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  1. Article ; Online: Severe Pulmonary Hypertension and Septum Left Shift.

    Yamaguchi, Craig T / Moody, Alastair E / Beutler, Bryce D / Lee, James P

    Anesthesiology

    2023  Volume 139, Issue 3, Page(s) 326–327

    MeSH term(s) Humans ; Hypertension, Pulmonary/diagnostic imaging
    Language English
    Publishing date 2023-07-10
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 269-0
    ISSN 1528-1175 ; 0003-3022
    ISSN (online) 1528-1175
    ISSN 0003-3022
    DOI 10.1097/ALN.0000000000004638
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  2. Article ; Online: Predicting cost of inhalational anesthesia at low fresh gas flows: impact of a new generation carbon dioxide absorbent.

    Moody, Alastair E / Beutler, Bryce D / Moody, Catriona E

    Medical gas research

    2020  Volume 10, Issue 2, Page(s) 64–66

    Abstract: It is well known that low fresh gas flows result in lower cost of inhalational agents. A new generation of carbon dioxide absorbents allows low flow anesthesia with all anesthetics but these new compounds are more expensive. This study examines the cost ... ...

    Abstract It is well known that low fresh gas flows result in lower cost of inhalational agents. A new generation of carbon dioxide absorbents allows low flow anesthesia with all anesthetics but these new compounds are more expensive. This study examines the cost of inhalational anesthesia at different fresh gas flows combined with the cost of absorbent. The cost of sevoflurane and desflurane is lower at low fresh gas flows. Paradoxically the cost of isoflurane is cheaper at 2 L/min than at lower fresh gas flows due to increased cost of carbon dioxide absorbent. Therefore low fresh gas flows should be used when feasible with sevoflurane and desflurane, but higher fresh gas flows up to 2 L/min may be more economical with isoflurane during maintenance phase of anesthesia.
    MeSH term(s) Absorption, Physicochemical ; Anesthetics, Inhalation/chemistry ; Anesthetics, Inhalation/economics ; Carbon Dioxide/chemistry ; Costs and Cost Analysis
    Chemical Substances Anesthetics, Inhalation ; Carbon Dioxide (142M471B3J)
    Language English
    Publishing date 2020-06-15
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2616230-1
    ISSN 2045-9912 ; 2045-9912
    ISSN (online) 2045-9912
    ISSN 2045-9912
    DOI 10.4103/2045-9912.285558
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Anti-N-methyl-D-aspartate receptor-associated encephalitis: A review of clinicopathologic hallmarks and multimodal imaging manifestations.

    Beutler, Bryce David / Moody, Alastair E / Thomas, Jerry Mathew / Sugar, Benjamin Phillip / Ulanja, Mark B / Antwi-Amoabeng, Daniel / Tsikitas, Lucas Anthony

    World journal of radiology

    2024  Volume 16, Issue 1, Page(s) 1–8

    Abstract: Anti-N-methyl-D-aspartate receptor-associated encephalitis (NMDARE) is a rare immune-mediated neuroinflammatory condition characterized by the rapid onset of neuropsychiatric symptoms and autonomic dysfunction. The mechanism of pathogenesis remains ... ...

    Abstract Anti-N-methyl-D-aspartate receptor-associated encephalitis (NMDARE) is a rare immune-mediated neuroinflammatory condition characterized by the rapid onset of neuropsychiatric symptoms and autonomic dysfunction. The mechanism of pathogenesis remains incompletely understood, but is thought to be related to antibodies targeting the GluN1 subunit of the NMDA receptor with resultant downstream dysregulation of dopaminergic pathways. Young adults are most frequently affected; the median age at diagnosis is 21 years. There is a strong female predilection with a female sex predominance of 4:1. NMDARE often develops as a paraneoplastic process and is most commonly associated with ovarian teratoma. However, NMDARE has also been described in patients with small cell lung cancer, clear cell renal carcinoma, and other benign and malignant neoplasms. Diagnosis is based on correlation of the clinical presentation, electroencephalography, laboratory studies, and imaging. Computed tomography, positron emission tomography, and magnetic resonance imaging are essential to identify an underlying tumor, exclude clinicopathologic mimics, and predict the likelihood of long-term functional impairment. Nuclear imaging may be of value for prognostication and to assess the response to therapy. Treatment may involve high-dose corticosteroids, intravenous immunoglobulin, and plasma exchange. Herein, we review the hallmark clinicopathologic features and imaging findings of this rare but potentially devastating condition and summarize diagnostic criteria, treatment regimens, and proposed pathogenetic mechanisms.
    Language English
    Publishing date 2024-01-19
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2573705-3
    ISSN 1949-8470
    ISSN 1949-8470
    DOI 10.4329/wjr.v16.i1.1
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  4. Article ; Online: Fascial plane approach to anesthetizing the radial, median, and ulnar nerves: an educational review.

    Moody, Alastair E / Miller, Sarah T / Tupinio, Maegan R / Newberry, Cynthia M / Mangleson, John / Swenson, Jeffrey D

    Regional anesthesia and pain medicine

    2024  Volume 49, Issue 4, Page(s) 285–288

    Abstract: Brachial plexus block provides effective anesthesia and analgesia for upper extremity surgery but requires injection of large anesthetic volumes near major vascular structures. Moreover, the extensive motor and sensory loss produced by plexus block often ...

    Abstract Brachial plexus block provides effective anesthesia and analgesia for upper extremity surgery but requires injection of large anesthetic volumes near major vascular structures. Moreover, the extensive motor and sensory loss produced by plexus block often exceeds the neural distribution needed for corresponding surgical procedures.High-resolution ultrasound facilitates selective nerve blocks at nearly every level of the upper extremity. We present fascial plane injection techniques for selective radial, median, and ulnar nerve blocks. These techniques can be used to match sensory distribution with specific surgical procedures. They are performed using low anesthetic volumes and without proximity to nerves or vascular structures. In this article, fresh cadaver dissections with corresponding ultrasound images are used to demonstrate stepwise fascial plane techniques for the radial, median, and ulnar nerves. These techniques are performed using familiar anatomic landmarks.Practical applications of these techniques are demonstrated for commonly performed procedures of the upper extremity. Corresponding injection volumes with duration of postoperative analgesia are presented. Selected injections are described for both surgical anesthesia and postoperative analgesia.Selective fascial plane injections can provide surgical anesthesia and postoperative analgesia in settings that might otherwise require much larger volumes of local anesthetic. These selective nerve blocks can match sensory loss with the anatomic pain distribution in each patient. Reliable techniques for selective nerve blocks of the upper extremity can expand the capabilities for ultrasound-guided regional anesthesia.
    MeSH term(s) Humans ; Anesthetics, Local ; Brachial Plexus/diagnostic imaging ; Brachial Plexus Block/methods ; Ulnar Nerve/diagnostic imaging ; Ultrasonography, Interventional/methods ; Upper Extremity/surgery
    Chemical Substances Anesthetics, Local
    Language English
    Publishing date 2024-04-02
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1425299-5
    ISSN 1532-8651 ; 1098-7339 ; 0146-521X
    ISSN (online) 1532-8651
    ISSN 1098-7339 ; 0146-521X
    DOI 10.1136/rapm-2023-104794
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  5. Article: Persistent Left Superior Vena Cava (PLSVC) with a Connection to the Azygos System: Case Report and Clinical Implications.

    Moody, Alastair E / Moody, Catriona E / Beutler, Bryce D / Koci, Micaela M

    Case reports in anesthesiology

    2019  Volume 2019, Page(s) 5390272

    Abstract: Persistent left superior vena cava (PLSVC) is a rare anatomic variant that has a significant effect on the structure of the heart and venous system with clinical implications that are far-reaching. The presence of this variant is relevant to central ... ...

    Abstract Persistent left superior vena cava (PLSVC) is a rare anatomic variant that has a significant effect on the structure of the heart and venous system with clinical implications that are far-reaching. The presence of this variant is relevant to central venous catheter insertion, cardioverter-defibrillator placement, coronary artery bypass grafting, and numerous other medical procedures. In this report, we describe a rare case of PLSVC with a connection to the azygos system; notably, the vast majority of PLSVCs connect to the coronary sinus. We also discuss the anatomic and anesthetic considerations for individuals with this uncommon variant.
    Language English
    Publishing date 2019-08-05
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2659087-6
    ISSN 2090-6390 ; 2090-6382
    ISSN (online) 2090-6390
    ISSN 2090-6382
    DOI 10.1155/2019/5390272
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  6. Article ; Online: Anaesthesia and orphan disease: A patient with neuromyotonia undergoing single lung ventilation.

    Moody, Alastair E / Beutler, Bryce D / Moody, Catriona E / Chang, Carina / Ulanja, Mark B / Gullapalli, Nageshwara / Moody, Eric J

    European journal of anaesthesiology

    2020  Volume 37, Issue 8, Page(s) 731–733

    MeSH term(s) Anesthesia, General/adverse effects ; Anesthesiology ; Humans ; Isaacs Syndrome ; One-Lung Ventilation ; Rare Diseases ; Respiration, Artificial
    Language English
    Publishing date 2020-07-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 605770-6
    ISSN 1365-2346 ; 0265-0215
    ISSN (online) 1365-2346
    ISSN 0265-0215
    DOI 10.1097/EJA.0000000000001233
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  7. Article ; Online: Early-onset pancreatic cancer: a review of molecular mechanisms, management, and survival.

    Ulanja, Mark B / Moody, Alastair E / Beutler, Bryce D / Antwi-Amoabeng, Daniel / Rahman, Ganiyu A / Alese, Olatunji B

    Oncotarget

    2022  Volume 13, Page(s) 828–841

    Abstract: Objectives: Early-onset pancreatic cancer (EOPC) - defined as pancreatic cancer diagnosed before the age of 50 years - is associated with a poor prognosis as compared to later-onset pancreatic cancer (LOPC). Emerging evidence suggests that EOPC may ... ...

    Abstract Objectives: Early-onset pancreatic cancer (EOPC) - defined as pancreatic cancer diagnosed before the age of 50 years - is associated with a poor prognosis as compared to later-onset pancreatic cancer (LOPC). Emerging evidence suggests that EOPC may exhibit a genetic signature and tumor biology that is distinct from that of LOPC. We review genetic mutations that are more prevalent in EOPC relative to LOPC and discuss the potential impact of these mutations on treatment and survival.
    Materials and methods: Using PubMed and Medline, the following terms were searched and relevant citations assessed: "early onset pancreatic cancer," "late onset pancreatic cancer," "pancreatic cancer," "pancreatic cancer genes," and "pancreatic cancer targeted therapy."
    Results: Mutations in
    Conclusions: Genetic mutations associated with EOPC are distinct from those of LOPC. The preponderance of the evidence suggest that poor outcomes in EOPC are related both to advanced stage of presentation and unique tumor biology. The molecular and genetic features of EOPC warrant further investigation in order to optimize management.
    MeSH term(s) Humans ; Middle Aged ; Mutation ; Pancreatic Neoplasms/epidemiology ; Pancreatic Neoplasms/genetics ; Pancreatic Neoplasms/therapy ; Proto-Oncogene Proteins p21(ras)/genetics ; Pancreatic Neoplasms
    Chemical Substances Proto-Oncogene Proteins p21(ras) (EC 3.6.5.2)
    Language English
    Publishing date 2022-06-15
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2560162-3
    ISSN 1949-2553 ; 1949-2553
    ISSN (online) 1949-2553
    ISSN 1949-2553
    DOI 10.18632/oncotarget.28242
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  8. Article ; Online: Cost Savings Opportunities in Perioperative Management of the Patients With Orthopaedic Trauma.

    Moody, Alastair E / Moody, Catriona E / Althausen, Peter L

    Journal of orthopaedic trauma

    2016  Volume 30 Suppl 5, Page(s) S7–S14

    Abstract: Considerable opportunities for cost savings exist surrounding the perioperative management of patients with orthopaedic fracture and trauma. Scientific evidence is available to support each potential cost savings measure. Much of these data had been ... ...

    Abstract Considerable opportunities for cost savings exist surrounding the perioperative management of patients with orthopaedic fracture and trauma. Scientific evidence is available to support each potential cost savings measure. Much of these data had been documented for years but has never been adhered to, resulting in millions of dollars in unnecessary testing and treatment. Careful attention to preoperative laboratory testing can save huge amounts of money and expedite medical clearance for injured patients. The use of a dedicated orthopaedic trauma operating room has been shown to improve resource utilization, decrease costs, and surgical complications. A variety of anesthetic techniques and agents can reduce operative time, recovery room time, and hospital lengths of stay. Strict adherence to blood utilization protocols, appropriate deep venous thrombosis prophylaxis, and multimodal postoperative pain control with oversight from dedicated hip fracture hospitalists is critical to cost containment. Careful attention to postoperative disposition to acute care and management of postoperative testing and radiographs can also be another area of cost containment. Institutional protocols must be created and followed by a team of orthopaedic surgeons, hospitalists, and anesthesiologists to significantly impact the costs associated with care of patient with orthopaedic trauma and fracture.
    MeSH term(s) Cost Savings/economics ; Fractures, Bone/economics ; Fractures, Bone/therapy ; Health Care Costs/statistics & numerical data ; Humans ; Models, Economic ; Orthopedic Procedures/economics ; Perioperative Care/economics ; United States
    Language English
    Publishing date 2016-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639099-7
    ISSN 1531-2291 ; 0890-5339
    ISSN (online) 1531-2291
    ISSN 0890-5339
    DOI 10.1097/BOT.0000000000000716
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  9. Article ; Online: True Cost of Operating Room Time: Implications for an Orthopaedic Trauma Service.

    Moody, Alastair E / Gurnea, Taylor P / Shul, Craig P / Althausen, Peter L

    Journal of orthopaedic trauma

    2019  Volume 34, Issue 5, Page(s) 271–275

    Abstract: Objective: To derive an accurate estimate of the operating cost per minute for an orthopaedic trauma room.: Study design: Retrospective economic analysis.: Setting: Level II Trauma Center.: Intervention: Hospital cost-accounting system query.!## ...

    Abstract Objective: To derive an accurate estimate of the operating cost per minute for an orthopaedic trauma room.
    Study design: Retrospective economic analysis.
    Setting: Level II Trauma Center.
    Intervention: Hospital cost-accounting system query.
    Main outcome measurements: Direct fixed costs, direct variable costs, and hospital overhead.
    Results: Operating room per minute costs include direct variable costs of $2.77, direct fixed costs of $2.47, and hospital overhead costs of $10.97. Total per minute costs amounted to $16.21. This does not include professional fees of anesthesiology or surgeons or the costs of soft goods or implants.
    Conclusions: This is the first published study to document the true per minute cost of an orthopaedic trauma operating room. Such information is valuable when defining the value of a dedicated operating room, negotiating employment contracts, defining call stipends, and brokering capital purchases for the orthopaedic trauma service.
    Level of evidence: Economic Level IV. See Instructions for Authors for a complete description of levels of evidence.
    MeSH term(s) Hospital Costs ; Humans ; Operating Rooms ; Orthopedics ; Retrospective Studies ; Trauma Centers
    Language English
    Publishing date 2019-12-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639099-7
    ISSN 1531-2291 ; 0890-5339
    ISSN (online) 1531-2291
    ISSN 0890-5339
    DOI 10.1097/BOT.0000000000001688
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  10. Article ; Online: Ventilator management in the age of COVID-19: response to "Logistic and organizational aspects of a dedicated intensive care unit for COVID-19 patients".

    Moody, Alastair E / Beutler, Bryce D / Antwi-Amoabeng, Daniel / Lu, Eric X / Willyard, Charles E / Ilyas, Irtqa / Gullapalli, Nageshwara

    Critical care (London, England)

    2020  Volume 24, Issue 1, Page(s) 329

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Intensive Care Units ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2 ; Ventilators, Mechanical
    Keywords covid19
    Language English
    Publishing date 2020-06-11
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2041406-7
    ISSN 1466-609X ; 1364-8535
    ISSN (online) 1466-609X
    ISSN 1364-8535
    DOI 10.1186/s13054-020-03069-0
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