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Article ; Online: Longitudinal Outcomes of Malignant Ureteral Obstruction Secondary to Ovarian Cancer: Predictors of Resolution and the Role of Surgical Management.

Faidley, Kathryn N / Botkin, Hannah E / Loeffler, Bradley T / Mott, Sarah L / Hansen, Samuel C / Hill, Emily K / Erickson, Bradley A

Urology

2024 Volume 186, Page(s) 101–106

Abstract: Objective: To review the management of ovarian cancer (OCa) associated hydronephrosis (HN). Specifically, we aim to identify optimal management of HN in the acute setting, predictors of HN resolution, and the role of surgery (tumor debulking/(+/-) ... ...

Abstract	Objective: To review the management of ovarian cancer (OCa) associated hydronephrosis (HN). Specifically, we aim to identify optimal management of HN in the acute setting, predictors of HN resolution, and the role of surgery (tumor debulking/(+/-)ureterolysis/hysterectomy). Materials/methods: The study cohort included OCa patients managed at our institution from 2004-2019 that developed OCa-associated HN. Initial HN management was recorded as none, retrograde ureteral stent (RUS) or percutaneous nephrostomy tube (PCN). Primary outcomes included (1) HN management failure, (2) HN management complications, and (3) HN resolution. Patient, cancer, and treatment predictors of outcomes were assessed using logistic regression and fine-Gray competing risk models. Results: Of 2580 OCa patients, 190 (7.4%) developed HN. HN was treated in 121; 90 (74.4%) with RUS, 31 (25.6%) with PCN. Complication rates were similar between PCN and RUS (83% vs 85.1%; P = .79; all Clavian Grade I/II). Initial HN treatment failure occurred in 28 patients, predicted by renal atrophy (hazard ratios (HR) 3.27, P <.01). HN resolution occurred in only 52 (27%) patients and was predicted by lower International Federation of Gynecology and Obstetrics (FIGO) stage (FIGO III/IV HR 0.42, P <.01) and surgical tumor debulking/ureterolysis (HR 2.83, P = .02). Conclusion: Resolution of HN associated with malignant obstruction from OCa is rare and is most closely associated with tumor debulking and International Federation of Gynecology and Obstetrics (FIGO) stage. Initial endoscopic treatment modality was not significantly associated with complications or resolution, though RUS failures were slightly more common. Ureteral reconstruction at time of debulking/ureterolysis is potentially underutilized.
MeSH term(s)	Humans ; Female ; Ureteral Obstruction/surgery ; Ureteral Obstruction/complications ; Ureter/surgery ; Hydronephrosis/surgery ; Ovarian Neoplasms/complications ; Ovarian Neoplasms/surgery ; Treatment Failure ; Stents/adverse effects ; Retrospective Studies
Language	English
Publishing date	2024-02-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	192062-5
ISSN	1527-9995 ; 0090-4295
ISSN (online)	1527-9995
ISSN	0090-4295
DOI	10.1016/j.urology.2024.02.001
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Zs.A 1142: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Partial wake therapy and luminotherapy as an adjunct to usual care in hospitalized patients with depression - a pilot study.

Singh, Balwinder / Kung, Simon / Poppe, Kathleen A / Brown, Sheryl L / Erickson, Carly / Hale, Ann M / Johnson, Bonnie L / Jones, Kelly L / Pazdernik, Vanessa K / Schak, Kathryn M / Betcher, Hannah K / Moore, Katherine M / Ozerdem, Aysegul / Veldic, Marin / Frye, Mark A / Bobo, William V

Psychiatry research

2024 Volume 337, Page(s) 115921

Language	English
Publishing date	2024-04-25
Publishing country	Ireland
Document type	Letter
ZDB-ID	445361-x
ISSN	1872-7123 ; 1872-7506 ; 0925-4927 ; 0165-1781
ISSN (online)	1872-7123 ; 1872-7506
ISSN	0925-4927 ; 0165-1781
DOI	10.1016/j.psychres.2024.115921
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Article: Is Workload Associated With Internal Impingement in Professional Baseball Pitchers? An Analysis of Days of Rest, Innings Pitched, and Batters Faced.

Chalmers, Peter N / Mcelheny, Kathryn / D'Angelo, John / Ma, Kevin / Rowe, Dana / Erickson, Brandon J

Orthopaedic journal of sports medicine

2023 Volume 11, Issue 8, Page(s) 23259671231191223

Abstract: Background: Internal impingement is a common cause of shoulder pain and dysfunction in baseball pitchers.: Purpose/hypothesis: The purpose of this study was to determine if the amount of rest days between outings, the number of innings pitched in ... ...

Abstract	Background: Internal impingement is a common cause of shoulder pain and dysfunction in baseball pitchers. Purpose/hypothesis: The purpose of this study was to determine if the amount of rest days between outings, the number of innings pitched in each outing, and the number of batters faced in each outing are risk factors for internal impingement in professional baseball pitchers. It was hypothesized that a higher workload would significantly increase a pitcher's risk of developing internal impingement. Study design: Case-control study; Level of evidence, 3. Methods: All professional (Major and Minor League) baseball pitchers who were diagnosed with internal impingement between 2011 and 2017 were identified using the Major League Baseball's Health and Injury Tracking System. A separate player usage data set was used to determine workload. The authors compared workload variables (days of rest, innings pitched, and batters faced per game) between each of 4 injury-exposure groups (pitchers with documented internal impingement <2, <6, <12, and >12 weeks after a game) and a control group of pitchers with no internal impingement using Student Results: Overall, there were 624 professional baseball pitchers diagnosed with internal impingement during the study period. Compared with pitcher games (n = 213,964), pitchers in all 4 injury-exposure groups had significantly more innings pitched per game ( Conclusion: This analysis revealed significantly greater pitcher workload and percentage of starting pitchers in professional baseball players diagnosed with internal impingement when compared with healthy controls. However, this injury did not seem to be associated with an acute increase in workload.
Language	English
Publishing date	2023-08-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	2706251-X
ISSN	2325-9671
ISSN	2325-9671
DOI	10.1177/23259671231191223
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Article ; Online: The future orientation of constructive memory: An evolutionary perspective on therapeutic hypnosis and brief psychotherapy.

Rossi, Ernest / Erickson-Klein, Roxanna / Rossi, Kathryn

The American journal of clinical hypnosis

2021 Volume 64, Issue 2, Page(s) 90–97

Abstract: We explore a new distinction between ... ...

Abstract	We explore a new distinction between the
MeSH term(s)	Biological Evolution ; Humans ; Hypnosis ; Psychotherapy ; Psychotherapy, Brief ; Retrospective Studies
Language	English
Publishing date	2021-12-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	219387-5
ISSN	2160-0562 ; 0002-9157
ISSN (online)	2160-0562
ISSN	0002-9157
DOI	10.1080/00029157.2021.1999141
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Article ; Online: Longitudinal Outcomes from Conservative Management of Cervical Cancer Associated Ureteral Obstruction.

Botkin, Hannah E / Faidley, Kathryn N / Loeffler, Bradley T / Mott, Sarah L / Hill, Emily K / Erickson, Bradley A

Urology

2021 Volume 158, Page(s) 208–214

Abstract: Objective: To identify predictors of hydronephrosis (HN) resolution and HN treatment failure. HN is a common comorbid condition with cervical cancer (CCa). Treatments for CCa continue to improve and long-term management strategies of HN are becoming ... ...

Abstract	Objective: To identify predictors of hydronephrosis (HN) resolution and HN treatment failure. HN is a common comorbid condition with cervical cancer (CCa). Treatments for CCa continue to improve and long-term management strategies of HN are becoming increasingly necessary. Methods: A query of a single hospital (2004 - 2019) ICD-9 and CPT codes was made to develop a cohort of CCa patients with HN. A retrospective review was performed. The effects of patient, renal/HN, and cancer covariates on time to HN treatment failure, treatment complications and time to HN resolution were evaluated using logistic regression and competing risk Cox regression models. Results: Of the 1670 women treated for CCa during the study period, 179 (10.7%) developed HN (n = 72 (40%) bilateral), 78 (44%) at time of CCa diagnosis and 101 (56%) as a result of treatment, of which 145 (81%) underwent initial treatment with a PCN (n = 77, 53%) or US (n = 68, 47%). Complication rates were similar between PCN (56%) and US (61%) when adjusting for treatment time. Initial treatment failure was more likely with US vs PCN (HR 3.2, P <0.01). HN resolution (n = 32, 22%) without reconstruction was predicted by HN concurrent with CCa diagnosis (HR 3.1, P <0.01) and bilateral HN (HR 0.2, P <0.01). Conclusion: CCa associated HN has a resolution rate of only 19% at 12 months. Those presenting with HN after CCa treatment are less likely to resolve without reconstruction. PCN and US have similar complication rates but initial US placement has a nearly three times increased risk of failing than PCN.
MeSH term(s)	Conservative Treatment ; Female ; Humans ; Hydronephrosis/etiology ; Hydronephrosis/therapy ; Middle Aged ; Retrospective Studies ; Time Factors ; Treatment Outcome ; Ureteral Obstruction/etiology ; Ureteral Obstruction/therapy ; Uterine Cervical Neoplasms/complications
Language	English
Publishing date	2021-09-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	192062-5
ISSN	1527-9995 ; 0090-4295
ISSN (online)	1527-9995
ISSN	0090-4295
DOI	10.1016/j.urology.2021.09.007
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Article ; Online: Knockdown of Placental Major Facilitator Superfamily Domain Containing 2a in Pregnant Mice Reduces Fetal Brain Growth and Phospholipid Docosahexaenoic Acid Content.

Powell, Theresa L / Barentsen, Kenneth / Vaughan, Owen / Uhlson, Charis / Zemski Berry, Karin / Erickson, Kathryn / Faer, Kelsey / Chassen, Stephanie S / Jansson, Thomas

Nutrients

2023 Volume 15, Issue 23

Abstract: Introduction: Docosahexaenoic acid (DHA) is an : Methods: Mouse blastocysts (E3.5) were transduced with an EGFP-expressing lentivirus containing either an shRNA targeting MFSD2a or a non-coding sequence (SCR), then transferred to pseudopregnant ... ...

Abstract	Introduction: Docosahexaenoic acid (DHA) is an Methods: Mouse blastocysts (E3.5) were transduced with an EGFP-expressing lentivirus containing either an shRNA targeting MFSD2a or a non-coding sequence (SCR), then transferred to pseudopregnant females. At E18.5, fetuses were weighed and their placenta, brain, liver and plasma were collected. MFSD2a mRNA expression was determined by qPCR in the brain, liver and placenta and phospholipid DHA was quantified by LC-MS/MS. Results: MFSD2a-targeting shRNA reduced placental mRNA MFSD2a expression by 38% at E18.5 ( Conclusions: Placenta-specific reduction in expression of the LPC-DHA transporter MFSD2a resulted in reduced fetal brain weight and lower phospholipid DHA content in the fetal brain. These data provide mechanistic evidence that placental MFSD2a mediates maternal-fetal transfer of LPC-DHA, which is critical for brain growth.
MeSH term(s)	Female ; Animals ; Pregnancy ; Humans ; Mice ; Docosahexaenoic Acids ; Phospholipids ; Chromatography, Liquid ; Symporters/metabolism ; Placenta/metabolism ; Tandem Mass Spectrometry ; Brain/metabolism ; Membrane Transport Proteins/metabolism ; Fatty Acids, Omega-3/metabolism ; RNA, Small Interfering/metabolism ; RNA, Messenger/metabolism
Chemical Substances	Docosahexaenoic Acids (25167-62-8) ; Phospholipids ; Symporters ; Membrane Transport Proteins ; Fatty Acids, Omega-3 ; RNA, Small Interfering ; RNA, Messenger
Language	English
Publishing date	2023-11-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu15234956
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Article ; Online: Is Workload Associated With Hamstring and Calf Strains in Professional Baseball Players? An Analysis of Days of Rest, Innings Fielded, and Plate Appearances.

Chalmers, Peter N / Mcelheny, Kathryn / D'Angelo, John / Ma, Kevin / Rowe, Dana / Erickson, Brandon J

Sports health

2022 Volume 15, Issue 4, Page(s) 479–485

Abstract: Background: The influence of player workload on hamstring and calf injuries in professional baseball players remains unknown.: Hypothesis: Increased workload would significantly increase hamstring and calf strain injury risk.: Study design: Case- ... ...

Abstract	Background: The influence of player workload on hamstring and calf injuries in professional baseball players remains unknown. Hypothesis: Increased workload would significantly increase hamstring and calf strain injury risk. Study design: Case-control. Level of evidence: Level 3. Methods: All professional baseball players who sustained a hamstring or calf injury between 2011 and 2017 were identified using the Major League Baseball (MLB) Health and Injury Tracking System (HITS). A separate player usage dataset was used to determine workload. We then compared these variables between player games 2, 6, 12, and >12 weeks before a documented calf strain to player games from a noncalf injury control group. In a paired analysis, we compared the acute workload (2, 6, and 12 weeks) before injury with the injured player's workload >12 weeks before injury. Results: There were 175 unique calf strains (71% occurred in position players) and 1042 unique hamstring strains (97.8% occurred in position players) documented in the MLB HITS database from 2011 to 2017. In all time periods, position players with fewer days rest, more innings fielded, and more plate appearances were associated with a higher risk of subsequent hamstring and calf strains. Having only 1 day rest was associated with a 2.08-fold increase in percentage of players who sustained a subsequent calf strain compared with those with 4 days rest. Position players with >5 days of rest had a 4.03-fold decrease in percentage of players who sustained a hamstring strain compared with players with 1 day rest. Position players who fielded >9 innings per game had a 2.01-fold increase in percentage of players with a subsequent calf strain and a 3.68-fold increase in percentage of players who sustained a subsequent hamstring strain compared with players who only fielded 1 innings per game. Conclusion: Position players with fewer days rest, more innings fielded, and more plate appearance per game had an increased risk of sustaining a hamstring or calf injury. Clinical relevance: Increased workload had a direct relationship with risk of hamstring and calf strains in professional baseball players. Teams should consider more days rest for position players to avoid calf injuries.
MeSH term(s)	Humans ; Baseball/injuries ; Workload ; Hamstring Muscles/injuries ; Athletic Injuries/epidemiology ; Sprains and Strains/epidemiology ; Leg Injuries/epidemiology
Language	English
Publishing date	2022-05-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	2508802-6
ISSN	1941-0921 ; 1941-7381
ISSN (online)	1941-0921
ISSN	1941-7381
DOI	10.1177/19417381221093557
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Article ; Online: Synthesis of phospholipids in human placenta.

Powell, Theresa L / Ferchaud-Roucher, Veronique / Madi, Lana / Uhlson, Charis / Zemski-Berry, Karin / Kramer, Avery C / Erickson, Kathryn / Palmer, Claire / Chassen, Stephanie S / Castillo-Castrejon, Marisol

Placenta

2024 Volume 147, Page(s) 12–20

Abstract: Introduction: Placental phospholipid synthesis is critical for the expansion of the placental exchange surface area and for production of signaling molecules. Despite their importance, it is not yet established which enzymes involved in the de novo ... ...

Abstract	Introduction: Placental phospholipid synthesis is critical for the expansion of the placental exchange surface area and for production of signaling molecules. Despite their importance, it is not yet established which enzymes involved in the de novo synthesis and remodeling of placental phospholipids are expressed and active in the human placenta. Methods: We identified phospholipid synthesis enzymes by immunoblotting in placental homogenates and immunofluorescence in placenta tissue sections. Primary human trophoblast (PHT) cells from term healthy placentas (n = 10) were cultured and exposed to Results: Acyl transferase and phospholipase enzymes were detected in human placenta homogenate and primarily expressed in the syncytiotrophoblast. Three representative Conclusions: Phospholipid synthesis and remodeling enzymes are present in the syncytiotrophoblast.
MeSH term(s)	Humans ; Pregnancy ; Female ; Placenta/metabolism ; Phospholipids/metabolism ; Lysophosphatidylcholines/metabolism ; Fatty Acids/metabolism ; Phosphatidylcholines/metabolism
Chemical Substances	Phospholipids ; Lysophosphatidylcholines ; Fatty Acids ; Phosphatidylcholines
Language	English
Publishing date	2024-01-21
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	603951-0
ISSN	1532-3102 ; 0143-4004
ISSN (online)	1532-3102
ISSN	0143-4004
DOI	10.1016/j.placenta.2024.01.007
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Article: Hip pain in young adults: diagnosing femoroacetabular impingement.

Swenson, Kathryn M / Erickson, Jill / Peters, Chris / Aoki, Stephen K

JAAPA : official journal of the American Academy of Physician Assistants

2015 Volume 28, Issue 9, Page(s) 39–45

Abstract: Symptomatic femoroacetabular impingement (FAI) predisposes patients to developing early osteoarthritis. This article reviews the criteria for diagnosing FAI, management strategies, and when to refer patients to an orthopedic provider for further ... ...

Abstract	Symptomatic femoroacetabular impingement (FAI) predisposes patients to developing early osteoarthritis. This article reviews the criteria for diagnosing FAI, management strategies, and when to refer patients to an orthopedic provider for further evaluation and possible surgical intervention.
MeSH term(s)	Acetabulum/abnormalities ; Acetabulum/diagnostic imaging ; Arthralgia/etiology ; Diagnosis, Differential ; Femoracetabular Impingement/complications ; Femoracetabular Impingement/diagnosis ; Femoracetabular Impingement/diagnostic imaging ; Femur Head/abnormalities ; Femur Head/diagnostic imaging ; Hip Joint ; Humans ; Medical History Taking ; Physical Examination ; Radiography ; Young Adult
Language	English
Publishing date	2015-09
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2415226-2
ISSN	0893-7400 ; 1547-1896
ISSN (online)	0893-7400
ISSN	1547-1896
DOI	10.1097/01.JAA.0000470976.08461.91
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Article ; Online: In vivo activity of the second-generation proteasome inhibitor ixazomib against pediatric T-cell acute lymphoblastic leukemia xenografts.

Randall, Joanna / Evans, Kathryn / Watts, Ben / Kosasih, Hansen J / Smith, Christopher M / Earley, Eric J / Erickson, Stephen W / Jocoy, Emily L / Bult, Carol J / Teicher, Beverly A / de Bock, Charles E / Smith, Malcolm A / Lock, Richard B

Experimental hematology

2024 Volume 132, Page(s) 104176

Abstract: The overall survival rate of patients with T-cell acute lymphoblastic leukemia (T-ALL) is now 90%, although patients with relapsed T-ALL face poor prognosis. The ubiquitin-proteasome system maintains normal protein homeostasis, and aberrations in this ... ...

Abstract	The overall survival rate of patients with T-cell acute lymphoblastic leukemia (T-ALL) is now 90%, although patients with relapsed T-ALL face poor prognosis. The ubiquitin-proteasome system maintains normal protein homeostasis, and aberrations in this pathway are associated with T-ALL. Here we demonstrate the in vitro and in vivo activity of ixazomib, a second-generation orally available, reversible, and selective proteasome inhibitor against pediatric T-ALL cell lines and patient-derived xenografts (PDXs) grown orthotopically in immunodeficient NOD.Cg-Prkdc
MeSH term(s)	Humans ; Child ; Animals ; Mice ; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/drug therapy ; Heterografts ; Proteasome Inhibitors/pharmacology ; Mice, Inbred NOD ; T-Lymphocytes ; Mice, SCID ; Boron Compounds ; Glycine/analogs & derivatives
Chemical Substances	Proteasome Inhibitors ; ixazomib (71050168A2) ; Boron Compounds ; Glycine (TE7660XO1C)
Language	English
Publishing date	2024-02-05
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	185107-x
ISSN	1873-2399 ; 0531-5573 ; 0301-472X
ISSN (online)	1873-2399
ISSN	0531-5573 ; 0301-472X
DOI	10.1016/j.exphem.2024.104176
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