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  1. Article ; Online: A Cast of the Left Bronchial Tree.

    Criel, Maarten / Gewillig, Marc

    Lung

    2019  Volume 197, Issue 6, Page(s) 825–826

    MeSH term(s) Adolescent ; Airway Obstruction/diagnostic imaging ; Airway Obstruction/drug therapy ; Airway Obstruction/etiology ; Bradycardia/therapy ; Bronchitis/diagnostic imaging ; Bronchitis/drug therapy ; Bronchitis/etiology ; Bronchoscopy ; Ethiodized Oil/therapeutic use ; Fontan Procedure ; Humans ; Lymphatic Diseases/complications ; Lymphatic Diseases/diagnostic imaging ; Lymphatic Diseases/drug therapy ; Lymphography ; Male ; Pacemaker, Artificial ; Postoperative Complications/diagnostic imaging ; Postoperative Complications/drug therapy ; Prosthesis Implantation
    Chemical Substances Ethiodized Oil (8008-53-5)
    Language English
    Publishing date 2019-08-31
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 6165-7
    ISSN 1432-1750 ; 0341-2040
    ISSN (online) 1432-1750
    ISSN 0341-2040
    DOI 10.1007/s00408-019-00267-8
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    In stock of ZB MED Cologne/Königswinter

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  2. Article ; Online: Unraveling the Rewired Metabolism in Lung Cancer Using Quantitative NMR Metabolomics.

    Vanhove, Karolien / Derveaux, Elien / Mesotten, Liesbet / Thomeer, Michiel / Criel, Maarten / Mariën, Hanne / Adriaensens, Peter

    International journal of molecular sciences

    2022  Volume 23, Issue 10

    Abstract: Lung cancer cells are well documented to rewire their metabolism and energy production networks to enable proliferation and survival in a nutrient-poor and hypoxic environment. Although metabolite profiling of blood plasma and tissue is still emerging in ...

    Abstract Lung cancer cells are well documented to rewire their metabolism and energy production networks to enable proliferation and survival in a nutrient-poor and hypoxic environment. Although metabolite profiling of blood plasma and tissue is still emerging in omics approaches, several techniques have shown potential in cancer diagnosis. In this paper, the authors describe the alterations in the metabolic phenotype of lung cancer patients. In addition, we focus on the metabolic cooperation between tumor cells and healthy tissue. Furthermore, the authors discuss how metabolomics could improve the management of lung cancer patients.
    MeSH term(s) Humans ; Lung Neoplasms/metabolism ; Magnetic Resonance Imaging ; Magnetic Resonance Spectroscopy/methods ; Metabolomics/methods ; Phenotype
    Language English
    Publishing date 2022-05-17
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23105602
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  3. Article ; Online: Remote patient monitoring in COVID-19: a critical appraisal.

    Gruwez, Henri / Bakelants, Emma / Dreesen, Pauline / Broekmans, Jolien / Criel, Maarten / Thomeer, Michiel / Vandervoort, Pieter / Ruttens, David

    The European respiratory journal

    2022  Volume 59, Issue 2

    MeSH term(s) COVID-19 ; Humans ; Monitoring, Physiologic ; SARS-CoV-2 ; Telemedicine
    Language English
    Publishing date 2022-02-03
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.02697-2021
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  4. Article ; Online: Unraveling the Rewired Metabolism in Lung Cancer Using Quantitative NMR Metabolomics

    Karolien Vanhove / Elien Derveaux / Liesbet Mesotten / Michiel Thomeer / Maarten Criel / Hanne Mariën / Peter Adriaensens

    International Journal of Molecular Sciences, Vol 23, Iss 5602, p

    2022  Volume 5602

    Abstract: Lung cancer cells are well documented to rewire their metabolism and energy production networks to enable proliferation and survival in a nutrient-poor and hypoxic environment. Although metabolite profiling of blood plasma and tissue is still emerging in ...

    Abstract Lung cancer cells are well documented to rewire their metabolism and energy production networks to enable proliferation and survival in a nutrient-poor and hypoxic environment. Although metabolite profiling of blood plasma and tissue is still emerging in omics approaches, several techniques have shown potential in cancer diagnosis. In this paper, the authors describe the alterations in the metabolic phenotype of lung cancer patients. In addition, we focus on the metabolic cooperation between tumor cells and healthy tissue. Furthermore, the authors discuss how metabolomics could improve the management of lung cancer patients.
    Keywords lung cancer ; NMR (nuclear magnetic resonance) ; metabolism ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Language English
    Publishing date 2022-05-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: NMR-Metabolomics Reveals a Metabolic Shift after Surgical Resection of Non-Small Cell Lung Cancer.

    Derveaux, Elien / Geubbelmans, Melvin / Criel, Maarten / Demedts, Ingel / Himpe, Ulrike / Tournoy, Kurt / Vercauter, Piet / Johansson, Erik / Valkenborg, Dirk / Vanhove, Karolien / Mesotten, Liesbet / Adriaensens, Peter / Thomeer, Michiel

    Cancers

    2023  Volume 15, Issue 7

    Abstract: Background: Lung cancer can be detected by measuring the patient's plasma metabolomic profile using nuclear magnetic resonance (NMR) spectroscopy. This NMR-based plasma metabolomic profile is patient-specific and represents a snapshot of the patient's ... ...

    Abstract Background: Lung cancer can be detected by measuring the patient's plasma metabolomic profile using nuclear magnetic resonance (NMR) spectroscopy. This NMR-based plasma metabolomic profile is patient-specific and represents a snapshot of the patient's metabolite concentrations. The onset of non-small cell lung cancer (NSCLC) causes a change in the metabolite profile. However, the level of metabolic changes after complete NSCLC removal is currently unknown.
    Patients and methods: Fasted pre- and postoperative plasma samples of 74 patients diagnosed with resectable stage I-IIIA NSCLC were analyzed using
    Results: A trained multivariate discriminant classification model shows a strong differentiation between the pre- and postoperative NSCLC profiles with a specificity of 96% (95% CI [86-100]) and a sensitivity of 92% (95% CI [81-98]). Validation of this model results in an excellent predictive accuracy of 90% (95% CI [77-97]) and an AUC value of 0.97 (95% CI [0.93-1]). The validation of a second trained model using an additional preoperative control sample dataset confirms the separation of the pre- and postoperative profiles with a predictive accuracy of 93% (95% CI [82-99]) and an AUC value of 0.97 (95% CI [0.93-1]). Metabolite analysis reveals significantly increased lactate, cysteine, asparagine and decreased acetate levels in the postoperative plasma metabolite profile.
    Conclusions: The results of this paper demonstrate that surgical removal of NSCLC generates a detectable metabolic shift in blood plasma. The observed metabolic shift indicates that the NSCLC metabolite profile is determined by the tumor's presence rather than donor-specific features. Furthermore, the ability to detect the metabolic difference before and after surgical tumor resection strongly supports the prospect that NMR-generated metabolite profiles via blood samples advance towards early detection of NSCLC recurrence.
    Language English
    Publishing date 2023-04-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15072127
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  6. Article ; Online: Venous thromboembolism in SARS-CoV-2 patients: only a problem in ventilated ICU patients, or is there more to it?

    Criel, Maarten / Falter, Maarten / Jaeken, Jasmien / Van Kerrebroeck, Margaretha / Lefere, Isabelle / Meylaerts, Liesbeth / Mesotten, Dieter / Vander Laenen, Margot / Fivez, Tom / Thomeer, Michiel / Ruttens, David

    The European respiratory journal

    2020  Volume 56, Issue 1

    MeSH term(s) Aged ; Betacoronavirus ; Body Mass Index ; COVID-19 ; Cohort Studies ; Coronavirus Infections/complications ; Critical Care ; Female ; Humans ; Intensive Care Units ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral/complications ; Respiration, Artificial/adverse effects ; Risk Factors ; SARS-CoV-2 ; Treatment Outcome ; Venous Thromboembolism/complications ; Venous Thromboembolism/prevention & control
    Keywords covid19
    Language English
    Publishing date 2020-07-30
    Publishing country England
    Document type Letter
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.01201-2020
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  7. Article ; Online: Randomised, controlled, open-label pragmatic trial evaluating changes in functional exercise capacity after primary care

    Volckaerts, Tess / Vissers, Dirk / Burtin, Chris / Van Meerbeeck, Xavier / de Soomer, Kevin / Oostveen, Ellie / Claes, Kim / Roelant, Ella / Verhaegen, Iris / Thomeer, Michiel / Criel, Maarten / Quadflieg, Kirsten / Cops, Dries / Ruttens, David / Lapperre, Thérèse S

    BMJ open

    2023  Volume 13, Issue 6, Page(s) e071098

    Abstract: Introduction: Long COVID is a prevalent condition with many multisystemic symptoms, such as fatigue, dyspnoea, muscle weakness, anxiety, depression and sleep difficulties, impacting daily life and (social and physical) functioning. Pulmonary ... ...

    Abstract Introduction: Long COVID is a prevalent condition with many multisystemic symptoms, such as fatigue, dyspnoea, muscle weakness, anxiety, depression and sleep difficulties, impacting daily life and (social and physical) functioning. Pulmonary rehabilitation (PR) may improve physical status and symptoms of patients with long COVID, yet the evidence is limited. Therefore, this trial aims to study the effect of primary care PR on exercise capacity, symptoms, physical activity and sleep in patients with long COVID.
    Methods and analysis: PuRe-COVID is a prospective, pragmatic, open-label, randomised controlled trial. A sample of 134 adult patients with long COVID will be randomised to a 12 week PR programme in primary care, supervised by a physiotherapist or to a control group, following no PR. A 3 month and 6 month follow-up period is foreseen. The primary endpoint will be the change in exercise capacity measured by 6-minute walk distance (6MWD) at 12 weeks, hypothesising a more significant improvement in the PR group. Other parameters, such as pulmonary function tests (including maximal inspiratory pressure/maximal expiratory pressure), patient-reported outcomes (COPD Assessment Test, modified Medical Research Council Dyspnoea Scale, Checklist Individual Strength, post-COVID-19 Functional Status, Nijmegen questionnaire, Hospital Anxiety and Depression Scale, Work Productivity and Activity Impairment Questionnaire and EuroQol-5D-5L), physical activity measured by an activity tracker, hand grip strength and sleep efficiency, are secondary and exploratory outcomes.The recruitment started on 19 April 2022, and 52 patients were included as of 14 December 2022.
    Ethics and dissemination: Ethical approval was obtained in Belgium from the relevant institutional review boards on 21 February 2022 (Antwerp University Hospital, approval number 2022-3067) and on 1 April 2022 (Ziekenhuis Oost-Limburg in Genk, approval number Z-2022-01). Findings from this randomised controlled trial will be disseminated in peer-reviewed publications and presentations at international scientific meetings.
    Trial registration number: NCT05244044.
    MeSH term(s) Adult ; Humans ; COVID-19 ; Post-Acute COVID-19 Syndrome ; Hand Strength ; Belgium ; Exercise Tolerance ; Prospective Studies ; Exercise ; Dyspnea/etiology ; Dyspnea/rehabilitation ; Primary Health Care ; Quality of Life ; Randomized Controlled Trials as Topic
    Language English
    Publishing date 2023-06-02
    Publishing country England
    Document type Clinical Trial Protocol ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2022-071098
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  8. Article ; Online: Randomised, controlled, open-label pragmatic trial evaluating changes in functional exercise capacity after primary care PUlmonary REhabilitation in patients with long COVID

    Dirk Vissers / Chris Burtin / Thérèse S Lapperre / Iris Verhaegen / Ella Roelant / Tess Volckaerts / Xavier Van Meerbeeck / Kevin de Soomer / Ellie Oostveen / Kim Claes / Michiel Thomeer / Maarten Criel / Kirsten Quadflieg / Dries Cops / David Ruttens

    BMJ Open, Vol 13, Iss

    protocol of the PuRe-COVID trial in Belgium

    2023  Volume 6

    Abstract: Introduction Long COVID is a prevalent condition with many multisystemic symptoms, such as fatigue, dyspnoea, muscle weakness, anxiety, depression and sleep difficulties, impacting daily life and (social and physical) functioning. Pulmonary ... ...

    Abstract Introduction Long COVID is a prevalent condition with many multisystemic symptoms, such as fatigue, dyspnoea, muscle weakness, anxiety, depression and sleep difficulties, impacting daily life and (social and physical) functioning. Pulmonary rehabilitation (PR) may improve physical status and symptoms of patients with long COVID, yet the evidence is limited. Therefore, this trial aims to study the effect of primary care PR on exercise capacity, symptoms, physical activity and sleep in patients with long COVID.Methods and analysis PuRe-COVID is a prospective, pragmatic, open-label, randomised controlled trial. A sample of 134 adult patients with long COVID will be randomised to a 12 week PR programme in primary care, supervised by a physiotherapist or to a control group, following no PR. A 3 month and 6 month follow-up period is foreseen. The primary endpoint will be the change in exercise capacity measured by 6-minute walk distance (6MWD) at 12 weeks, hypothesising a more significant improvement in the PR group. Other parameters, such as pulmonary function tests (including maximal inspiratory pressure/maximal expiratory pressure), patient-reported outcomes (COPD Assessment Test, modified Medical Research Council Dyspnoea Scale, Checklist Individual Strength, post-COVID-19 Functional Status, Nijmegen questionnaire, Hospital Anxiety and Depression Scale, Work Productivity and Activity Impairment Questionnaire and EuroQol-5D-5L), physical activity measured by an activity tracker, hand grip strength and sleep efficiency, are secondary and exploratory outcomes.The recruitment started on 19 April 2022, and 52 patients were included as of 14 December 2022.Ethics and dissemination Ethical approval was obtained in Belgium from the relevant institutional review boards on 21 February 2022 (Antwerp University Hospital, approval number 2022-3067) and on 1 April 2022 (Ziekenhuis Oost-Limburg in Genk, approval number Z-2022-01). Findings from this randomised controlled trial will be disseminated in peer-reviewed publications ...
    Keywords Medicine ; R
    Subject code 796
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher BMJ Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article: Venous thromboembolism in SARS-CoV-2 patients: only a problem in ventilated ICU patients, or is there more to it?

    Criel, Maarten / Falter, Maarten / Jaeken, Jasmien / Van Kerrebroeck, Margaretha / Lefere, Isabelle / Meylaerts, Liesbeth / Mesotten, Dieter / Vander Laenen, Margot / Fivez, Tom / Thomeer, Michiel / Ruttens, David

    Eur. respir. j

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #245660
    Database COVID19

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  10. Article ; Online: Venous thromboembolism in SARS-CoV-2 patients

    Criel, Maarten / FALTER, Maarten / Jaeken, Jasmien / Van Kerrebroeck, Margaretha / Lefere, Isabelle / MEYLAERTS, Liesbeth / MESOTTEN, Dieter / VANDER LAENEN, Margot / Fivez, Tom / THOMEER, Michiel / RUTTENS, David

    only a problem in ventilated ICU patients, or is there more to it?

    2020  

    Keywords covid19
    Language English
    Publishing date 2020-08-04T08:04:59Z
    Publishing country be
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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