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  1. Article ; Online: Clinical Updates in Women's Health Care Summary: Arthritis.

    Pattanaik, Debendra

    Obstetrics and gynecology

    2018  Volume 131, Issue 2, Page(s) 618

    Abstract: Arthritis is a commonly encountered problem in daily clinical practice, and with an aging population it will be as prevalent as any other chronic illness, such as diabetes mellitus, hypertension, and hypercholesterolemia. Obstetrician-gynecologists often ...

    Abstract Arthritis is a commonly encountered problem in daily clinical practice, and with an aging population it will be as prevalent as any other chronic illness, such as diabetes mellitus, hypertension, and hypercholesterolemia. Obstetrician-gynecologists often encounter patients with arthritic symptoms in their practices. They may find it challenging to identify the underlying cause of arthritis and provide recommendations, as well as provide obstetric care to patients with known arthritis. The monograph will discuss common forms of arthritis, diagnostic testing and appropriate management, and referral of patients who need specialized care. Commonly encountered forms of inflammatory arthritis are discussed in this monograph with special emphasis on diagnosis and management. Management of arthritis in the context of pregnancy and lactation also is discussed.
    Language English
    Publishing date 2018-02-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 207330-4
    ISSN 1873-233X ; 0029-7844
    ISSN (online) 1873-233X
    ISSN 0029-7844
    DOI 10.1097/AOG.0000000000002527
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Endothelial Dysfunction in Systemic Sclerosis.

    Patnaik, Eshaan / Lyons, Matthew / Tran, Kimberly / Pattanaik, Debendra

    International journal of molecular sciences

    2023  Volume 24, Issue 18

    Abstract: Systemic sclerosis, commonly known as scleroderma, is an autoimmune disorder characterized by vascular abnormalities, autoimmunity, and multiorgan fibrosis. The exact etiology is not known but believed to be triggered by environmental agents in a ... ...

    Abstract Systemic sclerosis, commonly known as scleroderma, is an autoimmune disorder characterized by vascular abnormalities, autoimmunity, and multiorgan fibrosis. The exact etiology is not known but believed to be triggered by environmental agents in a genetically susceptible host. Vascular symptoms such as the Raynaud phenomenon often precede other fibrotic manifestations such as skin thickening indicating that vascular dysfunction is the primary event. Endothelial damage and activation occur early, possibly triggered by various infectious agents and autoantibodies. Endothelial dysfunction, along with defects in endothelial progenitor cells, leads to defective angiogenesis and vasculogenesis. Endothelial to mesenchymal cell transformation is another seminal event during pathogenesis that progresses to tissue fibrosis. The goal of the review is to discuss the molecular aspect of the endothelial dysfunction that leads to the development of systemic sclerosis.
    MeSH term(s) Humans ; Vascular Diseases ; Scleroderma, Systemic/etiology ; Autoantibodies ; Autoimmunity ; Fibrosis
    Chemical Substances Autoantibodies
    Language English
    Publishing date 2023-09-21
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241814385
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Endothelial Dysfunction in Systemic Sclerosis

    Eshaan Patnaik / Matthew Lyons / Kimberly Tran / Debendra Pattanaik

    International Journal of Molecular Sciences, Vol 24, Iss 14385, p

    2023  Volume 14385

    Abstract: Systemic sclerosis, commonly known as scleroderma, is an autoimmune disorder characterized by vascular abnormalities, autoimmunity, and multiorgan fibrosis. The exact etiology is not known but believed to be triggered by environmental agents in a ... ...

    Abstract Systemic sclerosis, commonly known as scleroderma, is an autoimmune disorder characterized by vascular abnormalities, autoimmunity, and multiorgan fibrosis. The exact etiology is not known but believed to be triggered by environmental agents in a genetically susceptible host. Vascular symptoms such as the Raynaud phenomenon often precede other fibrotic manifestations such as skin thickening indicating that vascular dysfunction is the primary event. Endothelial damage and activation occur early, possibly triggered by various infectious agents and autoantibodies. Endothelial dysfunction, along with defects in endothelial progenitor cells, leads to defective angiogenesis and vasculogenesis. Endothelial to mesenchymal cell transformation is another seminal event during pathogenesis that progresses to tissue fibrosis. The goal of the review is to discuss the molecular aspect of the endothelial dysfunction that leads to the development of systemic sclerosis.
    Keywords systemic sclerosis ; endothelial cell ; angiogenesis ; vasculogenesis ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 616
    Language English
    Publishing date 2023-09-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: A case of perioperative anaphylaxis presenting as hereditary alpha tryptasemia.

    Ritter, Shaunah / Bowden, Jarred / Pattanaik, Debendra

    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology

    2022  Volume 129, Issue 1, Page(s) 13–16

    MeSH term(s) Anaphylaxis/diagnosis ; Anaphylaxis/genetics ; Humans ; Mast Cells ; Mastocytosis ; Tryptases/genetics
    Chemical Substances Tryptases (EC 3.4.21.59)
    Language English
    Publishing date 2022-03-12
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 1228189-x
    ISSN 1534-4436 ; 0003-4738 ; 1081-1206
    ISSN (online) 1534-4436
    ISSN 0003-4738 ; 1081-1206
    DOI 10.1016/j.anai.2022.03.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Safety of Recombinant Zoster Vaccine in Rheumatology Patients.

    Raza, Syed / Acharya, Saurav / Howard, Gabrielle / Pattanaik, Debendra

    Southern medical journal

    2022  Volume 115, Issue 2, Page(s) 125–128

    Abstract: Objectives: Recombinant zoster vaccine (RZV) is Food and Drug Administration approved for the prevention of herpes zoster (shingles) in adults 50 years old and older. Immunocompromised subjects were excluded from the pivotal vaccine trials. We studied ... ...

    Abstract Objectives: Recombinant zoster vaccine (RZV) is Food and Drug Administration approved for the prevention of herpes zoster (shingles) in adults 50 years old and older. Immunocompromised subjects were excluded from the pivotal vaccine trials. We studied the safety of this vaccine in our university-affiliated rheumatology practice.
    Methods: This was a single-center, retrospective study focusing on subjects who received RZV during 2018. We collected the demographic data, any self-reported adverse events after vaccination, C-reactive protein, Routine Assessment of Patient Index Data 3 (RAPID3) scores for subjects with rheumatoid arthritis, and available RAPID3 scores for all study subjects before and after the vaccination.
    Results: Comparision of C-reactive protein (n = 40), RAPID3 scores for subjects with rheumatoid arthritis (n = 16), and available RAPID3 scores for all subjects (n = 21) using the paired
    Conclusions: The RZV was safe and well tolerated among our study population.
    MeSH term(s) Adult ; Aged ; Arthritis, Rheumatoid/complications ; Arthritis, Rheumatoid/physiopathology ; Herpes Zoster/drug therapy ; Herpes Zoster/prevention & control ; Humans ; Male ; Middle Aged ; Patient Safety/standards ; Patient Safety/statistics & numerical data ; Retrospective Studies ; Rheumatology/methods ; Rheumatology/statistics & numerical data ; Vaccines, Synthetic/adverse effects ; Vaccines, Synthetic/therapeutic use
    Chemical Substances Vaccines, Synthetic
    Language English
    Publishing date 2022-02-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 185329-6
    ISSN 1541-8243 ; 0038-4348
    ISSN (online) 1541-8243
    ISSN 0038-4348
    DOI 10.14423/SMJ.0000000000001354
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Relapse and Outcome of Lupus Nephritis After Renal Transplantation in the Modern Immunosuppressive Era.

    Pattanaik, Debendra / Green, Joseph / Talwar, Manish / Molnar, Miklos

    Cureus

    2022  Volume 14, Issue 1, Page(s) e20863

    Abstract: Background Recurrence of lupus nephritis in the graft is a concern in lupus patients with end-stage renal disease undergoing renal transplantation. The recurrence of lupus nephritis has been variable among different studies depending on the patient ... ...

    Abstract Background Recurrence of lupus nephritis in the graft is a concern in lupus patients with end-stage renal disease undergoing renal transplantation. The recurrence of lupus nephritis has been variable among different studies depending on the patient characteristics, immunosuppressive regimen, and indications of renal biopsy. Therefore, we investigated the recurrence of lupus nephritis among our patients to see if the new post-transplant regimen has impacted the recurrence. Methods We collected data on all recipients with end-stage renal disease secondary to lupus nephritis, who received renal transplants between 2006-2017 in our center. Patient demographics, transplant, and dialysis-related information have been recorded including kidney biopsy, graft loss, and survival were recorded. An association between recurrent lupus nephritis with survival and/or graft loss was examined using survival models. Results The overall mean±SD age at baseline was 42±13 years; 89% were female; 89% were African American; the previous time on dialysis was a median of 4 years (IQR: 2-8 years), 81% received hemodialysis and 31% received living donor transplantation in the cohort. Our patients received the standard immunosuppressive regimen consisting of prednisone, tacrolimus, and mycophenolate mofetil. Four (10.5%) of the 38 patients had biopsy-proven lupus nephritis recurrence. A total of 10 patients (26%) had graft loss or died during the median follow-up time of 1,230 days (IQR: 460-2,227 days). Recurrence of lupus nephritis showed a trend for increased risk of graft loss or patient death (Hazard Ratio: 3.14, 95%Confidence Interval: 0.65-15.24) compared to the recipient without recurrence in our unadjusted proportional Cox regression model. Conclusion The recurrence rate of lupus nephritis in our patient population is much lower compared to past studies from different immunosuppressive eras. Patients with recurrent lupus nephritis showed an increased risk of graft loss or death.
    Language English
    Publishing date 2022-01-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.20863
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Eosinophilic Granulomatosis Polyangiitis (EGPA) Masquerading as a Mycotic Aneurysm of the Abdominal Aorta: Case Report and Review of Literature.

    Kumari, Pooja / Pattanaik, Debendra / Williamson, Claire

    Case reports in rheumatology

    2021  Volume 2021, Page(s) 7093607

    Abstract: Introduction: Aortic involvement leading to aortitis in eosinophilic granulomatosis polyangiitis (EGPA) is infrequent, and only 2 cases have been reported so far in the literature. Even more so, aortic aneurysm, secondary to EGPA, has never been ... ...

    Abstract Introduction: Aortic involvement leading to aortitis in eosinophilic granulomatosis polyangiitis (EGPA) is infrequent, and only 2 cases have been reported so far in the literature. Even more so, aortic aneurysm, secondary to EGPA, has never been reported and remains a diagnostic and therapeutic challenge.
    Conclusion: Abdominal aneurysms should be considered a complication of EGPA, and earlier immunosuppressive therapy should be considered to prevent further complications.
    Language English
    Publishing date 2021-09-13
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2666708-3
    ISSN 2090-6897 ; 2090-6889
    ISSN (online) 2090-6897
    ISSN 2090-6889
    DOI 10.1155/2021/7093607
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Common variable immunodeficiency (CVID) with granulomatous interstitial lung disease (GLILD) and SARS COVID-19 infection: case report and review of literature.

    Pattanaik, Debendra / Ritter, Shaunah / Fahhoum, Joseph

    Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology

    2021  Volume 17, Issue 1, Page(s) 98

    Abstract: Background: We present a case of CVID complicated by granulomatous interstitial lung disease (GLILD). This patient clinical course was further complicated by COVID-19 infection. This is only the 2nd known case report of COVID 19 in CVID with GLILD. The ... ...

    Abstract Background: We present a case of CVID complicated by granulomatous interstitial lung disease (GLILD). This patient clinical course was further complicated by COVID-19 infection. This is only the 2nd known case report of COVID 19 in CVID with GLILD. The clinical course and outcome of COVID 19 infection with common variable immunodeficiency (CVID) and GLILD is not well known.
    Case presentation: Our patient met the clinical features of CVID secondary to low IgG/IgA, recurrent infections, and failure to respond to pneumococcal vaccination. He was treated with monthly maintenance IVIG therapy. Our patient also was diagnosed with co-existing GLILD that despite IVIG treatment was progressing. The patient needed to be started on Rituxan and Mycophenolate mofetil to achieve control but unfortunately became infected with COVID19 delaying his treatment for GLILD. Our patient only suffered from mild COVID 19 infection and was able to make antibodies to this. We believe severe infection was avoided as his CVID was well controlled with IVIG therapy despite progression of his granulomatous interstitial lung disease.
    Conclusion: In conclusion, our patient with CVID with co-existing biopsy proven granulomatous interstitial lung disease despite being very high risk for severe COVID 19 infections only had mild infection. This was believed to be due to well controlled CVID with IVIG therapy.
    Language English
    Publishing date 2021-09-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 2434973-2
    ISSN 1710-1492 ; 1710-1484
    ISSN (online) 1710-1492
    ISSN 1710-1484
    DOI 10.1186/s13223-021-00600-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Cellular and Molecular Mechanisms of Anti-Phospholipid Syndrome.

    Radic, Marko / Pattanaik, Debendra

    Frontiers in immunology

    2018  Volume 9, Page(s) 969

    Abstract: The primary anti-phospholipid syndrome (APS) is characterized by the production of antibodies that bind the phospholipid-binding protein β2 glycoprotein I (β2GPI) or that directly recognize negatively charged membrane phospholipids in a manner that may ... ...

    Abstract The primary anti-phospholipid syndrome (APS) is characterized by the production of antibodies that bind the phospholipid-binding protein β2 glycoprotein I (β2GPI) or that directly recognize negatively charged membrane phospholipids in a manner that may contribute to arterial or venous thrombosis. Clinically, the binding of antibodies to β2GPI could contribute to pathogenesis by formation of immune complexes or modification of coagulation steps that operate along cell surfaces. However, additional events are likely to play a role in pathogenesis, including platelet and endothelial cell activation. Recent studies focus on neutrophil release of chromatin in the form of neutrophil extracellular traps as an important disease contributor. Jointly, the participation of both the innate and adaptive arms of the immune system in aspects of the APS make the complete understanding of crucial steps in pathogenesis extremely difficult. Only coordinated and comprehensive analyses, carried out in different clinical and research settings, are likely to advance the understanding of this complex disease condition.
    MeSH term(s) Animals ; Antibodies, Antiphospholipid/blood ; Antigen-Antibody Complex/immunology ; Antiphospholipid Syndrome/genetics ; Antiphospholipid Syndrome/immunology ; Autoantibodies ; Cell Membrane/immunology ; Extracellular Traps/immunology ; Female ; Genetic Predisposition to Disease ; Humans ; Immunity, Innate ; Mice ; Pregnancy ; Signal Transduction ; Thrombosis/immunology ; beta 2-Glycoprotein I/metabolism
    Chemical Substances Antibodies, Antiphospholipid ; Antigen-Antibody Complex ; Autoantibodies ; beta 2-Glycoprotein I
    Language English
    Publishing date 2018-05-07
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2018.00969
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Infusion-related angioedema associated with infliximab-abda: Case report.

    Herndon, Kyle / Dewitt, Alexandra / Gillion, Amanda / Pattanaik, Debendra

    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists

    2020  Volume 78, Issue 2, Page(s) 108–112

    Abstract: Purpose: A case of infusion-related angioedema associated with the use of an infliximab biosimilar (infliximab-abda) is reported in order to bring awareness that this adverse effect is still highly possible in biosimilars, similar to the reference ... ...

    Abstract Purpose: A case of infusion-related angioedema associated with the use of an infliximab biosimilar (infliximab-abda) is reported in order to bring awareness that this adverse effect is still highly possible in biosimilars, similar to the reference infliximab biologic.
    Summary: A 37-year-old white male with a past medical history significant for ileocolonic fistulizing Crohn's disease, depression, and gastroesophageal reflux disease (GERD) presented to an emergency department with shortness of breath, urticaria, and tongue swelling that had developed shortly after initiation of an infusion of infliximab-abda. The patient had no documented allergies at the time of presentation. The patient was taking oral budesonide 9 mg daily and oral azathioprine 50 mg daily for treatment of Crohn's disease. Other medications included oral omeprazole 40 mg every morning for GERD and oral sertraline 100 mg daily for depression. The patient's tongue swelling worsened, and he was intubated for airway protection. The patient received supportive care treatment for angioedema with intravenous (IV) dexamethasone 8 mg every 8 hours, IV diphenhydramine 50 mg every 8 hours, and IV famotidine 20 mg every 12 hours. He was extubated approximately 43 hours later and observed overnight in a medical intensive care unit. He was transferred to a general medicine unit the next day for further care. The total hospital length of stay was 4 days.
    Conclusion: A 37-year-old man developed infusion-related angioedema with use of infliximab-abda. Discontinuation of the biosimilar product along with supportive care brought about resolution of angioedema. There are no prior published reports of infusion-related angioedema reactions secondary to infliximab-abda use.
    MeSH term(s) Adult ; Angioedema/chemically induced ; Angioedema/diagnosis ; Biosimilar Pharmaceuticals ; Crohn Disease ; Drug-Related Side Effects and Adverse Reactions ; Humans ; Infliximab/adverse effects ; Male
    Chemical Substances Biosimilar Pharmaceuticals ; Infliximab (B72HH48FLU)
    Language English
    Publishing date 2020-10-08
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 1224627-x
    ISSN 1535-2900 ; 1079-2082
    ISSN (online) 1535-2900
    ISSN 1079-2082
    DOI 10.1093/ajhp/zxaa321
    Database MEDical Literature Analysis and Retrieval System OnLINE

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