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  1. Book ; Online ; E-Book: Neuroinflammation in vascular dementia

    Rosenberg, Gary A.

    2023  

    Author's details Gary A. Rosenberg
    Keywords Electronic books
    Language English
    Size 1 Online-Ressource (viii, 216 Seiten), Illustrationen, Diagramme, Karten
    Publisher Elsevier Academic Press
    Publishing place London
    Publishing country Great Britain
    Document type Book ; Online ; E-Book
    Note Description based on publisher supplied metadata and other sources
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT021482283
    ISBN 978-0-12-823456-3 ; 9780128234556 ; 0-12-823456-3 ; 0128234555
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book: Molecular physiology and metabolism of the nervous system

    Rosenberg, Gary A.

    [a clinical perspective]

    (Contemporary neurology series ; 82)

    2012  

    Author's details Gary A. Rosenberg
    Series title Contemporary neurology series ; 82
    Collection
    Keywords Cerebrospinal Fluid / physiology ; Cerebrospinal Fluid / metabolism ; Blood-Brain Barrier / physiology ; Cerebrovascular Circulation / physiology ; Brain Diseases / physiopathology
    Language English
    Publisher Oxford Univ. Press
    Publishing place Oxford u.a.
    Publishing country United States
    Document type Book
    Note Includes bibliographical references and index ; Anatomy of fluid interfaces that protect the microenvironment -- Physiology of the cerebrospinal and interstitial fluids -- Neurovascular unit -- Glucose, amino acid and lipid metabolism -- Disorders of cerebrospinal circulation : idiopathic intracranial hypertension (IIH) and hydrocephalus -- Quantification of cerebral blood flow and blood brain barrier transport by NMR and PET -- Mechanisms of ischemic/hypoxic brain injury -- Vascular cognitive impairment and Alzheimer's disease -- Effects of altitude on the brain -- Brain edema -- Intracerebral hemorrhage -- Autoimmunity, hypoxia, and inflammation in demyelinating diseases
    HBZ-ID HT017254117
    ISBN 978-0-19-539427-6 ; 0-19-539427-5
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2012 A 2439 order for loan Magazin

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  3. Article ; Online: Willis Lecture: Biomarkers for Inflammatory White Matter Injury in Binswanger Disease Provide Pathways to Precision Medicine.

    Rosenberg, Gary A

    Stroke

    2022  Volume 53, Issue 11, Page(s) 3514–3523

    Abstract: Binswanger disease is the small vessel form of vascular cognitive impairment and dementia. Deposition of Alzheimer disease proteins can begin in midlife and progress slowly, whereas aging of the vasculature also can begin in midlife, continuing to ... ...

    Abstract Binswanger disease is the small vessel form of vascular cognitive impairment and dementia. Deposition of Alzheimer disease proteins can begin in midlife and progress slowly, whereas aging of the vasculature also can begin in midlife, continuing to progress into old age, making mixed dementia the most common type of dementia. Biomarkers facilitate the early diagnosis of dementias. It is possible to diagnose mixed dementia before autopsy with biomarkers for vascular disease derived from diffusor tensor images on magnetic resonance imaging and Alzheimer disease proteins, Aβ (amyloid β), and phosphorylated tau, in cerebrospinal fluid or in brain with positron emission tomography. The presence of vascular disease accelerates cognitive decline. Both misfolded proteins and vascular disease promote inflammation, which can be detected in cerebrospinal fluid by the presence of MMPs (matrix metalloproteinases), angiogenic growth factors, and cytokines. MMPs disrupt the blood-brain barrier and break down myelin, producing Binswanger disease's 2 main pathological features. Advances in detecting biomarkers in plasma will provide early detection of dementia and aided by machine learning and artificial intelligence, will enhance diagnosis and form the basis for early treatments.
    MeSH term(s) Humans ; Dementia, Vascular/diagnosis ; Amyloid beta-Peptides/metabolism ; Alzheimer Disease/diagnostic imaging ; White Matter/pathology ; Precision Medicine ; Artificial Intelligence ; Cognitive Dysfunction/diagnostic imaging ; Biomarkers ; Positron-Emission Tomography ; Cerebrovascular Disorders/pathology ; Matrix Metalloproteinases/metabolism ; Cytokines/metabolism
    Chemical Substances Amyloid beta-Peptides ; Biomarkers ; Matrix Metalloproteinases (EC 3.4.24.-) ; Cytokines
    Language English
    Publishing date 2022-09-23
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 80381-9
    ISSN 1524-4628 ; 0039-2499 ; 0749-7954
    ISSN (online) 1524-4628
    ISSN 0039-2499 ; 0749-7954
    DOI 10.1161/STROKEAHA.122.039211
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Understanding aging effects on brain ischemia.

    Rosenberg, Gary A

    Neurobiology of disease

    2019  Volume 126, Page(s) 3–4

    MeSH term(s) Aging/pathology ; Aging/physiology ; Animals ; Brain Ischemia/physiopathology ; Humans ; Stroke/physiopathology
    Language English
    Publishing date 2019-03-19
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural
    ZDB-ID 1211786-9
    ISSN 1095-953X ; 0969-9961
    ISSN (online) 1095-953X
    ISSN 0969-9961
    DOI 10.1016/j.nbd.2019.04.002
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  5. Article ; Online: Shared Inflammatory Pathology of Stroke and COVID-19.

    Sánchez, Kathryn E / Rosenberg, Gary A

    International journal of molecular sciences

    2022  Volume 23, Issue 9

    Abstract: Though COVID-19 is primarily characterized by symptoms in the periphery, it can also affect the central nervous system (CNS). This has been established by the association between stroke and COVID-19. However, the molecular mechanisms that cause stroke ... ...

    Abstract Though COVID-19 is primarily characterized by symptoms in the periphery, it can also affect the central nervous system (CNS). This has been established by the association between stroke and COVID-19. However, the molecular mechanisms that cause stroke related to a COVID-19 infection have not been fully explored. More specifically, stroke and COVID-19 exhibit an overlap of molecular mechanisms. These similarities provide a way to better understand COVID-19 related stroke. We propose here that peripheral macrophages upregulate inflammatory proteins such as matrix metalloproteinases (MMPs) in response to SARS-CoV-2 infection. These inflammatory molecules and the SARS-CoV-2 virus have multiple negative effects related to endothelial dysfunction that results in the disruption of the blood-brain barrier (BBB). Finally, we discuss how the endothelial blood-brain barrier injury alters central nervous system function by leading to astrocyte dysfunction and inflammasome activation. Our goal is to elucidate such inflammatory pathways, which could provide insight into therapies to combat the negative neurological effects of COVID-19.
    MeSH term(s) Blood-Brain Barrier/metabolism ; COVID-19/complications ; Central Nervous System ; Humans ; SARS-CoV-2 ; Stroke/metabolism
    Language English
    Publishing date 2022-05-05
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23095150
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  6. Article ; Online: Perceived Experiences of racism in Relation to Genome-Wide DNA Methylation and Epigenetic Aging in the Black Women's Health Study.

    Ruiz-Narváez, Edward A / Cozier, Yvette / Zirpoli, Gary / Rosenberg, Lynn / Palmer, Julie R

    Journal of racial and ethnic health disparities

    2024  

    Abstract: Background: African American women have a disproportionate burden of disease compared to US non-Hispanic white women. Exposure to psychosocial stressors may contribute to these health disparities. Racial discrimination, a major stressor for African ... ...

    Abstract Background: African American women have a disproportionate burden of disease compared to US non-Hispanic white women. Exposure to psychosocial stressors may contribute to these health disparities. Racial discrimination, a major stressor for African American women, could affect health through epigenetic mechanisms.
    Methods: We conducted an epigenome-wide association study (EWAS) to examine the association of interpersonal racism (in daily life and in institutional settings) with DNA methylation in blood in 384 participants of the Black Women's Health Study (BWHS). We also evaluated whether a greater number of perceived experiences of racism was associated with epigenetic aging as measured using different methylation clocks. Models were adjusted for chronological age, body mass index, years of education, neighborhood SES, geographic region of residence, alcohol drinking, smoking, and technical covariates.
    Results: Higher scores of racism in daily life were associated with higher methylation levels at the cg04494873 site in chromosome 5 (β = 0.64%; 95% CI = 0.41%, 0.87%; P = 6.35E-08). We also replicated one CpG site, cg03317714, which was inversely associated with racial discrimination in a previous EWAS among African American women. In the BWHS, higher scores of racism in daily life were associated with lower methylation levels at that CpG site (β = -0.94%; 95% CI = -1.37%, -0.51%; P = 2.2E-05). Higher racism scores were associated with accelerated epigenetic aging in more than one methylation clock.
    Conclusions: Exposure to discriminatory events may affect the epigenome and accelerate biological aging, which may explain in part the earlier onset of disease in African American women.
    Language English
    Publishing date 2024-02-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2760524-3
    ISSN 2196-8837 ; 2197-3792
    ISSN (online) 2196-8837
    ISSN 2197-3792
    DOI 10.1007/s40615-024-01915-3
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  7. Article: Apoptosis-associated speck-like protein containing a CARD-mediated release of matrix metalloproteinase 10 stimulates a change in microglia phenotype.

    Sánchez, Kathryn E / Bhaskar, Kiran / Rosenberg, Gary A

    Frontiers in molecular neuroscience

    2022  Volume 15, Page(s) 976108

    Abstract: Inflammation contributes to amyloid-β and tau pathology in Alzheimer's disease (AD). Microglia facilitate an altered immune response that includes microgliosis, upregulation of inflammasome proteins, and elevation of matrix-metalloproteinases (MMPs). ... ...

    Abstract Inflammation contributes to amyloid-β and tau pathology in Alzheimer's disease (AD). Microglia facilitate an altered immune response that includes microgliosis, upregulation of inflammasome proteins, and elevation of matrix-metalloproteinases (MMPs). Studies of cerebrospinal fluid (CSF) and blood in dementia patients show upregulation of two potential biomarkers of inflammation at the cellular level, MMP10 and apoptosis-associated speck-like protein containing a CARD (ASC). However, little is known about their relationship in the context of brain inflammation. Therefore, we stimulated microglia cultures with purified insoluble ASC speck aggregates and MMP10 to elucidate their role. We found that ASC specks altered microglia shape and stimulated the release of MMP3 and MMP10. Furthermore, MMP10 stimulated microglia released additional MMP10 along with the inflammatory cytokines, tumor-necrosis factor-α (TNFα), Interleukin 6 (IL-6), and CXCL1 CXC motif chemokine ligand 1 (CXCL1). A broad-spectrum MMP inhibitor, GM6001, prevented TNFα release. With these results, we conclude that MMP10 and ASC specks act on microglial cells to propagate inflammation.
    Language English
    Publishing date 2022-10-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2452967-9
    ISSN 1662-5099
    ISSN 1662-5099
    DOI 10.3389/fnmol.2022.976108
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  8. Article ; Online: Binswanger's disease: biomarkers in the inflammatory form of vascular cognitive impairment and dementia.

    Rosenberg, Gary A

    Journal of neurochemistry

    2017  Volume 144, Issue 5, Page(s) 634–643

    Abstract: Vascular cognitive impairment and dementia (VCID) is a major public health concern because of the increased incidence of vascular disease in the aging population and the impact of vascular disease on Alzheimer's disease. VCID is a heterogeneous group of ... ...

    Abstract Vascular cognitive impairment and dementia (VCID) is a major public health concern because of the increased incidence of vascular disease in the aging population and the impact of vascular disease on Alzheimer's disease. VCID is a heterogeneous group of diseases for which there are no proven treatments. Biomarkers can be used to select more homogeneous populations. Small vessel disease is the most prevalent form of VCID and is the optimal form for treatment trials because there is a progressive course with characteristic pathological changes. Subcortical ischemic vascular disease of the Binswanger type (SIVD-BD) has a characteristic set of features that can be used both to identify patients and to follow treatment. SIVD-BD patients have clinical, neuropsychological, cerebrospinal fluid (CSF) and imaging features that can be used as biomarkers. No one feature is diagnostic, but a multimodal approach defines the SIVD-BD spectrum disorder. The most important features are large white matter lesions with axonal damage, blood-brain barrier disruption as shown by magnetic resonance imaging and CSF, and neuropsychological evidence of executive dysfunction. We have used these features to create a Binswanger Disease Scale and a probability of SIVD-BD, using a machine-learning algorithm. The patients discussed in this review are derived from published studies. Biomarkers not only aid in early diagnosis before the disease process has progressed too far for treatment, but also can indicate response to treatment. Refining the use of biomarkers will allow dementia treatment to enter the era of precision medicine. This article is part of the Special Issue "Vascular Dementia".
    MeSH term(s) Biomarkers/blood ; Biomarkers/cerebrospinal fluid ; Cognitive Dysfunction/blood ; Cognitive Dysfunction/cerebrospinal fluid ; Cognitive Dysfunction/complications ; Cognitive Dysfunction/diagnosis ; Dementia, Vascular/blood ; Dementia, Vascular/cerebrospinal fluid ; Dementia, Vascular/complications ; Dementia, Vascular/diagnosis ; Encephalitis/complications ; Encephalitis/diagnosis ; Humans
    Chemical Substances Biomarkers
    Language English
    Publishing date 2017-11-06
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
    ZDB-ID 80158-6
    ISSN 1471-4159 ; 0022-3042 ; 1474-1644
    ISSN (online) 1471-4159
    ISSN 0022-3042 ; 1474-1644
    DOI 10.1111/jnc.14218
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  9. Article ; Online: Protocol to measure apoptosis-associated speck-like protein containing a CARD specks in human cerebrospinal fluid via imaging flow cytometry.

    Sánchez, Kathryn E / Jiang, Shanya / Palencia Desai, Sharina / Thompson, Jeffery / Hobson, Sasha / Rosenberg, Gary A / Bhaskar, Kiran

    STAR protocols

    2024  Volume 5, Issue 1, Page(s) 102916

    Abstract: Apoptosis-associated speck-like protein containing a c-terminal caspase activation and recruitment domain (ASC) specks are elevated in the cerebrospinal fluid (CSF) of Alzheimer's disease and related dementias (AD/ADRDs) patients. Here, we present a flow ...

    Abstract Apoptosis-associated speck-like protein containing a c-terminal caspase activation and recruitment domain (ASC) specks are elevated in the cerebrospinal fluid (CSF) of Alzheimer's disease and related dementias (AD/ADRDs) patients. Here, we present a flow cytometry protocol to quantify ASC specks. We describe steps for fluorescently labeling ASC specks using antibody technology, visualizing with imaging flow cytometry, and gating based on physical characteristics. CSF ASC specks levels positively correlate with phosphorylated tau (Thr181) and negatively correlate with amyloid β ratio (42/40), thus serving as a neuroinflammatory biomarker for diagnosing AD/ADRDs. For complete details on the use and execution of this protocol, please refer to Jiang et al.
    MeSH term(s) Humans ; Flow Cytometry/methods ; CARD Signaling Adaptor Proteins/metabolism ; Amyloid beta-Peptides/metabolism ; Inflammasomes/metabolism ; Apoptosis
    Chemical Substances CARD Signaling Adaptor Proteins ; Amyloid beta-Peptides ; Inflammasomes
    Language English
    Publishing date 2024-03-06
    Publishing country United States
    Document type Journal Article
    ISSN 2666-1667
    ISSN (online) 2666-1667
    DOI 10.1016/j.xpro.2024.102916
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  10. Article ; Online: Vascular cognitive impairment: Biomarkers in diagnosis and molecular targets in therapy.

    Rosenberg, Gary A

    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

    2016  Volume 36, Issue 1, Page(s) 4–5

    MeSH term(s) Biomarkers/analysis ; Cognition Disorders/diagnosis ; Cognition Disorders/etiology ; Cognition Disorders/therapy ; Humans ; Magnetic Resonance Imaging ; Molecular Targeted Therapy ; Vascular Diseases/complications ; Vascular Diseases/diagnosis ; Vascular Diseases/therapy
    Chemical Substances Biomarkers
    Language English
    Publishing date 2016-01
    Publishing country United States
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 604628-9
    ISSN 1559-7016 ; 0271-678X
    ISSN (online) 1559-7016
    ISSN 0271-678X
    DOI 10.1177/0271678X15609542
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