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Article ; Online: Severe Back Pain and Fever in a 9-year-old Boy.

Conforti, Celine / Krueger, Carsten / Branson, Helen M / Manson, David / Morris, Shaun K / Yama, Brie A

2023 Volume 44, Issue 5, Page(s) 286–289

MeSH term(s)	Male ; Humans ; Child ; Back Pain/etiology ; Fever/etiology ; Back
Language	English
Publishing date	2023-04-25
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	774515-1
ISSN	1526-3347 ; 0191-9601
ISSN (online)	1526-3347
ISSN	0191-9601
DOI	10.1542/pir.2021-005170
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Zs.B 2595: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 53: Show issues

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Article ; Online: Travel-acquired paediatric tuberculosis in the Greater Toronto Area, Canada, 2002-2018.

Ali, Mohsin / El Hafid, Melanie / Farrar, Daniel S / Kourdi, Haifa / Rea, Elizabeth / Waters, Valerie / Lam, Ray / Morris, Shaun K / Kitai, Ian

The European respiratory journal

2024 Volume 63, Issue 2

MeSH term(s)	Humans ; Child ; Canada/epidemiology ; Tuberculosis/epidemiology ; Travel
Language	English
Publishing date	2024-02-22
Publishing country	England
Document type	Letter
ZDB-ID	639359-7
ISSN	1399-3003 ; 0903-1936
ISSN (online)	1399-3003
ISSN	0903-1936
DOI	10.1183/13993003.01533-2023
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Zs.A 2322: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 292: Show issues

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Article ; Online: TP53 status and impact on AML prognosis within the ELN 2022 risk classification.

Fleming, Shaun / Tsai, Xavier Cheng-Hong / Morris, Rhiannon / Hou, Hsin-An / Wei, Andrew H

Blood

2023 Volume 142, Issue 23, Page(s) 2029–2033

Abstract: This study reports the following: (1) frequency of TP53 comutation within each component of the European LeukemiaNet 2022 acute myeloid leukemia risk classification, (2) relevance of TP53 mutated variant allelic fraction <10%, (3) prognostic impact of -7, ...

Abstract	This study reports the following: (1) frequency of TP53 comutation within each component of the European LeukemiaNet 2022 acute myeloid leukemia risk classification, (2) relevance of TP53 mutated variant allelic fraction <10%, (3) prognostic impact of -7, -5/del(5q), -17/abn(17p), complex karyotype/monosomal karyotype, or myelodysplasia-related gene mutations with/without mutated TP53.
MeSH term(s)	Humans ; Leukemia, Myeloid, Acute/genetics ; Mutation ; Abnormal Karyotype ; Myelodysplastic Syndromes/genetics ; Prognosis ; Tumor Suppressor Protein p53/genetics
Chemical Substances	Tumor Suppressor Protein p53 ; TP53 protein, human
Language	English
Publishing date	2023-11-30
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80069-7
ISSN	1528-0020 ; 0006-4971
ISSN (online)	1528-0020
ISSN	0006-4971
DOI	10.1182/blood.2023020855
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Uh III Zs.140: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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Article: The role of the measles vaccine for travelling infants 6 to 11 months of age in the era of global outbreaks of disease.

Wong, Waison / Lam, Ray / Morris, Shaun K

Paediatrics & child health

2020 Volume 26, Issue 2, Page(s) 85–87

Language	English
Publishing date	2020-02-04
Publishing country	England
Document type	Journal Article
ZDB-ID	2106767-3
ISSN	1918-1485 ; 1205-7088
ISSN (online)	1918-1485
ISSN	1205-7088
DOI	10.1093/pch/pxaa005
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Article ; Online: Ventilatory management in extremely low birth weight infants

Shaun Morris / Karen Choong

McGill Journal of Medicine, Vol 9, Iss

2020 Volume 2

Abstract: The improvement in survival in premature infants associated with the evolution of mechanical ventilation has been accompanied by an increase in ventilator induced lung injury. High frequency ventilation has been shown to reduce the incidence of ... ...

Abstract	The improvement in survival in premature infants associated with the evolution of mechanical ventilation has been accompanied by an increase in ventilator induced lung injury. High frequency ventilation has been shown to reduce the incidence of ventilator induced lung injury and hence chronic lung disease in the very low birth weight infant. The evolution in understanding how to best use high frequency ventilation in this population has prompted us to ask whether similar strategies to optimize lung volumes on conventional mechanical ventilation can minimize chronic lung disease in the neonate. We retrospectively reviewed the medical charts of 51 extremely low birth weight infants born in Kingston, Ontario in two epochs, 1990 to 1991 and 1999 to 2000, for ventilatory strategy and outcome. From our review, it is clear that surfactant therapy rapidly changes lung mechanics by improving pulmonary compliance and that lung damage may result if there are not changes in the ventilatory management to reflect the altered compliance. Early ventilation strategies during the apparently stable "honeymoon period" in a patient with respiratory distress syndrome (RDS) has significant implications on long term morbidity. In the era prior to the use of surfactant, 30% of infants died and 40% developed chronic lung disease (CLD). Immediately following the use of surfactant, mortality was reduced to 18%, however, the incidence of CLD increased to 78%. In the most recent era, following 10 years of experience with surfactant and mechanical ventilation, morbidity was 17% and CLD 21%. This study demonstrates that a particularly crucial time is in the immediate period following surfactant administration. The use of lower peak inspiratory pressure (PIP) and mean airway pressure (MAP) over the first 24 hours and an increase in the use of synchronous intermittent mandatory ventilation (SIMV) was associated with an improved outcome. The challenge remaining is to determine how to best utilize a conventional mode of ventilation to best ...
Keywords	Ventilation ; Premature infants ; Medicine ; R
Subject code	610
Language	English
Publishing date	2020-12-01T00:00:00Z
Publisher	McGill University
Document type	Article ; Online
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Article ; Online: Precarity Before and During the Pandemic: International Student Employment and Personal Finances in Australia.

Hastings, Catherine / Ramia, Gaby / Wilson, Shaun / Mitchell, Emma / Morris, Alan

Journal of studies in international education

2022 Volume 27, Issue 1, Page(s) 39–63

Abstract: There is mounting evidence of increased international student financial and work precarity over the last decade in Australia. Yet, there has been a little scholarly analysis of which students are most affected by precarity and its sources. Drawing on two ...

Abstract	There is mounting evidence of increased international student financial and work precarity over the last decade in Australia. Yet, there has been a little scholarly analysis of which students are most affected by precarity and its sources. Drawing on two surveys of international students in Australia's two largest cities, conducted before and during the pandemic, we investigate the financial and work vulnerabilities of international students. We demonstrate that vulnerability is related to characteristics which describe particular cohorts of students: being from low-income countries, working class families, seeking a low-level qualification, enrolled in a non-university institution, and being without a scholarship. The concepts of "noncitizenship" and "work precarity" are used to explain how the mechanisms of each characteristic heighten vulnerability, thereby contributing to a broader evidence-base about the causality of international student precarity.
Language	English
Publishing date	2022-01-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	2075289-1
ISSN	1552-7808 ; 1028-3153
ISSN (online)	1552-7808
ISSN	1028-3153
DOI	10.1177/10283153211065136
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Article ; Online: Clinical prediction models in children that use repeated measurements with time-varying covariates: a scoping review.

Fung, Alastair / Loutet, Miranda / Roth, Daniel E / Wong, Elliott / Gill, Peter J / Morris, Shaun K / Beyene, Joseph

Academic pediatrics

2024

Abstract: Background: Emerging evidence suggests that clinical prediction models that use repeated (time-varying) measurements within each patient may have higher predictive accuracy than models that use patient information from a single measurement.: Objective! ...

Abstract	Background: Emerging evidence suggests that clinical prediction models that use repeated (time-varying) measurements within each patient may have higher predictive accuracy than models that use patient information from a single measurement. Objective: To determine the breadth of the published literature reporting the development of clinical prediction models in children that use time-varying predictors. Data sources: MEDLINE, EMBASE and Cochrane databases. Eligibility criteria: We included studies reporting the development of a multivariable clinical prediction model in children, with or without validation, to predict a repeatedly measured binary or time-to-event outcome and utilizing at least one repeatedly measured predictor. Synthesis methods: We categorized included studies by the method used to model time-varying predictors. Results: Of 99 clinical prediction model studies that had a repeated measurements data structure, only 27 (27%) used methods that incorporated the repeated measurements as time-varying predictors in a single model. Among these 27 time-varying prediction model studies, we grouped model types into nine categories: time-dependent Cox regression, generalized estimating equations, random effects model, landmark model, joint model, neural network, K-nearest neighbor, support vector machine and tree-based algorithms. Where there was comparison of time-varying models to single measurement models, using time-varying predictors improved predictive accuracy. Conclusions: Various methods have been used to develop time-varying prediction models in children, but there is a paucity of pediatric time-varying models in the literature. Incorporating time-varying covariates in pediatric prediction models may improve predictive accuracy. Future research in pediatric prediction model development should further investigate whether incorporation of time-varying covariates improves predictive accuracy. What this scoping review adds: Of 99 clinical prediction model studies that had a repeated measurements data structure, only 27% used analytical methods that incorporated time-varying covariates. Future research in pediatric prediction model development should further investigate whether incorporation of time-varying covariates improves predictive accuracy. How to use this scoping review: We summarized methods used to develop pediatric clinical prediction models that incorporate repeated measurements with time-varying covariates. Researchers may use the findings of this review to identify appropriate analytical methods for developing a time-varying prediction model in pediatric care.
Language	English
Publishing date	2024-03-30
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2483385-X
ISSN	1876-2867 ; 1876-2859
ISSN (online)	1876-2867
ISSN	1876-2859
DOI	10.1016/j.acap.2024.03.016
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Article ; Online: Impact of intrapartum antibiotics on the infant gastrointestinal microbiome: a narrative review.

Diamond, Laura / Wine, Rachel / Morris, Shaun K

Archives of disease in childhood

2021 Volume 107, Issue 7, Page(s) 627–634

Abstract: Background: The composition of the infant gastrointestinal (GI) microbiome has been linked to adverse long-term health outcomes and neonatal sepsis. Several factors are known to impact the composition of the microbiome, including mode of delivery, ... ...

Abstract	Background: The composition of the infant gastrointestinal (GI) microbiome has been linked to adverse long-term health outcomes and neonatal sepsis. Several factors are known to impact the composition of the microbiome, including mode of delivery, gestational age, feeding method and exposure to antibiotics. The impact of intrapartum antibiotics (IPAs) on the infant microbiome requires further research. Objective: We aimed to evaluate the impact of IPAs on the infant GI microbiome. Methods: We searched Ovid MEDLINE and Embase Classic+Embase for articles in English reporting on the microbiome of infants exposed to IPAs from the date of inception to 3 January 2021. Primary outcomes included abundance and colonisation of Results: 30 papers were included in this review. In the first year of life, following exposure to IPAs, 30% (6/20) of infant cohorts displayed significantly reduced Conclusions: IPAs impact the composition of the infant GI microbiome, resulting in possible reductions
MeSH term(s)	Anti-Bacterial Agents/adverse effects ; Gastrointestinal Microbiome ; Gestational Age ; Humans ; Infant ; Infant, Newborn ; Probiotics
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2021-10-29
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	524-1
ISSN	1468-2044 ; 0003-9888 ; 1359-2998
ISSN (online)	1468-2044
ISSN	0003-9888 ; 1359-2998
DOI	10.1136/archdischild-2021-322590
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Article ; Online: Area-based determinants of outreach vaccination for reaching vulnerable populations: A cross-sectional study in Pakistan.

Chen, Xiaoting / Porter, Allan / Abdur Rehman, Nabeel / Morris, Shaun K / Saif, Umar / Chunara, Rumi

PLOS global public health

2023 Volume 3, Issue 9, Page(s) e0001703

Abstract: The objective of this study is to gain a comparative understanding of spatial determinants for outreach and clinic vaccination, which is critical for operationalizing efforts and breaking down structural biases; particularly relevant in countries where ... ...

Abstract	The objective of this study is to gain a comparative understanding of spatial determinants for outreach and clinic vaccination, which is critical for operationalizing efforts and breaking down structural biases; particularly relevant in countries where resources are low, and sub-region variance is high. Leveraging a massive effort to digitize public system reporting by Lady and Community Health Workers (CHWs) with geo-located data on over 4 million public-sector vaccinations from September 2017 through 2019, understanding health service operations in relation to vulnerable spatial determinants were made feasible. Location and type of vaccinations (clinic or outreach) were compared to regional spatial attributes where they were performed. Important spatial attributes were assessed using three modeling approaches (ridge regression, gradient boosting, and a generalized additive model). Consistent predictors for outreach, clinic, and proportion of third dose pentavalent vaccinations by region were identified. Of all Penta-3 vaccination records, 86.3% were performed by outreach efforts. At the tehsil level (fourth-order administrative unit), controlling for child population, population density, proportion of population in urban areas, distance to cities, average maternal education, and other relevant factors, increased poverty was significantly associated with more in-clinic vaccinations (β = 0.077), and lower proportion of outreach vaccinations by region (β = -0.083). Analyses at the union council level (fifth-administrative unit) showed consistent results for the differential importance of poverty for outreach versus clinic vaccination. Relevant predictors for each type of vaccination (outreach vs. in-clinic) show how design of outreach vaccination can effectively augment vaccination efforts beyond healthcare services through clinics. As Pakistan is third among countries with the most unvaccinated and under-vaccinated children, understanding barriers and factors associated with vaccination can be demonstrative for other national and sub-national regions facing challenges and also inform guidelines on supporting CHWs in health systems.
Language	English
Publishing date	2023-09-27
Publishing country	United States
Document type	Journal Article
ISSN	2767-3375
ISSN (online)	2767-3375
DOI	10.1371/journal.pgph.0001703
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Article ; Online: A narrative review of vaccine pharmacovigilance during mass vaccination campaigns: Focus on myocarditis and pericarditis after COVID-19 mRNA vaccination.

Piché-Renaud, Pierre-Philippe / Morris, Shaun K / Top, Karina A

British journal of clinical pharmacology

2022 Volume 89, Issue 3, Page(s) 967–981

Abstract: Vaccines have had a tremendous impact on reducing the burden of infectious diseases; however, they have the potential to cause adverse events following immunization (AEFIs). Prelicensure clinical trials are limited in their ability to detect rare AEFIs ... ...

Abstract	Vaccines have had a tremendous impact on reducing the burden of infectious diseases; however, they have the potential to cause adverse events following immunization (AEFIs). Prelicensure clinical trials are limited in their ability to detect rare AEFIs that may occur in less than one per thousand individuals. While postmarketing surveillance systems have shown COVID-19 mRNA vaccines to be safe, they led to the identification of rare cases of myocarditis and pericarditis after COVID-19 vaccination that were not initially detected in clinical trials. In this narrative review, we highlight concepts of vaccine pharmacovigilance during mass vaccination campaigns and compare the approaches used in the context of myocarditis and pericarditis following COVID-19 vaccination to historical examples. We describe mechanisms of passive and active surveillance, their strengths and limitations, and how they interacted to identify and characterize the safety signal of myocarditis and pericarditis after COVID-19 mRNA vaccination. Articles were synthesized from a PubMed search using relevant keywords for articles published on vaccine surveillance systems and myocarditis and pericarditis after COVID-19 vaccination, as well as the authors' collections of relevant publications and grey literature reports. The global experience around the identification and monitoring of myocarditis and pericarditis after COVID-19 mRNA vaccination has provided important lessons for vaccine safety surveillance and highlighted its importance in maintaining public trust in mass vaccination programmes in a pandemic context.
MeSH term(s)	Humans ; COVID-19/prevention & control ; COVID-19 Vaccines/adverse effects ; Mass Vaccination/adverse effects ; Myocarditis/chemically induced ; Myocarditis/epidemiology ; Pericarditis/epidemiology ; Pericarditis/etiology ; Pharmacovigilance ; RNA, Messenger ; Vaccination ; Vaccines
Chemical Substances	COVID-19 Vaccines ; RNA, Messenger ; Vaccines
Language	English
Publishing date	2022-12-26
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	188974-6
ISSN	1365-2125 ; 0306-5251 ; 0264-3774
ISSN (online)	1365-2125
ISSN	0306-5251 ; 0264-3774
DOI	10.1111/bcp.15625
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