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  1. Article ; Online: Reply to B. Bennani-Baiti et al, H.J.A. Adams et al, E. Laffon et al, and E.A. Hawkes et al.

    Barrington, Sally F / Mikhaeel, N George / Kostakoglu, Lale / Meignan, Michel / Hutchings, Martin / Müeller, Stefan / Schwartz, Lawrence H / Zucca, Emanuele / Fisher, Richard I / Trotman, Judith / Hoekstra, Otto S / Hicks, Rodney J / O'Doherty, Michael J / Hustinx, Roland / Biggi, Alberto / Cavalli, Franco / Lister, T Andrew / Cheson, Bruce D

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology

    2015  Volume 33, Issue 10, Page(s) 1221–1223

    MeSH term(s) Fluorodeoxyglucose F18 ; Humans ; Lymphoma/diagnostic imaging ; Lymphoma/therapy ; Positron-Emission Tomography ; Radiopharmaceuticals ; Tomography, X-Ray Computed
    Chemical Substances Radiopharmaceuticals ; Fluorodeoxyglucose F18 (0Z5B2CJX4D)
    Language English
    Publishing date 2015-04-01
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 604914-x
    ISSN 1527-7755 ; 0732-183X
    ISSN (online) 1527-7755
    ISSN 0732-183X
    DOI 10.1200/JCO.2014.59.9373
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  2. Article: Genetic pathway to recurrent chromosome translocations in murine lymphoma involves V(D)J recombinase.

    Vanasse, G J / Halbrook, J / Thomas, S / Burgess, A / Hoekstra, M F / Disteche, C M / Willerford, D M

    The Journal of clinical investigation

    1999  Volume 103, Issue 12, Page(s) 1669–1675

    Abstract: ... expression. The V(D)J recombinase, which mediates physiologic rearrangements of antigen receptor genes ... mutation, demonstrating that DNA breaks generated during V(D)J recombination are required for oncogenic ... in vivo by efficient rejoining of DNA ends generated during V(D)J recombination and an intact cellular ...

    Abstract Chromosome translocations involving antigen receptor loci are a genetic hallmark of non-Hodgkin's lymphomas in humans. Most commonly, these translocations result in juxtaposition of the immunoglobulin heavy-chain (IgH) locus with one of several cellular proto-oncogenes, leading to deregulated oncogene expression. The V(D)J recombinase, which mediates physiologic rearrangements of antigen receptor genes, may play a mechanistic role in some lymphoma translocations, although evidence is indirect. A high incidence of B-lineage lymphomas has been observed in mice with severe combined immunodeficiency (SCID) and p53-null mutations. We show that these tumors are characteristic of the pro-B-cell stage of development and that they harbor recurrent translocations involving chromosomes 12 and 15. Fluorescence in situ hybridization (FISH) shows retention of IgH sequences on the derivative chromosome 12, implying that breakpoints involve the IgH locus. Pro-B-cell lymphomas were suppressed in SCID p53(-/-) mice by a Rag-2-null mutation, demonstrating that DNA breaks generated during V(D)J recombination are required for oncogenic transformation, and suggesting that t(12;15) arise during attempted IgH rearrangement in pro-B cells. These studies indicate that the oncogenic potential inherent in antigen receptor diversification is controlled in vivo by efficient rejoining of DNA ends generated during V(D)J recombination and an intact cellular response to DNA damage.
    MeSH term(s) Animals ; B-Lymphocytes/immunology ; DNA Nucleotidyltransferases/genetics ; Gene Rearrangement, B-Lymphocyte, Heavy Chain ; Immunoglobulin Heavy Chains/genetics ; Immunophenotyping ; Lymphoma, B-Cell/enzymology ; Lymphoma, B-Cell/genetics ; Lymphoma, B-Cell/immunology ; Mice ; Mice, Inbred C57BL ; Mice, Inbred ICR ; Mice, Knockout ; Mice, SCID ; Receptors, Antigen, B-Cell/genetics ; Stem Cells/immunology ; Translocation, Genetic/immunology ; Tumor Suppressor Protein p53/deficiency ; Tumor Suppressor Protein p53/genetics ; VDJ Recombinases
    Chemical Substances Immunoglobulin Heavy Chains ; Receptors, Antigen, B-Cell ; Tumor Suppressor Protein p53 ; DNA Nucleotidyltransferases (EC 2.7.7.-) ; VDJ Recombinases (EC 2.7.7.-)
    Language English
    Publishing date 1999-06
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 3067-3
    ISSN 1558-8238 ; 0021-9738
    ISSN (online) 1558-8238
    ISSN 0021-9738
    DOI 10.1172/JCI6658
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  3. Article ; Online: J. van Adrichem, De ontvangst van de moderne kunst in Nederland 1910-2000. Picasso als pars pro toto

    R. Hoekstra

    BMGN : Low Countries Historical Review, Vol 118, Iss 1, Pp 134-

    2003  Volume 136

    Keywords History (General) and history of Europe ; D ; History (General) ; D1-2009
    Publishing date 2003-01-01T00:00:00Z
    Publisher Utrecht University Library Open Access Journals
    Document type Article ; Online
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  4. Article ; Online: J. van Adrichem, De ontvangst van de moderne kunst in Nederland 1910-2000. Picasso als pars pro toto

    R. Hoekstra

    BMGN : Low Countries Historical Review, Vol 118, Iss 1, Pp 134-

    2003  Volume 136

    Keywords History (General) and history of Europe ; D ; History (General) ; D1-2009
    Publishing date 2003-01-01T00:00:00Z
    Document type Article ; Online
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  5. Article ; Online: Child and adolescent psychiatry in the post-COVID era: lessons learned and consequences for the future.

    Kaess, Michael / Hoekstra, Pieter J

    European child & adolescent psychiatry

    2023  Volume 32, Issue 6, Page(s) 917–919

    MeSH term(s) Adolescent ; Child ; Humans ; Adolescent Psychiatry ; COVID-19 ; Child Psychiatry ; Forecasting
    Language English
    Publishing date 2023-04-24
    Publishing country Germany
    Document type Editorial
    ZDB-ID 1118299-4
    ISSN 1435-165X ; 1018-8827 ; 1433-5719
    ISSN (online) 1435-165X
    ISSN 1018-8827 ; 1433-5719
    DOI 10.1007/s00787-023-02208-6
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  6. Article ; Online: Demographic history and genomic signatures of selection in a widespread vertebrate ectotherm.

    Judson, Jessica M / Hoekstra, Luke A / Janzen, Fredric J

    Molecular ecology

    2024  Volume 33, Issue 5, Page(s) e17269

    Abstract: Environmental conditions vary greatly across large geographic ranges, and yet certain species inhabit entire continents. In such species, genomic sequencing can inform our understanding of colonization history and the impact of selection on the genome as ...

    Abstract Environmental conditions vary greatly across large geographic ranges, and yet certain species inhabit entire continents. In such species, genomic sequencing can inform our understanding of colonization history and the impact of selection on the genome as populations experience diverse local environments. As ectothermic vertebrates are among the most vulnerable to environmental change, it is critical to understand the contributions of local adaptation to population survival. Widespread ectotherms offer an opportunity to explore how species can successfully inhabit such differing environments and how future climatic shifts will impact species' survival. In this study, we investigated the widespread painted turtle (Chrysemys picta) to assess population genomic structure, demographic history, and genomic signatures of selection in the western extent of the range. We found support for a substantial role of serial founder effects in shaping population genomic structure: demographic analysis and runs of homozygosity were consistent with bottlenecks of increasing severity from eastern to western populations during and following the Last Glacial Maximum, and edge populations were more strongly diverged and had less genetic diversity than those from the centre of the range. We also detected outlier loci, but allelic patterns in many loci could be explained by either genetic surfing or selection. While range expansion complicates the identification of loci under selection, we provide candidates for future study of local adaptation in a long-lived, widespread ectotherm that faces an uncertain future as the global climate continues to rapidly change.
    MeSH term(s) Animals ; Genome ; Genomics ; Vertebrates/genetics ; Demography ; Selection, Genetic
    Language English
    Publishing date 2024-01-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 1126687-9
    ISSN 1365-294X ; 0962-1083
    ISSN (online) 1365-294X
    ISSN 0962-1083
    DOI 10.1111/mec.17269
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  7. Article ; Online: Suicidality in children and adolescents: lessons to be learned from the COVID-19 crisis.

    Hoekstra, Pieter J

    European child & adolescent psychiatry

    2020  Volume 29, Issue 6, Page(s) 737–738

    Keywords covid19
    Language English
    Publishing date 2020-06-02
    Publishing country Germany
    Document type Editorial
    ZDB-ID 1118299-4
    ISSN 1435-165X ; 1018-8827 ; 1433-5719
    ISSN (online) 1435-165X
    ISSN 1018-8827 ; 1433-5719
    DOI 10.1007/s00787-020-01570-z
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  8. Article ; Online: Comment on "On the role of diurnal tides in contributing to asymmetries in tidal probability distribution functions in areas of predominantly semi-diurnal tide" by P.L. Woodworth, D.L. Blackman, D.T. Pugh and J.M. Vassie [Estuarine, Coastal and Shelf Science 64 (2005) 235-240]

    Hoitink, A.J.F. / Hoekstra, P. / van Maren, D.S.

    Estuarine Coastal and Shelf Science

    2006  Volume 67

    Abstract: ... D.L., Pugh, D.T., Vassie J.M., 2005. On the role of diurnal tides in contributing to asymmetries ...

    Abstract The present paper comments on a recent publication by Woodworth et al. [Woodworth, P.L., Blackman, D.L., Pugh, D.T., Vassie J.M., 2005. On the role of diurnal tides in contributing to asymmetries in tidal probability distribution functions in areas of predominantly semi-diurnal tide. Estuarine, Coastal and Shelf Science 64 (2¿3), 235¿240.]. It is shown how tidal asymmetries associated with astronomical tides can be accounted for in an extreme sea level analysis, despite the difficulty of deriving probability distribution functions if a large number of tidal constituents are considered. The use of the term spring¿neap cycle in a diurnal tidal regime is discussed
    Keywords sediment
    Language English
    Publishing country nl
    Document type Article ; Online
    ISSN 0272-7714
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  9. Article ; Online: Updated European guidelines for Tourette syndrome: and now use them!

    Hoekstra, Pieter J / Roessner, Veit

    European child & adolescent psychiatry

    2022  Volume 31, Issue 3, Page(s) 371–373

    MeSH term(s) Humans ; Tic Disorders ; Tourette Syndrome/therapy
    Language English
    Publishing date 2022-01-17
    Publishing country Germany
    Document type Editorial
    ZDB-ID 1118299-4
    ISSN 1435-165X ; 1018-8827 ; 1433-5719
    ISSN (online) 1435-165X
    ISSN 1018-8827 ; 1433-5719
    DOI 10.1007/s00787-021-01927-y
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  10. Article ; Online: First do no harm: use off-label antipsychotic medication in children and adolescents with great caution.

    Hoekstra, Pieter J / Dietrich, Andrea

    European child & adolescent psychiatry

    2022  Volume 31, Issue 1, Page(s) 1–3

    MeSH term(s) Adolescent ; Antipsychotic Agents/adverse effects ; Child ; Humans ; Mental Disorders/drug therapy ; Off-Label Use
    Chemical Substances Antipsychotic Agents
    Language English
    Publishing date 2022-01-19
    Publishing country Germany
    Document type Editorial
    ZDB-ID 1118299-4
    ISSN 1435-165X ; 1018-8827 ; 1433-5719
    ISSN (online) 1435-165X
    ISSN 1018-8827 ; 1433-5719
    DOI 10.1007/s00787-022-01950-7
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