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  1. Article: Radical Cystectomy after Previous Radiation or Pelvic Surgery: Is It Associated with Increased Morbidity?

    Croock, Roy / Modai, Jonathan / Avda, Yuval / Shpunt, Igal / Shilo, Yaniv / Peretz, Yamit / Lindner, Uri / Bercovich, Avraham / Leibovici, Dan

    The Israel Medical Association journal : IMAJ

    2021  Volume 23, Issue 9, Page(s) 545–549

    Abstract: Background: Radical cystectomy is a complicated surgery with significant risks. Complications of Clavien-Dindo grade 3-4 range from 25% to 40% while risk of mortality is 2%. Pelvic surgery or radiotherapy prior to radical cystectomy increases the ... ...

    Abstract Background: Radical cystectomy is a complicated surgery with significant risks. Complications of Clavien-Dindo grade 3-4 range from 25% to 40% while risk of mortality is 2%. Pelvic surgery or radiotherapy prior to radical cystectomy increases the challenges of this surgery.
    Objectives: To assess whether radical cystectomy performed in patients with prior history of pelvic surgery or radiation was associated with increased frequency of Clavien-Dindo grade 3 or higher complications compared to patients without prior pelvic intervention.
    Methods: We retrospectively evaluated all patients who underwent radical cystectomy at our center over a 7-year period. All patients with pelvic radiation or surgery prior to radical cystectomy comprised group 1, while group 2 included the remaining patients.
    Results: In our study, 65 patients required radical cystectomy at our institution during the study period. Group 1 was comprised of 17 patients and group 2 included 48 patients. Four patients from group 2 received orthotopic neobladder, while an ileal conduit procedure was performed in the remaining patients. Estimated blood loss and the amount of blood transfusions given was the only variable found to be statistically different between the two groups. One patient from group 1 had four pelvic interventions prior to surgery, and her cystectomy was aborted.
    Conclusions: Radical cystectomy may be safely performed in patients with a history of pelvic radiotherapy or surgery, with complication rates similar to those of non-irradiated or operated pelvises.
    MeSH term(s) Aged ; Aged, 80 and over ; Blood Loss, Surgical/statistics & numerical data ; Blood Transfusion/statistics & numerical data ; Cystectomy/adverse effects ; Cystectomy/methods ; Female ; Humans ; Male ; Middle Aged ; Postoperative Complications/epidemiology ; Retrospective Studies ; Surgically-Created Structures ; Urinary Bladder/surgery ; Urinary Bladder Neoplasms/radiotherapy ; Urinary Bladder Neoplasms/surgery ; Urinary Diversion/methods
    Language English
    Publishing date 2021-09-02
    Publishing country Israel
    Document type Comparative Study ; Journal Article
    ZDB-ID 2008291-5
    ISSN 1565-1088 ; 0021-2180
    ISSN 1565-1088 ; 0021-2180
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5470: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Intracranial Hemorrhage Segmentation Using A Deep Convolutional Model

    Murtadha D. Hssayeni / Muayad S. Croock / Aymen D. Salman / Hassan Falah Al-khafaji / Zakaria A. Yahya / Behnaz Ghoraani

    Data, Vol 5, Iss 1, p

    2020  Volume 14

    Abstract: Traumatic brain injuries may cause intracranial hemorrhages (ICH). ICH could lead to disability or death if it is not accurately diagnosed and treated in a time-sensitive procedure. The current clinical protocol to diagnose ICH is examining Computerized ... ...

    Abstract Traumatic brain injuries may cause intracranial hemorrhages (ICH). ICH could lead to disability or death if it is not accurately diagnosed and treated in a time-sensitive procedure. The current clinical protocol to diagnose ICH is examining Computerized Tomography (CT) scans by radiologists to detect ICH and localize its regions. However, this process relies heavily on the availability of an experienced radiologist. In this paper, we designed a study protocol to collect a dataset of 82 CT scans of subjects with a traumatic brain injury. Next, the ICH regions were manually delineated in each slice by a consensus decision of two radiologists. The dataset is publicly available online at the PhysioNet repository for future analysis and comparisons. In addition to publishing the dataset, which is the main purpose of this manuscript, we implemented a deep Fully Convolutional Networks (FCNs), known as U-Net, to segment the ICH regions from the CT scans in a fully-automated manner. The method as a proof of concept achieved a Dice coefficient of 0.31 for the ICH segmentation based on 5-fold cross-validation.
    Keywords intracranial hemorrhage segmentation ; ich detection ; fully convolutional network ; u-net ; ct scans dataset ; Bibliography. Library science. Information resources ; Z
    Language English
    Publishing date 2020-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: Tumoral calcinosis presenting as adhesive capsulitis: case report and literature review.

    Croock, A D / Silver, R M

    Arthritis and rheumatism

    1987  Volume 30, Issue 4, Page(s) 455–459

    Abstract: ... 25-dihydroxyvitamin D levels, normocalcemia, and calcific deposits. However, these features have been ...

    Abstract Tumoral calcinosis (TC) is an uncommon disorder characterized by large calcific soft tissue deposits, usually adjacent to large joints. In the past, the etiology was unclear, but recently, TC has been considered to be an inherited metabolic disorder, characterized by elevated serum phosphorus and 1,25-dihydroxyvitamin D levels, normocalcemia, and calcific deposits. However, these features have been shown to vary widely, with formes frustes of TC now being recognized. We report an unusual case of TC, which presented as an adhesive capsulitis, in an elderly North American black woman. The patient's nationality, late age of presentation, and multiple sites of involvement are uncommon features of TC. The clinicopathologic features and possible etiologies of this rare condition are briefly reviewed.
    MeSH term(s) African Continental Ancestry Group ; Age Factors ; Aged ; Arthritis/etiology ; Calcinosis/blood ; Calcinosis/complications ; Calcitriol/blood ; Female ; Hip Joint/diagnostic imaging ; Humans ; Parathyroid Hormone/blood ; Radiography ; Shoulder Joint/diagnostic imaging
    Chemical Substances Parathyroid Hormone ; Calcitriol (FXC9231JVH)
    Language English
    Publishing date 1987-04
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 127294-9
    ISSN 1529-0131 ; 0004-3591 ; 2326-5191
    ISSN (online) 1529-0131
    ISSN 0004-3591 ; 2326-5191
    DOI 10.1002/art.1780300416
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 24: Show issues Location:
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    Zs.MO 523: Show issues

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  4. Article ; Online: Validation of Arxula Yeast Estrogen Screen assay for detection of estrogenic activity in water samples: Results of an international interlaboratory study.

    Hettwer, Karina / Jähne, Martin / Frost, Kirstin / Giersberg, Martin / Kunze, Gotthard / Trimborn, Michael / Reif, Martin / Türk, Jochen / Gehrmann, Linda / Dardenne, Freddy / De Croock, Femke / Abraham, Marion / Schoop, Anne / Waniek, Joanna J / Bucher, Thomas / Simon, Eszter / Vermeirssen, Etienne / Werner, Anett / Hellauer, Karin /
    Wallentits, Ursula / Drewes, Jörg E / Dietzmann, Detlef / Routledge, Edwin / Beresford, Nicola / Zietek, Tamara / Siebler, Margot / Simon, Anne / Bielak, Helena / Hollert, Henner / Müller, Yvonne / Harff, Maike / Schiwy, Sabrina / Simon, Kirsten / Uhlig, Steffen

    The Science of the total environment

    2017  Volume 621, Page(s) 612–625

    Abstract: Endocrine-active substances can adversely impact the aquatic ecosystems. A special emphasis is laid, among others, on the effects of estrogens and estrogen mimicking compounds. Effect-based screening methods like in vitro bioassays are suitable tools to ... ...

    Abstract Endocrine-active substances can adversely impact the aquatic ecosystems. A special emphasis is laid, among others, on the effects of estrogens and estrogen mimicking compounds. Effect-based screening methods like in vitro bioassays are suitable tools to detect and quantify endocrine activities of known and unknown mixtures. This study describes the validation of the Arxula-Yeast Estrogen Screen (A-YES®) assay, an effect-based method for the detection of the estrogenic potential of water and waste water. This reporter gene assay, provided in ready to use format, is based on the activation of the human estrogen receptor alpha. The user-friendly A-YES® enables inexperienced operators to rapidly become competent with the assay. Fourteen laboratories from four countries with different training levels analyzed 17β-estradiol equivalent concentrations (EEQ) in spiked and unspiked waste water effluent and surface water samples, in waste water influent and spiked salt water samples and in a mixture of three bisphenols. The limit of detection (LOD) for untreated samples was 1.8ng/L 17β-estradiol (E2). Relative repeatability and reproducibility standard deviation for samples with EEQ above the LOD (mean EEQ values between 6.3 and 20.4ng/L) ranged from 7.5 to 21.4% and 16.6 to 28.0%, respectively. Precision results are comparable to other frequently used analytical methods for estrogens. The A-YES® has been demonstrated to be an accurate, precise and robust bioassay. The results have been included in the ISO draft standard. The assay was shown to be applicable for testing of typical waste water influent, effluent and saline water. Other studies have shown that the assay can be used with enriched samples, which lower the LOD to the pg/L range. The validation of the A-YES® and the development of a corresponding international standard constitute a step further towards harmonized and reliable bioassays for the effect-based analysis of estrogens and estrogen-like compounds in water samples.
    MeSH term(s) Biological Assay ; Endocrine Disruptors ; Environmental Monitoring/methods ; Estradiol/analysis ; Estrogen Receptor alpha/metabolism ; Estrogens/analysis ; Humans ; Limit of Detection ; Phenols/analysis ; Reproducibility of Results ; Saccharomycetales ; Water Pollutants, Chemical/analysis
    Chemical Substances Endocrine Disruptors ; Estrogen Receptor alpha ; Estrogens ; Phenols ; Water Pollutants, Chemical ; Estradiol (4TI98Z838E)
    Language English
    Publishing date 2017-11-29
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2017.11.211
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 949: Show issues Location:
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  5. Article: Vasculitis and renal disease in nail-patella syndrome: case report and literature review.

    Croock, A D / Bashar Kahaleh, M / Powers, J M

    Annals of the rheumatic diseases

    1987  Volume 46, Issue 7, Page(s) 562–565

    Abstract: A 57 year old man with nail-patella syndrome (NPS) and associated renal disease is described who developed an inflammatory polyarthropathy and polyarteritis-like vasculitis. Vasculitis and serum complement abnormalities have not previously been reported ... ...

    Abstract A 57 year old man with nail-patella syndrome (NPS) and associated renal disease is described who developed an inflammatory polyarthropathy and polyarteritis-like vasculitis. Vasculitis and serum complement abnormalities have not previously been reported in NPS. NPS is a rare autosomal dominant connective tissue disorder affecting both mesenchymal and ectodermal tissue. The condition is reviewed with particular reference to its renal pathology, including the distinctive electron microscopic (EM) finding of collagen deposition in the glomerular basement membrane (GBM). The possibility of the underlying collagen abnormality acting as a trigger for immune-inflammatory changes is discussed.
    MeSH term(s) Arteritis/etiology ; Arteritis/metabolism ; Collagen/metabolism ; Humans ; Kidney Diseases/etiology ; Kidney Diseases/metabolism ; Male ; Middle Aged ; Nail-Patella Syndrome/complications ; Nail-Patella Syndrome/metabolism
    Chemical Substances Collagen (9007-34-5)
    Language English
    Publishing date 1987-07
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 7090-7
    ISSN 1468-2060 ; 0003-4967
    ISSN (online) 1468-2060
    ISSN 0003-4967
    DOI 10.1136/ard.46.7.562
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uh III Zs.114: Show issues Location:
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    Zs.MO 167: Show issues

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