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  1. Article ; Online: A G₄·K⁺ hydrogel stabilized by an anion.

    Peters, Gretchen Marie / Skala, Luke P / Plank, Taylor N / Hyman, Brooke J / Manjunatha Reddy, G N / Marsh, Andrew / Brown, Steven P / Davis, Jeffery T

    Journal of the American Chemical Society

    2014  Volume 136, Issue 36, Page(s) 12596–12599

    Abstract: ... guanosine (G, 1) with 0.5 equiv of KB(OH)4. This ratio of borate anion to ligand is crucial for gelation ... as it links two molecules of 1, which facilitates cation-templated assembly of G4·K(+) quartets. The guanosine ... relevant concentrations of K(+). Furthermore, non-covalent interactions, such as electrostatics, π-stacking ...

    Abstract Supramolecular hydrogels derived from natural products have promising applications in diagnostics, drug delivery, and tissue engineering. We studied the formation of a long-lived hydrogel made by mixing guanosine (G, 1) with 0.5 equiv of KB(OH)4. This ratio of borate anion to ligand is crucial for gelation as it links two molecules of 1, which facilitates cation-templated assembly of G4·K(+) quartets. The guanosine-borate (GB) hydrogel, which was characterized by cryogenic transmission electron microscopy and circular dichroism and (11)B magic-angle-spinning NMR spectroscopy, is stable in water that contains physiologically relevant concentrations of K(+). Furthermore, non-covalent interactions, such as electrostatics, π-stacking, and hydrogen bonding, enable the incorporation of a cationic dye and nucleosides into the GB hydrogel.
    MeSH term(s) Anions/chemistry ; Borates/chemistry ; Guanosine/chemistry ; Hydrogel, Polyethylene Glycol Dimethacrylate/chemistry ; Magnetic Resonance Spectroscopy ; Molecular Structure ; Potassium/chemistry
    Chemical Substances Anions ; Borates ; Guanosine (12133JR80S) ; Hydrogel, Polyethylene Glycol Dimethacrylate (25852-47-5) ; Potassium (RWP5GA015D)
    Language English
    Publishing date 2014-09-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/ja507506c
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book ; Thesis: Wirkung von Herzglykosiden und Steroidhormonen sowie deren Guanylhydrazone auf isolierte linke Vorhöfe und auf Bindung von g-Strophantin an die Na + - K + ATPase des Meerschweinchenherzens

    Peters, Kay

    1992  

    Author's details vorgelegt von Kay Peters
    Size 78 S. : Ill., graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Kiel, Univ., Diss., 1992
    HBZ-ID HT004435032
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    93 D 535 order for loan Magazin

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  3. Article: Some Reminiscences of Sir Archibald E. Garrod, K.C.M.G., F.R.C.P., F.R.S.

    Peters, R A

    American journal of human genetics

    2007  Volume 10, Issue 1, Page(s) x–2

    Language English
    Publishing date 2007-10-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 219384-x
    ISSN 1537-6605 ; 0002-9297
    ISSN (online) 1537-6605
    ISSN 0002-9297
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  4. Article ; Online: Wide Complex Tachycardia in a Middle-Aged Woman With Diarrhea.

    Peters, Matthew G / Apte, Nachiket / Kalra, Dinesh K

    JAMA cardiology

    2024  

    Language English
    Publishing date 2024-05-01
    Publishing country United States
    Document type Journal Article
    ISSN 2380-6591
    ISSN (online) 2380-6591
    DOI 10.1001/jamacardio.2024.0744
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  5. Article ; Online: Arcsine Laws of Light.

    Ramesh, V G / Peters, K J H / Rodriguez, S R K

    Physical review letters

    2024  Volume 132, Issue 13, Page(s) 133801

    Abstract: ... optical sensors with zero energy cost, as shown in our companion manuscript [V. G. Ramesh et al ...

    Abstract We demonstrate that the time-integrated light intensity transmitted by a coherently driven resonator obeys Lévy's arcsine laws-a cornerstone of extreme value statistics. We show that convergence to the arcsine distribution is algebraic, universal, and independent of nonequilibrium behavior due to nonconservative forces or nonadiabatic driving. We furthermore verify, numerically, that the arcsine laws hold in the presence of frequency noise and in Kerr-nonlinear resonators supporting non-Gaussian states. The arcsine laws imply a weak ergodicity breaking which can be leveraged to enhance the precision of resonant optical sensors with zero energy cost, as shown in our companion manuscript [V. G. Ramesh et al., companion paper, Phys. Rev. Res. (2024).PPRHAI2643-1564]. Finally, we discuss perspectives for probing the possible breakdown of the arcsine laws in systems with memory.
    Language English
    Publishing date 2024-04-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208853-8
    ISSN 1079-7114 ; 0031-9007
    ISSN (online) 1079-7114
    ISSN 0031-9007
    DOI 10.1103/PhysRevLett.132.133801
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  6. Article: Genomic Prediction Accuracies for Growth and Carcass Traits in a Brangus Heifer Population.

    Peters, Sunday O / Kızılkaya, Kadir / Sinecen, Mahmut / Mestav, Burcu / Thiruvenkadan, Aranganoor K / Thomas, Milton G

    Animals : an open access journal from MDPI

    2023  Volume 13, Issue 7

    Abstract: ... to obtain the GEBV for growth and carcass traits within k-means and random clusters showed that k-means and ...

    Abstract The predictive abilities and accuracies of genomic best linear unbiased prediction (GBLUP) and the Bayesian (BayesA, BayesB, BayesC and Lasso) genomic selection (GS) methods for economically important growth (birth, weaning, and yearling weights) and carcass (depth of rib fat, apercent intramuscular fat and longissimus muscle area) traits were characterized by estimating the linkage disequilibrium (LD) structure in Brangus heifers using single nucleotide polymorphisms (SNP) markers. Sharp declines in LD were observed as distance among SNP markers increased. The application of the GBLUP and the Bayesian methods to obtain the GEBV for growth and carcass traits within k-means and random clusters showed that k-means and random clustering had quite similar heritability estimates, but the Bayesian methods resulted in the lower estimates of heritability between 0.06 and 0.21 for growth and carcass traits compared with those between 0.21 and 0.35 from the GBLUP methodologies. Although the prediction ability of the GBLUP and the Bayesian methods were quite similar for growth and carcass traits, the Bayesian methods overestimated the accuracies of GEBV because of the lower estimates of heritability of growth and carcass traits. However, GBLUP resulted in accuracy of GEBV for growth and carcass traits that parallels previous reports.
    Language English
    Publishing date 2023-04-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606558-7
    ISSN 2076-2615
    ISSN 2076-2615
    DOI 10.3390/ani13071272
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  7. Article: The first robotic-assisted hysterectomy below the bikini line with the Dexter robotic system™.

    Alkatout, I / Becker, T / Nuhn, P / Pochhammer, J / Peters, G / Donald, K M / Mettler, L / Ackermann, J

    Facts, views & vision in ObGyn

    2024  Volume 16, Issue 1, Page(s) 87–91

    Abstract: Background: Robotic-assisted hysterectomy (RAH) is a widely accepted minimally invasive approach for uterus removal. However, as RAH is typically performed in the umbilical region, it usually results in scars in cosmetically suboptimal locations. This ... ...

    Abstract Background: Robotic-assisted hysterectomy (RAH) is a widely accepted minimally invasive approach for uterus removal. However, as RAH is typically performed in the umbilical region, it usually results in scars in cosmetically suboptimal locations. This is the first case of RAH with cervicosacropexy performed below the bikini line, using the new Dexter robotic system™.
    Objectives: The aim of this article is to show the surgical steps of the first RAH with cervicosacropexy performed below the bikini line with the new Dexter robotic system™ (Distalmotion), and furthermore assess the feasibility of this approach using this robotic platform.
    Materials and methods: A 43-year-old woman with uterine adenomyosis and recurrent uterine prolapse underwent a robotic-assisted subtotal hysterectomy with cervicosacropexy, performed below the bikini line, using the Dexter robotic system™, at the Clinic of Gynecology and Obstetrics at Universitätsklinikum Schleswig-Holstein (UKHS) in Kiel, Germany.
    Main outcome measures: Perioperative data, surgical approach specifics, objective, and subjective outcomes of this new approach.
    Results: The procedure was performed without intra-operative complications; estimated blood loss was 10 ml. Operative time was 150 minutes, console time 120 minutes, total docking time 6 minutes. Dexter performed as expected; no device-related issues or robotic arm collisions occurred. The patient did not require pain medication and was released on the second postoperative day.
    Conclusion: RAH performed below the bikini line using the Dexter robotic system™ is a feasible, safe, and adequate procedure. These initial results should be confirmed and further extensively refurbished with larger patient cohorts, and functional and psychological outcomes need further investigation.
    Language English
    Publishing date 2024-03-29
    Publishing country Belgium
    Document type Journal Article
    ZDB-ID 2701574-9
    ISSN 2032-0418 ; 2684-4230
    ISSN 2032-0418 ; 2684-4230
    DOI 10.52054/FVVO.16.1.010
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  8. Article ; Online: Morphology of pulpal mineralizations: A scoping review.

    Marshall, Georgina / Verdelis, Konstantinos / Peters, Ove A

    Journal of dentistry

    2023  Volume 139, Page(s) 104745

    Abstract: Objective: The aim of this scoping review was to summarize and discuss the morphological features and associated factors of pulpal mineralizations (PMs) as described within the literature.: Data: The study protocol was registered on the Open Science ... ...

    Abstract Objective: The aim of this scoping review was to summarize and discuss the morphological features and associated factors of pulpal mineralizations (PMs) as described within the literature.
    Data: The study protocol was registered on the Open Science Framework platform and is available at the following link: https://osf.io/hfqwe. This scoping review was developed according to the PRISMA-ScR guidelines.
    Sources: A literature search of four electronic databases was performed in SCOPUS, MEDLINE (PubMed), EMBASE and Word of Science, with the last search on May 29, 2023. Study selection was completed by two reviewers independently. Data was extracted regarding study characteristics, types, and features of PM and associated factors.
    Study selection: Of 1016 studies initially identified ten which qualified were included in this scoping review. Systemic and local factors that result in pulpal insult can contribute to the development of PMs. Three forms of PM have been reported, pulp stones, diffuse mineralizations, and mineralized ectopic connective tissue, with discrete and diffuse mineralization being the two clinically relevant forms. The different forms of PMs exhibit dissimilar morphological features.
    Conclusion: Pulpal mineralizations exist in two clinically relevant forms: diffuse and discrete mineralizations and are likely associated with a pulpal insult.
    Clinical significance: Understanding the morphology of dental pulp mineralization is the first step to expanding the knowledge of pulp mineralization and could result in improved diagnosis of endodontic pathosis.
    MeSH term(s) Dental Pulp ; Dental Pulp Calcification ; Humans
    Language English
    Publishing date 2023-10-20
    Publishing country England
    Document type Journal Article ; Systematic Review
    ZDB-ID 186068-9
    ISSN 1879-176X ; 0300-5712
    ISSN (online) 1879-176X
    ISSN 0300-5712
    DOI 10.1016/j.jdent.2023.104745
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  9. Article: LRMP inhibits cAMP potentiation of HCN4 channels by disrupting intramolecular signal transduction.

    Peters, Colin H / Singh, Rohit K / Langley, Avery A / Nichols, William G / Ferris, Hannah R / Jeffrey, Danielle A / Proenza, Catherine / Bankston, John R

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Lymphoid restricted membrane protein (LRMP) is a specific regulator of the hyperpolarization-activated cyclic nucleotide-sensitive isoform 4 (HCN4) channel. LRMP prevents cAMP-dependent potentiation of HCN4 but the interaction domains, mechanisms of ... ...

    Abstract Lymphoid restricted membrane protein (LRMP) is a specific regulator of the hyperpolarization-activated cyclic nucleotide-sensitive isoform 4 (HCN4) channel. LRMP prevents cAMP-dependent potentiation of HCN4 but the interaction domains, mechanisms of action, and basis for isoform-specificity remain unknown. Here we identify the domains of LRMP essential for regulation. We show that LRMP acts by disrupting the intramolecular signal transduction between cyclic nucleotide binding and gating. And we demonstrate that multiple unique regions in HCN4 are required for LRMP isoform-specificity. Using patch clamp electrophysiology and Förster resonance energy transfer (FRET), we showed that the initial 227 residues of LRMP and the N-terminus of HCN4 are necessary for LRMP to interact with HCN4. We found that the HCN4 N-terminus and HCN4-specific residues in the C-linker are necessary for regulation of HCN4 by LRMP. And we demonstrate that LRMP-regulation can be conferred to HCN2 by addition of the HCN4 N-terminus along with mutation of 5 residues in the S5 region and C-linker to the cognate HCN4 residues. Taken together, these results suggest that LRMP inhibits HCN4 through an isoform-specific interaction involving the N-terminals of both proteins that prevents the transduction of cAMP binding into a change in channel gating via an HCN4-specific orientation of the N-terminus, C-linker, and S4-S5 linker.
    Language English
    Publishing date 2024-01-24
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.08.29.555242
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  10. Article ; Online: LRMP inhibits cAMP potentiation of HCN4 channels by disrupting intramolecular signal transduction.

    Peters, Colin H / Singh, Rohit K / Langley, Avery A / Nichols, William G / Ferris, Hannah R / Jeffrey, Danielle A / Proenza, Catherine / Bankston, John R

    eLife

    2024  Volume 12

    Abstract: Lymphoid restricted membrane protein (LRMP) is a specific regulator of the hyperpolarization-activated cyclic nucleotide-sensitive isoform 4 (HCN4) channel. LRMP prevents cAMP-dependent potentiation of HCN4, but the interaction domains, mechanisms of ... ...

    Abstract Lymphoid restricted membrane protein (LRMP) is a specific regulator of the hyperpolarization-activated cyclic nucleotide-sensitive isoform 4 (HCN4) channel. LRMP prevents cAMP-dependent potentiation of HCN4, but the interaction domains, mechanisms of action, and basis for isoform-specificity remain unknown. Here, we identify the domains of LRMP essential for this regulation, show that LRMP acts by disrupting the intramolecular signal transduction between cyclic nucleotide binding and gating, and demonstrate that multiple unique regions in HCN4 are required for LRMP isoform-specificity. Using patch clamp electrophysiology and Förster resonance energy transfer (FRET), we identified the initial 227 residues of LRMP and the N-terminus of HCN4 as necessary for LRMP to associate with HCN4. We found that the HCN4 N-terminus and HCN4-specific residues in the C-linker are necessary for regulation of HCN4 by LRMP. Finally, we demonstrated that LRMP-regulation can be conferred to HCN2 by addition of the HCN4 N-terminus along with mutation of five residues in the S5 region and C-linker to the cognate HCN4 residues. Taken together, these results suggest that LRMP inhibits HCN4 through an isoform-specific interaction involving the N-terminals of both proteins that prevents the transduction of cAMP binding into a change in channel gating, most likely via an HCN4-specific orientation of the N-terminus, C-linker, and S4-S5 linker.
    MeSH term(s) Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels/metabolism ; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels/genetics ; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels/chemistry ; Cyclic AMP/metabolism ; Signal Transduction ; Humans ; Membrane Proteins/metabolism ; Membrane Proteins/genetics ; Animals ; Protein Binding ; HEK293 Cells ; Potassium Channels/metabolism ; Potassium Channels/genetics ; Potassium Channels/chemistry ; Patch-Clamp Techniques ; Fluorescence Resonance Energy Transfer ; Protein Isoforms/metabolism ; Protein Isoforms/genetics ; Muscle Proteins ; Receptors, Cytoplasmic and Nuclear
    Chemical Substances Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels ; Cyclic AMP (E0399OZS9N) ; Membrane Proteins ; PEX5L protein, human ; HCN4 protein, human ; Potassium Channels ; Protein Isoforms ; Muscle Proteins ; Receptors, Cytoplasmic and Nuclear
    Language English
    Publishing date 2024-04-23
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.92411
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