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  1. Article ; Online: Ciclesonide-induced bronchospasm: an important but preventable side effect.

    Mandaliya, Payal H / Kennedy, Brendan / van Asperen, Peter / Robinson, Paul D

    The Medical journal of Australia

    2015  Volume 203, Issue 5, Page(s) 233–3e.1

    MeSH term(s) Adolescent ; Asthma/drug therapy ; Australia ; Bronchial Spasm/chemically induced ; Glucocorticoids/adverse effects ; Humans ; Pregnenediones/adverse effects
    Chemical Substances Glucocorticoids ; Pregnenediones ; ciclesonide (S59502J185)
    Language English
    Publishing date 2015-12-10
    Publishing country Australia
    Document type Case Reports ; Journal Article
    ZDB-ID 186082-3
    ISSN 1326-5377 ; 0025-729X
    ISSN (online) 1326-5377
    ISSN 0025-729X
    DOI 10.5694/mja15.00014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  2. Article ; Online: Ventilation inhomogeneities in children with congenital thoracic malformations.

    Mandaliya, Payal H / Morten, Matthew / Kumar, Rajendra / James, Alan / Deshpande, Aniruddh / Murphy, Vanessa E / Gibson, Peter G / Whitehead, Bruce / Robinson, Paul / Mattes, Joerg

    BMC pulmonary medicine

    2015  Volume 15, Page(s) 25

    Abstract: Background: Congenital thoracic malformations (CTM) are rare lung lesions that are managed with surgical resection or active surveillance. The objective of this study was to comprehensively assess large and small airway function in children with CTM who ...

    Abstract Background: Congenital thoracic malformations (CTM) are rare lung lesions that are managed with surgical resection or active surveillance. The objective of this study was to comprehensively assess large and small airway function in children with CTM who underwent lobectomy in early life. We hypothesise that sensitive measures of lung function will demonstrate residual impairments in CTM compared to healthy children.
    Methods: Nitrogen lung clearance index (LCI), reactance and resistance (X5Hz and R5Hz), forced expiratory volume in 1 s and forced vital capacity (FEV1 and FVC) were prospectively measured in 10 children with CTM (mean age/SD: 7.6/1.3) who had undergone surgical resection in early life and in 17 healthy children (mean age/SD: 4.8/0.4). Total lung capacity (TLC) was also conducted in children older than 7 years of age with CTM (n = 8).
    Results: Mean LCI was 8.0 (95% CI 7.5 to 8.5) in the CTM group and 7.3 (95% CI 7.0 to 7.6) in healthy children (p = 0.016). Mean X5Hz was -0.44kPa/l/s (95% CI -0.58 to -0.31) in the CTM group and -0.31kPa/l/s (95% CI -0.35 to -0.27) in healthy children (p = 0.02). Mean Z score for X5Hz was -2.11 (95% CI -3.59 to -0.63) in the CTM group and -0.11 (95% CI -0.55 to 0.33) in healthy children (p = 0.0008). Mean FEV1 was 1.21 L (95% CI 0.97 to 1.45) in the CTM group and 1.02 L (95% CI 0.90 to 1.15) in healthy children (p = 0.22). Mean % predicted FEV1 was 83% (95% CI 74 to 92) in the CTM group and 97% (95% CI 87 to 107) in healthy children (p < 0.05). Mean % predicted TLC in CTM children was 121.3% (95% CI 88.45 to 154.1). Mean LCI was inversely correlated with height z-scores in the CTM group (rs = -0.88, p = 0.002) but not in healthy children (rs = 0.22, p = 0.4).
    Conclusions: Children with CTM have impaired lung function as demonstrated by the significant differences in LCI, reactance and FEV1 but not FVC, resistance and TLC. These findings may be of clinical relevance as ventilation inhomogeneities are closely correlated with somatic growth in this study.
    MeSH term(s) Breath Tests ; Bronchogenic Cyst/physiopathology ; Bronchogenic Cyst/surgery ; Bronchopulmonary Sequestration/physiopathology ; Bronchopulmonary Sequestration/surgery ; Case-Control Studies ; Child ; Child, Preschool ; Cystic Adenomatoid Malformation of Lung, Congenital/physiopathology ; Cystic Adenomatoid Malformation of Lung, Congenital/surgery ; Female ; Forced Expiratory Volume/physiology ; Humans ; Lung/abnormalities ; Lung/physiopathology ; Lung/surgery ; Male ; Nitrogen/analysis ; Pneumonectomy ; Pulmonary Emphysema/congenital ; Pulmonary Emphysema/physiopathology ; Pulmonary Emphysema/surgery ; Pulmonary Ventilation/physiology ; Respiratory Function Tests ; Total Lung Capacity/physiology ; Vital Capacity/physiology
    Chemical Substances Nitrogen (N762921K75)
    Language English
    Publishing date 2015-03-25
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2059871-3
    ISSN 1471-2466 ; 1471-2466
    ISSN (online) 1471-2466
    ISSN 1471-2466
    DOI 10.1186/s12890-015-0023-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Association between bacterial vaginosis and fecundability in Kenyan women planning pregnancies: a prospective preconception cohort study.

    Lokken, Erica M / Manhart, Lisa E / Kinuthia, John / Hughes, James P / Jisuvei, Clayton / Mwinyikai, Khamis / Muller, Charles H / Mandaliya, Kishor / Jaoko, Walter / McClelland, R Scott

    Human reproduction (Oxford, England)

    2021  Volume 36, Issue 5, Page(s) 1279–1287

    Abstract: ... receives research funding, paid to the University of Washington, from Hologic Corporation, and has received ... honoraria for consulting from Lupin Pharmaceuticals. L.E.M. receives research funding, paid ...

    Abstract Study question: Is bacterial vaginosis (BV) associated with fecundability?
    Summary answer: Women with BV may be at increased risk for sub-fecundity.
    What is known already: While BV has been associated with poor IVF outcomes, the association between vaginal microbiota disruption and non-medically assisted conception has not been thoroughly explored.
    Study design, size, duration: Kenyan women with fertility intent were enrolled in prospective cohort that included monthly preconception visits with vaginal fluid specimen collection and pregnancy testing. Four hundred fifty-eight women attempting pregnancy for ≤3 menstrual cycles at enrollment were eligible for this fecundability analysis.
    Participants/materials, setting, methods: At monthly preconception visits, participants reported the first day of last menstrual period and sexual behavior, underwent pregnancy testing and provided vaginal specimens. Discrete time proportional probabilities models were used to estimate fecundability ratios (FRs) and 95% CI in menstrual cycles with and without BV (Nugent score ≥ 7) at the visit prior to each pregnancy test. We also assessed the association between persistent BV (BV at two consecutive visits) and fecundability.
    Main results and the role of chance: Participants contributed 1376 menstrual cycles; 18.5% (n = 255) resulted in pregnancy. After adjusting for age, frequency of condomless sex and study site, BV at the visit prior to pregnancy testing was associated with a 17% lower fecundability (adjusted FR (aFR) 0.83, 95% CI 0.6-1.1). Persistent BV was associated with a 43% reduction in fecundability compared to cycles characterized by optimal vaginal health (aFR 0.57, 95% CI 0.4-0.8).
    Limitations, reasons for caution: Detection of vaginal microbiota disruption using Gram stain and a point-of-care test for elevated sialidase identified a non-optimal vaginal environment, but these non-specific methods may miss important relationships that could be identified by characterizing individual vaginal bacteria and bacterial communities using molecular methods. In addition, results may be subject to residual confounding by condomless sex as this was reported for the prior month rather than for the fertile window during each cycle.
    Wider implications of the findings: Given the high global prevalence of BV and infertility, an association between BV and reduced fecundability could have important implications for a large number of women who wish to conceive. Multi-omics approaches to studying the vaginal microbiota may provide key insights into this association and identify potential targets for intervention.
    Study funding/competing interest(s): This work was supported by a National Institutes of Health grant (NICHD R01 HD087346-R.S.M.). R.S.M. received additional support for mentoring (NICHD K24 HD88229). E.M.L. was supported by pre- and post-doctoral fellowships (NIAID T32 AI07140, NICHD F32 HD100202). Data collection and management were made possible using REDCap electronic data capture tools hosted at the University of Washington's Institute of Translational Health Science supported by grants from NCATS/NIH (UL1 TR002319). The content of this paper is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. R.S.M. receives research funding, paid to the University of Washington, from Hologic Corporation, and has received honoraria for consulting from Lupin Pharmaceuticals. L.E.M. receives research funding, paid to the University of Washington, from Hologic Corporation, and has received honoraria for service on scientific advisory boards from Hologic and Nabriva Therapeutics.
    Trial registration number: N/A.
    MeSH term(s) Cohort Studies ; Female ; Fertility ; Humans ; Kenya/epidemiology ; Pregnancy ; Prospective Studies ; Vaginosis, Bacterial/complications ; Vaginosis, Bacterial/epidemiology
    Language English
    Publishing date 2021-02-13
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 632776-x
    ISSN 1460-2350 ; 0268-1161 ; 1477-741X
    ISSN (online) 1460-2350
    ISSN 0268-1161 ; 1477-741X
    DOI 10.1093/humrep/deab002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 2892: Show issues Location:
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  4. Article ; Online: Exercise capacity is not decreased in children who have undergone lung resection early in life for congenital thoracic malformations compared to healthy age-matched children.

    Dunn, Ashlee / Pearce, Kasey / Callister, Robin / Collison, Adam / Morten, Matthew / Mandaliya, Payal / Platt, Lauren / Dascombe, Ben / Kumar, Rajendra / Selvadurai, Hiran / Robinson, Paul D / Mattes, Joerg

    Pediatric pulmonology

    2017  Volume 52, Issue 10, Page(s) 1340–1348

    Abstract: Purpose: The purpose of this study was to compare (i) the exercise capacity and (ii) lung function prior to and immediately post cardiopulmonary exercise tests (CPET) of children who underwent early life lung resection for Congenital Pulmonary Airway ... ...

    Abstract Purpose: The purpose of this study was to compare (i) the exercise capacity and (ii) lung function prior to and immediately post cardiopulmonary exercise tests (CPET) of children who underwent early life lung resection for Congenital Pulmonary Airway Malformations (CPAM) to healthy control children.
    Method: Eight children with CPAM (four males, age 9.6 ± 1.8 years) and eight control children without respiratory disease (three males, age 9.4 ± 1.4 years) performed a CPET on a cycle ergometer, during which maximal oxygen consumption (V̇O
    Results: There were no significant between group differences in pre CPET lung function (P > 0.05) or maximal exercise capacity (V̇O
    Conclusion: Early life lung resection for CPAM does not appear to have negative implications for exercise capacity later in childhood. Clinicians should be aware that dyspnoea following exercise may be due to asthma rather than residual effects of CPAM in these children.
    MeSH term(s) Child ; Exercise Test ; Exercise Tolerance ; Female ; Forced Expiratory Volume ; Heart Rate ; Humans ; Lung/abnormalities ; Lung/physiopathology ; Lung/surgery ; Male ; Oxygen Consumption ; Respiratory System Abnormalities/physiopathology ; Respiratory System Abnormalities/surgery ; Spirometry
    Language English
    Publishing date 2017-07-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 632784-9
    ISSN 1099-0496 ; 8755-6863
    ISSN (online) 1099-0496
    ISSN 8755-6863
    DOI 10.1002/ppul.23772
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2143: Show issues Location:
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