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  1. Article ; Conference proceedings: 21. Workshop des Arbeitskreises "Respiratorisches System" der Deutschen Veterinärmedizinischen Gesellschaft (DVG) in Kooperation mit der Deutschen Gesellschaft für Pneumologie und Beatmungsmedizin (DPG)

    Gutbier, Birgitt

    Pneumologie 72. Jahrgang, 7 (Juli 2018), Seite 534-537

    14. März 2018, Dresden

    2018  

    Title variant Abstracts DVG/DPG
    Event/congress Deutsche Veterinärmedizinische Gesellschaft (21., 2018, Dresden, Arbeitskreis Respiratorisches System)
    Author's details Kongresspräsidenten: Birgitt Gutbier, Martin Rosenbruch, Petra Reinhold
    Collection Pneumologie
    Language German
    Publishing place Stuttgart
    Publishing country Germany
    Document type Article ; Conference proceedings
    HBZ-ID HT020185755
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Uh II Zs 142 -72- Location:
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  2. Article ; Conference proceedings: 20. Workshop des Arbeitskreises "Respiratorisches System" der Deutschen Veterinärmedizinischen Gesellschaft (DVG) in Kooperation mit der Deutschen Gesellschaft für Pneumologie und Beatmungsmedizin (DPG)

    Gutbier, Birgitt

    Pneumologie 71. Jahrgang, 6 (Juni 2017), Seite 412-416

    Datum/Ort: 22. März 2017, Stuttgart

    2018  

    Title variant Abstracts DVG/DPG
    Event/congress Deutsche Veterinärmedizinische Gesellschaft (20., 2017, Stuttgart, Arbeitskreis Respiratorisches System)
    Author's details Kongresspräsidenten: Birgitt Gutbier, Martin Rosenbruch und Petra Reinhold
    Collection Pneumologie
    Language German
    Publishing place Stuttgart
    Publishing country Germany
    Document type Article ; Conference proceedings
    HBZ-ID HT020188363
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Uh II Zs 142 -71- Location:
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  3. Book ; Thesis: Die Bedeutung von Pneumolysin für die Entstehung des akuten Lungenversagens bei Pneumokokkenpneumonie

    Gutbier, Birgitt

    eine experimentelle Untersuchung

    2009  

    Author's details vorgelegt von Birgitt Gutbier
    Keywords Streptococcus pneumoniae ; Exotoxin ; ARDS ; Pathogenese ; Platelet activating Factor ; Tiermodell
    Subject Acute respiratory distress syndrome ; Adult respiratory distress syndrome ; Schocklunge ; Akute respiratorische Insuffizienz ; Atemnotsyndrom ; Akutes Lungenversagen ; PAF ; Thrombozytenaktivierender Faktor ; Plättchenaktivierender Faktor ; Ektotoxin ; Exotoxine ; Pneumococcus ; Pneumokokken
    Subject code 616.200471
    Language German
    Size III, 144 S. : Ill., graph. Darst., 21 cm
    Publisher mbv, Mensch-und-Buch-Verl
    Publishing place Berlin
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Berlin ; Freie Univ., Diss., 2008
    HBZ-ID HT016470187
    ISBN 978-3-86664-704-6 ; 3-86664-704-2
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2010 A 4445 order for loan Magazin

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  4. Article ; Online: Efficacy and safety of intratracheal IFN-γ treatment to reverse stroke-induced susceptibility to pulmonary bacterial infections.

    Jagdmann, Sandra / Berchtold, Daniel / Gutbier, Birgitt / Witzenrath, Martin / Meisel, Andreas / Meisel, Christian / Dames, Claudia

    Journal of neuroimmunology

    2021  Volume 355, Page(s) 577568

    Abstract: Stroke-induced immunosuppression contributes to the development of stroke-associated pneumonia (SAP). Experiments in mice demonstrated that apoptosis of IFN-γ producing cells and reduced IFN-γ secretion resulted in impaired immune responses and the ... ...

    Abstract Stroke-induced immunosuppression contributes to the development of stroke-associated pneumonia (SAP). Experiments in mice demonstrated that apoptosis of IFN-γ producing cells and reduced IFN-γ secretion resulted in impaired immune responses and the development of pneumonia after middle cerebral artery occlusion (MCAo). In the present study, we investigated the efficacy of intratracheal IFN-γ treatment to prevent SAP and demonstrated that modest benefits on pulmonary cytokine response in IFN-γ treated stroke mice did not prevent spontaneously developing infections and even slightly reduced bacterial clearance of aspirated pneumococci. Our results suggest that pulmonary IFN-γ treatment is not an effective preventive measure for SAP.
    MeSH term(s) Animals ; Injections, Spinal ; Interferon-gamma/administration & dosage ; Male ; Mice ; Mice, Inbred C57BL ; Pneumococcal Infections/drug therapy ; Pneumococcal Infections/etiology ; Pneumococcal Infections/immunology ; Respiratory Tract Infections/drug therapy ; Respiratory Tract Infections/etiology ; Respiratory Tract Infections/immunology ; Stroke/complications ; Stroke/drug therapy ; Stroke/immunology ; Treatment Outcome
    Chemical Substances Interferon-gamma (82115-62-6)
    Language English
    Publishing date 2021-04-03
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 8335-5
    ISSN 1872-8421 ; 0165-5728
    ISSN (online) 1872-8421
    ISSN 0165-5728
    DOI 10.1016/j.jneuroim.2021.577568
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1646: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: 22. Workshop des Arbeitskreises "Respiratorisches System"

    Gutbier, Birgitt / Rosenbruch, Martin / Reinhold, Petra

    2019  

    Keywords Text ; ddc:610
    Language German
    Publishing date 2019-07-01
    Publishing country de
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: The unremarkable alveolar epithelial glycocalyx: a thorium dioxide-based electron microscopic comparison after heparinase or pneumolysin treatment.

    Timm, Sara / Lettau, Marie / Hegermann, Jan / Rocha, Maria Linda / Weidenfeld, Sarah / Fatykhova, Diana / Gutbier, Birgitt / Nouailles, Geraldine / Lopez-Rodriguez, Elena / Hocke, Andreas / Hippenstiel, Stefan / Witzenrath, Martin / Kuebler, Wolfgang M / Ochs, Matthias

    Histochemistry and cell biology

    2023  Volume 160, Issue 2, Page(s) 83–96

    Abstract: Recent investigations analyzed in depth the biochemical and biophysical properties of the endothelial glycocalyx. In comparison, this complex cell-covering structure is largely understudied in alveolar epithelial cells. To better characterize the ... ...

    Abstract Recent investigations analyzed in depth the biochemical and biophysical properties of the endothelial glycocalyx. In comparison, this complex cell-covering structure is largely understudied in alveolar epithelial cells. To better characterize the alveolar glycocalyx ultrastructure, unaffected versus injured human lung tissue explants and mouse lungs were analyzed by transmission electron microscopy. Lung tissue was treated with either heparinase (HEP), known to shed glycocalyx components, or pneumolysin (PLY), the exotoxin of Streptococcus pneumoniae not investigated for structural glycocalyx effects so far. Cationic colloidal thorium dioxide (cThO
    MeSH term(s) Mice ; Humans ; Animals ; Glycocalyx ; Heparin Lyase ; Thorium Dioxide ; Electrons ; Glycosaminoglycans
    Chemical Substances plY protein, Streptococcus pneumoniae ; Heparin Lyase (EC 4.2.2.7) ; Thorium Dioxide (9XA7X17UQC) ; Glycosaminoglycans
    Language English
    Publishing date 2023-06-29
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1222930-1
    ISSN 1432-119X ; 0301-5564 ; 0948-6143
    ISSN (online) 1432-119X
    ISSN 0301-5564 ; 0948-6143
    DOI 10.1007/s00418-023-02211-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Activin A levels are raised during human tuberculosis and blockade of the activin signaling axis influences murine responses to

    Nieuwenhuizen, Natalie E / Nouailles, Geraldine / Sutherland, Jayne S / Zyla, Joanna / Pasternack, Arja H / Heyckendorf, Jan / Frye, Björn C / Höhne, Kerstin / Zedler, Ulrike / Bandermann, Silke / Abu Abed, Ulrike / Brinkmann, Volker / Gutbier, Birgitt / Witzenrath, Martin / Suttorp, Norbert / Zissel, Gernot / Lange, Christoph / Ritvos, Olli / Kaufmann, Stefan H E

    mBio

    2024  Volume 15, Issue 3, Page(s) e0340823

    Abstract: Activin A strongly influences immune responses; yet, few studies have examined its role in infectious diseases. We measured serum activin A levels in two independent tuberculosis (TB) patient cohorts and in patients with pneumonia and sarcoidosis. Serum ... ...

    Abstract Activin A strongly influences immune responses; yet, few studies have examined its role in infectious diseases. We measured serum activin A levels in two independent tuberculosis (TB) patient cohorts and in patients with pneumonia and sarcoidosis. Serum activin A levels were increased in TB patients compared to healthy controls, including those with positive tuberculin skin tests, and paralleled severity of disease, assessed by X-ray scores. In pneumonia patients, serum activin A levels were also raised, but in sarcoidosis patients, levels were lower. To determine whether blockade of the activin A signaling axis could play a functional role in TB, we harnessed a soluble activin type IIB receptor fused to human IgG1 Fc, ActRIIB-Fc, as a ligand trap in a murine TB model. The administration of ActRIIB-Fc to
    Importance: Tuberculosis remains the leading cause of death by a bacterial pathogen. The etiologic agent of tuberculosis,
    MeSH term(s) Humans ; Mice ; Animals ; Mycobacterium tuberculosis ; Ligands ; Tuberculin ; Activins ; Tuberculosis ; Immunoglobulin G ; Biomarkers ; Pneumonia ; Sarcoidosis
    Chemical Substances activin A ; Ligands ; Tuberculin ; Activins (104625-48-1) ; Immunoglobulin G ; Biomarkers
    Language English
    Publishing date 2024-02-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mbio.03408-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Cationic LNP-formulated mRNA expressing Tie2-agonist in the lung endothelium prevents pulmonary vascular leakage.

    Radloff, Katrin / Gutbier, Birgitt / Dunne, Charlotte Maeve / Moradian, Hanieh / Schwestka, Marko / Gossen, Manfred / Ahrens, Katharina / Kneller, Laura / Wang, Yadong / Moga, Akanksha / Gkionis, Leonidas / Keil, Oliver / Fehring, Volker / Tondera, Daniel / Giese, Klaus / Santel, Ansgar / Kaufmann, Jörg / Witzenrath, Martin

    Molecular therapy. Nucleic acids

    2023  Volume 34, Page(s) 102068

    Abstract: Dysfunction of endothelial cells (ECs) lining the inner surface of blood vessels are causative for a number of diseases. Hence, the ability to therapeutically modulate gene expression within ECs is of high therapeutic value in treating diseases such as ... ...

    Abstract Dysfunction of endothelial cells (ECs) lining the inner surface of blood vessels are causative for a number of diseases. Hence, the ability to therapeutically modulate gene expression within ECs is of high therapeutic value in treating diseases such as those associated with lung edema. mRNAs formulated with lipid nanoparticles (LNPs) have emerged as a new drug modality to induce transient protein expression for modulating disease-relevant signal transduction pathways. In the study presented here, we tested the effect of a novel synthetic, nucleoside-modified mRNA encoding COMP-Ang1 (mRNA-76) formulated into a cationic LNP on attenuating inflammation-induced vascular leakage. After intravenous injection, the respective mRNA was found to be delivered almost exclusively to the ECs of the lung, while sparing other vascular beds and bypassing the liver. The mode of action of mRNA-76, such as its activation of the Tie2 signal transduction pathway, was tested by pharmacological studies
    Language English
    Publishing date 2023-10-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2662631-7
    ISSN 2162-2531
    ISSN 2162-2531
    DOI 10.1016/j.omtn.2023.102068
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Book ; Online: Editorial

    Gutbier, Birgitt / Rosenbruch, Martin / Reinhold, Petra

    2017  

    Keywords Text ; ddc:610
    Language German
    Publishing date 2017-06-01
    Publishing country de
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Book ; Online ; Thesis: Die Bedeutung von Pneumolysin für die Entstehung des akuten Lungenversagens bei Pneumokokkenpneumonie

    Gutbier, Birgitt [Verfasser]

    eine experimentelle Untersuchung

    2010  

    Author's details Birgitt Gutbier
    Keywords Landwirtschaft, Veterinärmedizin ; Agriculture, Veterinary Science
    Subject code sg630
    Language German
    Publisher Freie Universität Berlin
    Publishing place Berlin
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

    Full text online

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