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Article ; Online: Call for Special Issue Papers:

Seth, Prem

2020 Volume 31, Issue 19-20, Page(s) 1026

Language	English
Publishing date	2020-10-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	1028152-6
ISSN	1557-7422 ; 1043-0342
ISSN (online)	1557-7422
ISSN	1043-0342
DOI	10.1089/hum.2020.29127.cfp4
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Zs.A 2988: Show issues

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Article ; Online: Call for Special Issue Papers:

Seth, Prem

Human gene therapy

2020 Volume 31, Issue 17-18, Page(s) 907

Language	English
Publishing date	2020-09-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	1028152-6
ISSN	1557-7422 ; 1043-0342
ISSN (online)	1557-7422
ISSN	1043-0342
DOI	10.1089/hum.2020.29127.cfp3
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Article ; Online: Call for Special Issue Papers:

Seth, Prem

Human gene therapy

2020 Volume 31, Issue 13-14, Page(s) 704

Language	English
Publishing date	2020-06-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	1028152-6
ISSN	1557-7422 ; 1043-0342
ISSN (online)	1557-7422
ISSN	1043-0342
DOI	10.1089/hum.2020.29127.cfp
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Article ; Online: Structure and mechanical behavior of

Seth, Prem Prakash / Parkash, Om / Kumar, Devendra

RSC advances

2020 Volume 10, Issue 61, Page(s) 37327–37345

Abstract: The demand for lightweight, high specific strength alloys has drastically increased in the last two decades. Magnesium and aluminum alloys are very suitable candidate materials. Research on alloys with an ... ...

Abstract	The demand for lightweight, high specific strength alloys has drastically increased in the last two decades. Magnesium and aluminum alloys are very suitable candidate materials. Research on alloys with an Mg
Language	English
Publishing date	2020-10-08
Publishing country	England
Document type	Journal Article ; Review
ISSN	2046-2069
ISSN (online)	2046-2069
DOI	10.1039/d0ra02744h
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Article ; Online: Analysis of causes of failure of medical treatment in patients undergoing surgery for benign prostate enlargement.

Anand, Ajay / Gupta, Narmada P / Dogra, Prem Nath / Seth, Amlesh

Urologia

2021 Volume 89, Issue 4, Page(s) 553–558

Abstract: Background: To analyse causes of failure of medical management in benign prostate enlargement (BPE) in patients who undergo surgery following medical treatment and to elucidate parameters which warrant for early surgical treatment.: Methods: Records ... ...

Abstract	Background: To analyse causes of failure of medical management in benign prostate enlargement (BPE) in patients who undergo surgery following medical treatment and to elucidate parameters which warrant for early surgical treatment. Methods: Records of 747 patients who underwent surgery for BPE were reviewed for prostate volume, median lobe enlargement, post void residual urine, duration and type of medical treatment given for BPE. We used univariate and multivariate analysis to find out significant parameters for medical treatment failure. Results: A total of 601 patients (80.45%) received medical treatment for their lower urinary tract symptoms (LUTS), for a duration ranging between 3 months and 2 years. Statistically significant difference was found between age, prostate volume, intravesical projection, PSA and acute urinary retention with failure of medical treatment. Conclusions: BPE patients with failure to respond with medical management within 3-6 months and/or associated with large size prostate, intravesical projection and raised serum PSA should better be offered surgical treatment.
MeSH term(s)	Humans ; Lower Urinary Tract Symptoms/drug therapy ; Lower Urinary Tract Symptoms/etiology ; Lower Urinary Tract Symptoms/surgery ; Male ; Prostate ; Prostate-Specific Antigen ; Prostatic Hyperplasia/complications ; Prostatic Hyperplasia/drug therapy ; Prostatic Hyperplasia/surgery
Chemical Substances	Prostate-Specific Antigen (EC 3.4.21.77)
Language	English
Publishing date	2021-12-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	204043-8
ISSN	1724-6075 ; 0376-0057 ; 0391-5603
ISSN (online)	1724-6075
ISSN	0376-0057 ; 0391-5603
DOI	10.1177/03915603211037603
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Zs.B 891: Show issues

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Article: Structure and mechanical behavior of in situ developed Mg₂Si phase in magnesium and aluminum alloys – a review

Seth, Prem Prakash / Parkash, Om / Kumar, Devendra

RSC advances. 2020 Oct. 08, v. 10, no. 61

2020

Abstract	The demand for lightweight, high specific strength alloys has drastically increased in the last two decades. Magnesium and aluminum alloys are very suitable candidate materials. Research on alloys with an Mg₂Si phase started about three decades ago. The current scenario is that magnesium and aluminum alloys containing an Mg₂Si phase are very popular in the scientific community and extensively used in the automotive and aerospace industries. Mg₂Si is a very stable phase and exhibits excellent mechanical, thermal, electrochemical and tribological properties. This paper presents a brief review of Mg–Si binary alloys, and Mg–Si–Al and Al–Si–Mg alloys. Grain refinement methods and mechanical properties have been reported on lightweight alloys containing Mg and Si. The available results show that silicon reacts with magnesium and forms an intermetallic compound with the stoichiometric formula Mg₂Si. There is in situ formation of an Mg₂Si phase in Mg–Si, Mg–Si–Al and Al–Mg–Si alloys by the diffusion or precipitation process. The morphology and size of an in situ developed Mg₂Si phase depend on the synthesis route and base metal or matrix. In the liquid metallurgy process the precipitation sequence depends on the cooling rate. The morphology of the Mg₂Si phase depends on the precipitation sequence and the mechanical properties depend on the morphology and size of the Mg₂Si phase within the alloy matrix.
Keywords	aluminum alloys ; diffusion ; electrochemistry ; exhibitions ; industry ; liquids ; magnesium ; mechanical properties ; metallurgy ; methodology ; paper ; research ; silicon ; stoichiometry ; synthesis
Language	English
Dates of publication	2020-1008
Size	p. 37327-37345.
Publishing place	The Royal Society of Chemistry
Document type	Article
Note	NAL-light
ISSN	2046-2069
DOI	10.1039/d0ra02744h
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Real-Time Machine Learning Alerts to Prevent Escalation of Care: A Nonrandomized Clustered Pragmatic Clinical Trial.

Levin, Matthew A / Kia, Arash / Timsina, Prem / Cheng, Fu-Yuan / Nguyen, Kim-Anh-Nhi / Kohli-Seth, Roopa / Lin, Hung-Mo / Ouyang, Yuxia / Freeman, Robert / Reich, David L

Critical care medicine

2024

Abstract: Objectives: Machine learning algorithms can outperform older methods in predicting clinical deterioration, but rigorous prospective data on their real-world efficacy are limited. We hypothesized that real-time machine learning generated alerts sent ... ...

Abstract	Objectives: Machine learning algorithms can outperform older methods in predicting clinical deterioration, but rigorous prospective data on their real-world efficacy are limited. We hypothesized that real-time machine learning generated alerts sent directly to front-line providers would reduce escalations. Design: Single-center prospective pragmatic nonrandomized clustered clinical trial. Setting: Academic tertiary care medical center. Patients: Adult patients admitted to four medical-surgical units. Assignment to intervention or control arms was determined by initial unit admission. Interventions: Real-time alerts stratified according to predicted likelihood of deterioration sent either to the primary team or directly to the rapid response team (RRT). Clinical care and interventions were at the providers' discretion. For the control units, alerts were generated but not sent, and standard RRT activation criteria were used. Measurements and main results: The primary outcome was the rate of escalation per 1000 patient bed days. Secondary outcomes included the frequency of orders for fluids, medications, and diagnostic tests, and combined in-hospital and 30-day mortality. Propensity score modeling with stabilized inverse probability of treatment weight (IPTW) was used to account for differences between groups. Data from 2740 patients enrolled between July 2019 and March 2020 were analyzed (1488 intervention, 1252 control). Average age was 66.3 years and 1428 participants (52%) were female. The rate of escalation was 12.3 vs. 11.3 per 1000 patient bed days (difference, 1.0; 95% CI, -2.8 to 4.7) and IPTW adjusted incidence rate ratio 1.43 (95% CI, 1.16-1.78; p < 0.001). Patients in the intervention group were more likely to receive cardiovascular medication orders (16.1% vs. 11.3%; 4.7%; 95% CI, 2.1-7.4%) and IPTW adjusted relative risk (RR) (1.74; 95% CI, 1.39-2.18; p < 0.001). Combined in-hospital and 30-day-mortality was lower in the intervention group (7% vs. 9.3%; -2.4%; 95% CI, -4.5% to -0.2%) and IPTW adjusted RR (0.76; 95% CI, 0.58-0.99; p = 0.045). Conclusions: Real-time machine learning alerts do not reduce the rate of escalation but may reduce mortality.
Language	English
Publishing date	2024-02-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	197890-1
ISSN	1530-0293 ; 0090-3493
ISSN (online)	1530-0293
ISSN	0090-3493
DOI	10.1097/CCM.0000000000006243
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Zs.A 1261: Show issues

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Article: Vector-mediated cancer gene therapy: an overview.

Seth, Prem

Cancer biology & therapy

2005 Volume 4, Issue 5, Page(s) 512–517

Abstract: In recent years there has been a dramatic increase in developing gene therapy approaches for the treatment of cancer. The two events that have permitted the formulation of concept of cancer gene therapy are the new understanding of the molecular ... ...

Abstract	In recent years there has been a dramatic increase in developing gene therapy approaches for the treatment of cancer. The two events that have permitted the formulation of concept of cancer gene therapy are the new understanding of the molecular mechanisms underlying oncogenesis, and the development of the DNA-delivery vehicles or vectors. Many approaches to cancer gene therapy have been proposed, and several viral and non-viral vectors have been utilized. The purpose of this review article is to describe the various strategies of cancer gene therapy (transfer of tumor suppressor genes, suicide genes-enzyme/pro-drug approach, inhibition of dominant oncogenes, immunomodulation approaches, expression of molecules that affect angiogenesis, tumor invasion and metastasis, chemosensitization and radiosensitization approaches, and chemoprotection of stem cells). The chapter also reviews the commonly used vectors (retroviral vectors, adenoviral vectors, adeno-associated viral vectors, pox viruses, herpes simplex viruses, HIV- vectors, non-viral vectors and targetable vectors) for cancer gene therapy. Some of the important issues in cancer gene therapy, and the potential future directions are also being discussed.
MeSH term(s)	Forecasting ; Gene Transfer Techniques/trends ; Genetic Therapy/methods ; Genetic Therapy/trends ; Genetic Vectors ; Humans ; Neoplasms/genetics ; Neoplasms/therapy
Language	English
Publishing date	2005-05-05
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
ZDB-ID	2146305-0
ISSN	1538-4047
ISSN	1538-4047
DOI	10.4161/cbt.4.5.1705
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Zs.A 5887: Show issues

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Article ; Online: A comparative study of the effects of medical versus surgical androgen deprivation therapy on health-related quality of life in patients with metastatic carcinoma prostate.

Singh, Prabhjot / Agrawal, Tapan / Yadav, Siddharth / Nayak, Brusabhanu / Seth, Amlesh / Dogra, Prem Nath

Indian journal of cancer

2019 Volume 55, Issue 2, Page(s) 148–153

Abstract: Introduction: Androgen deprivation therapy (ADT) is known to adversely affect the quality of life (QoL). One may choose between surgical and medical forms depending on his economic status, education status, and taboos. The aim of this study was to ... ...

Abstract	Introduction: Androgen deprivation therapy (ADT) is known to adversely affect the quality of life (QoL). One may choose between surgical and medical forms depending on his economic status, education status, and taboos. The aim of this study was to assess the impact of medical versus surgical ADT on health-related quality of life (HRQoL) in patients with metastatic cancer prostate in Indian population. Materials and methods: From July 2012 to December 2014, 50 patients (10 medical castration and 40 surgical castration) of hormone-naïve metastatic prostate cancer who were started on combined ADT were included in this study. Before starting therapy, baseline data and QoL score (short form [SF-36] scale) were noted and all patients were followed up at 3 months, 6 months, and 1 year. Baseline data and HRQoL at all time intervals between surgical and medical castration groups were compared. Results: All patients, except two, completed the 1-year follow-up period. Patients who opted for medical castration were more educated and belonged to higher socioeconomic status. For all the domains of SF-36 QoL questionnaire, a similar improvement in the score was noted at first 3-month follow-up which deteriorated in the next follow-up at 6 months and then further at 1 year. There was no difference in HRQoL after medical or surgical castration. Conclusions: In patients with metastatic cancer, prostate initiation of ADT, irrespective of method, causes an initial improvement in HRQoL followed later by a more gradual decline below the baseline.
MeSH term(s)	Aged ; Androgen Antagonists/pharmacology ; Androgen Antagonists/therapeutic use ; Humans ; Male ; Middle Aged ; Neoplasm Metastasis ; Prostatic Neoplasms ; Quality of Life/psychology ; Treatment Outcome
Chemical Substances	Androgen Antagonists
Language	English
Publishing date	2019-02-18
Publishing country	India
Document type	Journal Article
ZDB-ID	410194-7
ISSN	1998-4774 ; 0019-509X
ISSN (online)	1998-4774
ISSN	0019-509X
DOI	10.4103/ijc.IJC_531_17
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Zs.B 581: Show issues

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Article ; Online: Risk and safety profile of electronic nicotine delivery systems (ENDS): an umbrella review to inform ENDS health communication strategies.

Asfar, Taghrid / Jebai, Rime / Li, Wei / Oluwole, Olusanya Joshua / Ferdous, Tarana / Gautam, Prem / Schmidt, Michael / Noar, Seth M / Lindblom, Eric N / Eissenberg, Thomas / Bursac, Zoran / Vallone, Donna / Maziak, Wasim

Tobacco control

2022

Abstract: Objectives: This umbrella review aims to summarise the evidence about electronic nicotine delivery systems' (ENDS) risk and safety health profile to inform ENDS health communication strategies.: Data sources and study selection: Six databases were ... ...

Abstract	Objectives: This umbrella review aims to summarise the evidence about electronic nicotine delivery systems' (ENDS) risk and safety health profile to inform ENDS health communication strategies. Data sources and study selection: Six databases were searched for systematic reviews presenting evidence on ENDS-related health effects. Ninety reviews divided into five categories were included: toxicity=20, health effects=40, role in smoking cessation=24, role in transition to combustible cigarettes (CCs)=13 and industry marketing claims=4. Data extraction: Findings were synthesised in narrative summaries. Meta-analyses were conducted by study type when appropriate. Quality assessment was conducted using the Measurement Tool to Assess Systematic Reviews. The Institute of Medicine's Levels of Evidence Framework was used to classify the evidence into high-level, moderate, limited-suggestive and limited-not-conclusive. Data synthesis: We found high-level evidence that ENDS exposes users to toxic substances; increases the risk of respiratory disease; leads to nicotine dependence; causes serious injuries due to explosion or poisoning; increases smoking cessation in clinical trials but not in observational studies; increases CC initiation; and exposure to ENDS marketing increases its use/intention to use. Evidence was moderate for ENDS association with mental health and substance use, limited-suggestive for cardiovascular, and limited-not-conclusive for cancer, ear, ocular and oral diseases, and pregnancy outcomes. Conclusions: As evidence is accumulating, ENDS communication can focus on high-level evidence on ENDS association with toxicity, nicotine addiction, respiratory disease, ENDS-specific harm (explosion, poisoning) and anti-ENDS industry sentiment. Direct comparison between the harm of CCs and ENDS should be avoided. Prospero registration number: CRD42021241630.
Language	English
Publishing date	2022-09-08
Publishing country	England
Document type	Journal Article
ZDB-ID	1146554-2
ISSN	1468-3318 ; 0964-4563
ISSN (online)	1468-3318
ISSN	0964-4563
DOI	10.1136/tc-2022-057495
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Zs.A 3651: Show issues

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