressive results, and counter-intuitively, do not collapse to trivial representations. In this work, we aim at exploring the simplest possible mathematical arguments ... ...

    Abstract Self-predictive unsupervised learning methods such as BYOL or SimSiam have shown impressive results, and counter-intuitively, do not collapse to trivial representations. In this work, we aim at exploring the simplest possible mathematical arguments towards explaining the underlying mechanisms behind self-predictive unsupervised learning. We start with the observation that those methods crucially rely on the presence of a predictor network (and stop-gradient). With simple linear algebra, we show that when using a linear predictor, the optimal predictor is close to an orthogonal projection, and propose a general framework based on orthonormalization that enables to interpret and give intuition on why BYOL works. In addition, this framework demonstrates the crucial role of the exponential moving average and stop-gradient operator in BYOL as an efficient orthonormalization mechanism. We use these insights to propose four new \emph{closed-form predictor} variants of BYOL to support our analysis. Our closed-form predictors outperform standard linear trainable predictor BYOL at $100$ and $300$ epochs (top-$1$ linear accuracy on ImageNet).
    Keywords Computer Science - Machine Learning
    Subject code 519
    Publishing date 2023-02-09
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top