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  1. Article ; Online: The matrix reloaded - Addressing structural integrity of the aortic wall in aneurysmal disease.

    Wagenseil, Jessica E

    Biomaterials and biosystems

    2023  Volume 9, Page(s) 100072

    Abstract: Thoracic aortic aneurysms and dissections (TAADs) involve dilation of the aortic wall that can lead to tearing or rupture. Progressive extracellular matrix (ECM) degradation is common in TAAD, regardless of the underlying cause. TAAD treatments typically ...

    Abstract Thoracic aortic aneurysms and dissections (TAADs) involve dilation of the aortic wall that can lead to tearing or rupture. Progressive extracellular matrix (ECM) degradation is common in TAAD, regardless of the underlying cause. TAAD treatments typically target cellular signaling pathways, rather than the ECM itself, due to the complex assembly process and long half-life of ECM proteins. Compounds that stabilize the ECM are proposed as an alternative TAAD therapy that addresses the underlying cause of aortic wall failure, namely compromised structural integrity. Compounds are discussed that revisit historical approaches to maintain and preserve structural integrity of biological tissues.
    Language English
    Publishing date 2023-01-18
    Publishing country England
    Document type Journal Article
    ISSN 2666-5344
    ISSN (online) 2666-5344
    DOI 10.1016/j.bbiosy.2023.100072
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  2. Article: Editorial: Putting engineering back in vascular tissue engineering to advance basic science and clinical applications.

    Murfee, Walter L / Wagenseil, Jessica E

    Frontiers in cardiovascular medicine

    2022  Volume 9, Page(s) 1025465

    Language English
    Publishing date 2022-09-21
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2022.1025465
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  3. Article ; Online: Reduced Amount or Integrity of Arterial Elastic Fibers Alters Allometric Scaling Relationships for Aortic Diameter and Heart Weight, But Not Cardiac Function in Maturing Mice.

    Wagenseil, Jessica E

    Journal of biomechanical engineering

    2019  Volume 141, Issue 4

    Abstract: Allometric scaling laws relate physiologic parameters to body weight. Genetically modified mice allow investigation of allometric scaling laws when fundamental cardiovascular components are altered. Elastin haploinsufficient (Eln+/-) mice have reduced ... ...

    Abstract Allometric scaling laws relate physiologic parameters to body weight. Genetically modified mice allow investigation of allometric scaling laws when fundamental cardiovascular components are altered. Elastin haploinsufficient (Eln+/-) mice have reduced elastin amounts, and fibulin-5 knockout (Fbln5-/-) mice have compromised elastic fiber integrity in the large arteries which may alter cardiovascular scaling laws. Previously published echocardiography data used to investigate aortic and left ventricular function in Eln+/- and Fbln5-/- mice throughout postnatal development and early adulthood were reanalyzed to determine cardiovascular scaling laws. Aortic diameter, heart weight, stroke volume, and cardiac output have scaling exponents within 1-32% of the predicted theoretical range, indicating that the scaling laws apply to maturing mice. For aortic diameter, Eln+/- and Eln+/+ mice have similar scaling exponents, but different scaling constants, suggesting a shift in starting diameter, but no changes in aortic growth with body weight. In contrast, the scaling exponent for aortic diameter in Fbln5-/- mice is lower than Fbln5+/+ mice, but the scaling constant is similar, suggesting that aortic growth with body weight is compromised in Fbln5-/- mice. For both Eln+/- and Fbln5-/- groups, the scaling constant for heart weight is increased compared to the respective control group, suggesting an increase in starting heart weight, but no change in the increase with body weight during maturation. The scaling exponents and constants for stroke volume and cardiac output are not significantly affected by reduced elastin amounts or compromised elastic fiber integrity in the large arteries, highlighting a robust cardiac adaptation despite arterial defects.
    Language English
    Publishing date 2019-01-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 243094-0
    ISSN 1528-8951 ; 0148-0731
    ISSN (online) 1528-8951
    ISSN 0148-0731
    DOI 10.1115/1.4042766
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  4. Article: Bio-chemo-mechanics of thoracic aortic aneurysms.

    Wagenseil, Jessica E

    Current opinion in biomedical engineering

    2018  Volume 5, Page(s) 50–57

    Abstract: Most thoracic aortic aneurysms (TAAs) occur in the ascending aorta. This review focuses on the unique bio-chemo-mechanical environment that makes the ascending aorta susceptible to TAA. The environment includes solid mechanics, fluid mechanics, cell ... ...

    Abstract Most thoracic aortic aneurysms (TAAs) occur in the ascending aorta. This review focuses on the unique bio-chemo-mechanical environment that makes the ascending aorta susceptible to TAA. The environment includes solid mechanics, fluid mechanics, cell phenotype, and extracellular matrix composition. Advances in solid mechanics include quantification of biaxial deformation and complex failure behavior of the TAA wall. Advances in fluid mechanics include imaging and modeling of hemodynamics that may lead to TAA formation. For cell phenotype, studies demonstrate changes in cell contractility that may serve to sense mechanical changes and transduce chemical signals. Studies on matrix defects highlight the multi-factorial nature of the disease. We conclude that future work should integrate the effects of bio-chemo-mechanical factors for improved TAA treatment.
    Language English
    Publishing date 2018-02-07
    Publishing country England
    Document type Journal Article
    ISSN 2468-4511
    ISSN 2468-4511
    DOI 10.1016/j.cobme.2018.01.002
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  5. Article ; Online: Does elastin deficiency cause chronic kidney disease?

    Wagenseil, Jessica E

    Kidney international

    2017  Volume 92, Issue 5, Page(s) 1036–1038

    Abstract: Elastin deficiency in aging and disease is linked to increased vascular stiffness and hypertension, which are both associated with chronic kidney disease. Owens et al. show that alterations in renal arteries and kidney structure precede or are ... ...

    Abstract Elastin deficiency in aging and disease is linked to increased vascular stiffness and hypertension, which are both associated with chronic kidney disease. Owens et al. show that alterations in renal arteries and kidney structure precede or are independent of hypertension in elastin haploinsufficient mice. This commentary addresses the authors' findings in light of the relationships between elastin amounts, vascular stiffness, and pressure wave reflection and transmission in the kidney vasculature.
    MeSH term(s) Animals ; Elastin ; Humans ; Hypertension ; Kidney ; Mice ; Renal Insufficiency, Chronic ; Vascular Stiffness
    Chemical Substances Elastin (9007-58-3)
    Language English
    Publishing date 2017
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2017.05.027
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  6. Article ; Online: Elastin, arterial mechanics, and stenosis.

    Lin, Chien-Jung / Cocciolone, Austin J / Wagenseil, Jessica E

    American journal of physiology. Cell physiology

    2022  Volume 322, Issue 5, Page(s) C875–C886

    Abstract: Elastin is a long-lived extracellular matrix protein that is organized into elastic fibers that provide elasticity to the arterial wall, allowing stretch and recoil with each cardiac cycle. By forming lamellar units with smooth muscle cells, elastic ... ...

    Abstract Elastin is a long-lived extracellular matrix protein that is organized into elastic fibers that provide elasticity to the arterial wall, allowing stretch and recoil with each cardiac cycle. By forming lamellar units with smooth muscle cells, elastic fibers transduce tissue-level mechanics to cell-level changes through mechanobiological signaling. Altered amounts or assembly of elastic fibers leads to changes in arterial structure and mechanical behavior that compromise cardiovascular function. In particular, genetic mutations in the elastin gene (
    MeSH term(s) Animals ; Aorta/metabolism ; Arteries/metabolism ; Constriction, Pathologic/metabolism ; Elastin/genetics ; Elastin/metabolism ; Elastin/pharmacology ; Mice ; Myocytes, Smooth Muscle/metabolism
    Chemical Substances Elastin (9007-58-3)
    Language English
    Publishing date 2022-02-23
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 392098-7
    ISSN 1522-1563 ; 0363-6143
    ISSN (online) 1522-1563
    ISSN 0363-6143
    DOI 10.1152/ajpcell.00448.2021
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  7. Article ; Online: Severing umbilical ties.

    Wagenseil, Jessica E / Downs, Karen M

    eLife

    2020  Volume 9

    Abstract: High levels of proteins called proteoglycans in the walls of umbilical arteries enable these arteries to close rapidly after birth and thus prevent blood loss in newborns. ...

    Abstract High levels of proteins called proteoglycans in the walls of umbilical arteries enable these arteries to close rapidly after birth and thus prevent blood loss in newborns.
    MeSH term(s) Cell Division ; Humans ; Infant, Newborn ; Proteoglycans ; Sex Characteristics ; Umbilical Arteries
    Chemical Substances Proteoglycans
    Language English
    Publishing date 2020-10-12
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.63128
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  8. Article ; Online: Constitutive Modeling of Mouse Arteries Suggests Changes in Directional Coupling and Extracellular Matrix Remodeling That Depend on Artery Type, Age, Sex, and Elastin Amounts.

    Kailash, Keshav A / Hawes, Jie Z / Cocciolone, Austin J / Bersi, Matthew R / Mecham, Robert P / Wagenseil, Jessica E

    Journal of biomechanical engineering

    2024  Volume 146, Issue 5

    Abstract: ... We also find that remodeling to maintain homeostatic (i.e., young, wildtype) values of biomechanical ...

    Abstract Arterial stiffening occurs during natural aging, is associated with an increased risk of adverse cardiovascular events, and can follow different timelines in males and females. One mechanism of arterial stiffening includes remodeling of the extracellular matrix (ECM), which alters the wall material properties. We used elastin haploinsufficient (Eln+/-) and wildtype (Eln+/+) mice to investigate how material properties of two different arteries (ascending aorta and carotid artery) change with age, sex, and ECM composition. We used a constitutive model by Dong and Sun that is based on the Holzapfel-Gasser-Ogden (HGO) type, but does not require a discrete number of fibrous ECM families and allows varied deformation coupling. We find that the amount of deformation coupling for the best fit model depends on the artery type. We also find that remodeling to maintain homeostatic (i.e., young, wildtype) values of biomechanical parameters with age, sex, and ECM composition depends on the artery type, with ascending aorta being more adaptable than carotid artery. Fitted material constants indicate sex-dependent remodeling that may be important for determining the time course of arterial stiffening in males and females. We correlated fitted material constants with ECM composition measured by biochemical (ascending aorta) or histological (carotid artery) methods. We show significant correlations between ECM composition and material parameters for the mean values for each group, with biochemical measurements correlating more strongly than histological measurements. Understanding how arterial stiffening depends on age, sex, ECM composition, and artery type may help design effective, personalized clinical treatment strategies.
    MeSH term(s) Animals ; Female ; Humans ; Male ; Mice ; Aorta/pathology ; Carotid Arteries ; Elastin ; Extracellular Matrix ; Extracellular Matrix Proteins
    Chemical Substances Elastin (9007-58-3) ; Extracellular Matrix Proteins ; Eln protein, mouse
    Language English
    Publishing date 2024-03-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 243094-0
    ISSN 1528-8951 ; 0148-0731
    ISSN (online) 1528-8951
    ISSN 0148-0731
    DOI 10.1115/1.4063272
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  9. Article ; Online: Pentagalloyl Glucose (PGG) Prevents and Restores Mechanical Changes Caused by Elastic Fiber Fragmentation in the Mouse Ascending Aorta.

    Crandall, Christie L / Caballero, Bryant / Viso, Mariana E / Vyavahare, Naren R / Wagenseil, Jessica E

    Annals of biomedical engineering

    2022  Volume 51, Issue 4, Page(s) 806–819

    Abstract: Thoracic aortic aneurysm (TAA) is characterized by dilation of the aorta that can lead to dissection or rupture. Degradation of elastic fibers is a consistent histopathological feature of TAA that likely contributes to disease progression. Pentagalloyl ... ...

    Abstract Thoracic aortic aneurysm (TAA) is characterized by dilation of the aorta that can lead to dissection or rupture. Degradation of elastic fibers is a consistent histopathological feature of TAA that likely contributes to disease progression. Pentagalloyl glucose (PGG) shows promise for stabilizing elastic fibers in abdominal aortic aneurysms, but its efficacy and mechanical effects in the thoracic aorta are unknown. We simulated TAAs using elastase (ELA) to degrade elastic fibers in the mouse ascending aorta and determined the preventative and restorative potential of PGG. Biaxial mechanical tests, constitutive model fitting, and multiphoton imaging were performed on untreated (UNT), PGG, ELA, PGG + ELA, and ELA + PGG treated aortas. PGG treatment alone does not significantly alter mechanical properties or wall structure compared to UNT. ELA treatment alone causes an increase in the unloaded diameter and length, decreased compliance, significant changes in the material constants, and separation of the outer layers of the aortic wall compared to UNT. PGG treatment before or after ELA ameliorates the mechanical and structural changes associated with elastic fiber degradation, with preventative PGG treatment being most effective. These results suggest that PGG is a potential pharmaceutical option to stabilize elastic fibers in TAA.
    MeSH term(s) Mice ; Animals ; Elastic Tissue/metabolism ; Aorta/pathology ; Aortic Aneurysm, Thoracic ; Pancreatic Elastase ; Pharmaceutical Preparations/metabolism ; Glucose/metabolism
    Chemical Substances Pancreatic Elastase (EC 3.4.21.36) ; Pharmaceutical Preparations ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2022-10-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 185984-5
    ISSN 1573-9686 ; 0191-5649 ; 0090-6964
    ISSN (online) 1573-9686
    ISSN 0191-5649 ; 0090-6964
    DOI 10.1007/s10439-022-03093-x
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  10. Article ; Online: Statistical shape representation of the thoracic aorta: accounting for major branches of the aortic arch.

    Wiputra, Hadi / Matsumoto, Shion / Wagenseil, Jessica E / Braverman, Alan C / Voeller, Rochus K / Barocas, Victor H

    Computer methods in biomechanics and biomedical engineering

    2022  Volume 26, Issue 13, Page(s) 1557–1571

    Abstract: Statistical shape modeling (SSM) is an emerging tool for risk assessment of thoracic aortic aneurysm. However, the head branches of the aortic arch are often excluded in SSM. We introduced an SSM strategy based on principal component analysis that ... ...

    Abstract Statistical shape modeling (SSM) is an emerging tool for risk assessment of thoracic aortic aneurysm. However, the head branches of the aortic arch are often excluded in SSM. We introduced an SSM strategy based on principal component analysis that accounts for aortic branches and applied it to a set of patient scans. Computational fluid dynamics were performed on the reconstructed geometries to identify the extent to which branch model accuracy affects the calculated wall shear stress (WSS) and pressure. Surface-averaged and location-specific values of pressure did not change significantly, but local WSS error was high near branches when inaccurately modeled.
    MeSH term(s) Humans ; Aorta, Thoracic/diagnostic imaging ; Hemodynamics ; Aorta ; Aortic Aneurysm, Thoracic ; Models, Statistical ; Stress, Mechanical ; Models, Cardiovascular ; Blood Flow Velocity
    Language English
    Publishing date 2022-09-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2071764-7
    ISSN 1476-8259 ; 1025-5842
    ISSN (online) 1476-8259
    ISSN 1025-5842
    DOI 10.1080/10255842.2022.2128672
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