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Article: Harry L. Reynolds, Jr., M.D.

Beck, David E

(Rectal Cancer)

2007 Volume 20, Issue 03, Page(s) 139–139

Series title	Rectal Cancer
Language	English
Publishing date	2007-07-31
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	2072321-0
ISSN	1530-9681 ; 1531-0043
ISSN (online)	1530-9681
ISSN	1531-0043
DOI	10.1055/s-2007-984856
Database	Thieme publisher's database

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Article ; Online: Dietary phosphorus consumption alters T cell populations, cytokine production, and bone volume in mice

Joseph L. Roberts / Mingcan Yu / Manjula Viggeswarapu / Jamie L. Arnst / Roberto Pacifici / George R. Beck Jr

JCI Insight, Vol 8, Iss

2023 Volume 10

Abstract: The intake of dietary phosphate far exceeds recommended levels; however, the long-term health consequences remain relatively unknown. Here, the chronic physiological response to sustained elevated and reduced dietary phosphate consumption was ... ...

Abstract	The intake of dietary phosphate far exceeds recommended levels; however, the long-term health consequences remain relatively unknown. Here, the chronic physiological response to sustained elevated and reduced dietary phosphate consumption was investigated in mice. Although serum phosphate levels were brought into homeostatic balance, the prolonged intake of a high-phosphate diet dramatically and negatively impacted bone volume; generated a sustained increase in the phosphate responsive circulating factors FGF23, PTH, osteopontin and osteocalcin; and produced a chronic low-grade inflammatory state in the BM, marked by increased numbers of T cells expressing IL-17a, RANKL, and TNF-α. In contrast, a low-phosphate diet preserved trabecular bone while increasing cortical bone volume over time, and it reduced inflammatory T cell populations. Cell-based studies identified a direct response of T cells to elevated extracellular phosphate. Neutralizing antibodies against proosteoclastic cytokines RANKL, TNF-α, and IL-17a blunted the high-phosphate diet–induced bone loss identifying bone resorption as a regulatory mechanism. Collectively, this study illuminates that habitual consumption of a high-phosphate diet in mice induces chronic inflammation in bone, even in the absence of elevated serum phosphate. Furthermore, the study supports the concept that a reduced phosphate diet may be a simple yet effective strategy to reduce inflammation and improve bone health during aging.
Keywords	Bone biology ; Medicine ; R
Subject code	616
Language	English
Publishing date	2023-05-01T00:00:00Z
Publisher	American Society for Clinical investigation
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Quasistatic Solutions versus Full-Wave Solutions of Single-Channel Circular RF Receive Coils on Phantoms of Varying Conductivities at 3 Tesla.

Beck, Michael J / Parker, Dennis L / Hadley, J Rock

Concepts in magnetic resonance. Part B, Magnetic resonance engineering

2021 Volume 2021

Abstract: Purpose: Although full-wave simulations could be used to aid in RF coil design, the algorithms may be too slow for an iterative optimization algorithm. If quasistatic simulations are accurate within the design tolerance, then their use could reduce ... ...

Abstract	Purpose: Although full-wave simulations could be used to aid in RF coil design, the algorithms may be too slow for an iterative optimization algorithm. If quasistatic simulations are accurate within the design tolerance, then their use could reduce simulation time by orders of magnitude compared to full-wave simulations. This paper examines the accuracy of quasistatic and full-wave simulations at 3 Tesla. Methods: Three sets of eight coils ranging from 3-10 cm (24 total) were used to measure SNR on three phantoms with conductivities of 0.3, 0.6, and 0.9 S/m. The phantom conductivities were chosen to represent those typically found in human tissues. The range of coil element sizes represents the sizes of coil elements seen in typical coil designs. SNR was determined using the magnetic and electric fields calculated by quasistatic and full-wave simulations. Each simulated SNR dataset was scaled to minimize the root mean squared error (RMSE) when compared against measured SNR data. In addition, the noise values calculated by each simulation were compared against benchtop measured noise values. Results: The RMSE was 0.285 and 0.087 for the quasistatic and full-wave simulations, respectively. The maximum and minimum quotient values, when taking the ratio of simulated to measured SNR values, were 1.69 and 0.20 for the quasistatic simulations and 1.29 and 0.75 for the full-wave simulations, respectively. The ratio ranges, for the calculated quasistatic and full-wave total noise values compared to benchtop measured noise values, were 0.83-1.06 and 0.27-3.02, respectively. Conclusions: Full-wave simulations were on average 3x more accurate than the quasistatic simulations. Full-wave simulations were more accurate in characterizing the wave effects within the sample, though they were not able to fully account for the skin effect when calculating coil noise.
Language	English
Publishing date	2021-04-29
Publishing country	England
Document type	Journal Article
ZDB-ID	2113479-0
ISSN	1552-504X ; 1552-5031
ISSN (online)	1552-504X
ISSN	1552-5031
DOI	10.1155/2021/6638576
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Article: Capacitive versus Overlap Decoupling of Adjacent Radio Frequency Phased Array Coil Elements: An Imaging Robustness Comparison When Sample Load Varies for 3 Tesla MRI.

Beck, Michael J / Parker, Dennis L / Hadley, J Rock

Concepts in magnetic resonance. Part B, Magnetic resonance engineering

2020 Volume 2020

Abstract: Phased array (PA) receive coils are built such that coil elements approximate independent antenna behavior. One method of achieving this goal is to use an available decoupling method to decouple adjacent coil elements. The purpose of this work was to ... ...

Abstract	Phased array (PA) receive coils are built such that coil elements approximate independent antenna behavior. One method of achieving this goal is to use an available decoupling method to decouple adjacent coil elements. The purpose of this work was to compare the relative performance of two decoupling methods as a function of variation in sample load. Two PA receive coils with 5 channels (5-ch) each, equal outer dimensions, and formed on 12 cm diameter cylindrical phantoms of conductivities 0.3, 0.6, and 0.9 S/m were evaluated for relative signal-to-noise ratio (SNR) and parallel imaging performance. They were only tuned and matched to the 0.6 S/m phantom. Simulated and measured axial, sagittal, and coronal 5-ch PA coil SNR ratios were compared by dividing the overlap by the capacitive decoupled coil SNR results. Issues related to the selection of capacitor values for the two decoupling methods were evaluated by taking the ratio of the match and tune capacitors for large and small 2 channel (2-ch) PA coils. The SNR ratios showed that the SNR of the two decoupling methods were very similar. The inverse geometry-factor maps showed similar but better overall parallel imaging performance for the capacitive decoupled method. The quotients for the 2-ch PA coils' maximum and minimum capacitor value ratios are 3.28 and 1.38 for the large and 3.28 and 2.22 for the small PA. The results of this paper demonstrate that as the sample load varies, the capacitive and overlap decoupling methods are very similar in relative SNR and this similarity continues for parallel imaging performance. Although, for the 5-ch coils studied, the capacitive decoupling method has a slight SNR and parallel imaging advantage and it was noted that the capacitive decoupled coil is more likely to encounter unbuildable PA coil configurations.
Language	English
Publishing date	2020-12-15
Publishing country	England
Document type	Journal Article
ZDB-ID	2113479-0
ISSN	1552-504X ; 1552-5031
ISSN (online)	1552-504X
ISSN	1552-5031
DOI	10.1155/2020/8828047
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Article ; Online: Reduced Achilles Tendon Stiffness Disrupts Calf Muscle Neuromechanics in Elderly Gait.

Krupenevich, Rebecca L / Beck, Owen N / Sawicki, Gregory S / Franz, Jason R

Gerontology

2021 Volume 68, Issue 3, Page(s) 241–251

Abstract: Older adults walk slower and with a higher metabolic energy expenditure than younger adults. In this review, we explore the hypothesis that age-related declines in Achilles tendon stiffness increase the metabolic cost of walking due to less economical ... ...

Abstract	Older adults walk slower and with a higher metabolic energy expenditure than younger adults. In this review, we explore the hypothesis that age-related declines in Achilles tendon stiffness increase the metabolic cost of walking due to less economical calf muscle contractions and increased proximal joint work. This viewpoint may motivate interventions to restore ankle muscle-tendon stiffness, improve walking mechanics, and reduce metabolic cost in older adults.
MeSH term(s)	Achilles Tendon/physiology ; Aged ; Ankle/physiology ; Ankle Joint/physiology ; Biomechanical Phenomena/physiology ; Gait/physiology ; Humans ; Muscle, Skeletal/physiology ; Walking/physiology
Language	English
Publishing date	2021-07-16
Publishing country	Switzerland
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	193798-4
ISSN	1423-0003 ; 0304-324X
ISSN (online)	1423-0003
ISSN	0304-324X
DOI	10.1159/000516910
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Article ; Online: Acute exercise performed before and after motor practice enhances the positive effects on motor memory consolidation.

Jespersen, Lasse / Maes, Katrine Matlok / Ardenkjær-Skinnerup, Nicoline / Roig, Marc / Bjørndal, Jonas Rud / Beck, Mikkel Malling / Lundbye-Jensen, Jesper

Neurobiology of learning and memory

2023 Volume 205, Page(s) 107830

Abstract: Performing a single bout of exercise can enhance motor learning and long-term retention of motor skills. Parameters such as the intensity and when the exercise bout is performed in relation to skill practice (i.e., timing) likely influence the ... ...

Abstract	Performing a single bout of exercise can enhance motor learning and long-term retention of motor skills. Parameters such as the intensity and when the exercise bout is performed in relation to skill practice (i.e., timing) likely influence the effectiveness. However, it is still not fully understood how exercise should be administered to maximize its effects and how exercise interacts with distinct components of skill learning. Here, we expand this knowledge by investigating the potential synergistic effects of performing acute exercise both prior to and following motor practice. Sixty-four, able-bodied, young adult male participants practiced a sequential visuomotor accuracy tracking (SVAT) task requiring rapid and accurate force modulation and high levels of precision control using intrinsic hand muscles. The task also contained a repeated pattern of targets that allowed sequence-specific skill improvements. Sequential and non-sequential motor performance was assessed at baseline, immediately after motor practice, and again seven days later. One group performed moderate-intensity exercise before practice (PRE
MeSH term(s)	Young Adult ; Humans ; Male ; Memory Consolidation/physiology ; Exercise/physiology ; Learning/physiology ; Motor Skills/physiology
Language	English
Publishing date	2023-09-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	1223366-3
ISSN	1095-9564 ; 1074-7427
ISSN (online)	1095-9564
ISSN	1074-7427
DOI	10.1016/j.nlm.2023.107830
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Article ; Online: Impact of impaired awareness of hypoglycemia on glucose decline during and after exercise in T1D: The T1DEXI Study.

Kamimoto, Jorge L Jo / Li, Zoey / Gal, Robin L / Castle, Jessica R / Doyle, Francis J / Jacobs, Peter G / Martin, Corby K / Beck, Roy W / Calhoun, Peter / Riddell, Michael C / Rickels, Michael R

The Journal of clinical endocrinology and metabolism

2024

Abstract: ... mmol/L], adjusted group difference of -4.2 [95% CI: -8.4 to 0.05] mg/dL [-0.23 95% CI: -0.47 to 0.003 ... mmol/L], P = 0.051). Individuals with IAH had higher proportion of days with hypoglycemic events <70 mg ... dL[3.89 mmol/L] (≥15 minutes <70 mg/dL[<3.89 mmol/L]) both on exercise days (51% vs. 43%, P = 0.006 ...

Abstract	Objective: To assess whether impaired awareness of hypoglycemia (IAH) affects exercise-associated hypoglycemia in adults with type 1 diabetes (T1D). Methods: We compared continuous glucose monitoring (CGM)-measured glucose during exercise and for 24-hours following exercise from 95 adults with T1D and IAH (Clarke score ≥4 or ≥1 severe hypoglycemic event within the past year) to 95 'Aware' adults (Clarke score ≤2 and no severe hypoglycemic event within the past year) matched on sex, age, insulin delivery modality, and HbA1c. A total of 4,236 exercise sessions, and 1,794 exercise days and 839 sedentary days, defined as 24-hours following exercise or a day without exercise, respectively, were available for analysis. Results: Participants with IAH exhibited a non-significant trend towards greater decline in glucose during exercise compared to 'Aware' (-21 ± 44 vs. -19 ± 43 mg/dL [-1.17 ± 2.44 vs. -1.05 ± 2.39 mmol/L], adjusted group difference of -4.2 [95% CI: -8.4 to 0.05] mg/dL [-0.23 95% CI: -0.47 to 0.003 mmol/L], P = 0.051). Individuals with IAH had higher proportion of days with hypoglycemic events <70 mg/dL[3.89 mmol/L] (≥15 minutes <70 mg/dL[<3.89 mmol/L]) both on exercise days (51% vs. 43%, P = 0.006) and sedentary days (48% vs. 30%, P = 0.001). The increased odds of experiencing a hypoglycemic event <70 mg/dL[<3.89 mmol/L] for individuals with IAH compared to 'Aware' did not differ significantly between exercise and sedentary days (interaction P = 0.36). Conclusion: Individuals with IAH have a higher underlying risk of hypoglycemia than 'Aware' individuals. Exercise does not appear to differentially increase risk for hypoglycemia during the activity, or in the subsequent 24-hours for IAH compared to Aware individuals with T1D.
Language	English
Publishing date	2024-03-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	3029-6
ISSN	1945-7197 ; 0021-972X
ISSN (online)	1945-7197
ISSN	0021-972X
DOI	10.1210/clinem/dgae115
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Article ; Online: Factors Affecting Reproducibility of Change in Glucose During Exercise: Results From the Type 1 Diabetes and EXercise Initiative.

Li, Zoey / Calhoun, Peter / Rickels, Michael R / Gal, Robin L / Beck, Roy W / Jacobs, Peter G / Clements, Mark A / Patton, Susana R / Castle, Jessica R / Martin, Corby K / Gillingham, Melanie B / Doyle, Francis J / Riddell, Michael C

Journal of diabetes science and technology

2024 , Page(s) 19322968241234687

Abstract: Aims: To evaluate factors affecting within-participant reproducibility in glycemic response to different forms of exercise.: Methods: Structured exercise sessions ~30 minutes in length from the Type 1 Diabetes Exercise Initiative (T1DEXI) study were ... ...

Abstract	Aims: To evaluate factors affecting within-participant reproducibility in glycemic response to different forms of exercise. Methods: Structured exercise sessions ~30 minutes in length from the Type 1 Diabetes Exercise Initiative (T1DEXI) study were used to assess within-participant glycemic variability during and after exercise. The effect of several pre-exercise factors on the within-participant glycemic variability was evaluated. Results: Data from 476 adults with type 1 diabetes were analyzed. A participant's change in glucose during exercise was reproducible within 15 mg/dL of the participant's other exercise sessions only 32% of the time. Participants who exercised with lower and more consistent glucose level, insulin on board (IOB), and carbohydrate intake at exercise start had less variability in glycemic change during exercise. Participants with lower mean glucose ( Conclusions: Reproducibility of change in glucose during exercise was low in this cohort of adults with T1D, but more consistency in pre-exercise glucose levels, IOB, and carbohydrates may increase this reproducibility. Mean glucose variability in the 24 hours after exercise is influenced more by the participant's overall glycemic control than other modifiable factors.
Language	English
Publishing date	2024-03-08
Publishing country	United States
Document type	Journal Article
ISSN	1932-2968
ISSN (online)	1932-2968
DOI	10.1177/19322968241234687
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Article ; Online: Influence of endocrine multidisciplinary tumor board on patient management and treatment decision making.

Kelley, Sarah / Beck, Anna C / Weigel, Ronald J / Howe, James R / Sugg, Sonia L / Lal, Geeta

American journal of surgery

2021 Volume 223, Issue 1, Page(s) 76–80

Abstract: Background: Multidisciplinary Tumor Boards (MDT) are used to obtain input regarding cancer management. This study assessed the impact of our institutional Endocrine MDT.: Methods: MDT notes on patients with thyroid cancer treated during 2012-2018 ... ...

Abstract	Background: Multidisciplinary Tumor Boards (MDT) are used to obtain input regarding cancer management. This study assessed the impact of our institutional Endocrine MDT. Methods: MDT notes on patients with thyroid cancer treated during 2012-2018 were abstracted retrospectively from the electronic medical record. Management change (MC) was prospectively collected by the MDT coordinator. Biannual evaluations reviewed the impact of the MDT as observed by attendees. Results: MC was recommended in 47 (15%) of 286 presentations, with additional imaging being the most frequent (43%). Presentation of recurrences were more likely to result in MC (24% vs. 13% initial, p = 0.03). Overall, 98% of attendees found the conference exceeded educational expectations. About 24% reported intending to use a more evidence/guideline-based approach after attending and this trend increased over time (p = 0.002). Conclusion: MDT presentations led to a higher rate of MC particularly in recurrent TC patients and increased evidenced-based practice for attendees.
MeSH term(s)	Adolescent ; Clinical Decision-Making/methods ; Endocrinology/standards ; Evidence-Based Medicine/standards ; Female ; Humans ; Male ; Medical Oncology/standards ; Patient Care Team/standards ; Practice Guidelines as Topic ; Retrospective Studies ; Thyroid Cancer, Papillary/diagnosis ; Thyroid Cancer, Papillary/therapy ; Thyroid Gland/diagnostic imaging ; Thyroid Neoplasms/diagnosis ; Thyroid Neoplasms/therapy ; Young Adult
Language	English
Publishing date	2021-07-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	2953-1
ISSN	1879-1883 ; 0002-9610
ISSN (online)	1879-1883
ISSN	0002-9610
DOI	10.1016/j.amjsurg.2021.07.013
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Article ; Online: Low albumin level is more strongly associated with adverse outcomes and Staphylococcus aureus infection than hemoglobin A1C or smoking tobacco.

Campbell, Michael P / Mott, Makinzie D / Owen, John R / Reznicek, Julie E / Beck, Christopher A / Muthukrishnan, Gowrishankar / Golladay, Gregory J / Kates, Stephen L

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

2022 Volume 40, Issue 11, Page(s) 2670–2677

Abstract: Postsurgical deep musculoskeletal infections are a major clinical problem in Orthopaedic Surgery. A serum-based nomogram, which can objectively risk-stratify patients, and aid surgeons in delineating infection risk associated with orthopedic surgical ... ...

Abstract	Postsurgical deep musculoskeletal infections are a major clinical problem in Orthopaedic Surgery. A serum-based nomogram, which can objectively risk-stratify patients, and aid surgeons in delineating infection risk associated with orthopedic surgical interventions, would be immensely helpful. Here, we constructed a multi-parametric nomogram based on serum anti-Staphylococcus aureus antibody responses, patient characteristics including demographics and standard clinical tests. This nomogram was formally tested in a prospective cohort study comparing 303 hospitalized patients with culture-confirmed S. aureus infection compared with a cohort of 223 healthy screened preoperative patients. Serum anti-S. aureus antibody responses, standard of care clinical tests, and patient demographic data were utilized to perform multivariate logistic regression analysis to quantify the presence of infection and adverse outcome using odds ratios (OR) and to assess predictive ability via area under the ROC curve (AUC). At enrollment, high anti-S. aureus IgG titers were predictive of infection. Remarkably, low serum albumin was found to be significantly associated with infection (OR = 479.963, 95% CI 61.59 - 3740.33, p < 0.0001) and this finding was surprisingly higher than BMI or HbA1c-associations. Combining all risk factors in the nomogram yielded a diagnostic AUC of 0.949 for predicting S. aureus infection. Our results indicate that a serum-based multi-parametric nomogram can be useful in diagnosing S. aureus infections, and importantly, malnourishment is significantly associated with these infections.
MeSH term(s)	Glycated Hemoglobin ; Humans ; Immunoglobulin G ; Prospective Studies ; Serum Albumin ; Smoking ; Staphylococcal Infections ; Nicotiana
Chemical Substances	Glycated Hemoglobin A ; Immunoglobulin G ; Serum Albumin
Language	English
Publishing date	2022-02-04
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	605542-4
ISSN	1554-527X ; 0736-0266
ISSN (online)	1554-527X
ISSN	0736-0266
DOI	10.1002/jor.25282
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