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  1. Article ; Online: Rebuttal from Jeremy R. Beitler, Rolf D. Hubmayr and Atul Malhotra.

    Beitler, Jeremy R / Hubmayr, Rolf D / Malhotra, Atul

    The Journal of physiology

    2013  Volume 591, Issue 11, Page(s) 2773

    MeSH term(s) Animals ; Humans ; Hypercapnia/physiopathology ; Respiratory Distress Syndrome/therapy
    Language English
    Publishing date 2013-05-31
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 3115-x
    ISSN 1469-7793 ; 0022-3751
    ISSN (online) 1469-7793
    ISSN 0022-3751
    DOI 10.1113/jphysiol.2013.255646
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Monitoring esophageal pressure.

    Piquilloud, Lise / Beitler, Jeremy R / Beloncle, François M

    Intensive care medicine

    2024  

    Language English
    Publishing date 2024-04-11
    Publishing country United States
    Document type Editorial
    ZDB-ID 80387-x
    ISSN 1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
    ISSN (online) 1432-1238
    ISSN 0340-0964 ; 0342-4642 ; 0935-1701
    DOI 10.1007/s00134-024-07401-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1089: Show issues Location:
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  3. Article ; Online: Spring in New York.

    Beitler, Jeremy R

    American journal of respiratory and critical care medicine

    2021  Volume 203, Issue 4, Page(s) 504

    MeSH term(s) Attitude of Health Personnel ; COVID-19/epidemiology ; COVID-19/psychology ; Health Personnel/psychology ; Humans ; New York City/epidemiology ; Poetry as Topic
    Language English
    Publishing date 2021-01-08
    Publishing country United States
    Document type Letter
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202012-4465LE
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Treatment Mechanism and Inflammatory Subphenotyping in Acute Respiratory Distress Syndrome.

    Serra, Alexis L / Meyer, Nuala J / Beitler, Jeremy R

    American journal of respiratory and critical care medicine

    2024  Volume 209, Issue 7, Page(s) 774–776

    MeSH term(s) Humans ; Respiratory Distress Syndrome/therapy ; Respiration, Artificial ; Phenotype ; Gene Expression
    Language English
    Publishing date 2024-02-14
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202402-0340ED
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Volatile anesthetics for ICU sedation: the future of critical care or niche therapy?

    Beitler, Jeremy R / Talmor, Daniel

    Intensive care medicine

    2022  Volume 48, Issue 10, Page(s) 1413–1417

    MeSH term(s) Anesthetics, Inhalation ; Anesthetics, Intravenous ; Conscious Sedation ; Critical Care ; Humans ; Hypnotics and Sedatives/therapeutic use ; Intensive Care Units
    Chemical Substances Anesthetics, Inhalation ; Anesthetics, Intravenous ; Hypnotics and Sedatives
    Language English
    Publishing date 2022-09-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80387-x
    ISSN 1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
    ISSN (online) 1432-1238
    ISSN 0340-0964 ; 0342-4642 ; 0935-1701
    DOI 10.1007/s00134-022-06842-7
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    Zs.A 1089: Show issues Location:
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  6. Article ; Online: Bedside respiratory physiology to detect risk of lung injury in acute respiratory distress syndrome.

    Beitler, Jeremy R

    Current opinion in critical care

    2019  Volume 25, Issue 1, Page(s) 3–11

    Abstract: Purpose of review: The most effective strategies for treating the patient with acute respiratory distress syndrome center on minimizing ventilation-induced lung injury (VILI). Yet, current standard-of-care does little to modify mechanical ventilation to ...

    Abstract Purpose of review: The most effective strategies for treating the patient with acute respiratory distress syndrome center on minimizing ventilation-induced lung injury (VILI). Yet, current standard-of-care does little to modify mechanical ventilation to patient-specific risk. This review focuses on evaluation of bedside respiratory mechanics, which when interpreted in patient-specific context, affords opportunity to individualize lung-protective ventilation in patients with acute respiratory distress syndrome.
    Recent findings: Four biophysical mechanisms of VILI are widely accepted: volutrauma, barotrauma, atelectrauma, and stress concentration. Resulting biotrauma, that is, local and systemic inflammation and endothelial activation, may be thought of as the final common pathway that propagates VILI-mediated multiorgan failure. Conventional, widely utilized techniques to assess VILI risk rely on airway pressure, flow, and volume changes, and remain essential tools for determining overdistension of aerated lung regions, particularly when interpreted cognizant of their limitations. Emerging bedside tools identify regional differences in mechanics, but further study is required to identify how they might best be incorporated into clinical practice.
    Summary: Quantifying patient-specific risk of VILI requires understanding each patient's pulmonary mechanics in context of biological predisposition. Tailoring support at bedside according to these factors affords the greatest opportunity to date for mitigating VILI and alleviating associated morbidity.
    MeSH term(s) Barotrauma ; Humans ; Inflammation ; Lung ; Lung Injury ; Multiple Organ Failure ; Positive-Pressure Respiration/methods ; Respiration, Artificial/methods ; Respiratory Distress Syndrome, Adult/therapy ; Respiratory Mechanics/physiology ; Tidal Volume/physiology ; Ventilator-Induced Lung Injury
    Language English
    Publishing date 2019-02-04
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1235629-3
    ISSN 1531-7072 ; 1070-5295
    ISSN (online) 1531-7072
    ISSN 1070-5295
    DOI 10.1097/MCC.0000000000000579
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4999: Show issues Location:
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  7. Article ; Online: Lung protection in acute respiratory distress syndrome: what should we target?

    Beitler, Jeremy R

    Current opinion in critical care

    2019  Volume 26, Issue 1, Page(s) 26–34

    Abstract: Purpose of review: Most clinical trials of lung-protective ventilation have tested one-size-fits-all strategies with mixed results. Data are lacking on how best to tailor mechanical ventilation to patient-specific risk of lung injury.: Recent findings! ...

    Abstract Purpose of review: Most clinical trials of lung-protective ventilation have tested one-size-fits-all strategies with mixed results. Data are lacking on how best to tailor mechanical ventilation to patient-specific risk of lung injury.
    Recent findings: Risk of ventilation-induced lung injury is determined by biological predisposition to biophysical lung injury and physical mechanical perturbations that concentrate stress and strain regionally within the lung. Recent investigations have identified molecular subphenotypes classified as hyperinflammatory and hypoinflammatory acute respiratory distress syndrome (ARDS), which may have dissimilar risk for ventilation-induced lung injury. Mechanically, gravity-dependent atelectasis has long been recognized to decrease total aerated lung volume available for tidal ventilation, a concept termed the 'ARDS baby lung'. Recent studies have demonstrated that the aerated baby lung also has nonuniform stress/strain distribution, with potentially injurious forces concentrated in zones of heterogeneity where aerated alveoli are adjacent to flooded or atelectatic alveoli. The preponderance of evidence also indicates that current standard-of-care tidal volume management is not universally protective in ARDS. When considering escalation of lung-protective interventions, potential benefits of the intervention should be weighed against tradeoffs of accompanying cointerventions required, for example, deeper sedation or neuromuscular blockade. A precision medicine approach to lung-protection would weigh.
    Summary: A precision medicine approach to lung-protective ventilation requires weighing four key factors in each patient: biological predisposition to biophysical lung injury, mechanical predisposition to biophysical injury accounting for spatial mechanical heterogeneity within the lung, anticipated benefits of escalating lung-protective interventions, and potential unintended adverse effects of mandatory cointerventions.
    MeSH term(s) Humans ; Lung ; Lung Injury/prevention & control ; Respiration, Artificial/adverse effects ; Respiratory Distress Syndrome/prevention & control ; Tidal Volume
    Language English
    Publishing date 2019-12-08
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1235629-3
    ISSN 1531-7072 ; 1070-5295
    ISSN (online) 1531-7072
    ISSN 1070-5295
    DOI 10.1097/MCC.0000000000000692
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4999: Show issues Location:
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  8. Article ; Online: The Staying Power of Pressure- and Volume-limited Ventilation in Acute Respiratory Distress Syndrome.

    Beitler, Jeremy R / Walkey, Allan J

    American journal of respiratory and critical care medicine

    2021  Volume 204, Issue 3, Page(s) 247–249

    MeSH term(s) Humans ; Respiratory Distress Syndrome/therapy ; Tidal Volume
    Language English
    Publishing date 2021-05-08
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202104-0839ED
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  9. Article ; Online: Lung-protective sedation: moving toward a new paradigm of precision sedation.

    Kassis, Elias Baedorf / Beitler, Jeremy R / Talmor, Daniel

    Intensive care medicine

    2022  Volume 49, Issue 1, Page(s) 91–94

    MeSH term(s) Humans ; Lung ; Thorax ; Conscious Sedation ; Hypnotics and Sedatives/pharmacology ; Hypnotics and Sedatives/therapeutic use
    Chemical Substances Hypnotics and Sedatives
    Language English
    Publishing date 2022-10-14
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80387-x
    ISSN 1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
    ISSN (online) 1432-1238
    ISSN 0340-0964 ; 0342-4642 ; 0935-1701
    DOI 10.1007/s00134-022-06901-z
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  10. Article: Hypoxemia on life support for guiding acute respiratory distress syndrome therapy?

    Gusman, Elen / Beitler, Jeremy R

    Journal of thoracic disease

    2020  Volume 12, Issue 6, Page(s) 3010–3012

    Language English
    Publishing date 2020-07-06
    Publishing country China
    Document type Editorial ; Comment
    ZDB-ID 2573571-8
    ISSN 2077-6624 ; 2072-1439
    ISSN (online) 2077-6624
    ISSN 2072-1439
    DOI 10.21037/jtd.2020.03.72
    Database MEDical Literature Analysis and Retrieval System OnLINE

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