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  1. Article ; Online: Design Considerations for Pharmacokinetic Studies During Pregnancy.

    Stika, Catherine S / Hebert, Mary F

    Journal of clinical pharmacology

    2023  Volume 63 Suppl 1, Page(s) S126–S136

    Abstract: Most of the interventions performed by obstetric providers involve the administration of drugs. Pregnant patients are pharmacologically and physiologically different from nonpregnant young adults. Therefore, dosages that are effective and safe for the ... ...

    Abstract Most of the interventions performed by obstetric providers involve the administration of drugs. Pregnant patients are pharmacologically and physiologically different from nonpregnant young adults. Therefore, dosages that are effective and safe for the general public may be inadequate or unsafe for the pregnant patient and her fetus. Establishing dosing regimens appropriate for pregnancy requires evidence generated from pharmacokinetic studies performed in pregnant people. However, performing these studies during pregnancy often requires special design considerations, evaluations of both maternal and fetal exposures, and recognition that pregnancy is a dynamic process that changes as gestational age advances. In this article, we address design challenges unique to pregnancy and discuss options for investigators, including timing of drug sampling during pregnancy, appropriate selection of control groups, pros and cons of dedicated and nested pharmacokinetic studies, single-dose and multiple-dose analyses, dose selection strategies, and the importance of integrating pharmacodynamic changes into these protocols. Examples of completed pharmacokinetic studies in pregnancy are provided for illustration.
    MeSH term(s) Humans ; Female ; Pregnancy ; Young Adult ; Fetus ; Gestational Age ; Research Personnel
    Language English
    Publishing date 2023-06-14
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 188980-1
    ISSN 1552-4604 ; 0091-2700 ; 0021-9754
    ISSN (online) 1552-4604
    ISSN 0091-2700 ; 0021-9754
    DOI 10.1002/jcph.2238
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  2. Article ; Online: Erratum to "The challenge of defining women at low-risk for childbirth: analysis of peripartum severe acute maternal morbidity in women considered at low-risk according to French guidelines." [Journal of Gynecology Obstetrics and Human Reproduction 52 (2023) 102551].

    Chantry, Anne Alice / Peretout, Pauline / Chiesa-Dubruille, Coralie / Crenn-Hébert, Catherine / Vendittelli, Françoise / Ray, Camille Le / Deneux-Tharaux, Catherine

    Journal of gynecology obstetrics and human reproduction

    2024  Volume 53, Issue 4, Page(s) 102755

    Language English
    Publishing date 2024-03-02
    Publishing country France
    Document type Published Erratum
    ISSN 2468-7847
    ISSN (online) 2468-7847
    DOI 10.1016/j.jogoh.2024.102755
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  3. Article ; Online: Author Correction: Alexithymia as a mediator of the associations between child maltreatment and internalizing and externalizing behaviors in adolescence.

    Hamel, Catherine / Rodrigue, Christopher / Clermont, Camille / Hébert, Martine / Paquette, Linda / Dion, Jacinthe

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 8786

    Language English
    Publishing date 2024-04-16
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-59645-9
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  4. Article: A New Genus and Species of Gall-Forming Fordini (Hemiptera: Aphididae) on

    Hébert, Catherine / Xu, Xin / Yang, Zixiang / Favret, Colin

    Insects

    2022  Volume 13, Issue 12

    Abstract: A new species of gall-forming aphid from China, ...

    Abstract A new species of gall-forming aphid from China,
    Language English
    Publishing date 2022-11-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662247-6
    ISSN 2075-4450
    ISSN 2075-4450
    DOI 10.3390/insects13121104
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  5. Article ; Online: Alexithymia as a mediator of the associations between child maltreatment and internalizing and externalizing behaviors in adolescence.

    Hamel, Catherine / Rodrigue, Christopher / Clermont, Camille / Hébert, Martine / Paquette, Linda / Dion, Jacinthe

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 6359

    Abstract: Child maltreatment is a global concern that profoundly affects individuals throughout their lives. This study investigated the relationships between various forms of child maltreatment and behavior problems involving internalization and externalization ... ...

    Abstract Child maltreatment is a global concern that profoundly affects individuals throughout their lives. This study investigated the relationships between various forms of child maltreatment and behavior problems involving internalization and externalization during adolescence. Data obtained from a diverse sample of 1802 Canadians aged 14-18 years was used to examine the mediating role of alexithymia-a difficulty in recognizing and expressing emotions-in these associations. Results indicated that adolescents who experienced sexual abuse, emotional abuse, and exposure to intimate partner violence (IPV) in their childhood exhibited higher levels of alexithymia, which was correlated with elevated levels of both internalizing and externalizing problems. Physical abuse and parental neglect were only associated with externalizing problems. Gender differences also emerged, with gender-diverse adolescents reporting a higher prevalence of maltreatment, alexithymia, and behavior problems compared with their peers. However, alexithymia's mediating role was consistent across genders. Overall, this study highlights the intricate relationships between child maltreatment, alexithymia, and adolescent behavior problems. The findings of this study how different forms of child maltreatment significantly shape behavioral outcomes and indicate the importance of interventions in enhancing emotional awareness and expression in adolescents with a childhood history of maltreatment.
    MeSH term(s) Child ; Humans ; Adolescent ; Male ; Female ; Affective Symptoms/epidemiology ; Affective Symptoms/psychology ; Canada ; Child Abuse/psychology ; Physical Abuse/psychology ; North American People
    Language English
    Publishing date 2024-03-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-56909-2
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  6. Article ; Online: The challenge of defining women at low-risk for childbirth: analysis of peripartum severe acute maternal morbidity in women considered at low-risk according to French guidelines.

    Chantry, Anne Alice / Peretout, Pauline / Chiesa-Dubruille, Coralie / Crenn-Hébert, Catherine / Vendittelli, Françoise / LeRay, Camille / Deneux-Tharaux, Catherine

    Journal of gynecology obstetrics and human reproduction

    2023  Volume 52, Issue 4, Page(s) 102551

    MeSH term(s) Pregnancy ; Female ; Humans ; Peripartum Period ; Parturition ; Delivery, Obstetric ; Risk
    Language English
    Publishing date 2023-02-12
    Publishing country France
    Document type Journal Article
    ISSN 2468-7847
    ISSN (online) 2468-7847
    DOI 10.1016/j.jogoh.2023.102551
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  7. Article ; Online: Evidence-Based Practice in Perianesthesia Nursing: Application of the American Geriatrics Society Clinical Practice Guideline for Postoperative Delirium in Older Adults.

    Hebert, Catherine

    Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses

    2017  Volume 33, Issue 3, Page(s) 253–264

    Abstract: Delirium is a pervasive and dangerous syndrome for older adults in the perianesthesia setting, occurring in up to 60% of surgical cases. The American Geriatrics Society performed a systematic review to develop recommendations for the prevention and ... ...

    Abstract Delirium is a pervasive and dangerous syndrome for older adults in the perianesthesia setting, occurring in up to 60% of surgical cases. The American Geriatrics Society performed a systematic review to develop recommendations for the prevention and management of postoperative delirium in older adults. The recommendations emphasize nonpharmacologic interventions with a strong focus on reducing the use of psychoactive medication. Perianesthesia nurses can serve as leaders in translating these recommendations into evidence-based practice at the bedside for older adults.
    MeSH term(s) Aged ; Delirium/etiology ; Delirium/prevention & control ; Delirium/therapy ; Evidence-Based Nursing ; Humans ; Perioperative Nursing ; Postoperative Complications ; Practice Guidelines as Topic ; Risk Factors ; United States
    Language English
    Publishing date 2017-04-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1329844-6
    ISSN 1532-8473 ; 0883-9433 ; 1089-9472
    ISSN (online) 1532-8473
    ISSN 0883-9433 ; 1089-9472
    DOI 10.1016/j.jopan.2016.02.011
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    Zs.A 2458: Show issues Location:
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  8. Article ; Online: The Living Planet Index's ability to capture biodiversity change from uncertain data.

    Hébert, Katherine / Gravel, Dominique

    Ecology

    2023  Volume 104, Issue 6, Page(s) e4044

    Abstract: The Living Planet Index (LPI) is a crucial tool to track global biodiversity change, but necessarily sacrifices information to summarize thousands of population trends into a single communicable index. Evaluating when and how this information loss ... ...

    Abstract The Living Planet Index (LPI) is a crucial tool to track global biodiversity change, but necessarily sacrifices information to summarize thousands of population trends into a single communicable index. Evaluating when and how this information loss affects the LPI's performance is essential to ensure interpretations of the index reflect the truth as reliably as possible. Here, we evaluated the ability of the LPI to accurately and precisely capture trends of population change from uncertain data. We derived a mathematical analysis of uncertainty propagation in the LPI to track how measurement and process uncertainty may bias estimates of population growth rate trends, and to measure the overall uncertainty of the LPI. We demonstrated the propagation of uncertainty using simulated scenarios of declining, stable, or growing populations fluctuating independently, synchronously, or asynchronously, to assess the bias and uncertainty of the LPI in each scenario. We found that measurement and process uncertainty consistently pull the index below the expected true trend. Importantly, variability in the raw data scales up to draw the index further below the expected trend and to amplify its uncertainty, particularly when populations are small. These findings echo suggestions that a more complete assessment of the variability in population change trends, with particular attention to covarying populations, would enrich the LPI's already critical influence on conservation communication and decisions.
    MeSH term(s) Uncertainty ; Planets ; Conservation of Natural Resources ; Biodiversity ; Population Growth
    Language English
    Publishing date 2023-04-11
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2010140-5
    ISSN 1939-9170 ; 0012-9658
    ISSN (online) 1939-9170
    ISSN 0012-9658
    DOI 10.1002/ecy.4044
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  9. Article ; Online: Socio-ecological predictors of dietary inflammatory scores and associations with childhood and adolescent adiposity: A protocol for a rapid scoping review of observational studies.

    Vingrys, Kristina / McCarthy, Helen / Segurado, Ricardo / Hébert, James R / Phillips, Catherine M

    PloS one

    2023  Volume 18, Issue 5, Page(s) e0286200

    Abstract: Introduction: Diet-related inflammation is associated with adiposity. Obesity and inflammation in early life may have adverse health outcomes in later life; however, the socio-ecological predictors of a pro-inflammatory diet in childhood and adolescence ...

    Abstract Introduction: Diet-related inflammation is associated with adiposity. Obesity and inflammation in early life may have adverse health outcomes in later life; however, the socio-ecological predictors of a pro-inflammatory diet in childhood and adolescence are not well understood. This rapid scoping review aims to summarise the current state of research from observational studies investigating socio-ecological predictors (childhood, parental, familial, demographic and chronobiological risk factors) and their association with diet-associated inflammation and adiposity in children and adolescents.
    Methods: This scoping review will be conducted using the frameworks based on the Joanna Briggs Institute and Arksey and O'Malley and the Population, Concept and Context (PCC) mnemonic. Searches were conducted in OVID Medline, Cinahl and Embase, with adaptations as required. The piloted study selection process will utilise two reviewers for study selection, with reference lists checked for included studies. A third reviewer will moderate disagreements. Data will be extracted by one reviewer and calibrated by a second reviewer.
    Results: The results will be reported using the Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) checklist and PRISMA-ScR flow diagram. The main findings will be synthesised into themes and concepts narratively. Tables and graphs will present frequencies, study details and categorical descriptions.
    Discussion: This scoping review will provide an overview of the research conducted to date regarding predictors of diet-related inflammation in childhood and their associations with adiposity. Better understanding of the factors associated with a more inflammatory diet in childhood may be useful for clinicians and policy makers when designing and implementing health interventions.
    MeSH term(s) Child ; Adolescent ; Humans ; Adiposity ; Obesity ; Diet ; Risk Factors ; Inflammation ; Research Design ; Systematic Reviews as Topic ; Review Literature as Topic
    Language English
    Publishing date 2023-05-25
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0286200
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  10. Article ; Online: Conditioned pain modulation, kinesiophobia, and pain catastrophizing as prognostic factors for chronicity in a population with acute low back pain: An exploratory prospective study.

    Meilleur-Durand, Melody / Dubé, Marc-Olivier / Hébert, Luc J / Mercier, Catherine / Léonard, Guillaume / Roy, Jean-Sébastien

    Musculoskeletal science & practice

    2024  Volume 70, Page(s) 102920

    Abstract: Background: Psychosocial factors and alteration of the somatosensory functions have been associated with persistent low back pain (LBP). A decreased capacity of the central nervous system to modulate pain has been suggested as a potential contributor to ...

    Abstract Background: Psychosocial factors and alteration of the somatosensory functions have been associated with persistent low back pain (LBP). A decreased capacity of the central nervous system to modulate pain has been suggested as a potential contributor to the persistence of pain.
    Objective: To investigate whether conditioned pain modulation (CPM), initial symptoms/disability, kinesiophobia, and pain catastrophizing is associated with the transition from acute to chronic LBP.
    Design: Prospective cohort study.
    Method: Fifty participants presenting with acute LBP (<6 weeks) took part in three evaluation sessions (baseline, 3 and 6 months). At baseline and 3-month evaluations, all participants completed self-administered questionnaires (Oswestry Disability Index [ODI], Short Form of Brief Pain Inventory [BPI-SF], Tampa Scale of Kinesiophobia [TSK] and Pain Catastrophizing Scale [PCS]) and CPM was assessed. At the 6-month evaluation, questionnaires were readministered, and participants were dichotomized according to their status (Non-chronic LBP [NCLBP] or chronic LBP [CLBP]). Univariate tests were used to compare baseline variables between NCLBP and CLBP.
    Results: No significant baseline difference was found for TSK (p = 0.48), PCS (p = 0.78), CPM (p = 0.82), ODI (p = 0.78), BPI-SF severity (p = 0.50), and interference subscales (p = 0.54) between those categorized as NCLBP or CLBP at 6 months.
    Conclusions: This exploratory study failed to support the hypothesis that inefficient CPM mechanisms and the presence of psychological factors could be factors associated with the transition to chronic pain in individuals with acute LBP.
    MeSH term(s) Humans ; Prospective Studies ; Kinesiophobia ; Low Back Pain/psychology ; Prognosis ; Catastrophization/psychology
    Language English
    Publishing date 2024-02-06
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2888772-4
    ISSN 2468-7812
    ISSN (online) 2468-7812
    DOI 10.1016/j.msksp.2024.102920
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