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  1. Book ; Thesis: Molekulare Mechanismen der Tumormetastasierung über das P-Selektin CD24 Rezeptor-Liganden-System in vitro und in vivo

    Medinger, Michael Adrian

    2000  

    Author's details vorgelegt von Michael Adrian Medinger
    Language German
    Size 101 S., Ill., graph. Darst., 21 cm
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Tübingen, Univ., Diss., 2000
    HBZ-ID HT013179542
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2001 D 2571 order for loan Magazin

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  2. Article ; Online: Mocravimod, a S1P receptor modulator, increases T cell counts in bone marrow biopsies from patients undergoing allogeneic hematopoietic stem cell transplantation.

    Dertschnig, Simone / Passweg, Jakob / Bucher, Christoph / Medinger, Michael / Tzankov, Alexandar

    Cellular immunology

    2023  Volume 388-389, Page(s) 104719

    Abstract: Graft-versus-leukemia (GvL) effects are critical to prevent relapses after allogeneic hematopoietic cell transplantation (allo-HCT). However, the success of allo-HCT is limited by graft-versus-host disease (GvHD). Both, ... ...

    Abstract Graft-versus-leukemia (GvL) effects are critical to prevent relapses after allogeneic hematopoietic cell transplantation (allo-HCT). However, the success of allo-HCT is limited by graft-versus-host disease (GvHD). Both, CD4
    MeSH term(s) Humans ; Mice ; Animals ; Bone Marrow/pathology ; Sphingosine-1-Phosphate Receptors ; CD8-Positive T-Lymphocytes/pathology ; Transplantation, Homologous ; Hematopoietic Stem Cell Transplantation/adverse effects ; Bone Marrow Transplantation ; Graft vs Host Disease/prevention & control ; Cell Count
    Chemical Substances Sphingosine-1-Phosphate Receptors
    Language English
    Publishing date 2023-04-26
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 80094-6
    ISSN 1090-2163 ; 0008-8749
    ISSN (online) 1090-2163
    ISSN 0008-8749
    DOI 10.1016/j.cellimm.2023.104719
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 417: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Influence of HLA-DPB1 mismatches on outcome after allogeneic hematopoietic stem cell transplantation.

    Hunziker, Mireille / Passweg, Jakob / Medinger, Michael

    Leukemia research reports

    2021  Volume 16, Page(s) 100259

    Language English
    Publishing date 2021-07-14
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2706248-X
    ISSN 2213-0489
    ISSN 2213-0489
    DOI 10.1016/j.lrr.2021.100259
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  4. Article ; Online: Does the order of busulfan and cyclophosphamide affect allogeneic stem cell transplantation related liver toxicity?

    Seydoux, Claire / Passweg, Jakob R / Medinger, Michael

    Annals of hematology

    2021  Volume 100, Issue 5, Page(s) 1349–1350

    MeSH term(s) Busulfan ; Cyclophosphamide ; Hematopoietic Stem Cell Transplantation ; Liver
    Chemical Substances Cyclophosphamide (8N3DW7272P) ; Busulfan (G1LN9045DK)
    Language English
    Publishing date 2021-03-10
    Publishing country Germany
    Document type Letter ; Comment
    ZDB-ID 1064950-5
    ISSN 1432-0584 ; 0939-5555 ; 0945-8077
    ISSN (online) 1432-0584
    ISSN 0939-5555 ; 0945-8077
    DOI 10.1007/s00277-021-04479-y
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    Uh III Zs.181: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Incidence and impact of Epstein-Barr virus events in the early phase after allogeneic hematopoietic cell transplantation.

    Macy, Samuel / Passweg, Jakob / Medinger, Michael

    Annals of hematology

    2021  Volume 100, Issue 7, Page(s) 1913–1915

    MeSH term(s) Epstein-Barr Virus Infections/diagnosis ; Epstein-Barr Virus Infections/etiology ; Female ; Hematopoietic Stem Cell Transplantation/adverse effects ; Herpesvirus 4, Human/isolation & purification ; Herpesvirus 4, Human/physiology ; Humans ; Incidence ; Male ; Retrospective Studies ; Transplantation, Homologous/adverse effects ; Virus Activation
    Language English
    Publishing date 2021-06-03
    Publishing country Germany
    Document type Letter
    ZDB-ID 1064950-5
    ISSN 1432-0584 ; 0939-5555 ; 0945-8077
    ISSN (online) 1432-0584
    ISSN 0939-5555 ; 0945-8077
    DOI 10.1007/s00277-021-04563-3
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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.181: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: What the internist should know about stem cell transplant in the elderly patient.

    Medinger, Michael / Passweg, Jakob

    European journal of internal medicine

    2018  Volume 58, Page(s) 43–47

    Abstract: Most hematological malignancies are increasing in frequency with age. Allogeneic hematopoietic cell transplantation (allo-HCT) is a potentially curative therapeutic option for patients with malignant and non-malignant hematological diseases. The ... ...

    Abstract Most hematological malignancies are increasing in frequency with age. Allogeneic hematopoietic cell transplantation (allo-HCT) is a potentially curative therapeutic option for patients with malignant and non-malignant hematological diseases. The treatment of elderly patients with advanced hematological malignancies has expanded to include reduced intensity conditioning allo-HCT. Physicians increasingly refer older patients for allo-HCT due to more experience and improved supportive care in allo-HCT. This review article discusses the available data regarding the feasibility, tolerability, toxicity, and effectiveness of allo-HCT in different hematological diseases in the elderly. Over the past decade, utilization and survival after allo-HCT have increased in patients ≥70 years. Selected adults ≥70 years with hematological diseases should be evaluated for transplantation.
    MeSH term(s) Aged ; Comorbidity ; Geriatric Assessment ; Hematologic Neoplasms/therapy ; Hematopoietic Stem Cell Transplantation/methods ; Hematopoietic Stem Cell Transplantation/mortality ; Humans ; Immunotherapy ; Transplantation Conditioning/methods ; Transplantation, Homologous/methods
    Language English
    Publishing date 2018-06-28
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 1038679-8
    ISSN 1879-0828 ; 0953-6205
    ISSN (online) 1879-0828
    ISSN 0953-6205
    DOI 10.1016/j.ejim.2018.06.018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2608: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: Blinatumomab in Relapsed/Refractory Burkitt Lymphoma.

    Bohler, Jeanne / Bacher, Ulrike / Banz, Yara / Stadelmann, Raphael / Medinger, Michael / Zander, Thilo / Pabst, Thomas

    Cancers

    2022  Volume 15, Issue 1

    Abstract: In patients with relapsed/refractory Burkitt lymphoma (r/r BL), overall survival (OS) is poor, and effective therapies and evidence for the best therapy are lacking. The monoclonal antibody blinatumomab may represent a novel option. However, only limited ...

    Abstract In patients with relapsed/refractory Burkitt lymphoma (r/r BL), overall survival (OS) is poor, and effective therapies and evidence for the best therapy are lacking. The monoclonal antibody blinatumomab may represent a novel option. However, only limited data on the use of blinatumomab in r/r BL are so far available. This multi-center, retrospective case series investigated nine patients with r/r BL treated with blinatumomab. The safety of blinatumomab was assessed with respect to frequency and severity of adverse effects (AEs) infections, cytokine release syndrome (CRS) and neurotoxicity. Progression-free survival (PFS), OS and overall response rate (ORR) were analyzed to assess efficacy. No AEs > grade 2 occurred, and AEs were generally treatable and fully reversible. The best response to blinatumomab was complete remission in 3/9 patients and partial remission in 2/9, whilst 4/9 presented with progressive disease. Median PFS and OS were 2 and 6 months, respectively, ranging from 5 days to 32 months and 11 days to 32 months, respectively. Blinatumomab treatment was a successful bridging treatment to stem cell transplantation in 3/9 patients. The response to blinatumomab varied widely, and only one patient survived longer term, but activity in patients with r/r BL was evident in some patients, with its use being safe, warranting its prospective investigation.
    Language English
    Publishing date 2022-12-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15010044
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  8. Article ; Online: Low Incidence of hepatic sinusoidal obstruction syndrome/veno-occlusive disease in adults undergoing allogenic stem cell transplantation with prophylactic ursodiol and low-dose heparin.

    Stutz, Lina / Halter, Jörg P / Heim, Dominik / Passweg, Jakob R / Medinger, Michael

    Bone marrow transplantation

    2022  Volume 57, Issue 3, Page(s) 391–398

    Abstract: Hepatic sinusoidal obstruction syndrome (SOS)/veno-occlusive disease (VOD) is a complication after allogenic hematopoietic stem-cell transplantation (allo-HSCT) with high mortality. The purpose of this study was to assess the incidence and outcome of SOS ...

    Abstract Hepatic sinusoidal obstruction syndrome (SOS)/veno-occlusive disease (VOD) is a complication after allogenic hematopoietic stem-cell transplantation (allo-HSCT) with high mortality. The purpose of this study was to assess the incidence and outcome of SOS in patients after allo-HSCT with the impact of ursodeoxycholic acid (UDCA) and low-dose heparin as SOS prophylaxis. Out of 1016 patients, 23 developed SOS, with a cumulative incidence of 2.3% (95% CI 1.3-3.3) 6 months after HSCT. Approximately one quarter of these patients (26.1%) had late-onset SOS. A high proportion were very severe SOS cases (74%), and 83% of the patients were treated with defibrotide (DF). In multivariate analysis, advanced disease (p = 0.003), previous HSCT (p = 0.025) and graft versus host disease (GvHD) prophylaxis by post-transplant cyclophosphamide (PTCy) (p = 0.055) were associated with the development of SOS. The 1-year overall survival (OS) was significantly lower in the SOS group compared to patients without SOS (13% versus 70%, p = 0.0001). In conclusion, we found a low incidence of SOS in patients receiving low-dose heparin and UDCA prophylactically, but among SOS patients, a high mortality. Low-dose heparin and UDCA might be a prophylactic approach for SOS.
    MeSH term(s) Adult ; Hematopoietic Stem Cell Transplantation/adverse effects ; Heparin/therapeutic use ; Hepatic Veno-Occlusive Disease/epidemiology ; Hepatic Veno-Occlusive Disease/etiology ; Hepatic Veno-Occlusive Disease/prevention & control ; Humans ; Incidence ; Polydeoxyribonucleotides/therapeutic use ; Ursodeoxycholic Acid/therapeutic use
    Chemical Substances Polydeoxyribonucleotides ; Ursodeoxycholic Acid (724L30Y2QR) ; Heparin (9005-49-6)
    Language English
    Publishing date 2022-01-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 632854-4
    ISSN 1476-5365 ; 0268-3369 ; 0951-3078
    ISSN (online) 1476-5365
    ISSN 0268-3369 ; 0951-3078
    DOI 10.1038/s41409-021-01546-w
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2168: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article: Characterization of engraftment dynamics in myelofibrosis after allogeneic hematopoietic cell transplantation including novel conditioning schemes.

    Jungius, Sarah / Adam, Franziska C / Grosheintz, Kerstin / Medinger, Michael / Buser, Andreas / Passweg, Jakob R / Halter, Jörg P / Meyer, Sara C

    Frontiers in oncology

    2023  Volume 13, Page(s) 1205387

    Abstract: Introduction: Myelofibrosis (MF) is a rare hematopoietic stem cell disorder progressing to bone marrow (BM) failure or blast phase. Allogeneic hematopoietic cell transplantation (HCT) represents a potentially curative therapy for a limited subset of ... ...

    Abstract Introduction: Myelofibrosis (MF) is a rare hematopoietic stem cell disorder progressing to bone marrow (BM) failure or blast phase. Allogeneic hematopoietic cell transplantation (HCT) represents a potentially curative therapy for a limited subset of patients with advanced MF, who are eligible, but engraftment in MF vs. AML is delayed which promotes complications. As determinants of engraftment in MF are incompletely characterized, we studied engraftment dynamics at our center.
    Methods: A longitudinal cohort of 71 allogeneic HCT performed 2000-2019 with >50% after 2015 was evaluated.
    Results: Median time to neutrophil engraftment ≥0.5x109/l was +20 days post-transplant and associated with BM fibrosis, splenomegaly and infused CD34+ cell number. Engraftment dynamics were similar in primary vs. secondary MF and were independent of MF driver mutations in JAK2, CALR and MPL. Neutrophil engraftment occurred later upon haploidentical HCT with thiotepa-busulfan-fludarabine conditioning, post-transplant cyclophosphamide and G-CSF (TBF-PTCy/G-CSF) administered to 9.9% and 15.6% of patients in 2000-2019 and after 2015, respectively. Engraftment of platelets was similarly delayed, while reconstitution of reticulocytes was not affected.
    Conclusions: Since MF is a rare hematologic malignancy, this data from a large number of HCT for MF is essential to substantiate that later neutrophil and platelet engraftment in MF relates both to host and treatment-related factors. Observations from this longitudinal cohort support that novel conditioning schemes administered also to rare entities such as MF, require detailed evaluation in larger, multi-center cohorts to assess also indicators of long-term graft function and overall outcome in patients with this infrequent hematopoietic neoplasm undergoing allogeneic transplantation.
    Language English
    Publishing date 2023-08-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2023.1205387
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  10. Article ; Online: Acute myeloid leukaemia genomics.

    Medinger, Michael / Passweg, Jakob R

    British journal of haematology

    2017  Volume 179, Issue 4, Page(s) 530–542

    Abstract: Acute myeloid leukaemia (AML) is a biologically complex, molecularly and clinically heterogeneous disease. Despite major advances in understanding the genetic landscape of AML and its impact on the pathophysiology and biology of the disease, standard ... ...

    Abstract Acute myeloid leukaemia (AML) is a biologically complex, molecularly and clinically heterogeneous disease. Despite major advances in understanding the genetic landscape of AML and its impact on the pathophysiology and biology of the disease, standard treatment options have not significantly changed during the past three decades. AML is characterized by multiple somatically acquired mutations that affect genes of different functional categories. Mutations in genes encoding epigenetic modifiers, such as DNMT3A, ASXL1, TET2, IDH1, and IDH2, are commonly acquired early and are present in the founding clone. By contrast, mutations involving NPM1 or signalling molecules (e.g., FLT3, RAS gene family) are typically secondary events that occur later during leukaemogenesis. This review aims to provide an overview of advances in new prognostic markers, including targetable mutations that will probably guide the development and use of novel molecularly targeted therapies.
    Language English
    Publishing date 2017-11
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.14823
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    Uh III Zs.182: Show issues Location:
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