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  1. Article: Cilostazol for peripheral arterial disease - a position paper from the Italian Society for Angiology and Vascular Medicine.

    Martini, Romeo / Ageno, Walter / Amato, Corrado / Favaretto, Elisabetta / Porfidia, Angelo / Visonà, Adriana

    VASA. Zeitschrift fur Gefasskrankheiten

    2024  Volume 53, Issue 2, Page(s) 109–119

    Abstract: Cilostazol is a quinolinone-derivative selective phosphodiesterase inhibitor and is a platelet-aggregation inhibitor and arterial vasodilator for the symptomatic treatment of intermittent claudication (IC). Cilostazol has been shown to improve walking ... ...

    Abstract Cilostazol is a quinolinone-derivative selective phosphodiesterase inhibitor and is a platelet-aggregation inhibitor and arterial vasodilator for the symptomatic treatment of intermittent claudication (IC). Cilostazol has been shown to improve walking distance for patients with moderate to severe disabling intermittent claudication who do not respond to exercise therapy and who are not candidates for vascular surgical or endovascular procedures. Several studies evaluated the pharmacological effects of cilostazol for restenosis prevention and indicated a possible effect on re-endothelialization mediated by hepatocyte growth factor and endothelial precursor cells, as well as inhibiting smooth muscle cell proliferation and leukocyte adhesion to endothelium, thereby exerting an anti-inflammatory effect. These effects may suggest a potential effectiveness of cilostazol in preventing restenosis and promoting the long-term outcome of revascularization interventions. This review aimed to point out the role of cilostazol in treating patients with peripheral arterial disease, particularly with IC, and to explore its possible role in restenosis after lower limb revascularization.
    MeSH term(s) Humans ; Cilostazol/adverse effects ; Intermittent Claudication/diagnosis ; Intermittent Claudication/drug therapy ; Tetrazoles ; Vasodilator Agents/adverse effects ; Peripheral Arterial Disease/diagnosis ; Peripheral Arterial Disease/drug therapy ; Cardiology ; Italy
    Chemical Substances Cilostazol (N7Z035406B) ; Tetrazoles ; Vasodilator Agents
    Language English
    Publishing date 2024-03-01
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 120977-2
    ISSN 1664-2872 ; 0301-1526
    ISSN (online) 1664-2872
    ISSN 0301-1526
    DOI 10.1024/0301-1526/a001114
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 808: Show issues Location:
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  2. Article: Clinical Correlates of In-Hospital Mortality in Patients Undergoing Inferior Vena Cava Filter Placement for Acute Deep Vein Thrombosis.

    Porceddu, Enrica / Talerico, Rosa / Ciasca, Gabriele / Cammà, Giulia / Di Santo, Riccardo / Peri, Matilde / Cina, Alessandro / Pola, Roberto / Porfidia, Angelo

    Journal of clinical medicine

    2024  Volume 13, Issue 8

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2024-04-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13082285
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Venous thromboembolism in COVID-19 patients.

    Porfidia, Angelo / Pola, Roberto

    Journal of thrombosis and haemostasis : JTH

    2020  Volume 18, Issue 6, Page(s) 1516–1517

    MeSH term(s) Anticoagulants ; Betacoronavirus ; COVID-19 ; Coronavirus ; Coronavirus Infections ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2 ; Venous Thromboembolism
    Chemical Substances Anticoagulants
    Keywords covid19
    Language English
    Publishing date 2020-05-27
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2112661-6
    ISSN 1538-7836 ; 1538-7933
    ISSN (online) 1538-7836
    ISSN 1538-7933
    DOI 10.1111/jth.14842
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    Zs.A 5805: Show issues Location:
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  4. Article ; Online: Correction to: Venous thromboembolism and heparin use in COVID-19 patients: juggling between pragmatic choices, suggestions of medical societies and the lack of guidelines.

    Porfidia, Angelo / Pola, Roberto

    Journal of thrombosis and thrombolysis

    2020  Volume 50, Issue 2, Page(s) 477

    Abstract: In the original version of the article, the article title was processed incorrectly. The correct article title is "Venous Thromboembolism and Heparin Use in COVID-19 Patients: Juggling between Pragmatic Choices, Suggestions of Medical Societies and the ... ...

    Abstract In the original version of the article, the article title was processed incorrectly. The correct article title is "Venous Thromboembolism and Heparin Use in COVID-19 Patients: Juggling between Pragmatic Choices, Suggestions of Medical Societies and the Lack of Guidelines". This has been corrected with this erratum and the original article has also been updated to reflect the change in article title.
    Keywords covid19
    Language English
    Publishing date 2020-05-16
    Publishing country Netherlands
    Document type Journal Article ; Published Erratum
    ZDB-ID 1230645-9
    ISSN 1573-742X ; 0929-5305
    ISSN (online) 1573-742X
    ISSN 0929-5305
    DOI 10.1007/s11239-020-02139-y
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    Zs.A 4352: Show issues Location:
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  5. Article ; Online: Venous Thromboembolism and Heparin Use in COVID-19 Patients: Juggling between Pragmatic Choices, Suggestions of Medical Societies and the Lack of Guidelines.

    Porfidia, Angelo / Pola, Roberto

    Journal of thrombosis and thrombolysis

    2020  Volume 50, Issue 1, Page(s) 68–71

    MeSH term(s) Anticoagulants/adverse effects ; Anticoagulants/therapeutic use ; Betacoronavirus/pathogenicity ; Blood Coagulation/drug effects ; COVID-19 ; COVID-19 Testing ; Choice Behavior ; Clinical Decision-Making ; Clinical Laboratory Techniques ; Coronavirus Infections/blood ; Coronavirus Infections/diagnosis ; Coronavirus Infections/drug therapy ; Coronavirus Infections/epidemiology ; Coronavirus Infections/virology ; Evidence-Based Medicine/standards ; Heparin/adverse effects ; Heparin/therapeutic use ; Host-Pathogen Interactions ; Humans ; Pandemics ; Patient Safety ; Patient Selection ; Pneumonia, Viral/blood ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/virology ; Practice Guidelines as Topic/standards ; Prevalence ; Risk Assessment ; Risk Factors ; SARS-CoV-2 ; Treatment Outcome ; Venous Thromboembolism/blood ; Venous Thromboembolism/epidemiology ; Venous Thromboembolism/prevention & control ; Venous Thromboembolism/virology
    Chemical Substances Anticoagulants ; Heparin (9005-49-6)
    Keywords covid19
    Language English
    Publishing date 2020-05-05
    Publishing country Netherlands
    Document type Editorial
    ZDB-ID 1230645-9
    ISSN 1573-742X ; 0929-5305
    ISSN (online) 1573-742X
    ISSN 0929-5305
    DOI 10.1007/s11239-020-02125-4
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  6. Article ; Online: No evidence of increased rate of thrombotic recurrences in patients with history of venous thromboembolism after vaccination for COVID-19.

    Porfidia, Angelo / Esposto, Giorgio / Manzo, Chiara / Santini, Paolo / Pola, Roberto

    Thrombosis research

    2022  Volume 214, Page(s) 44–46

    MeSH term(s) Anticoagulants/therapeutic use ; COVID-19 ; Humans ; Recurrence ; Thrombosis/etiology ; Vaccination ; Venous Thromboembolism/etiology ; Venous Thromboembolism/prevention & control
    Chemical Substances Anticoagulants
    Language English
    Publishing date 2022-04-20
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 121852-9
    ISSN 1879-2472 ; 0049-3848
    ISSN (online) 1879-2472
    ISSN 0049-3848
    DOI 10.1016/j.thromres.2022.04.010
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    Zs.A 863: Show issues Location:
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  7. Article ; Online: Prevalence of pulmonary embolism on hospital admission in COVID-19 patients: is there a role for pre-test probability scores and home treatment?

    Porfidia, Angelo / Pola, Enrico / Pola, Roberto

    The European respiratory journal

    2021  Volume 58, Issue 2

    MeSH term(s) COVID-19 ; Hospitals ; Humans ; Prevalence ; Probability ; Pulmonary Embolism/diagnosis ; Pulmonary Embolism/epidemiology ; Pulmonary Embolism/therapy ; SARS-CoV-2
    Language English
    Publishing date 2021-08-05
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.00785-2021
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    Zs.A 2322: Show issues Location:
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    Zs.MO 292: Show issues

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  8. Article ; Online: Midregional-proAdrenomedullin as a prognostic tool in sepsis and septic shock: A systematic review and meta-analysis.

    Valeriani, Emanuele / Falletta, Antonio / Pastori, Daniele / Porfidia, Angelo / Mastroianni, Claudio Maria / Di Bari, Silvia / Motta, Eleonora / Pignatelli, Pasquale / Oliva, Alessandra

    European journal of clinical investigation

    2024  , Page(s) e14225

    Abstract: Background: Midregional-proAdrenomedullin (MR-proADM) has been recently proposed as a tool in patients with sepsis and septic shock. Our aim was to evaluate the prognostic role of MR-proADM in hospitalized patients with sepsis and septic shock.: ... ...

    Abstract Background: Midregional-proAdrenomedullin (MR-proADM) has been recently proposed as a tool in patients with sepsis and septic shock. Our aim was to evaluate the prognostic role of MR-proADM in hospitalized patients with sepsis and septic shock.
    Methods: PRISMA guideline was followed. MEDLINE and EMBASE were searched up to June 2023. Primary outcome was mean difference in MR-proADM among survivors and nonsurvivors, secondary outcome mean difference in MR-proADM according to infection severity and type. Risk of bias was evaluated using Newcastle-Ottawa scale for observational studies and Cochrane tool for randomized trials. Pooled mean differences (MD) with corresponding 95% confidence intervals (CIs) were calculated in a random-effects model.
    Results: Twenty-four studies included 6730 adult patients (1208 nonsurvivors and 5522 survivors) and three studies included 195 paediatric patients (30 nonsurvivors and 165 survivors). A total of 10, 4 and 13 studies included, respectively, patients with sepsis (3602 patients), septic shock (386 patients) and a mixed population (2937 patients). Twenty-one studies included patients with different source of infection, three with pneumonia and one with a catheter-related infection. Most studies (n = 12) had a follow-up of 28 days. In adult cohort, pooled mean difference between nonsurvivors and survivors of MR-proADM was 2.55 mmol/L (95% CI: 1.95-3.15) with higher values in patients with septic shock (4.25 mmol/L; 95% CI, 2.23-6.26 mmol/L) than in patients with sepsis (1.77 mmol/L; 95% CI: 1.11-2.44 mmol/L). In paediatric cohort, pooled mean difference was 3.11 mmol/L (95% CI: -0.02-6.24 mmol/L).
    Conclusions: Higher values of MR-proADM are detectable in nonsurvivors adult and paediatric-hospitalized patients with sepsis or septic shock.
    Language English
    Publishing date 2024-04-17
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 186196-7
    ISSN 1365-2362 ; 0014-2972 ; 0960-135X
    ISSN (online) 1365-2362
    ISSN 0014-2972 ; 0960-135X
    DOI 10.1111/eci.14225
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    Zs.A 677: Show issues Location:
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  9. Article ; Online: Factor V Leiden, prothrombin, MTHFR, and PAI-1 gene polymorphisms in patients with arterial disease: A comprehensive systematic-review and meta-analysis.

    Valeriani, Emanuele / Pastori, Daniele / Astorri, Giulia / Porfidia, Angelo / Menichelli, Danilo / Pignatelli, Pasquale

    Thrombosis research

    2023  Volume 230, Page(s) 74–83

    Abstract: Introduction: The role of inherited thrombophilia in arterial disease is uncertain. We performed a systematic-review and meta-analysis of inherited thrombophilia in cerebrovascular (CVD), coronary heart (CHD), and peripheral artery disease (PAD) ... ...

    Abstract Introduction: The role of inherited thrombophilia in arterial disease is uncertain. We performed a systematic-review and meta-analysis of inherited thrombophilia in cerebrovascular (CVD), coronary heart (CHD), and peripheral artery disease (PAD) patients.
    Materials and methods: MEDLINE and EMBASE were searched up to February 2022. Pooled prevalences (PPs) and odds ratios (ORs) with 95 % confidence intervals (95%CI) were calculated in a random-effects model. Factor V Leiden (G1691A), prothrombin (G20210A), MTHFR C677T/A1298C and PAI-1 4G/5G were evaluated.
    Results: 377 studies for 98,186 patients (32,791 CVD, 62,266 CHD, 3129 PAD) and 108,569 controls were included. Overall, 37,249 patients had G1691A, 32,254 G20210A, 42,546 MTHFR C677T, 8889 MTHFR A1298C, and 19,861 PAI-1 4G/5G gene polymorphisms. In CVD patients, PPs were 6.5 % for G1691A, 3.9 % for G20210A, 56.4 % for MTHFR C677T, 51.9 % for MTHFR A1298C, and 77.6 % for PAI-1. In CHD, corresponding PPs were 7.2 %, 3.8 %, 52.3 %, 53.9 %, and 76.4 %. In PAD, PPs were 6.9 %, 4.7 %, 55.1 %, 52.1 %, and 75.0 %, respectively. Strongest ORs in CVD were for homozygous G1691A (2.76; 95 %CI, 1.83-4.18) and for homozygous G20210A (3.96; 95 %CI, 2.05-7.64). Strongest ORs in CHD were for homozygous G1691A (OR 1.68; 95%CI, 1.02-2.77) and G20210A (heterozygous 1.49 95%CI, 1.22-1.82; homozygous 1.54 95%CI, 0.79-2.99). The OR for PAI-1 4G/4G in PAD was 5.44 (95%CI, 1.80-16.43). Specific subgroups with higher PPs and ORs were identified according to age and region.
    Conclusions: Patients with arterial disease have an increased prevalence and odds of having some inherited thrombophilia. Some thrombophilia testing may be considered in specific subgroups of patients.
    Language English
    Publishing date 2023-08-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 121852-9
    ISSN 1879-2472 ; 0049-3848
    ISSN (online) 1879-2472
    ISSN 0049-3848
    DOI 10.1016/j.thromres.2023.08.006
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