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Article: Nakaseomyces glabrata

Jim, Kin Ki / Daems, Joelle J N / Boekholdt, S Matthijs / van Dijk, Karin

2023 Volume 40, Page(s) 54–57

Abstract: ... ...

Abstract	Candida
Language	English
Publishing date	2023-04-28
Publishing country	Netherlands
Document type	Case Reports
ZDB-ID	2670415-8
ISSN	2211-7539
ISSN	2211-7539
DOI	10.1016/j.mmcr.2023.04.002
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Lipoprotein(a) and progression of aortic valve calcification: a case of collider bias? Reply.

Kaiser, Yannick / Labrecque, Jeremy / Stroes, Erik S G / Boekholdt, S Matthijs / Bos, Daniel

European heart journal

2023 Volume 44, Issue 7, Page(s) 626

MeSH term(s)	Humans ; Aortic Valve/diagnostic imaging ; Lipoprotein(a) ; Aortic Valve Stenosis/surgery ; Aortic Valve Stenosis/complications ; Calcinosis/diagnostic imaging ; Calcinosis/complications
Chemical Substances	Lipoprotein(a)
Language	English
Publishing date	2023-01-05
Publishing country	England
Document type	Journal Article ; Comment
ZDB-ID	603098-1
ISSN	1522-9645 ; 0195-668X
ISSN (online)	1522-9645
ISSN	0195-668X
DOI	10.1093/eurheartj/ehac742
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Zs.A 1563: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Response to: Correspondence on "Lipoprotein(a) has no major impact on calcification activity in patients with mild to moderate aortic valve stenosis" by Pantelidis et al.

Kaiser, Yannick / Nurmohamed, Nick S / Stroes, Erik S G / Boekholdt, S Matthijs

Heart (British Cardiac Society)

2022 Volume 108, Issue 7, Page(s) 576–577

MeSH term(s)	Aortic Valve Stenosis/surgery ; Calcinosis/diagnostic imaging ; Humans ; Lipoprotein(a)
Chemical Substances	Lipoprotein(a)
Language	English
Publishing date	2022-01-27
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	1303417-0
ISSN	1468-201X ; 1355-6037
ISSN (online)	1468-201X
ISSN	1355-6037
DOI	10.1136/heartjnl-2021-320644
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Zs.MO 112: Show issues

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Article ; Online: Nakaseomyces glabrata endocarditis

Kin Ki Jim / Joelle J.N. Daems / S. Matthijs Boekholdt / Karin van Dijk

Medical Mycology Case Reports, Vol 40, Iss , Pp 54-

A therapeutic dilemma

2023 Volume 57

Abstract: Candida infective endocarditis is a rare but serious entity that often requires aggressive treatment. However, treatment can be challenging in patients infected with drug-resistant fungi and/or with substantial comorbidity. Moreover, recommendations in ... ...

Abstract	Candida infective endocarditis is a rare but serious entity that often requires aggressive treatment. However, treatment can be challenging in patients infected with drug-resistant fungi and/or with substantial comorbidity. Moreover, recommendations in treatment guidelines for these patients are based on limited clinical data due to their rarity. Here we report a case of Nakaseomyces glabrata (Candida glabrata) prosthetic valve endocarditis in a patient with congenital heart disease. This case illustrates a therapeutic dilemma for Nakaseomyces glabrata prosthetic valve endocarditis and the need for novel antifungal drugs and further clinical studies.
Keywords	Nakaseomyces glabrata ; Candida glabrata ; Endocarditis ; Invasive candidiasis ; Anti-fungal therapy ; Medicine (General) ; R5-920 ; Biology (General) ; QH301-705.5
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: An Evidence-Based Guide to Cholesterol-Lowering Guidelines.

Waters, David D / Boekholdt, S Matthijs

The Canadian journal of cardiology

2017 Volume 33, Issue 3, Page(s) 343–349

Abstract: Since 2014, guidelines for the management of lipid disorders to reduce cardiovascular (CV) events have been updated in the United States, the United Kingdom, Europe, and Canada. Some of these guidelines are almost entirely evidence-based whereas others ... ...

Abstract	Since 2014, guidelines for the management of lipid disorders to reduce cardiovascular (CV) events have been updated in the United States, the United Kingdom, Europe, and Canada. Some of these guidelines are almost entirely evidence-based whereas others are a mix of evidence and expert opinion. Guidelines differ on such simple questions as to whether blood samples should be fasting or nonfasting, and whether low-density lipoprotein cholesterol (LDL-C) or another lipid parameter should be the primary focus of treatment. Different risk assessment tools are recommended by different guidelines. Lifetime risk is highlighted in some guidelines, with the suggestion that earlier treatment will reduce lifetime risk in younger people even when short-term risk is low. Some guidelines have numerical treatment targets that differ according to level of risk, while others eschew targets but recommend statins at high or moderate intensity to reduce LDL-C by ≥ 50% or 30%-50%, respectively. Statins are the backbone of therapy in all guidelines. Ezetimibe produced a 6.4% relative risk reduction in the only large clinical outcomes trial in which it was tested, and is recommended for high-risk patients with an inadequate response to statins, despite the high number needed to treat to prevent 1 CV event. Proprotein convertase subtilisin/kexin 9 inhibitors lack outcome data to support their use, but are approved for patients with familial hypercholesterolemia or clinical atherosclerotic CV disease who require additional LDL-C lowering beyond statins. All these new guidelines are aimed at improving the problem of undertreatment of high-risk groups, leading to better outcomes for these patients.
MeSH term(s)	Anticholesteremic Agents/therapeutic use ; Cholesterol/blood ; Evidence-Based Medicine ; Humans ; Hypercholesterolemia/blood ; Hypercholesterolemia/drug therapy ; Practice Guidelines as Topic
Chemical Substances	Anticholesteremic Agents ; Cholesterol (97C5T2UQ7J)
Language	English
Publishing date	2017-03
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	632813-1
ISSN	1916-7075 ; 0828-282X
ISSN (online)	1916-7075
ISSN	0828-282X
DOI	10.1016/j.cjca.2016.10.019
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Article ; Online: Pre-participation screenings frequently miss occult cardiovascular conditions in apparently healthy male middle-aged first-time marathon runners.

Laily, Inarota / Wiggers, Tom G H / van Steijn, Niels / Bijsterveld, Nick / Bakermans, Adrianus J / Froeling, Martijn / van den Berg-Faay, Sandra / de Haan, Ferdinand H / de Bruin-Bon, Rianne H A C M / Boekholdt, S Matthijs / Planken, R Nils / Verhagen, Evert / Jorstad, Harald T

Cardiology

2024

Abstract: Introduction: The optimal pre-participation screening strategy to identify athletes at risk for exercise-induced cardiovascular events is unknown. We therefore aimed to compare the American College of Sports Medicine (ACSM) and European Society of ... ...

Abstract	Introduction: The optimal pre-participation screening strategy to identify athletes at risk for exercise-induced cardiovascular events is unknown. We therefore aimed to compare the American College of Sports Medicine (ACSM) and European Society of Cardiology (ESC) pre-participation screening strategies against extensive cardiovascular evaluations in identifying high-risk individuals among 35-50-year-old apparently healthy men. Methods: We applied ACSM and ESC pre-participation screenings to 25 men participating in a study on first-time marathon running. We compared screening outcomes against medical history, physical examination, electrocardiography, blood tests, echocardiography, cardiopulmonary exercise testing, and magnetic resonance imaging. Results: ACSM screening classified all participants as 'medical clearance not necessary'. ESC screening classified two participants as 'high-risk'. Extensive cardiovascular evaluations revealed ≥1 minor abnormality and/or cardiovascular condition in 17 participants, including three subjects with mitral regurgitation and one with a small atrial septal defect. Eleven participants had dyslipidaemia, six had hypertension, and two had premature atherosclerosis. Ultimately, three (12%) subjects had a serious cardiovascular condition warranting sports restrictions: aortic aneurysm, hypertrophic cardiomyopathy (HCM), and myocardial fibrosis post-myocarditis. Of these three participants, only one had been identified as 'high-risk' by the ESC screening (for dyslipidaemia, not HCM) and none by the ACSM screening. Conclusion: Numerous occult cardiovascular conditions are missed when applying current ACSM/ESC screening strategies to apparently healthy middle-aged men engaging in their first high-intensity endurance sports event.
Language	English
Publishing date	2024-02-07
Publishing country	Switzerland
Document type	News
ZDB-ID	80092-2
ISSN	1421-9751 ; 0008-6312
ISSN (online)	1421-9751
ISSN	0008-6312
DOI	10.1159/000536553
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Article ; Online: Long-term cardiac follow-up of athletes infected with SARS-CoV-2 after resumption of elite-level sports.

van Hattum, Juliette C / Daems, Joëlle J N / Verwijs, Sjoerd M / Wismans, Leonoor V / van Diepen, Maarten A / Groenink, Maarten / Boekholdt, S Matthijs / Planken, R Nils / van Randen, Adrienne / Hirsch, Alexander / Moen, Maarten H / Pinto, Yigal M / Wilde, Arthur A M / Jørstad, Harald T

Heart (British Cardiac Society)

2024 Volume 110, Issue 4, Page(s) 254–262

Abstract: Objective: Longitudinal consequences and potential interactions of COVID-19 and elite-level sports and exercise are unclear. Therefore, we determined the long-term detrimental cardiac effects of the interaction between SARS-CoV-2 infection and the ... ...

Abstract	Objective: Longitudinal consequences and potential interactions of COVID-19 and elite-level sports and exercise are unclear. Therefore, we determined the long-term detrimental cardiac effects of the interaction between SARS-CoV-2 infection and the highest level of sports and exercise. Methods: This prospective controlled study included elite athletes from the Evaluation of Lifetime participation in Intensive Top-level sports and Exercise cohort. Athletes infected with SARS-CoV-2were offered structured, additional cardiovascular screenings, including cardiovascular MRI (CMR). We compared ventricular volumes and function, late gadolinium enhancement (LGE) and T1 relaxation times, between infected and non-infected elite athletes, and collected follow-up data on cardiac adverse events, ventricular arrhythmia burden and the cessation of sports careers. Results: We included 259 elite athletes (mean age 26±5 years; 40% women), of whom 123 were infected (9% cardiovascular symptoms) and 136 were controls. We found no differences in function and volumetric CMR parameters. Four infected athletes (3%) demonstrated LGE (one reversible), compared with none of the controls. During the 26.7 (±5.8) months follow-up, all four athletes resumed elite-level sports, without an increase in ventricular arrhythmias or adverse cardiac remodelling. None of the infected athletes reported new cardiac symptoms or events. The majority (n=118; 96%) still participated in elite-level sports; no sports careers were terminated due to SARS-CoV-2. Conclusions: This prospective study demonstrates the safety of resuming elite-level sports after SARS-CoV-2 infection. The medium-term risks associated with SARS-CoV-2 infection and elite-level sports appear low, as the resumption of elite sports did not lead to detrimental cardiac effects or increases in clinical events, even in the four elite athletes with SARS-CoV-2 associated myocardial involvement.
MeSH term(s)	Humans ; Female ; Young Adult ; Adult ; Male ; SARS-CoV-2 ; Prospective Studies ; Follow-Up Studies ; Contrast Media ; COVID-19/epidemiology ; Gadolinium ; Athletes ; Arrhythmias, Cardiac/epidemiology ; Arrhythmias, Cardiac/etiology
Chemical Substances	Contrast Media ; Gadolinium (AU0V1LM3JT)
Language	English
Publishing date	2024-01-29
Publishing country	England
Document type	Journal Article
ZDB-ID	1303417-0
ISSN	1468-201X ; 1355-6037
ISSN (online)	1468-201X
ISSN	1355-6037
DOI	10.1136/heartjnl-2023-323058
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Article: Leisure time physical activity is associated with improved diastolic heart function and is partly mediated by unsupervised quantified metabolic health.

Klarenberg, Hugo / van der Velde, Jeroen Hpm / Peeters, Carel Fw / Dekkers, Ilona A / de Mutsert, R / Jukema, J Wouter / Rosendaal, Frits R / Leiner, Tim / Froeling, Martijn / Jorstad, Harald / Boekholdt, S Matthijs / Strijkers, Gustav J / Lamb, Hildo J

BMJ open sport & exercise medicine

2024 Volume 10, Issue 1, Page(s) e001778

Abstract: Objectives: To investigate the association between leisure time physical activity (LTPA) and MRI-based diastolic function and the mediating role of metabolic health.: Methods: This cross-sectional analysis comprised 901 participants (46% women, mean ... ...

Abstract	Objectives: To investigate the association between leisure time physical activity (LTPA) and MRI-based diastolic function and the mediating role of metabolic health. Methods: This cross-sectional analysis comprised 901 participants (46% women, mean age (SD): 56 (6) years (The Netherlands, 2008-2012)). LTPA was assessed via questionnaire, quantified in metabolic equivalent of tasks (METs)-minutes per week and participants underwent abdominal and cardiovascular MRI. Confirmatory factor analysis was used to construct the metabolic load factor. Piecewise structural equation model with adjustments for confounders was used to determine associations between LTPA and diastolic function and the mediating effect of metabolic load. Results: Significant differences in mitral early/late peak filling rate (E/A) ratio per SD of LTPA (men=1999, women=1870 MET-min/week) of 0.18, (95% CI= 0.03 to 0.33, p=0.021) were observed in men, but not in women: -0.01 (-0.01 to 0.34, p=0.058). Difference in deceleration time of mitral early filling (E-DT) was 0.13 (0.01 to 0.24, p=0.030) in men and 0.17 (0.05 to 0.28, p=0.005) in women. Metabolic load, including MRI-based visceral and subcutaneous adipose tissue, fasting glucose, high-density lipoprotein cholesterol and triglycerides, mediated these associations as follows: E/A-ratio of 0.030 (0.000 to 0.067, 19% mediated, p=0.047) in men but not in women: 0.058 (0.027 to 0.089, p<0.001) and E-DT not in men 0.004 (-0.012 to 0.021, p=0.602) but did in women 0.044 (0.013 to 0.057, 27% mediated, p=0.006). Conclusions: A larger amount of LTPA was associated with improved diastolic function where confirmatory factor analysis-based metabolic load partly mediated this effect. Future studies should assess whether improving indicators of metabolic load alongside LTPA will benefit healthy diastolic function even more.
Language	English
Publishing date	2024-02-06
Publishing country	England
Document type	Journal Article
ZDB-ID	2817580-3
ISSN	2055-7647
ISSN	2055-7647
DOI	10.1136/bmjsem-2023-001778
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Article: Standardizing the Cardiac Radioablation Targeting Workflow: Enabling Semi-Automated Angulation and Segmentation of the Heart According to the American Heart Association Segmented Model.

van der Ree, Martijn H / Visser, Jorrit / Planken, R Nils / Dieleman, Edith M T / Boekholdt, S Matthijs / Balgobind, Brian V / Postema, Pieter G

Advances in radiation oncology

2022 Volume 7, Issue 4, Page(s) 100928

Abstract: Purpose: Cardiac radioablation has evolved as a potential treatment modality for therapy-refractory ventricular tachycardia. To standardize cardiac radioablation treatments, promote accurate communication and target identification, and to assess ... ...

Abstract	Purpose: Cardiac radioablation has evolved as a potential treatment modality for therapy-refractory ventricular tachycardia. To standardize cardiac radioablation treatments, promote accurate communication and target identification, and to assess toxicity, robust, and reproducible methods for angulation and cardiac segmentation are paramount. In this study, we developed and evaluated a tool for semiautomated angulation and segmentation according to the American Heart Association 17-segment model. Methods and materials: The semiautomated angulation and segmentation of the planning-computed tomography (CT) was based on an in-house developed tool requiring placement of only 4 point-markers and a rotation matrix. For angulation, 2 markers defining the cardiac long-axis were placed: at the cardiac apex and at the center of the mitral valve. A rotation matrix was derived that angulates the CT volume, resulting in the cardiac short axis. Segmentation was subsequently performed based on marking the 2 left ventricular hinge points. To evaluate reproducibility, 5 observers independently placed markers in planning CTs of 6 patients. Results: The root mean square of the standard deviation for the angulation and segmentation marker positions were ≤0.5 cm. The 17 segments were subsequently generated and compared between the observers resulting in a median Dice coefficient of 0.8 (interquartile range: 0.70-0.87) and a median of the mean Hausdorff distance of 0.09 cm (interquartile range: 0.05-0.17). The interquartile ranges of Euler angles α and β, determined by the angulation markers, was less than 3 degrees for all patients except one. For the γ angle, determined by the hinge point markers, the interquartile range was up to 12 degrees. Conclusions: In this study a method for semiautomatic angulation and segmentation of the heart for cardiac radioablation according to the American Heart Association Segmented Model is presented and evaluated. Based on our results we believe that the segmentation is reproducible and that it can be used to promote communication between radiation oncology and cardiology, enables cardiology-oriented targeting and permits focused toxicity evaluations.
Language	English
Publishing date	2022-03-01
Publishing country	United States
Document type	Journal Article
ISSN	2452-1094
ISSN	2452-1094
DOI	10.1016/j.adro.2022.100928
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Article ; Online: Coronary Artery Disease Affects Symptomatology of Aortic Valve Stenosis.

Boekholdt, S Matthijs / Arsenault, Benoit J / Mathieu, Patrick

Journal of the American College of Cardiology

2017 Volume 70, Issue 8, Page(s) 1103–1104

MeSH term(s)	Aortic Valve Stenosis ; Cardiovascular Diseases ; Coronary Artery Disease ; Humans ; Risk Factors
Language	English
Publishing date	2017-08-17
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	605507-2
ISSN	1558-3597 ; 0735-1097
ISSN (online)	1558-3597
ISSN	0735-1097
DOI	10.1016/j.jacc.2017.04.072
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