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  1. Article ; Online: Successful valganciclovir treatment initiated beyond 60 days of age in a preterm infant with congenital cytomegalovirus disease.

    Okahashi, Aya / Hijikata, Midori / Seimiya, Ayako / Nagano, Nobuhiko / Yokota, Harumasa / Kimura, Yusuke / Morioka, Ichiro

    Pediatrics international : official journal of the Japan Pediatric Society

    2024  Volume 66, Issue 1, Page(s) e15755

    MeSH term(s) Infant ; Infant, Newborn ; Humans ; Valganciclovir/therapeutic use ; Cytomegalovirus ; Infant, Premature ; Cytomegalovirus Infections/diagnosis ; Cytomegalovirus Infections/drug therapy ; Cytomegalovirus Infections/congenital ; Antiviral Agents/therapeutic use ; Infant, Newborn, Diseases ; Hearing Loss, Sensorineural
    Chemical Substances Valganciclovir (GCU97FKN3R) ; Antiviral Agents
    Language English
    Publishing date 2024-04-02
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 1470376-2
    ISSN 1442-200X ; 1328-8067
    ISSN (online) 1442-200X
    ISSN 1328-8067
    DOI 10.1111/ped.15755
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  2. Article ; Online: Distal femoral epiphyseal ossification center absence in congenital syphilis: A case series.

    Aoki, Ryoji / Nagano, Nobuhiko / Hijikata, Midori / Seimiya, Ayako / Morioka, Ichiro

    Pediatrics international : official journal of the Japan Pediatric Society

    2022  Volume 64, Issue 1, Page(s) e15234

    MeSH term(s) Femur/diagnostic imaging ; Humans ; Osteogenesis ; Syphilis ; Syphilis, Congenital/diagnosis
    Language English
    Publishing date 2022-08-06
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 1470376-2
    ISSN 1442-200X ; 1328-8067
    ISSN (online) 1442-200X
    ISSN 1328-8067
    DOI 10.1111/ped.15234
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  3. Article ; Online: Low-tone hearing impairment in a newborn with congenital cytomegalovirus infection.

    Okahashi, Aya / Hijikata, Midori / Kimura, Yusuke / Nagano, Nobuhiko / Morioka, Ichiro

    Pediatrics international : official journal of the Japan Pediatric Society

    2022  Volume 64, Issue 1, Page(s) e15218

    MeSH term(s) Auditory Perceptual Disorders/diagnosis ; Auditory Perceptual Disorders/etiology ; Cytomegalovirus Infections/complications ; Cytomegalovirus Infections/congenital ; Cytomegalovirus Infections/diagnosis ; Hearing Loss/diagnosis ; Hearing Loss/etiology ; Humans ; Infant, Newborn
    Language English
    Publishing date 2022-07-05
    Publishing country Australia
    Document type Case Reports ; Journal Article
    ZDB-ID 1470376-2
    ISSN 1442-200X ; 1328-8067
    ISSN (online) 1442-200X
    ISSN 1328-8067
    DOI 10.1111/ped.15218
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  4. Article ; Online: Fluctuations in unbound bilirubin levels during acetaminophen therapy for patent ductus arteriosus.

    Nagano, Nobuhiko / Katayama, Daichi / Imaizumi, Takayuki / Hijikata, Midori / Okahashi, Aya / Tsuji, Yasuhiro / Morioka, Ichiro

    Pediatrics international : official journal of the Japan Pediatric Society

    2022  Volume 65, Issue 1, Page(s) e15434

    MeSH term(s) Infant, Newborn ; Humans ; Acetaminophen ; Ductus Arteriosus, Patent ; Infant, Premature ; Persistent Fetal Circulation Syndrome ; Bilirubin
    Chemical Substances Acetaminophen (362O9ITL9D) ; Bilirubin (RFM9X3LJ49)
    Language English
    Publishing date 2022-12-07
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 1470376-2
    ISSN 1442-200X ; 1328-8067
    ISSN (online) 1442-200X
    ISSN 1328-8067
    DOI 10.1111/ped.15434
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  5. Article ; Online: Vertical Transmission of Severe Acute Respiratory Syndrome Coronavirus 2 From the Mother to the Infant.

    Hijikata, Midori / Okahashi, Aya / Morioka, Ichiro

    JAMA pediatrics

    2020  Volume 174, Issue 10, Page(s) 1006–1007

    MeSH term(s) Betacoronavirus ; COVID-19 ; China ; Coronavirus Infections ; Female ; Humans ; Infant ; Infant, Newborn ; Infectious Disease Transmission, Vertical ; Mothers ; Pandemics ; Pneumonia, Viral ; SARS Virus ; SARS-CoV-2 ; Severe Acute Respiratory Syndrome
    Keywords covid19
    Language English
    Publishing date 2020-07-20
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2701223-2
    ISSN 2168-6211 ; 2168-6203
    ISSN (online) 2168-6211
    ISSN 2168-6203
    DOI 10.1001/jamapediatrics.2020.2147
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  6. Article ; Online: Clinical characteristics of congenital toxoplasmosis with poor outcome in Japan: A nationwide survey and literature review.

    Hijikata, Midori / Okahashi, Aya / Nagano, Nobuhiko / Morioka, Ichiro

    Congenital anomalies

    2020  Volume 60, Issue 6, Page(s) 194–198

    Abstract: The clinical characteristics of congenital toxoplasmosis cases with poor outcomes in Japan were analyzed. Ten cases were selected, identified from a nationwide survey by the Japan Society for Neonatal Health and Development and a literature review. Based ...

    Abstract The clinical characteristics of congenital toxoplasmosis cases with poor outcomes in Japan were analyzed. Ten cases were selected, identified from a nationwide survey by the Japan Society for Neonatal Health and Development and a literature review. Based on outcomes, two fatal cases showed generalized symptoms at birth; four cases with neurological sequelae showed the three main congenital toxoplasmosis manifestations (chorioretinitis, intracranial calcification, hydrocephalus); four cases with ophthalmological sequelae showed only one or two of the three main manifestations. Eight cases with poor outcomes were not prenatally diagnosed with congenital toxoplasma infection or suspected maternal toxoplasma infection. The outcome of congenital toxoplasmosis might differ depending on the symptomology.
    MeSH term(s) Humans ; Infant, Newborn ; Japan/epidemiology ; Phenotype ; Public Health Surveillance ; Symptom Assessment ; Toxoplasma/immunology ; Toxoplasmosis, Congenital/diagnosis ; Toxoplasmosis, Congenital/epidemiology ; Toxoplasmosis, Congenital/parasitology
    Language English
    Publishing date 2020-08-07
    Publishing country Australia
    Document type Journal Article ; Meta-Analysis ; Review
    ZDB-ID 228664-6
    ISSN 1741-4520 ; 0037-2285 ; 0914-3505
    ISSN (online) 1741-4520
    ISSN 0037-2285 ; 0914-3505
    DOI 10.1111/cga.12385
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  8. Article: Procalcitonin-Based Antibiotic Use for Neonatal Early-Onset Bacterial Infections: Pre- and Post-Intervention Clinical Study.

    Go, Hidetoshi / Nagano, Nobuhiko / Sato, Yuki / Katayama, Daichi / Hara, Koichiro / Akimoto, Takuya / Imaizumi, Takayuki / Aoki, Ryoji / Hijikata, Midori / Seimiya, Ayako / Okahashi, Aya / Morioka, Ichiro

    Antibiotics (Basel, Switzerland)

    2023  Volume 12, Issue 9

    Abstract: We previously reported the 95th percentile cutoff value of the serum procalcitonin (PCT) reference curve for diagnosing early-onset bacterial infection. We aimed to verify the effectivity of these novel diagnostic criteria by comparing antibiotic use and ...

    Abstract We previously reported the 95th percentile cutoff value of the serum procalcitonin (PCT) reference curve for diagnosing early-onset bacterial infection. We aimed to verify the effectivity of these novel diagnostic criteria by comparing antibiotic use and incidence of early-onset bacterial infection between pre- and post-introduction periods. We included newborns admitted to our neonatal intensive care unit who underwent blood tests within 72 h after birth between 2018 and 2022. The neonates were divided into the pre-intervention (admitted before the introduction,
    Language English
    Publishing date 2023-09-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics12091426
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  9. Article: Correction: Go et al. Diagnostic Accuracy of Biomarkers for Early-Onset Neonatal Bacterial Infections: Evaluation of Serum Procalcitonin Reference Curves.

    Go, Hidetoshi / Nagano, Nobuhiko / Katayama, Daichi / Akimoto, Takuya / Imaizumi, Takayuki / Aoki, Ryoji / Hijikata, Midori / Seimiya, Ayako / Kato, Ryota / Okahashi, Aya / Morioka, Ichiro

    Diagnostics (Basel, Switzerland)

    2022  Volume 12, Issue 10

    Abstract: In the original publication [ ... ]. ...

    Abstract In the original publication [...].
    Language English
    Publishing date 2022-09-21
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics12102277
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  10. Article ; Online: Association of umbilical cord insulin-like growth factor 1 levels with severe retinopathy in extremely preterm infants.

    Nagano, Nobuhiko / Katayama, Daichi / Hara, Koichiro / Akimoto, Takuya / Imaizumi, Takayuki / Seimiya, Ayako / Aoki, Ryoji / Hijikata, Midori / Fuwa, Kazumasa / Okahashi, Aya / Morioka, Ichiro

    Pediatrics and neonatology

    2022  Volume 64, Issue 2, Page(s) 126–132

    Abstract: Background: The association between umbilical cord blood insulin-like growth factor 1 (IGF-1) levels and retinopathy of prematurity (ROP) remains unclear. This study aimed to investigate whether umbilical cord blood IGF-1 levels can predict the ... ...

    Abstract Background: The association between umbilical cord blood insulin-like growth factor 1 (IGF-1) levels and retinopathy of prematurity (ROP) remains unclear. This study aimed to investigate whether umbilical cord blood IGF-1 levels can predict the development of severe ROP in extremely preterm infants.
    Methods: This hospital-based retrospective cohort study included infants born at <37 weeks gestational age (GA) between 2019 and 2021 and then classified them into the two GA groups: extremely preterm, <28 weeks and preterm infants, 28-36 weeks. Extremely preterm infants were further subclassified into two groups according to the laser treatment as follows: the severe ROP (ROP-Tx) and ROP (No ROP-Tx) groups. Median umbilical cord blood IGF-1 values were compared between the groups. Perinatal risk factors were identified by univariate and multivariate analyses. Finally, umbilical cord IGF-1 cut-off values requiring ROP treatment with laser were determined by receiver operating characteristic (ROC) curve analyses.
    Results: A total of 205 infants were enrolled, with 32 being extremely preterm (ROP-Tx: n = 11; No ROP-Tx: n = 21) and 173 being preterm. IGF-1 levels were significantly lower in extremely preterm (13.5 ng/mL) than preterm infants (36 ng/mL, p < 0.001). In extremely preterm infants, IGF-1 levels were significantly lower in the ROP-Tx group than the No ROP-Tx group (10 vs. 19 ng/mL, respectively, p = 0.024). Only GA, umbilical cord blood IGF-1 levels, birth head circumference, and birth chest circumference were identified as risk factors by univariate analysis (p < 0.05). Multivariate analysis showed that only umbilical cord blood IGF-1 was an independent risk factor (odds ratio: 1.26, p = 0.021). ROC curves revealed an IGF-1 cut-off value of 14 ng/mL.
    Conclusion: The need of laser treatment for ROP was found to be associated with low umbilical cord blood IGF-1 levels in extremely preterm infants. Umbilical cord blood IGF-1 can be used as a biomarker for the risk of developing severe ROP.
    MeSH term(s) Infant ; Infant, Newborn ; Humans ; Infant, Extremely Premature ; Insulin-Like Growth Factor I/analysis ; Retrospective Studies ; Gestational Age ; Retinopathy of Prematurity/diagnosis ; Risk Factors
    Chemical Substances Insulin-Like Growth Factor I (67763-96-6)
    Language English
    Publishing date 2022-09-17
    Publishing country Singapore
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2441816-X
    ISSN 2212-1692 ; 1875-9572
    ISSN (online) 2212-1692
    ISSN 1875-9572
    DOI 10.1016/j.pedneo.2022.05.015
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