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  1. Book: Chondrocytes

    Haqqi, Tariq M. / Lefebvre, Véronique

    methods and protocols

    (Methods in molecular biology ; 2245 ; Springer protocols)

    2021  

    Author's details edited by Tariq M. Haqqi, Véronique Lefebvre
    Series title Methods in molecular biology ; 2245
    Springer protocols
    Collection
    Language English
    Size xiii, 229 Seiten, Illustrationen, Diagramme
    Publisher Humana Press
    Publishing place New York, NY
    Publishing country United States
    Document type Book
    HBZ-ID HT020685753
    ISBN 978-1-0716-1118-0 ; 9781071611197 ; 1-0716-1118-6 ; 1071611194
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 7042 -2245- verfügbar in Königswinter Königswinter

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  2. Article ; Online: SOXC are critical regulators of adult bone mass.

    Angelozzi, Marco / Karvande, Anirudha / Lefebvre, Véronique

    Nature communications

    2024  Volume 15, Issue 1, Page(s) 2956

    Abstract: Pivotal in many ways for human health, the control of adult bone mass is governed by complex, incompletely understood crosstalk namely between mesenchymal stem cells, osteoblasts and osteoclasts. The SOX4, SOX11 and SOX12 (SOXC) transcription factors ... ...

    Abstract Pivotal in many ways for human health, the control of adult bone mass is governed by complex, incompletely understood crosstalk namely between mesenchymal stem cells, osteoblasts and osteoclasts. The SOX4, SOX11 and SOX12 (SOXC) transcription factors were previously shown to control many developmental processes, including skeletogenesis, and SOX4 was linked to osteoporosis, but how SOXC control adult bone mass remains unknown. Using SOXC loss- and gain-of-function mouse models, we show here that SOXC redundantly promote prepubertal cortical bone mass strengthening whereas only SOX4 mitigates adult trabecular bone mass accrual in early adulthood and subsequent maintenance. SOX4 favors bone resorption over formation by lowering osteoblastogenesis and increasing osteoclastogenesis. Single-cell transcriptomics reveals its prevalent expression in Lepr
    MeSH term(s) Mice ; Animals ; Humans ; Adult ; Mesenchymal Stem Cells/metabolism ; SOXC Transcription Factors/genetics ; SOXC Transcription Factors/metabolism
    Chemical Substances SOXC Transcription Factors ; SOX4 protein, human ; SOX12 protein, human
    Language English
    Publishing date 2024-04-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-024-47413-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Roles and regulation of SOX transcription factors in skeletogenesis.

    Lefebvre, Véronique

    Current topics in developmental biology

    2019  Volume 133, Page(s) 171–193

    Abstract: SOX transcription factors participate in the specification, differentiation and activities of many cell types in development and beyond. The 20 mammalian family members are distributed into eight groups based on sequence identity, and while co-expressed ... ...

    Abstract SOX transcription factors participate in the specification, differentiation and activities of many cell types in development and beyond. The 20 mammalian family members are distributed into eight groups based on sequence identity, and while co-expressed same-group proteins often have redundant functions, different-group proteins typically have distinct functions. More than a handful of SOX proteins have pivotal roles in skeletogenesis. Heterozygous mutations in their genes cause human diseases, in which skeletal dysmorphism is a major feature, such as campomelic dysplasia (SOX9), or a minor feature, such as LAMSHF syndrome (SOX5) and Coffin-Siris-like syndromes (SOX4 and SOX11). Loss- and gain-of-function experiments in animal models have revealed that SOX4 and SOX11 (SOXC group) promote skeletal progenitor survival and control skeleton patterning and growth; SOX8 (SOXE group) delays the differentiation of osteoblast progenitors; SOX9 (SOXE group) is essential for chondrocyte fate maintenance and differentiation, and works in cooperation with SOX5 and SOX6 (SOXD group) and other types of transcription factors. These and other SOX proteins have also been proposed, mainly through in vitro experiments, to have key roles in other aspects of skeletogenesis, such as SOX2 in osteoblast stem cell self-renewal. We here review current knowledge of well-established and proposed skeletogenic roles of SOX proteins, their transcriptional and non-transcriptional actions, and their modes of regulation at the gene, RNA and protein levels. We also discuss gaps in knowledge and directions for future research to further decipher mechanisms underlying skeletogenesis in health and diseases and identify treatment options for skeletal malformation and degeneration diseases.
    MeSH term(s) Animals ; Bone and Bones/pathology ; Chondrogenesis/genetics ; Gene Expression Regulation, Developmental ; Humans ; Mutation/genetics ; Osteogenesis/genetics ; SOX Transcription Factors/genetics ; SOX Transcription Factors/metabolism
    Chemical Substances SOX Transcription Factors
    Language English
    Publishing date 2019-02-26
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ISSN 1557-8933 ; 0070-2153
    ISSN (online) 1557-8933
    ISSN 0070-2153
    DOI 10.1016/bs.ctdb.2019.01.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Editorial for the special issue on Cartilage Biology and Pathology.

    Lefebvre, Véronique

    Seminars in cell & developmental biology

    2017  Volume 62, Page(s) 1–2

    MeSH term(s) Cartilage/metabolism ; Cartilage/pathology ; Humans
    Language English
    Publishing date 2017-02-03
    Publishing country England
    Document type Editorial
    ZDB-ID 1312473-0
    ISSN 1096-3634 ; 1084-9521
    ISSN (online) 1096-3634
    ISSN 1084-9521
    DOI 10.1016/j.semcdb.2017.01.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2918: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
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  5. Article: En bloc resection of pararectal ectopic thyroid tissue: a case report.

    Charbonneau, Janyssa / Lefebvre, Véronique / Bouchard, Philippe

    Journal of surgical case reports

    2023  Volume 2023, Issue 9, Page(s) rjad515

    Abstract: A pararectal mass' specific diagnosis can be challenging as a broad range of both benign and malignant tumors are possible. Many of these lesions are congenital and do not require treatment, if asymptomatic. Special attention is to be paid when imaging ... ...

    Abstract A pararectal mass' specific diagnosis can be challenging as a broad range of both benign and malignant tumors are possible. Many of these lesions are congenital and do not require treatment, if asymptomatic. Special attention is to be paid when imaging findings are not typical. In such cases, definitive diagnostic can require surgical excision. To this day, ectopic thyroid tissue was not part of known differential diagnosis. This is the first reported case of thyroid adenoma found in the perirectal area. Ectopic thyroid gland can progress over time and include malignant transformation, although rare. It needs to be considered when managing these cases, especially in unusual locations. This case report offers a systematic approach to the atypical pararectal tumor. It shares new specific clinical experience in managing a case  of pararectal ectopic thyroid adenoma, from both a surgical and a histopathological point of view.
    Language English
    Publishing date 2023-09-30
    Publishing country England
    Document type Case Reports
    ZDB-ID 2580919-2
    ISSN 2042-8812
    ISSN 2042-8812
    DOI 10.1093/jscr/rjad515
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  6. Article ; Online: Isolation of Mouse Growth Plate and Articular Chondrocytes for Primary Cultures.

    Haseeb, Abdul / Lefebvre, Véronique

    Methods in molecular biology (Clifton, N.J.)

    2020  Volume 2245, Page(s) 39–51

    Abstract: Cartilage is a connective tissue presenting in several forms that are all essential components of the vertebrate skeleton. Complementing in vivo models, cultures of its resident cells-chondrocytes-are important experimental models in mechanistic and ... ...

    Abstract Cartilage is a connective tissue presenting in several forms that are all essential components of the vertebrate skeleton. Complementing in vivo models, cultures of its resident cells-chondrocytes-are important experimental models in mechanistic and preclinical studies relevant to skeletal development and adult homeostasis and to such human pathologies as chondrodysplasias and osteoarthritis. Both growth plate and articular chondrocytes produce pancartilaginous extracellular matrix components, but the two cell subtypes also have distinct phenotypic properties that account for different structural features, functions, and fates of their tissues. Based on study goals, primary chondrocyte cultures should therefore be established from either growth plate or articular cartilage. Here, we describe the methods used in our laboratory to isolate and culture growth plate and articular chondrocytes from neonatal and adult mice, respectively. Both methods involve manual and enzymatic procedures to clean cartilage samples from contaminating tissues and to release chondrocytes as single-cell suspensions from their cartilage matrix.
    MeSH term(s) Animals ; Biomarkers ; Cartilage, Articular/cytology ; Cartilage, Articular/metabolism ; Cell Separation/methods ; Cells, Cultured ; Chondrocytes/cytology ; Chondrocytes/metabolism ; Extracellular Matrix/metabolism ; Growth Plate/cytology ; Growth Plate/metabolism ; Immunohistochemistry ; Mice ; Primary Cell Culture
    Chemical Substances Biomarkers
    Language English
    Publishing date 2020-12-14
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-1119-7_4
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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  7. Article ; Online: Skeletal growth is enhanced by a shared role for SOX8 and SOX9 in promoting reserve chondrocyte commitment to columnar proliferation.

    Molin, Arnaud N / Contentin, Romain / Angelozzi, Marco / Karvande, Anirudha / Kc, Ranjan / Haseeb, Abdul / Voskamp, Chantal / de Charleroy, Charles / Lefebvre, Véronique

    Proceedings of the National Academy of Sciences of the United States of America

    2024  Volume 121, Issue 8, Page(s) e2316969121

    Abstract: SOX8 was linked in a genome-wide association study to human height heritability, but roles in chondrocytes for this close relative of the master chondrogenic transcription factor SOX9 remain unknown. We undertook here to fill this knowledge gap. High- ... ...

    Abstract SOX8 was linked in a genome-wide association study to human height heritability, but roles in chondrocytes for this close relative of the master chondrogenic transcription factor SOX9 remain unknown. We undertook here to fill this knowledge gap. High-throughput assays demonstrate expression of human
    MeSH term(s) Mice ; Humans ; Animals ; Chondrocytes/metabolism ; Genome-Wide Association Study ; SOX9 Transcription Factor/genetics ; SOX9 Transcription Factor/metabolism ; Gene Expression Regulation ; Cell Differentiation ; Cell Proliferation ; SOXE Transcription Factors/genetics ; SOXE Transcription Factors/metabolism
    Chemical Substances SOX9 Transcription Factor ; SOX8 protein, human ; SOXE Transcription Factors ; SOX9 protein, human
    Language English
    Publishing date 2024-02-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2316969121
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1148: Show issues Location:
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  8. Article ; Online: Phytophthora capsici

    Szadkowski, Emmanuel / Lagnel, Jacques / Touhami, Nasradin / Sayeh, Amalia / Lopez-Roques, Céline / Bouchez, Olivier / Lefebvre, Véronique

    Microbiology resource announcements

    2023  Volume 12, Issue 12, Page(s) e0019623

    Abstract: ... The ... ...

    Abstract The oomycete
    Language English
    Publishing date 2023-11-10
    Publishing country United States
    Document type Journal Article
    ISSN 2576-098X
    ISSN (online) 2576-098X
    DOI 10.1128/MRA.00196-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: L'infirmière de l'Education nationale, acteur de prévention et d'education en santé publique.

    Lefebvre, Véronique

    Soins; la revue de reference infirmiere

    2014  Volume Spec No, Page(s) 1S12

    Title translation The nurse and health education, a player in prevention and public health.
    MeSH term(s) Adolescent ; Contraceptives, Oral, Hormonal ; Drug Prescriptions ; Female ; Humans ; Nurse's Role ; Nurse-Patient Relations ; Patient Education as Topic ; Practice Patterns, Nurses' ; Public Health
    Chemical Substances Contraceptives, Oral, Hormonal
    Language French
    Publishing date 2014-06
    Publishing country France
    Document type Journal Article
    ZDB-ID 604655-1
    ISSN 0038-0814
    ISSN 0038-0814
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: L'infirmière de l'Education nationale, acteur de prévention et d'education en santé publique.

    Lefebvre, Véronique

    Revue de l'infirmiere

    2014  Volume Spec No, Page(s) 1S12

    Title translation National education nurse, actor for prevention and education on public health.
    MeSH term(s) Adolescent ; Adolescent Health Services/manpower ; Contraceptives, Oral ; Drug Prescriptions/nursing ; Humans ; Nurse's Role ; Patient Education as Topic/manpower ; Public Health/education ; Sex Education/manpower ; Sexuality
    Chemical Substances Contraceptives, Oral
    Language French
    Publishing date 2014-06
    Publishing country France
    Document type Journal Article ; Personal Narratives
    ZDB-ID 632538-5
    ISSN 1293-8505 ; 0397-7900
    ISSN 1293-8505 ; 0397-7900
    Database MEDical Literature Analysis and Retrieval System OnLINE

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