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  1. Book ; Online: Atherosclerosis, large arteries and cardiovascular risk

    Safar, Michel E.

    new perspectives for the prevention and treatment of cardiovascular events

    2007  

    Author's details vol. ed.: Michel E. Safar
    Language English
    Size VIII + 360 S.
    Publisher Karger
    Publishing place Basel
    Publishing country Switzerland
    Document type Book ; Online
    HBZ-ID TT050388034
    ISBN 978-3-318-01395-5 ; 3-318-01395-1
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

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  2. Book: Arterial stiffness in hypertension

    Safar, Michel E.

    (Handbook of hypertension ; 23)

    2006  

    Author's details ed. M. E. Safar
    Series title Handbook of hypertension ; 23
    Collection
    Language English
    Size XIX, 598 S. : Ill., graph. Darst.
    Publisher Elsevier
    Publishing place Edinburgh u.a.
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT014642986
    ISBN 0-444-51758-8 ; 978-0-444-51758-6
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2006 A 1861 order for loan Magazin

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  3. Article ; Online: Current assessment of pulse wave velocity: comprehensive review of validation studies.

    Safar, Michel E

    Journal of hypertension

    2019  Volume 38, Issue 1, Page(s) 178

    MeSH term(s) Blood Flow Velocity ; Blood Pressure ; Pulse Wave Analysis
    Language English
    Publishing date 2019-12-02
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 605532-1
    ISSN 1473-5598 ; 0263-6352 ; 0952-1178
    ISSN (online) 1473-5598
    ISSN 0263-6352 ; 0952-1178
    DOI 10.1097/HJH.0000000000002261
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1885: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 614: Show issues

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  4. Book: Atherosclerosis, large arteries and cardiovascular risk

    Safar, Michel E.

    29 tables

    (Advances in cardiology ; 44)

    2007  

    Author's details vol. ed. Michel E. Safar
    Series title Advances in cardiology ; 44
    Collection
    Keywords Arteriosklerose ; Pathophysiologie ; Kardiovaskuläre Krankheit ; Risikofaktor
    Subject Risikofaktoren ; Herz-Kreislauf-Krankheit ; Herz-Kreislauf-Erkrankung ; Kardiovaskuläres System ; Cardiovasculäre Krankheit ; Kardiovaskuläre Krankheiten ; Pathologische Physiologie ; Physiologische Pathologie ; Physiopathologie ; Arterienverkalkung ; Atherosklerose ; Arteriosclerosis
    Language English
    Size VIII, 359 S. : Ill., graph. Darst., 245 mm x 175 mm
    Publisher Karger
    Publishing place Basel u.a.
    Publishing country Switzerland
    Document type Book
    HBZ-ID HT014912137
    ISBN 978-3-8055-8176-9 ; 3-8055-8176-9
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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    2007 A 87 order for loan Magazin

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  5. Article ; Online: A Short Insight on 2 Different Aspects of Arterial Stiffness.

    Safar, Michel E

    American journal of hypertension

    2017  Volume 30, Issue 4, Page(s) e1–e2

    MeSH term(s) Arteries ; Risk Factors ; Vascular Stiffness
    Language English
    Publishing date 2017-01-04
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 639383-4
    ISSN 1941-7225 ; 1879-1905 ; 0895-7061
    ISSN (online) 1941-7225 ; 1879-1905
    ISSN 0895-7061
    DOI 10.1093/ajh/hpw166
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2329: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  6. Book: Blood pressure and arterial wall mechanics in cardiovascular diseases

    Safar, Michel E. / O'Rourke, Michael F. / Frohlich, Edward D.

    (Cardiology)

    2014  

    Author's details Michel E. Safar, Michael F. O'Rourke, Edward D. Frohlich ed
    Series title Cardiology
    Keywords Cardiovascular system/Diseases ; Blood pressure ; Arteries/Physiology
    Subject code 616.13
    Language English
    Size XX, 567 S. : Ill., graf. Darst., illustrations (black and white, and colour), 26 cm
    Publisher Springer
    Publishing place London
    Publishing country Great Britain
    Document type Book
    Note Includes bibliographical references
    HBZ-ID HT018378436
    ISBN 978-1-4471-5197-5 ; 9781447151982 ; 1-4471-5197-6 ; 1447151984
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2014 A 3431 available for loan (reading room) Lesesaal EG

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  7. Article ; Online: The Age–Stiffness Relationships of Elastic and Muscular Arteries in a Control Population and in End-Stage Renal Disease Patients

    Gerard M. London / Michel E. Safar / Bruno Pannier

    Kidney and Dialysis, Vol 3, Iss 3, Pp 36-

    2023  Volume 45

    Abstract: Arterial dysfunction is major risk factor for cardiovascular complications, and arterial stiffness is an independent risk factor in end-stage renal disease patients. As the distance from the heart increases, arterial stiffness (pulse wave velocity) ... ...

    Abstract Arterial dysfunction is major risk factor for cardiovascular complications, and arterial stiffness is an independent risk factor in end-stage renal disease patients. As the distance from the heart increases, arterial stiffness (pulse wave velocity) becomes progressively more marked. This generates a centrifugal stiffness gradient, which leads to partial, continuous local wave reflections, which in turn attenuate the transmission of pulsatile pressure into the microcirculation, thus limiting the potentially deleterious outcomes both upstream (on the heart: left-ventricular hypertrophy and coronary perfusion) and downstream (on the renal and cerebral microcirculation: reduced glomerular filtration and impaired cognitive functions). The impact of arterial aging is greater on the aorta and central capacitive arteries, and it is characterized by a loss or reversal of the physiological stiffness gradient between central and peripheral arteries. Recently, however, in contrast to observations on the aorta, several studies have shown less pronounced, absent, or even negative associations between muscular peripheral arteries and age–stiffness relationships, which may be associated with a decrease in or reversal of the stiffness gradient. These findings point to a potential benefit of assessing the muscular peripheral arteries to predict the risk of cardiovascular disease and suggest that reversal of the stiffness gradient may be an independent risk factor for all-cause mortality.
    Keywords arterial aging ; arterial stiffness ; elastic arteries ; muscular arteries ; Internal medicine ; RC31-1245
    Subject code 610
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

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  8. Article ; Conference proceedings: Fourth Workshop on Structure and Function of Large Arteries

    Safar, Michel E.

    April 27 and 28, 2001

    2001  

    Institution Workshop on Structure and Function of Large Arteries
    Author's details Michel E. Safar, guest ed
    Keywords Arteries / anatomy & histology / congresses ; Arteries / physiology / congresses
    Language English
    Publishing country United States
    Document type Article ; Conference proceedings
    Note In: Hypertension. - ISSN 0194-911X. - 38 (2001),4, S. 913 - 961; 5, S. 1150 - 1197
    HBZ-ID HT013194863
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 1488 -38- not available for loan Zeitschriften-Lesesaal

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  9. Article ; Online: Arterial stiffness as a risk factor for clinical hypertension.

    Safar, Michel E

    Nature reviews. Cardiology

    2017  Volume 15, Issue 2, Page(s) 97–105

    Abstract: In patients with uncomplicated essential hypertension, cardiac output remains within normal ranges and intravascular volume is normal or low, assuming the presence of a sufficient Windkessel effect and usual resistance and compliance calculations. ... ...

    Abstract In patients with uncomplicated essential hypertension, cardiac output remains within normal ranges and intravascular volume is normal or low, assuming the presence of a sufficient Windkessel effect and usual resistance and compliance calculations. However, mean circulatory pressure is elevated in these patients. In addition, vascular resistance is augmented, and most importantly, the viscoelasticity of the cardiovascular system is substantially impaired. Such considerations are essential to understanding the mechanisms behind carotid-femoral arterial stiffness, a major risk factor in individuals with hypertension. Arterial stiffness, measured from pulse wave velocity, is substantially increased in hypertension even independently of blood pressure levels. Structural vascular changes and endothelial dysfunction are consistently associated with vessel impairments in animal models of hypertension. Increased arterial stiffness has a major effect on pulse pressure (the difference between systolic and diastolic blood pressure), wave reflections, kidney function, and above all, cardiovascular risk. This increased cardiovascular risk is particularly deleterious in patients with hypertension and/or type 2 diabetes mellitus, who are at risk of both renal and cardiovascular events. In this Review, we discuss the importance of arterial stiffness in the diagnosis and management of hypertension and the need for new approaches for the treatment of hypertension in patients with or without diabetes and/or renal impairment.
    MeSH term(s) Animals ; Antihypertensive Agents/therapeutic use ; Arterial Pressure/drug effects ; Cardiac Output ; Essential Hypertension/diagnosis ; Essential Hypertension/drug therapy ; Essential Hypertension/epidemiology ; Essential Hypertension/physiopathology ; Humans ; Models, Cardiovascular ; Pulse Wave Analysis ; Risk Assessment ; Risk Factors ; Treatment Outcome ; Vascular Stiffness/drug effects
    Chemical Substances Antihypertensive Agents
    Language English
    Publishing date 2017-10-12
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2490375-9
    ISSN 1759-5010 ; 1759-5002
    ISSN (online) 1759-5010
    ISSN 1759-5002
    DOI 10.1038/nrcardio.2017.155
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6019: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 98: Show issues

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  10. Article ; Online: A reappraisal of clinical research on arterial stiffness in hypertension in France.

    Safar, Michel E

    Journal of the American Society of Hypertension : JASH

    2016  Volume 10, Issue 6, Page(s) 482–488

    MeSH term(s) Blood Pressure ; France ; Hypertension/physiopathology ; Risk Factors ; Vascular Stiffness
    Language English
    Publishing date 2016-05-14
    Publishing country United States
    Document type Editorial
    ZDB-ID 2276144-5
    ISSN 1878-7436 ; 1933-1711
    ISSN (online) 1878-7436
    ISSN 1933-1711
    DOI 10.1016/j.jash.2016.04.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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