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  1. AU=Hanjaya-Putra Donny
  2. AU=Powell James
  3. AU="Russell, Todd"
  4. AU=Forth Scott
  5. AU="Kreutzer, Susanne" AU="Kreutzer, Susanne"
  6. AU="St John, Maie"
  7. AU=Gerhardy A
  8. AU="Qi, Huixin"
  9. AU="Dobosiewicz, May"
  10. AU="Srivastava, Rakesh"
  11. AU="Grevtsov K.I."

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  1. Artikel: Mimicking blood and lymphatic vasculatures using microfluidic systems.

    Hall, Eva / Mendiola, Kailee / Lightsey, N Keilany / Hanjaya-Putra, Donny

    Biomicrofluidics

    2024  Band 18, Heft 3, Seite(n) 31502

    Abstract: The role of the circulatory system, containing the blood and lymphatic vasculatures, within the body, has become increasingly focused on by researchers as dysfunction of either of the systems has been linked to serious complications and disease. ... ...

    Abstract The role of the circulatory system, containing the blood and lymphatic vasculatures, within the body, has become increasingly focused on by researchers as dysfunction of either of the systems has been linked to serious complications and disease. Currently,
    Sprache Englisch
    Erscheinungsdatum 2024-05-06
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ISSN 1932-1058
    ISSN 1932-1058
    DOI 10.1063/5.0175154
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Fractal dimension to characterize interactions between blood and lymphatic endothelial cells.

    Jeong, Donghyun Paul / Montes, Daniel / Chang, Hsueh-Chia / Hanjaya-Putra, Donny

    Physical biology

    2023  Band 20, Heft 4

    Abstract: Spatial patterning of different cell types is crucial for tissue engineering and is characterized by the formation of sharp boundary between segregated groups of cells of different lineages. The cell-cell boundary layers, depending on the relative ... ...

    Abstract Spatial patterning of different cell types is crucial for tissue engineering and is characterized by the formation of sharp boundary between segregated groups of cells of different lineages. The cell-cell boundary layers, depending on the relative adhesion forces, can result in kinks in the border, similar to fingering patterns between two viscous partially miscible fluids which can be characterized by its fractal dimension. This suggests that mathematical models used to analyze the fingering patterns can be applied to cell migration data as a metric for intercellular adhesion forces. In this study, we develop a novel computational analysis method to characterize the interactions between blood endothelial cells (BECs) and lymphatic endothelial cells (LECs), which form segregated vasculature by recognizing each other through podoplanin. We observed indiscriminate mixing with LEC-LEC and BEC-BEC pairs and a sharp boundary between LEC-BEC pair, and fingering-like patterns with pseudo-LEC-BEC pairs. We found that the box counting method yields fractal dimension between 1 for sharp boundaries and 1.3 for indiscriminate mixing, and intermediate values for fingering-like boundaries. We further verify that these results are due to differential affinity by performing random walk simulations with differential attraction to nearby cells and generate similar migration pattern, confirming that higher differential attraction between different cell types result in lower fractal dimensions. We estimate the characteristic velocity and interfacial tension for our simulated and experimental data to show that the fractal dimension negatively correlates with capillary number (
    Mesh-Begriff(e) Fractals ; Endothelial Cells ; Cell Movement
    Sprache Englisch
    Erscheinungsdatum 2023-06-12
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2133216-2
    ISSN 1478-3975 ; 1478-3967
    ISSN (online) 1478-3975
    ISSN 1478-3967
    DOI 10.1088/1478-3975/acd898
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Synthetic hyaluronic acid coating preserves the phenotypes of lymphatic endothelial cells.

    Saha, Sanjoy / Fan, Fei / Alderfer, Laura / Graham, Francine / Hall, Eva / Hanjaya-Putra, Donny

    Biomaterials science

    2023  Band 11, Heft 22, Seite(n) 7346–7357

    Abstract: Lymphatic endothelial cells (LECs) play a critical role in the formation and maintenance of the lymphatic vasculature, which is essential for the immune system, fluid balance, and tissue repair. However, LECs are often difficult to ... ...

    Abstract Lymphatic endothelial cells (LECs) play a critical role in the formation and maintenance of the lymphatic vasculature, which is essential for the immune system, fluid balance, and tissue repair. However, LECs are often difficult to study
    Mesh-Begriff(e) Humans ; Hyaluronic Acid/metabolism ; Endothelial Cells ; Phenotype
    Chemische Substanzen Hyaluronic Acid (9004-61-9)
    Sprache Englisch
    Erscheinungsdatum 2023-11-07
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2693928-9
    ISSN 2047-4849 ; 2047-4830
    ISSN (online) 2047-4849
    ISSN 2047-4830
    DOI 10.1039/d3bm00873h
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel: Optimal Performance Objectives in the Highly Conserved Bone Morphogenetic Protein Signaling Pathway.

    Shaikh, Razeen / Larson, Nissa J / Hanjaya-Putra, Donny / Zartman, Jeremiah / Umulis, David M / Li, Linlin / Reeves, Gregory T

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Throughout development, complex networks of cell signaling pathways drive cellular decision-making across different tissues and contexts. The transforming growth factor β (TGF-β) pathways, including the BMP/Smad pathway, play crucial roles in these ... ...

    Abstract Throughout development, complex networks of cell signaling pathways drive cellular decision-making across different tissues and contexts. The transforming growth factor β (TGF-β) pathways, including the BMP/Smad pathway, play crucial roles in these cellular responses. However, as the Smad pathway is used reiteratively throughout the life cycle of all animals, its systems-level behavior varies from one context to another, despite the pathway connectivity remaining nearly constant. For instance, some cellular systems require a rapid response, while others require high noise filtering. In this paper, we examine how the BMP- Smad pathway balances trade-offs among three such systems-level behaviors, or "Performance Objectives (POs)": response speed, noise amplification, and the sensitivity of pathway output to receptor input. Using a Smad pathway model fit to human cell data, we show that varying non-conserved parameters (NCPs) such as protein concentrations, the Smad pathway can be tuned to emphasize any of the three POs and that the concentration of nuclear phosphatase has the greatest effect on tuning the POs. However, due to competition among the POs, the pathway cannot simultaneously optimize all three, but at best must balance trade-offs among the POs. We applied the multi-objective optimization concept of the Pareto Front, a widely used concept in economics to identify optimal trade-offs among various requirements. We show that the BMP pathway efficiently balances competing POs across species and is largely Pareto optimal. Our findings reveal that varying the concentration of NCPs allows the Smad signaling pathway to generate a diverse range of POs. This insight identifies how signaling pathways can be optimally tuned for each context.
    Sprache Englisch
    Erscheinungsdatum 2024-02-07
    Erscheinungsland United States
    Dokumenttyp Preprint
    DOI 10.1101/2024.02.01.578451
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel: Podoplanin is Responsible for the Distinct Blood and Lymphatic Capillaries.

    Jeong, Donghyun Paul / Hall, Eva / Neu, Erin / Hanjaya-Putra, Donny

    Cellular and molecular bioengineering

    2022  Band 15, Heft 5, Seite(n) 467–478

    Abstract: Introduction: Controlling the formation of blood and lymphatic vasculatures is crucial for engineered tissues. Although the lymphatic vessels originate from embryonic blood vessels, the two retain functional and physiological differences even as they ... ...

    Abstract Introduction: Controlling the formation of blood and lymphatic vasculatures is crucial for engineered tissues. Although the lymphatic vessels originate from embryonic blood vessels, the two retain functional and physiological differences even as they develop in the vicinity of each other. This suggests that there is a previously unknown molecular mechanism by which blood (BECs) and lymphatic endothelial cells (LECs) recognize each other and coordinate to generate distinct capillary networks.
    Methods: We utilized Matrigel and fibrin assays to determine how cord-like structures (CLS) can be controlled by altering LEC and BEC identity through podoplanin (
    Results: We observed that LECs and BECs form distinct CLS in Matrigel and fibrin gels despite being cultured in close proximity with each other. We confirmed that the LECs and BECs do not recognize each other through paracrine signaling, as proliferation and migration of both cells were unaffected by paracrine signals. On the other hand, we found
    Conclusions: Overall, these observations reveal a new molecular pathway through which LECs and BECs form distinct CLS through physical contact by
    Supplementary information: The online version contains supplementary material available at 10.1007/s12195-022-00730-2.
    Sprache Englisch
    Erscheinungsdatum 2022-08-06
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2416037-4
    ISSN 1865-5033 ; 1865-5025
    ISSN (online) 1865-5033
    ISSN 1865-5025
    DOI 10.1007/s12195-022-00730-2
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  6. Artikel: Biomimetic Hydrogels to Promote Wound Healing.

    Fan, Fei / Saha, Sanjoy / Hanjaya-Putra, Donny

    Frontiers in bioengineering and biotechnology

    2021  Band 9, Seite(n) 718377

    Abstract: Wound healing is a common physiological process which consists of a sequence of molecular and cellular events that occur following the onset of a tissue lesion in order to reconstitute barrier between body and external environment. The inherent ... ...

    Abstract Wound healing is a common physiological process which consists of a sequence of molecular and cellular events that occur following the onset of a tissue lesion in order to reconstitute barrier between body and external environment. The inherent properties of hydrogels allow the damaged tissue to heal by supporting a hydrated environment which has long been explored in wound management to aid in autolytic debridement. However, chronic non-healing wounds require added therapeutic features that can be achieved by incorporation of biomolecules and supporting cells to promote faster and better healing outcomes. In recent decades, numerous hydrogels have been developed and modified to match the time scale for distinct stages of wound healing. This review will discuss the effects of various types of hydrogels on wound pathophysiology, as well as the ideal characteristics of hydrogels for wound healing, crosslinking mechanism, fabrication techniques and design considerations of hydrogel engineering. Finally, several challenges related to adopting hydrogels to promote wound healing and future perspectives are discussed.
    Sprache Englisch
    Erscheinungsdatum 2021-09-20
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2719493-0
    ISSN 2296-4185
    ISSN 2296-4185
    DOI 10.3389/fbioe.2021.718377
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Harnessing biomaterials for lymphatic system modulation.

    Alderfer, Laura / Hall, Eva / Hanjaya-Putra, Donny

    Acta biomaterialia

    2021  Band 133, Seite(n) 34–45

    Abstract: The lymphatic system plays an integral part in regulating immune cell trafficking and the transport of macromolecules. However, its influence on disease progression and drug uptake is understood less than that of the vascular system. To bridge this ... ...

    Abstract The lymphatic system plays an integral part in regulating immune cell trafficking and the transport of macromolecules. However, its influence on disease progression and drug uptake is understood less than that of the vascular system. To bridge this knowledge gap, biomaterials can be used to investigate the lymphatic system and to provide novel understanding into complex disease processes, including cancer metastasis and inflammation. Insight gained from these mechanistic studies can be further used to design innovative biomaterials to modulate the immune system, improve drug delivery, and promote tissue regeneration. This review article focuses on recent advances in (i) biomaterials used for lymphatic vessel formation, (ii) models for studying lymphatic-immune cells interactions, (iii) pharmaceuticals and their interactions with the lymphatic system, (iv) and strategies for drug delivery via the lymphatic system. Finally, several challenges regarding adopting biomaterials for immunomodulation and future perspectives are discussed. STATEMENT OF SIGNIFICANCE: The lymphatic system plays an integral part in regulating immune cell trafficking and the transport of macromolecules. However, its influence on disease progression and drug uptake is understood less than that of the vascular system. This review article focuses on recent progresses in biomaterials to investigate the lymphatic system and to provide novel understanding into complex disease states. Insight gained from these mechanistic studies can be further used to design innovative biomaterials to modulate the immune system, improve drug delivery, and promote tissue regeneration. Finally, a number of challenges in adopting biomaterials for immunomodulation and future perspectives are discussed.
    Mesh-Begriff(e) Biocompatible Materials/pharmacology ; Drug Delivery Systems ; Lymphangiogenesis ; Lymphatic System ; Lymphatic Vessels
    Chemische Substanzen Biocompatible Materials
    Sprache Englisch
    Erscheinungsdatum 2021-06-09
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
    ZDB-ID 2173841-5
    ISSN 1878-7568 ; 1742-7061
    ISSN (online) 1878-7568
    ISSN 1742-7061
    DOI 10.1016/j.actbio.2021.06.006
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: Hyaluronic Acid Hydrogels with Phototunable Supramolecular Cross-Linking for Spatially Controlled Lymphatic Tube Formation.

    Fan, Fei / Su, Bo / Kolodychak, Alexander / Ekwueme, Ephraim / Alderfer, Laura / Saha, Sanjoy / Webber, Matthew J / Hanjaya-Putra, Donny

    ACS applied materials & interfaces

    2023  Band 15, Heft 50, Seite(n) 58181–58195

    Abstract: The dynamics of the extracellular matrix (ECM) influences stem cell differentiation and morphogenesis into complex lymphatic networks. While dynamic hydrogels with stress relaxation properties have been developed, many require detailed chemical ... ...

    Abstract The dynamics of the extracellular matrix (ECM) influences stem cell differentiation and morphogenesis into complex lymphatic networks. While dynamic hydrogels with stress relaxation properties have been developed, many require detailed chemical processing to tune viscoelasticity, offering a limited opportunity for
    Mesh-Begriff(e) Humans ; Hydrogels/chemistry ; Hyaluronic Acid/chemistry ; Endothelial Cells ; Extracellular Matrix/chemistry ; Morphogenesis ; Transcription Factors
    Chemische Substanzen Hydrogels ; Hyaluronic Acid (9004-61-9) ; Transcription Factors
    Sprache Englisch
    Erscheinungsdatum 2023-12-08
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.3c12514
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  9. Artikel: The Effects of Preeclamptic Milieu on Cord Blood Derived Endothelial Colony-Forming Cells.

    Hall, Eva / Alderfer, Laura / Neu, Erin / Saha, Sanjoy / Johandes, Ellie / Haas, David M / Haneline, Laura S / Hanjaya-Putra, Donny

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Preeclampsia is one of the leading causes of infant and maternal mortality worldwide. Many infants born from preeclamptic pregnancies are born prematurely with higher risk of developing cardiovascular later in their life. A key mechanism by which these ... ...

    Abstract Preeclampsia is one of the leading causes of infant and maternal mortality worldwide. Many infants born from preeclamptic pregnancies are born prematurely with higher risk of developing cardiovascular later in their life. A key mechanism by which these complications occur is through stress-induced dysfunction of endothelial progenitor cells (EPCs), including endothelial colony-forming cells (ECFCs). To gain insight into this, cord blood derived ECFCs isolated from preeclamptic pregnancies (PRECs) were analyzed and compared to their healthy counterparts. While PRECs preserve key endothelial markers, they upregulate several markers associated with oxidative stress and inflammatory response. Compared to ECFCs, PRECs also exhibit lower migratory behaviors and impaired angiogenic potential. Interestingly, treatment of neuropilin-1 can improve tube formation
    Sprache Englisch
    Erscheinungsdatum 2023-12-05
    Erscheinungsland United States
    Dokumenttyp Preprint
    DOI 10.1101/2023.12.03.569585
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: Membrane-Based Affinity Purification to Identify Target Proteins of a Small-Molecule Drug.

    Yang, Liu / Bui, Loan / Hanjaya-Putra, Donny / Bruening, Merlin L

    Analytical chemistry

    2020  Band 92, Heft 17, Seite(n) 11912–11920

    Abstract: Identifying the target proteins of small-molecule drug candidates is important for determining their molecular mechanisms of action. Porous membranes derivatized with such small molecules may provide an attractive target-identification platform due to a ... ...

    Abstract Identifying the target proteins of small-molecule drug candidates is important for determining their molecular mechanisms of action. Porous membranes derivatized with such small molecules may provide an attractive target-identification platform due to a high protein-capture efficiency during flow through membrane pores. This work employs carbonic anhydrase II (CAII) binding to immobilized 4-(2-aminoethyl)benzenesulfonamide (AEBSA) to examine the efficiency and selectivity of affinity capture in modified membranes. Selective elution of captured protein, tryptic digestion, tandem mass spectrometry analysis, and label-free quantification (LFQ) identify CAII as the dominant AEBSA target in diluted serum or cell lysate. CAII identification relies on determining the ratio of protein LFQ intensities in sample and control experiments, where free AEBSA added to the control loading solution limits CAII capture. Global proteomics shows that the spiked CAII is the only protein with a log
    Mesh-Begriff(e) Chromatography, Affinity/methods ; Humans ; Membranes/metabolism ; Protein Binding/physiology
    Sprache Englisch
    Erscheinungsdatum 2020-08-11
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 1508-8
    ISSN 1520-6882 ; 0003-2700
    ISSN (online) 1520-6882
    ISSN 0003-2700
    DOI 10.1021/acs.analchem.0c02316
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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