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  1. Article ; Online: When to Consider Coronary Revascularization for Stable Coronary Artery Disease.

    Cheng, Andrew M / Doll, Jacob A

    The Medical clinics of North America

    2023  Volume 108, Issue 3, Page(s) 517–538

    Abstract: Revascularization is an effective adjunct to medical therapy for some patients with chronic coronary disease. Despite numerous randomized trials, there remains significant uncertainty regarding if and how to revascularize many patients. Coronary artery ... ...

    Abstract Revascularization is an effective adjunct to medical therapy for some patients with chronic coronary disease. Despite numerous randomized trials, there remains significant uncertainty regarding if and how to revascularize many patients. Coronary artery bypass grafting is a class I indication for patients with significant left main stenosis or multivessel disease with ejection fraction ≤ 35%. For other patients, clinicians must carefully consider the potential benefits of symptom improvement and reduction of future myocardial infarction or CV death against the risk and cost of revascularization. Although guidelines provide a framework for these decisions, each individual patient will have distinct coronary anatomy, clinical factors, and preferences.
    MeSH term(s) Humans ; Coronary Artery Disease/surgery ; Treatment Outcome ; Coronary Artery Bypass ; Myocardial Infarction/surgery ; Percutaneous Coronary Intervention
    Language English
    Publishing date 2023-12-18
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 215710-x
    ISSN 1557-9859 ; 0025-7125
    ISSN (online) 1557-9859
    ISSN 0025-7125
    DOI 10.1016/j.mcna.2023.11.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.158: Show issues Location:
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  2. Article ; Online: Semiempirical Methods for Molecular Systems in Strong Magnetic Fields.

    Cheng, Chi Y / Wibowo-Teale, Andrew M

    Journal of chemical theory and computation

    2023  Volume 19, Issue 18, Page(s) 6226–6241

    Abstract: A general scheme is presented to extend semiempirical methods to include the effects of arbitrary strength magnetic fields, while maintaining computational efficiency. The approach utilizes three main modifications; a London atomic orbital (LAO) basis ... ...

    Abstract A general scheme is presented to extend semiempirical methods to include the effects of arbitrary strength magnetic fields, while maintaining computational efficiency. The approach utilizes three main modifications; a London atomic orbital (LAO) basis set is introduced, field-dependent kinetic energy corrections are added to the model Hamiltonian, and spin-Zeeman interaction energy terms are included. The approach is applied to the widely available density-functional tight-binding method GFN1-xTB. Considering the basis set requirements for the kinetic energy corrections in a magnetic field leads to two variants: a single-basis approach GFN1-xTB-M0 and a dual-basis approach GFN1-xTB-M1. The LAO basis in the latter includes the appropriate nodal structure for an accurate representation of the kinetic energy corrections. The variants are assessed by benchmarking magnetizabilities and nuclear magnetic resonance shielding constants calculated using weak magnetic fields. Remarkably, the GFN1-xTB-M1 approach also exhibits excellent performance for strong fields, |
    Language English
    Publishing date 2023-09-06
    Publishing country United States
    Document type Journal Article
    ISSN 1549-9626
    ISSN (online) 1549-9626
    DOI 10.1021/acs.jctc.3c00671
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Thyroid neoplasia associated with nutritional deficiency in cultured jade perch in Hong Kong.

    Chan, Stephen C H / Lim, Zwok Zu / Leung, Aaron C F / Cheng, Tzu Hsuan / Cheng, Ka Po F / St-Hilaire, Sophie / Ferguson, Andrew M D

    Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc

    2024  , Page(s) 10406387231218733

    Abstract: Non-neoplastic thyroid hyperplasia is common in terrestrial animals, secondary to nutritional imbalances or other goitrogenic compounds. Thyroid hyperplasia is relatively common in teleost fish; however, malignant thyroid neoplasia is rarely reported. We ...

    Abstract Non-neoplastic thyroid hyperplasia is common in terrestrial animals, secondary to nutritional imbalances or other goitrogenic compounds. Thyroid hyperplasia is relatively common in teleost fish; however, malignant thyroid neoplasia is rarely reported. We diagnosed cases of thyroid neoplasia in a population of jade perch (
    Language English
    Publishing date 2024-01-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 287603-6
    ISSN 1943-4936 ; 1040-6387
    ISSN (online) 1943-4936
    ISSN 1040-6387
    DOI 10.1177/10406387231218733
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    Zs.A 3645: Show issues Location:
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  4. Article ; Online: Theranostic Phthalocyanine and Naphthalocyanine Nanoparticles for Photoacoustic Imaging and Photothermal Therapy of Tumors.

    Tian, Yiran / Carrillo-Malani, Nicole / Feng, Kailin / Miller, Joann / Busch, Theresa M / Sundaram, Karthik M / Cheng, Zhiliang / Amirshaghaghi, Ahmad / Tsourkas, Andrew

    Nanotheranostics

    2024  Volume 8, Issue 1, Page(s) 100–111

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Animals ; Mice ; Micelles ; Photothermal Therapy ; Precision Medicine ; Photoacoustic Techniques/methods ; Nanoparticles/therapeutic use ; Indoles ; Coloring Agents/therapeutic use ; Neoplasms/therapy ; Neoplasms/drug therapy
    Chemical Substances phthalocyanine (V5PUF4VLGY) ; Micelles ; Indoles ; Coloring Agents
    Language English
    Publishing date 2024-01-01
    Publishing country Australia
    Document type Journal Article
    ISSN 2206-7418
    ISSN (online) 2206-7418
    DOI 10.7150/ntno.88892
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Screening left ventricular systolic dysfunction in children using intrinsic frequencies of carotid pressure waveforms measured by a novel smartphone-based device.

    Cheng, Andrew L / Liu, Jing / Bravo, Stephen / Miller, Jennifer C / Pahlevan, Niema M

    Physiological measurement

    2023  Volume 44, Issue 3

    Abstract: Objective. ...

    Abstract Objective.
    MeSH term(s) Humans ; Child ; Infant, Newborn ; Infant ; Child, Preschool ; Adolescent ; Young Adult ; Adult ; Smartphone ; Reproducibility of Results ; Ventricular Dysfunction, Left/diagnosis ; Ventricular Function, Left ; Stroke Volume ; Carotid Arteries/diagnostic imaging
    Language English
    Publishing date 2023-03-01
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1149545-5
    ISSN 1361-6579 ; 0967-3334
    ISSN (online) 1361-6579
    ISSN 0967-3334
    DOI 10.1088/1361-6579/acba7b
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1559: Show issues Location:
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  6. Article: In vivo

    McAlinden, Niall / Reiche, Christopher F / Clark, Andrew M / Scharf, Robert / Cheng, Yunzhou / Sharma, Rohit / Rieth, Loren / Dawson, Martin D / Angelucci, Alessandra / Mathieson, Keith / Blair, Steve

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Optogenetics allows manipulation of neural ... ...

    Abstract Optogenetics allows manipulation of neural circuits
    Language English
    Publishing date 2024-03-18
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.03.18.585479
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Azathioprine, risk of skin cancer and use of photoprotection: a cross-sectional survey of patients with inflammatory bowel disease and gastroenterology clinicians.

    Howard, Lucy / Deane, Eleanor M / O'Kelly, Sara L / Al-Tayeb, Alla / Walker-Smith, Philippa K / Lim, Zhi Cheng / Birnie, Andrew

    Clinical and experimental dermatology

    2024  

    Language English
    Publishing date 2024-03-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 195504-4
    ISSN 1365-2230 ; 0307-6938
    ISSN (online) 1365-2230
    ISSN 0307-6938
    DOI 10.1093/ced/llae070
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    Zs.A 1278: Show issues Location:
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  8. Article ; Online: Evaluating alerts: All alerts are not equally effective.

    Cheng, Eric M / Wu, Allan D / Wilson, Andrew M

    Muscle & nerve

    2020  Volume 61, Issue 5, Page(s) 552–553

    MeSH term(s) Decision Support Systems, Clinical ; Humans ; Polyneuropathies
    Language English
    Publishing date 2020-02-05
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 438353-9
    ISSN 1097-4598 ; 0148-639X
    ISSN (online) 1097-4598
    ISSN 0148-639X
    DOI 10.1002/mus.26843
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1449: Show issues Location:
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    Zs.MO 551: Show issues

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  9. Article ; Online: A Panel of miRNA Biomarkers Common to Serum and Brain-Derived Extracellular Vesicles Identified in Mouse Model of Amyotrophic Lateral Sclerosis.

    Vassileff, Natasha / Spiers, Jereme G / Lee, John D / Woodruff, Trent M / Ebrahimie, Esmaeil / Mohammadi Dehcheshmeh, Manijeh / Hill, Andrew F / Cheng, Lesley

    Molecular neurobiology

    2024  

    Abstract: Amyotrophic lateral sclerosis (ALS) is a progressive motor neuron disease characterised by the deposition of aggregated proteins including TAR DNA-binding protein 43 (TDP-43) in vulnerable motor neurons and the brain. Extracellular vesicles (EVs) ... ...

    Abstract Amyotrophic lateral sclerosis (ALS) is a progressive motor neuron disease characterised by the deposition of aggregated proteins including TAR DNA-binding protein 43 (TDP-43) in vulnerable motor neurons and the brain. Extracellular vesicles (EVs) facilitate the spread of neurodegenerative diseases and can be easily accessed in the bloodstream. This study aimed to identify a panel of EV miRNAs that can capture the pathology occurring in the brain and peripheral circulation. EVs were isolated from the cortex (BDEVs) and serum (serum EVs) of 3 month-old and 6-month-old TDP-43*Q331K and TDP-43*WT mice. Following characterisation and miRNA isolation, the EVs underwent next-generation sequencing where 24 differentially packaged miRNAs were identified in the TDP-43*Q331K BDEVs and 7 in the TDP-43*Q331K serum EVs. Several miRNAs, including miR-183-5p, were linked to ALS. Additionally, miR-122-5p and miR-486b-5p were identified in both panels, demonstrating the ability of the serum EVs to capture the dysregulation occurring in the brain. This is the first study to identify miRNAs common to both the serum EVs and BDEVs in a mouse model of ALS.
    Language English
    Publishing date 2024-01-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 645020-9
    ISSN 1559-1182 ; 0893-7648
    ISSN (online) 1559-1182
    ISSN 0893-7648
    DOI 10.1007/s12035-023-03857-z
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    Zs.A 2411: Show issues Location:
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  10. Article ; Online: Environment and phenology shape local adaptation in thermal performance.

    Villeneuve, Andrew R / Komoroske, Lisa M / Cheng, Brian S

    Proceedings. Biological sciences

    2021  Volume 288, Issue 1955, Page(s) 20210741

    Abstract: Populations within species often exhibit variation in traits that reflect local adaptation and further shape existing adaptive potential for species to respond to climate change. However, our mechanistic understanding of how the environment shapes trait ... ...

    Abstract Populations within species often exhibit variation in traits that reflect local adaptation and further shape existing adaptive potential for species to respond to climate change. However, our mechanistic understanding of how the environment shapes trait variation remains poor. Here, we used common garden experiments to quantify thermal performance in eight populations of the marine snail
    MeSH term(s) Acclimatization ; Adaptation, Physiological ; Climate Change ; North America ; Temperature
    Language English
    Publishing date 2021-07-28
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 209242-6
    ISSN 1471-2954 ; 0080-4649 ; 0962-8452 ; 0950-1193
    ISSN (online) 1471-2954
    ISSN 0080-4649 ; 0962-8452 ; 0950-1193
    DOI 10.1098/rspb.2021.0741
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